Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book MHC Ligands and Peptide Motifs written by Hans-Georg Rammensee and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.
Download or read book MHC Molecules and Peptides written by and published by . This book was released on 1994 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book MHC Molecules Expression Assembly and Function written by Robert G. Urban and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3 nant expression systems have been used to make MHC molecules con taining a single peptide of interest. To date, fifteen single peptide class I structures (incorporating three different HLA and two different H-2 allotypes/isotypes) and four additional class II structures (two single peptide complexes and two superantigen complexes) have been reported. These advances have enabled us to study the atomic detail of antigen presentation and the general mechanisms behind peptide binding, and begin to construct models of T cell recognition. Another area of research which has exploded over the past five years has been the identification of MHC-associated peptides. There are several methods one can use to determine the sequence identity of MHC restricted peptides. Historically, the most successful technique, albeit crude and encumbered with serious limitations, has been the use of overlapping synthetic peptides and T cell clones. Unfortunately, this method absolutely requires: (i) knowledge of the target antigen; (ii) availability of T cell clones; and (iii) a relatively short overall length for the target source protein, such that a set of overlapping pep tides can be affordably synthesized. Briefly, the entire sequence of the tar get protein is chemically synthesized using overlapping peptides which are then screened for biological activity using standard T cell presen tation assays. Despite its limitations, this method was used to identify the first immunodominant epitopes reported in the literature and con tinues to be used successfully today.
Download or read book Molecular Mechanism of Peptide Selection by MHC Molecules written by Hirstova Rakina Yaneva and published by . This book was released on 2009 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major histocompatibility complex (MHC) class I and II proteins are intracellular receptors that bind peptides derived from endogenous and exogenous proteins, resp., and display them on the cell surface for surveillance by T cells of the immune system. The presented peptides help the T cells to discriminate between self and non-self and to eliminate the pathogen infected or abnormal cells. After their synthesis, both class I and II molecules first bind suboptimal low-affinity ligand peptides and only later exchange them for high-affinity ones. For this exchange process, most class I and II molecules need the assistance of specific helper chaperones (tapasin and HLA-DM, resp.), the exact role of which is not well understood. In my thesis work, I have studied the molecular mechanism of peptide binding to MHC molecules with biochemical and computational methods, with a special emphasis on the mechanism of action of the helper chaperones. A comprehensive understanding of this process promises important clinical applications, for example in the development of new vaccines against viruses and in the suppression of autoimmune disorders
Download or read book Immunological Recognition of Peptides in Medicine and Biology written by N. D. Zegers and published by CRC Press. This book was released on 1995-07-19 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Recognition of Peptides in Medicine and Biology gives a state-of-the-art overview on the use of peptides and peptide-ligand interactions, and the critical role they play in recognition patterns for the regulation of various biological functions. A wide range of applications are discussed, including some experimental preclinical ones such as epitope mapping, peptide libraries, and production of amino acid-specific antibodies and their therapeutic use in oncology and infectious disease vaccines. Each chapter also includes step-by-step protocols to aid in actual experiments. Several alternative techniques and strategies are discussed by different authors offering the reader an opportunity to select the most favorable application for a specific biological problem.
Download or read book Antigen Processing and Presentation written by Robert Edward Humphreys and published by . This book was released on 1994 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the few volumes dedicated to antigen processing, this unique text is not only especially current but also valuable for its description of petentially "hot" areas with its "Future Directions" sections. * Current, important topics covered by this text include: Processing and presentation of foreign and self protein antigens to T lymphocytes Intracellular assembley and transport of MHC proteins Regulation of the assembley and expression of processed antigen-MHC complexes
Download or read book Requirements for Association of Exogenous and Endogenous Antigenic Peptides with Class I MHC Molecules written by Nancy Ann Hosken and published by . This book was released on 1992 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cytokines of the Immune System written by Zlatko Dembic and published by Academic Press. This book was released on 2015-05-23 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. - Supplies new ideas for basic and clinical research - Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials - Offers a textbook-style view on the immune system with the immunologic role of each cytokine
Download or read book HLA and MHC written by Michael J. Browning and published by Taylor & Francis. This book was released on 1996 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
Download or read book Antigen Processing and Recognition written by James McCluskey and published by CRC Press. This book was released on 1991-09-03 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a state-of-the-art review of the processing, presentation, and subsequent recognition of antigens by T cells. Topics discussed include the structure of MHC molecules, the nature and specificity of human class II molecule interactions with peptide antigens, the class II invariant chain, antigen processing and presentation by class I MHC molecules, the biology of antigen processing, and the presentation and role of accessory molecules in T cell recognition. Other chapters feature discussions about the T cell allorecognition of MHC molecules, the recognition of minor antigens, and the concept of "superantigens." Color plates demonstrate the three-dimensional structure of MHC molecules and peptide antigen interaction with MHC molecules. Diagrams illustrate antigen presentation pathways, T cell receptor-MHC interaction and accessory molecule interactions. Antigen Processing and Recognition will be a valuable addition to the libraries of students and teachers of immunology, as well as cell biologists who are looking for a unified view of this rapidly expanding subject.
Download or read book In Silico Immunology written by Darren D.R. Flower and published by Springer Science & Business Media. This book was released on 2007-04-16 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care.
Download or read book MHC molecules and peptides written by Hans-Georg Rammensee and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Generation of Naturally Processed Peptide MHC Class I Complexes is Independent of the Stability of the Endogenously Synthesized Precursors written by Samuel Ray Goth and published by . This book was released on 1996 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antigen Processing and Presentation Protocols written by Joyce C. Solheim and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antigen processing and presentation, as a field, explores a broad range of protein interactions and functions, both intracellular (in the cytoplasm and in the endoplasmic reticulum) and at the cell surface (between T cells and MHC molecules). To investigate such a diverse array, it is necessary that biochemical, cell biology, and immunological techniques all be employed. The purpose of Antigen Processing and Presentation Protocols is therefore to detail the most up-to-date techniques being used in this burgeoning field. Such techniques include those used to question how MHC-binding peptides are generated, to test how peptides are delivered to MHC molecules, to analyze MHC peptide-binding patterns, and to assay the T-cell response to MHC/peptide. Antigen Processing and Presentation Protocols should aid both those new and those experienced in this area of research in extending the questions that can be asked and answered by the application of these current methods. For editorial assistance, I would like to thank Angela Beninga and Rachael Turnquist.
Download or read book Bioinformatics written by Venkatarajan Mathura and published by Springer Science & Business Media. This book was released on 2008-10-11 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics is an evolving field that is gaining popularity due to genomics, proteomics and other high-throughput biological methods. The function of bioinformatic scientists includes biological data storage, retrieval and in silico analysis of the results from large-scale experiments. This requires a grasp of knowledge mining algorithms, a thorough understanding of biological knowledge base, and the logical relationship of entities that describe a process or the system. Bioinformatics researchers are required to be trained in multidisciplinary fields of biology, mathematics and computer science. Currently the requirements are satisfied by ad hoc researchers who have specific skills in biology or mathematics/computer science. But the learning curve is steep and the time required to communicate using domain specific terms is becoming a major bottle neck in scientific productivity. This workbook provides hands-on experience which has been lacking for qualified bioinformatics researchers.
