Download or read book Microfluidic Synthesis and Properties of Bio inspired Colloids written by Harry Zijian An and published by . This book was released on 2014 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, custom-tailored polymeric hydrogel microparticles are routinely used for drug delivery, medical diagnostics, as well as many fundamental studies in colloidal science. There is growing consensus that physical attributes, such as size, shape, internal structure, and mechanical deformability, of the particles can influence material performance, especially when they are placed into a biological setting. Over the past two decades, a host of particle fabrication techniques have been proposed, which are able to produce microgels with various physical properties, though maintaining independent control over them remains to be difficult. This thesis explores the synthesis of a new class of functional microparticles bearing the likeness of mammalian cells through the use of a new microfluidics-based lithography process, and demonstrates the utility of these biomimetic microparticles in novel biomedical applications. First, we devise a microscope projection technique based on stop-flow lithography (SFL), which allows free-standing microparticles of any arbitrary 2D-extruded, mask-defined shape to be patterned down to the cellular size regime (>/= 10 [mu]m) from UV-crosslinkable oligomer formulations in a semi-continuous fashion. By modulating the degree of oxygen inhibition during synthesis, we achieve previously unattainable particle sizes. Brownian diffusion of colloidal discs in bulk suggests the out-of-plane dimension can be as small as 0.8 [mu]m, which agrees with confocal microscopy measurements. We measure the hindered diffusion of microdiscs near a solid interface and compared our results to theoretical predictions. These biocompatible colloidal particles can also flow through physiological microvascular networks formed by endothelial cells undergoing vasculogensis under minimal hydrostatic pressure. Second, inspired by the hierarchical structure of eukaryotic cells, we synthesize composite microparticles containing a homogenous distribution of hydrophobic compartments from crosslinkable silicone oil-in-water nanoemulsions. The nanoemulsion loadings achieved in our composite microgels have, to our knowledge, among the highest ever demonstrated in a hydrogel material. In addition, we perform proof-of-concept assays to show several orthogonal motifs, such as tunable hydrophobic anchoring at the oil/water interface and matrix degradation at high pH, by which both hydrophobic and hydrophilic compounds, including small molecules, proteins and the nanoemulsion droplets themselves, can be effectively encapsulated in and released from the resulting microparticles over a wide range of timescales. And last, we fabricate red blood cell-mimicking, oxygen-carrying composite microparticles from perfluorocalin-in-water nanoemulsions. Unlike silicone oil nanoemulsions, the PFD-based formulations require osmotic stabilization due to a finite solubility of oil in the aqueous continuous phase. The presence of perfluorocarbon oil droplets increases the solubility and diffusivity of oxygen in the prepolymer solution, thereby enhancing the rate of O2 inhibition during microparticle synthesis. We develop a simple model that successfully predicts the augmented O2 mass transport, which agrees well with experimental data. Encapsulating nanodroplets in the hydrogel network allows us to generate and preserve small droplets under nearly surfactant-free conditions via quick washing steps post-synthesis.

Download or read book Microfluidic Synthesis Characterization and Applications of Bioinspired Deformable Microparticles written by Lynna Chen and published by . This book was released on 2018 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric microparticles have a wide variety of uses, ranging from traditional applications in paints and coatings, to specialized applications in medical therapeutics and diagnostics. For biological applications - including drug delivery, analytical assays, and tissue engineering - it is important to tailor the interactions between the microparticles and their external environment. To do this, it is necessary to precisely control the physical and chemical properties of the engineered microparticles. Recently, it has become apparent that in addition to particle chemistry, the physical properties of a particle - for example, size, shape, internal structure, and mechanical deformability - play an important role in determining particle behaviour in biological environments. However, it remains largely unknown exactly how these various physical properties influence particle behaviour and function, and how these properties should be exploited for different applications. This thesis focuses on the development and characterization of polymeric hydrogel microparticles with well-controlled physical and chemical properties, and shows several applications of these custom microparticles. In particular, we explore particle motifs inspired by biological entities, designing particles with different shapes, internal structure, and mechanical deformability, functionalized with proteins and nucleic acids. We employ microfluidic tools for synthesis and characterization of these hydrogel microparticles, and also investigate the interaction of functionalized particles with nucleic acids and cells, in the context of biomolecule detection and specific cell capture, respectively. Based on the microfluidic particle synthesis technique, stop flow lithography, we fabricate custom particles - including non-spherical 3D capsules and 2D extruded cylindrical rings with systematically varied internal architecture. We design microfluidic channels to study the flow and deformation of these particles, investigating the effects of internal structure, size, and stiffness on passage through microfluidic constrictions. We expand on this work, designing a microfluidic platform to specifically position particles in hydrodynamic traps, based on particle physical properties. This platform enables subsequent encapsulation of immobilized particles in monodisperse, isolated aqueous droplets. We demonstrate the platform's utility with chemically functionalized microparticles enabling sensitive, multiplexed microRNA detection. To further explore the interactions of functionalized microparticles with biological systems, we study how antibody-functionalized microparticles of varying shape can capture specific cells for future diagnostic applications.

Download or read book Nanobiomaterials written by Dong Yi and published by CRC Press. This book was released on 2013-08-14 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a continuous exchange of ideas taking place at the border of the biological and physical sciences in many areas of nanoscience. Nanotechnology uses biomimetic or bio-inspired processes to produce nanosized materials for applications in biology and other fields. In return, the fruits of nanotechnology are applied to expanding areas of biome

Download or read book Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials written by Munmaya Mishra and published by CRC Press. This book was released on 2017-08-16 with total page 2663 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents new and selected content from the 11-volume Biomedical Polymers and Polymeric Biomaterials Encyclopedia. The carefully culled content includes groundbreaking work from the earlier published work as well as exclusive online material added since its publication in print. A diverse and global team of renowned scientists provide cutting edge information concerning polymers and polymeric biomaterials. Acknowledging the evolving nature of the field, the encyclopedia also features newly added content in areas such as tissue engineering, tissue repair and reconstruction, and biomimetic materials.

Download or read book Manufacturing Techniques for Materials written by T.S. Srivatsan and published by CRC Press. This book was released on 2018-04-09 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Manufacturing Techniques for Materials: Engineering and Engineered provides a cohesive and comprehensive overview of the following: (i) prevailing and emerging trends, (ii) emerging developments and related technology, and (iii) potential for the commercialization of techniques specific to manufacturing of materials. The first half of the book provides the interested reader with detailed chapters specific to the manufacturing of emerging materials, such as additive manufacturing, with a valued emphasis on the science, technology, and potentially viable practices specific to the manufacturing technique used. This section also attempts to discuss in a lucid and easily understandable manner the specific advantages and limitations of each technique and goes on to highlight all of the potentially viable and emerging technological applications. The second half of this archival volume focuses on a wide spectrum of conventional techniques currently available and being used in the manufacturing of both materials and resultant products. Manufacturing Techniques for Materials is an invaluable tool for a cross-section of readers including engineers, researchers, technologists, students at both the graduate level and undergraduate level, and even entrepreneurs.

Download or read book Nanotechnology for Microfluidics written by Xingyu Jiang and published by John Wiley & Sons. This book was released on 2020-09-08 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on microfluidics with applications in nanotechnology. The first part summarizes the recent advances and achievements in the field of microfluidic technology, with emphasize on the the influence of nanotechnology. The second part introduces various applications of microfluidics in nanotechnology, such as drug delivery, tissue engineering and biomedical diagnosis.

Download or read book Industrial Applications of Nanoparticles written by Marta Irene Litter and published by CRC Press. This book was released on 2023-03-31 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is one of the most rapidly developing areas of science, with great potential to solve the developmental challenges in a wide range of industries such as aerospace, agriculture, bioengineering, cosmetics, chemicals, electronics, energy, renewables, surface coatings, textiles, medicine, materials manufacturing, military equipment, etc. To compile this book, distinguished scientists, engineers, and industrial professionals from different parts of the world have been invited. An array of 17 high-quality science-based chapters covering recent advancements, challenges, and future trends in industrial applications of nanotechnology is presented. The book is aimed at industrial professionals and graduate-level students and researchers.

Download or read book Bio inspired Polymers written by Nico Bruns and published by Royal Society of Chemistry. This book was released on 2016-10-14 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many key aspects of life are based on naturally occurring polymers, such as polysaccharides, proteins and DNA. Unsurprisingly, their molecular functionalities, macromolecular structures and material properties are providing inspiration for designing new polymeric materials with specific functions, for example, responsive, adaptive and self-healing materials. Bio-inspired Polymers covers all aspects of the subject, ranging from the synthesis of novel polymers, to structure-property relationships, materials with advanced properties and applications of bio-inspired polymers in such diverse fields as drug delivery, tissue engineering, optical materials and lightweight structural materials. Written and edited by leading experts on the topic, the book provides a comprehensive review and essential graduate level text on bio-inspired polymers for biochemists, materials scientists and chemists working in both industry and academia.

Download or read book Colloid Chemistry written by Clemens K. Weiss and published by MDPI. This book was released on 2019-01-15 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Colloid Chemistry" that was published in Gels

Download or read book Polymer Colloids written by Rodney Priestley and published by Royal Society of Chemistry. This book was released on 2019-12-02 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Academic and industrial research around polymer-based colloids is huge, driven both by the development of mature technologies, e.g. latexes for coatings, as well as the advancement of new materials and applications, such as building blocks for 2D/3D structures and medicine. Edited by two world-renowned leaders in polymer science and engineering, this is a fundamental text for the field. Based on a specialised course by the editors, this book provides the reader with an invaluable single source of reference. The first section describes formation, explaining basic properties of emulsions and dispersion polymerization, microfluidic approaches to produce polymer-based colloids and formation via directed self-assembly. The next section details characterisation methodologies from microscopy and small angle scattering, to surface science and simulations. The final chapters close with applications, including Pickering emulsions and molecular engineering for materials development. A comprehensive guide to polymer colloids, with contributions by leaders in their respective areas, this book is a must-have for researchers and practitioners working across polymers, soft matter and chemical and molecular engineering.

Download or read book Advances in Microfluidic Technologies for Energy and Environmental Applications written by Yong Ren and published by BoD – Books on Demand. This book was released on 2020-05-20 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics have aroused a new surge of interest in recent years in environmental and energy areas, and inspired novel applications to tackle the worldwide challenges for sustainable development. This book aims to present readers with a valuable compendium of significant advances in applying the multidisciplinary microfluidic technologies to address energy and environmental problems in a plethora of areas such as environmental monitoring and detection, new nanofluid application in traditional mechanical manufacturing processes, development of novel biosensors, and thermal management. This book will provide a new perspective to the understanding of the ever-growing importance of microfluidics.

Download or read book Optical Properties of Metal Oxide Nanostructures written by Vijay Kumar and published by Springer Nature. This book was released on 2023-10-25 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the optical properties of metal oxides at both the fundamental and applied level and their use in various applications. The book offers a basic understanding of the optical properties and related spectroscopic techniques essential for anyone interested in learning about metal oxide nanostructures. This is partly due to the fact that optical properties are closely associated with other properties and functionalities (e.g., electronic, magnetic, and thermal), which are of essential significance to many technological applications, such as optical data communications, imaging, lighting, and displays, life sciences, health care, security, and safety. The book also highlights the fundamentals and systematic developments in various optical techniques to achieve better characterization, cost-effective, user-friendly approaches, and most importantly, state-of-the-art developing methodologies for various scientific and technological applications. It provides an adequate understanding of the imposed limitations and highlights the prospects and challenges associated with optical analytical methods to achieve the desired performance in targeted applications.

Download or read book Microfluidics written by Yu Song and published by John Wiley & Sons. This book was released on 2018-05-07 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science. As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials. A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.

Download or read book Biomimicked Biomaterials written by Heung Jae Chun and published by Springer Nature. This book was released on 2020-06-29 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.

Download or read book Peptide Based Materials written by Timothy Deming and published by Springer Science & Business Media. This book was released on 2012-01-10 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.-

Download or read book Green Polymer Composites Technology written by Inamuddin and published by CRC Press. This book was released on 2016-11-03 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive introduction to "green" or environmentally friendly polymer composites developed using renewable polymers of natural origin such as starch, lignin, cellulose acetate, poly-lactic acid (PLA), polyhydroxylalkanoates (PHA), polyhydroxylbutyrate (PHB), etc., and the development of modern technologies for preparing green composites with various applications. The book also discusses major applications of green polymer composites in industries such as medicine, biotechnology, fine chemicals and engineering.

Download or read book Current Trends and Future Developments on Bio Membranes written by Angelo Basile and published by Elsevier. This book was released on 2024-01-10 with total page 919 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Trends and Future Developments on (Bio-) Membranes: Engineering with Membranes discusses various aspects of membrane engineering. This includes, but is not limited to, the role of membranes in food production, treatment and recovery, their applications in electrochemical processes and devices, in drug delivery and in ionic materials, such as salts, acids and bases, recovery. In addition, this book approaches the above topics in a different angle than the existing publications, i.e., reviews technical difficulties, environmental challenges and economic analysis. Membranes are one of the technologies which can affect various aspects of engineering dealing with feeds and products. Membranes demonstrate selective purifying properties, hence, membranes can help in the removal of various pollutants onsite and without the need of adding extra units and apparatuses. Besides that, membranes help reactions shift forward and make the whole process more efficient. - Describes the role of membrane in food production, treatment and purification - Discusses the membrane applications in electronic processes and electrochemical devices - Covers membranes in drug delivery systems and drug industries - Reviews membranes in ionic materials recovery, such as salts, acids and bases