Download or read book Methods for Addressing Uncertainty and Variability to Characterize Potential Health Risk From Trichloroethylene Contaminated Ground Water Beale Air Force Base in California written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditional estimates of health risk are typically inflated, particularly if cancer is the dominant endpoint and there is fundamental uncertainty as to mechanism(s) of action. Risk is more realistically characterized if it accounts for joint uncertainty and interindividual variability after applying a unified probabilistic approach to the distributed parameters of all (linear as well as nonlinear) risk-extrapolation models involved. Such an approach was applied to characterize risks to potential future residents posed by trichloroethylene (TCE) in ground water at an inactive landfill site on Beale Air Force Base in California. Variability and uncertainty were addressed in exposure-route-specific estimates of applied dose, in pharmacokinetically based estimates of route-specific metabolized fractions of absorbed TCE, and in corresponding biologically effective doses estimated under a genotoxic/linear (MA{sub g}) vs. a cytotoxic/nonlinear (MA{sub c}) mechanistic assumption for TCE-induced cancer. Increased risk conditional on effective dose was estimated under MA{sub G} based on seven rodent-bioassay data sets, and under MA, based on mouse hepatotoxicity data. Mean and upper-bound estimates of combined risk calculated by the unified approach were 10−6 and 10−4, respectively, while corresponding estimates based on traditional deterministic methods were10−5 and10−4, respectively. It was estimated that no TCE-related harm is likely occur due any plausible residential exposure scenario involving the site. The unified approach illustrated is particularly suited to characterizing risks that involve uncertain and/or diverse mechanisms of action.
Download or read book Methods for Addressing Uncertainty and Variability to Characterize Potential Health Risk from Trichloroethylene Contaminated Ground Water at Beale Air Force Base in California written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditional estimates of health risk are typically inflated, particularly if cancer is the dominant endpoint and there is fundamental uncertainty as to mechanism(s) of action. Risk is more realistically characterized if it accounts for joint uncertainty and interindividual variability within a systematic probabilistic framework to integrate the joint effects on risk of distributed parameters of all (linear as well as nonlinear) risk-extrapolation models involved. Such a framework was used to characterize risks to potential future residents posed by trichloroethylene (TCE) in ground water at an inactive landfill site on Beale Air Force Base in California. Variability and uncertainty were addressed in exposure-route-specific estimates of applied dose, in pharmacokinetically based estimates of route-specific metabolized fractions of absorbed TCE, and in corresponding biologically effective doses estimated under a genotoxic/linear (MA{sub G}) vs. a cytotoxic/nonlinear (MA{sub c}) mechanistic assumption for TCE-induced cancer. Increased risk conditional on effective dose was estimated under MA{sub G} based on seven rodent-bioassay data sets, and under MA{sub c} based on mouse hepatotoxicity data. Mean and upper-bound estimates of combined risk calculated by the unified approach were 10−6 and 10−4, respectively, while corresponding estimates based on traditional deterministic methods were10−5 and 10−4, respectively. It was estimated that no TCE-related harm is likely to occur due to any plausible residential exposure scenario involving the site. The systematic probabilistic framework illustrated is particularly suited to characterizing risks that involve uncertain and/or diverse mechanisms of action.
Download or read book Methods for Addressing Uncertainty and Variability to Characterize Potential Health Risk from Trichloroethylene contaminated Ground Water at Beale Air Force Base in California written by Boger, K.T. and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Procedures for Addressing Uncertainty and Variability in Exposure to Characterize Potential Health Risk from Trichloroethylene Contaminated Groundwater at Beale Air Force Base in California written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This study was designed to accomplish two objectives. The first was to provide to the US Air Force and the regulatory community quantitative procedures that they might want to consider using for addressing uncertainty and variability in exposure to better characterize potential health risk. Such methods could be used at sites where populations may now or in the future be faced with using groundwater contaminated with low concentrations of the chemical trichloroethylene (TCE). The second was to illustrate and explain the application of these procedures with respect to available data for TCE in ground water beneath an inactive landfill site that is undergoing remediation at Beale Air Force Base in California. The results from this illustration provide more detail than the more traditional conservative deterministic, screening-level calculations of risk, also computed for purposes of comparison. Application of the procedures described in this report can lead to more reasonable and equitable risk-acceptability criteria for potentially exposed populations at specific sites.
Download or read book Procedures for Addressing Uncertainty and Variability in Exposure to Characterize Potential Health Risk from Trichloroethylene Contaminated Ground Water at Beale Air Force Base in California written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Conservative deterministic, screening-level calculations of exposure and risk commonly are used in quantitative assessments of potential human-health consequences from contaminants in environmental media. However, these calculations generally are based on multiple upper-bound point estimates of input parameters, particularly for exposure attributes, and can therefore produce results for decision makers that actually overstate the need for costly remediation. Alternatively, a more informative and quantitative characterization of health risk can be obtained by quantifying uncertainty and variability in exposure. This process is illustrated in this report for a hypothetical population at a specific site at Beale Air Force Base in California, where there is trichloroethylene (TCE) contaminated ground water and a potential for future residential use. When uncertainty and variability in exposure were addressed jointly for this case, the 95th-percentile upper-bound value of individual excess lifetime cancer risk was a factor approaching 10 lower than the most conservative deterministic estimate. Additionally, the probability of more than zero additional cases of cancer can be estimated, and in this case it is less than 0.5 for a hypothetical future residential population of up to 26,900 individuals present for any 7.6-y interval of a 70-y time period. Clearly, the results from application of this probabilistic approach can provide reasonable and equitable risk-acceptability criteria for a contaminated site.
Download or read book Review of the Army s Technical Guides on Assessing and Managing Chemical Hazards to Deployed Personnel written by National Research Council and published by National Academies Press. This book was released on 2004-09-03 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: To guide mission planning, military decision makers need information on the health risks of potential exposures to individual soldiers and their potential impact on mission operations. To help with the assessment of chemical hazards, the U.S. Army Center for Health Promotion and Preventive Medicine developed three technical guides for characterizing chemicals in terms of their risks to the mission and to the health of the force. The report reviews these guides for their scientific validity and conformance with current risk-assessment practices. The report finds that the military exposure guidelines are appropriate (with some modification) for providing force health protection, but that for assessing mission risk, a new set of exposure guidelines is needed that predict concentrations at which health effects would degrade the performance of enough soldiers to hinder mission accomplishment.
Download or read book Framework for cumulative risk assessmentexternal review draft written by and published by DIANE Publishing. This book was released on 2002 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Environmental Challenges written by Shimson Belkin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 1999, an international group of experts convened in Jerusalem, Israel, in order to define the major environmental challenges facing humanity at the dawn of the new millennium and - where possible - propose ways of addressing them. Almost 50 selected articles are collected in the present book, which constitutes a striking interdisciplinary combination of state-of-the-art science with the latest views on environmental law, education, and international cooperation. Whilst a major fraction of the book is devoted to water-related issues (water quality monitoring, water and wastewater treatment, water-based international cooperation, and more), other sections deal with timely topics relating to air pollution, biodiversity, conservation, and education. The book is intended for environmental scientists, professionals, and students of all disciplines.
Download or read book Law of Toxic Torts written by Michael Dore and published by . This book was released on 1987 with total page 2332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Assessing the Human Health Risks of Trichloroethylene written by National Research Council and published by National Academies Press. This book was released on 2007-01-08 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trichloroethylene is a chlorinated solvent widely used as a degreasing agent in industrial and manufacturing settings. It is also used as a chemical intermediate in making other chemicals and is a component of products such as typewriter correction fluid, paint removers, adhesives, and spot removers. In 2001, EPA issued a draft health risk assessment and proposed exposure standards for trichloroethylene. PA's Scientific Advisory Board (SAB) reviewed the draft and it was issued for public comment. A number of scientific issues were raised during the course of these reviews. Assessing the Human Health Risks of Trichloroethylene identifies and assesses the key scientific issues relevant to analyzing the human health risks of trichloroethylene, considering pertinent toxicologic, epidemiologic, population susceptibility, and other available information, including relevant published scientific literature, EPA's 2001 draft health risk assessment of trichloroethylene, scientific and technical comments received by EPA from public and private sources, and additional relevant information to be provided by the sponsoring agencies. This report highlights issues critical to the development of an objective, realistic, and scientifically balanced trichloroethylene health risk assessment. Guidance for hazard characterization of trichloroethylene is presented in Chapters 2 through 10. Chapter 2 provides guidance for evaluating large sets of epidemiologic data. In Chapter 3, the committee applies this guidance as an example in its evaluation of the epidemiologic data on trichloroethylene and kidney cancer, and this example should help guide evaluations of other cancer risks. Chapter 3 also assesses new information on the kidney toxicity of trichloroethylene and its metabolites and potential modes of action. Chapters 4, 5, 6, 7, and 8 evaluate the key issues regarding liver toxicity and cancer, reproductive and developmental toxicity, neurotoxicity, respiratory tract toxicity and cancer, and immunotoxicity, respectively. However, the committee's review focused on mode-of-action information to understand how trichloroethylene might affect certain processes differently in different species. Chapter 9 discusses susceptibility to trichloroethylene and its metabolites, and Chapter 10 describes important factors in considering trichloroethylene in mixtures. Physiologically based pharmacokinetic models are evaluated in Chapter 11, and guidance is provided on future directions for model development. Finally, Chapter 12 considers issues related to dose-response assessment and quantitative assessment of risk.
Download or read book Understanding the Effects of Uncertainty and Variability on Groundwater driven Health Risk Assessment written by Reed Mailer Maxwell and published by . This book was released on 1998 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Health Risk Assessment of Trichloroethylene TCE in California Drinking Water written by and published by . This book was released on 1988 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Chemical Scythe written by Alastair Hay and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemical Scythe is the first book in a projected series to be published by Plenum Press in association with the International Disaster Institute. The aim of the series, Disaster Research in Practice, is to provide scientific and readable accounts on the most urgent areas of disaster research. It is fitting, therefore, that Dr. Hay's investigation into the nature and effects of dioxins heralds the new series. The problem of chemical hazards is one that we will have to learn to live with in future decades. Dr. Hay's book is an authoritative account of the chemistry and proven and potential effects of dioxins, and of the impli cations for safety planning. He concludes with a cautious, yet optimistic note-that indeed we can learn to live with such hazards, providing that we are prepared to understand and plan for the unexpected. The accident at Seveso in 1976 alerted the world to an imperfectly un derstood but immensely alarming environmental hazard. Public debate and argument as to the implications of dioxins and, indeed, the use of herbicides as aggressive weapons in Vietnam, rage on. And yet it is only through the painstaking research exemplified in this book that it will eventually be pos sible to promote the vital accountability on the part of industrialists and governments.
Download or read book Ocean Atmosphere Interactions of Gases and Particles written by Peter S. Liss and published by Springer. This book was released on 2013-12-18 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The oceans and atmosphere interact through various processes, including the transfer of momentum, heat, gases and particles. In this book leading international experts come together to provide a state-of-the-art account of these exchanges and their role in the Earth-system, with particular focus on gases and particles. Chapters in the book cover: i) the ocean-atmosphere exchange of short-lived trace gases; ii) mechanisms and models of interfacial exchange (including transfer velocity parameterisations); iii) ocean-atmosphere exchange of the greenhouse gases carbon dioxide, methane and nitrous oxide; iv) ocean atmosphere exchange of particles and v) current and future data collection and synthesis efforts. The scope of the book extends to the biogeochemical responses to emitted / deposited material and interactions and feedbacks in the wider Earth-system context. This work constitutes a highly detailed synthesis and reference; of interest to higher-level university students (Masters, PhD) and researchers in ocean-atmosphere interactions and related fields (Earth-system science, marine / atmospheric biogeochemistry / climate). Production of this book was supported and funded by the EU COST Action 735 and coordinated by the International SOLAS (Surface Ocean- Lower Atmosphere Study) project office.
Download or read book Treatment of Micropollutants in Water and Wastewater written by Jurate Virkutyte and published by IWA Publishing. This book was released on 2010-08-14 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last few years there has been a growing concern over the increasing concentration of micropollutants originating from a great variety of sources including pharmaceutical, chemical engineering and personal care product industries in rivers, lakes, soil and groundwater. As most of the micropollutants are polar and persistent compounds, they are only partially or not at all removed from wastewater and thus can enter the environment posing a great risk to the biota. It is hypothesized that wastewater is one of the most important point sources for micropollutants. Treatment of Micropollutants in Water and Wastewater gives a comprehensive overview of modern analytical methods and will summarize novel single and hybrid methods to remove continuously emerging contaminants - micropollutants from the aqueous phase. New trends (e.g. sensor technology, nanotechnology and hybrid treatment technologies) are described in detail. The book is very timely because the new techniques are still in the development phase and have to be realized not only in the laboratory but also on a larger scale. The content of the book is divided into chapters that present current descriptive and analytical methods that are available to detect and measure micropollutants together with detailed information on various chemical, biological and physicochemical methods that have evolved over the last few decades. Treatment of Micropollutants in Water and Wastewater will also enable readers to make well informed choices through providing an understanding of why and how micropollutants must be removed from water sources, and what are the most appropriate and available techniques for providing a cost and technologically effective and sustainable solutions for reaching the goal of micropollutant-free water and wastewater. The book will be suitable for water and wastewater professionals as well for students and researchers in civil engineering, environmental engineering and process engineering fields.
Download or read book Principles of Fabric Formation written by Prabir Kumar Banerjee and published by CRC Press. This book was released on 2014-12-19 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: How Are Textile Fabrics Formed? Principles of Fabric Formation is a treatise on the modern production systems of woven, knitted, braided, nonwoven, triaxial, multiaxial, and 3D fabrics. This book offers a basic understanding of the technicalities involved in the formation of different types of textile fabrics, and brings out the relative merits and limitations of each production process in one single volume. Gain Insight into the World of Textile Fabrics Providing readers with an appreciation of the technicalities involved in the formation of different types of textile fabrics, the author describes all major fabric formation methods, and explains each stage of formation in the text. He also addresses all major topics related to the formation of different classes of textile fabrics, including yarn winding, warping, yarn sizing, woven fabric construction, weaving, weft knitting, warp knitting, braiding, nonwovens, and triaxial, multiaxial and 3D fabrics. Comprised of 16 chapters, this multifaceted work: Provides a technical description of fabric formation systems Focuses on the diverse technicalities involved in each and every stage of formation Contains a comprehensive compilation of the major principles involved Principles of Fabric Formation is an exclusive junior/senior undergraduate-level textbook with a focus on the diverse technical principles involved in production of the entire gamut of textile fabrics.
Download or read book Emerging Contaminants Vol 1 written by Nadia Morin-Crini and published by Springer Nature. This book was released on 2021-04-21 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging contaminants are chemical and biological agents for which there is growing concern about their potential health and environmental effects. The threat lies in the fact that the sources, fate and toxicology of most of these compounds have not yet been studied. Emerging contaminants, therefore, include a large number of both recently discovered and well-known compounds such as rare earth elements, viruses, bacteria, nanomaterials, microplastics, pharmaceuticals, endocrine disruptors, hormones, personal care products, cosmetics, pesticides, surfactants and industrial chemicals. Emerging contaminants have been found in many daily products, and some of them accumulate in the food chain. Correlations have been observed between aquatic pollution by emerging contaminants and discharges from wastewater treatment plants. Most actual remediation methods are not effective at removing emerging contaminants. This first volume presents comprehensive knowledge on emerging contaminants with a focus on analysis, toxicity, antibiotic resistance and human health.
