Download or read book Metabolism and Metabolomics of Liver in Health and Disease written by Walter Wahli and published by MDPI. This book was released on 2021-02-19 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.

Download or read book Metabolism and Metabolomics of Liver in Health and Disease written by Walter Wahli and published by . This book was released on 2021 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.

Download or read book Metabolomics in Health and Disease Biology written by and published by Elsevier. This book was released on 2024-02-26 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolomics in Health and Disease Biology, Volume 104 covers this rapidly emerging field that aims for metabolic phenotyping and understanding the blueprint of metabolic pathways under various health and disease conditions by comprehensive analysis of metabolites. Chapters in this new release include Metabolomics approaches: Biomarkers to Disease mechanisms, Metabolomics in sleep disorders, Metabolomics in predicting the hallmark of Cancer Metabolism, Spectroscopic based rapid metabolic fingerprinting approaches for Cancer diagnosis, Lipidomics in assessing the health of osteoarthritis, Metabolomics Applications in Type 2 Diabetes mellitus, Metabolomics of Diabetic retinopathy, Metabolomics in Neurodegenerative disorders- Parkinson's disease, and Metabolomic of Neurodegenerative disorder: Alzheimer's Disease. Presents crucial reviews from selected experts in the field of metabolomics, with cross-disciplinary contributions Provides the latest insights into our understanding of diseases using metabolomics-based approaches Includes graphical material for metabolomics application that provide useful information for ease of reading of audience

Download or read book Liver Metabolism and Diseases written by Joseph Curtis and published by Murphy & Moore Publishing. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver is an integral part of the process of metabolism. It helps in the preservation and regulation of the lipid and glucose levels in the body, as well as in energy metabolism. The most common metabolic diseases which can affect the liver are Wilson disease, hereditary hemochromatosis, and Alpha-I antitrypsin deficiency (AATD). Some of the other types of disorders which affect the liver are infections, immune system issues, cancers, and heritable conditions. One of the upcoming methods of study which is used to study the cell metabolism within the liver is metabolomics. It refers to the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Metabolomics has a very high potential to detect biomarker candidates for the prospective advancement of new therapeutics. The book aims to shed light on some of the unexplored aspects of liver metabolism and the recent researches in this field with respect to liver diseases. It will provide comprehensive knowledge to both medical students and professionals.

Download or read book Metabolic and Clinical Perspectives on the Functions of the Liver written by Åke Nilsson and published by Cambridge Scholars Publishing. This book was released on 2024-02-07 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how the liver executes and coordinates numerous physiological processes including metabolism, innate immunity, blood coagulation, bile secretion, and our symbiotic relation with the gut microbiome. It places the functions in clinical contexts, such as the pathogenesis of alcohol-related liver disease and metabolic (obesity) associated liver disease. It describes how in severe catabolic diseases such as cancer and sepsis, the liver redistributes bodily resources to increase chances of survival and recovery, and how the liver exemplifies many of the effects of diet and physical activity on health and wellbeing, via its regulation of glucose, lipid and cholesterol metabolism, and inflammation. The book is for professionals working in gastroenterology, hepatology, metabolic disorders, and many other medical disciplines, and for scientists and curious students of medicine, nutrition and biosciences.

Download or read book Metabolism of Human Diseases written by Eckhard Lammert and published by Springer Science & Business Media. This book was released on 2014-06-02 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Metabolism of Human Diseases” examines the physiology of key organs (e.g. brain, eye, lung, heart, blood vessels, blood, immune system, gastrointestinal tract, pancreas, liver, fat tissue, kidney, reproductive system, teeth, bone and joints) and how defective metabolism and signaling pathways within these organs contribute to common human diseases. The latter include depression, schizophrenia, epilepsy, Parkinson's disease, Alzheimer's disease, migraine, multiple sclerosis, Down syndrome, macular degeneration, glaucoma, asthma, COPD, pneumonia, atherosclerotic heart disease, heart failure, stroke, varicose veins, Sickle cell disease, hyperlipidemia, fever, sepsis, allergies, peptic ulcer, gastroenteritis, lactose intolerance, colon cancer, diabetes, cirrhosis, metabolic syndrome, hypertension, chronic kidney disease, gout, urinary tract infections, kidney stones, dental caries, osteoporosis, osteoarthritis, rheumatoid arthritis, breast cancer and prostate cancer. The book also describes commonly used drugs and explains their molecular targets. It provides the first comprehensive and detailed summary of the metabolism of individual organs and their physiological and pathological functioning. Thus it serves as a useful supplement to previous textbooks of human physiology. “Metabolism of Human Diseases” is a must-have, state-of-the-art textbook written by International experts for graduate students, postdocs and scientists in metabolic research, biochemistry, physiology and pharmacy as well as for physicians interested in molecular mechanisms underlying common human diseases.

Download or read book A Practical Guide to Metabolomics Applications in Health and Disease written by Julijana Ivanisevic and published by Springer Nature. This book was released on with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Regenerative Health written by Kristin Kirkpatrick and published by Hachette GO. This book was released on 2023-06-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors of Skinny Liver offer a new look at liver disease through four types of conditions, with practical plans for liver health--aka "eat right for your liver type." Since Skinny Liver was published, the prevalence and severity of fatty liver disease has only gotten worse--now one in four people worldwide has been diagnosed with it, while millions more remain unaware that they are somewhere on the liver disease spectrum. Most alarmingly, this worsening trend is also true for children and young people--and since the longer you have the disease the more likely it is to progress past the reversible stage, this is not good news. Now dietitian Kristin Kirkpatrick and gastroenterologist Dr. Ibrahim Hanouneh offer the latest research and treatment plans to love your liver for life. New research has evolved our medical understanding of obesity, which has been viewed as a primary risk factor for fatty liver. We now know that metabolic health is a better indicator of risk than weight. In fact, there is a movement afoot to change the name of non-alcoholic fatty liver disease (NAFLD; the first phase of fatty liver disease) to metabolic associated fatty liver disease (MAFLD). What this all means is that the focus on treating fatty liver is less on losing weight by following a diet and more on changing how you eat and adopting the lifestyle habits that have been shown to reduce risk of liver disease and the metabolic dysfunction that so often precedes it. The approach to treating fatty liver disease is now much more individualized. Regenerative Health introduces the four metabolic profiles--lean, metabolically healthy; lean, metabolically unhealthy; non-lean, metabolically healthy; and non-lean, metabolically unhealthy. Once you determine which quadrant you fall into, you'll learn how to customize the Regenerative Health eating and lifestyle plan to your particular metabolic profile. Not only will you treat your current issues, but you'll also learn to how to prevent more from developing. With practical tips on nutrition, exercise, and wellness, Regenerative Health allows you to discover that you can impact almost all factors that put you at a greater risk for fatty liver disease, putting your health back in your own hands.

Download or read book Metabolism and Nutrition in Liver Disease written by E. Holm and published by Springer Science & Business Media. This book was released on 1985-10-31 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Liver Metabolism and Fatty Liver Disease written by Oren Tirosh and published by CRC Press. This book was released on 2014-08-27 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonalcoholic fatty liver disease is one of the most common liver diseases worldwide affecting patients from all ages, races, and ethnic backgrounds. It comprises a spectrum of hepatic pathology ranging from simple steatosis, in which there is an increase of fat accumulation in hepatocytes, to nonalcoholic steatohepatitis and cirrhosis. The significant prevalence of this disease—between 15 and 45 percent of the general population—means that it contributes to an increased burden of ill health both today and in the future. Liver Metabolism and Fatty Liver Disease addresses the current understanding of the development of nonalcoholic fatty liver disease as well as the clinical aspects of the disease by examining the current knowledge surrounding metabolism in the liver. The book discusses various topics including the involvement of oxidative stress, metabolic effects, and inflammation as well as the effect of nutrition on the development and progression of the disease.

Download or read book Cellular Senescence and Their Role in Liver Metabolism in Health and Disease Overview and Future Directions written by Matthew Schade and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic liver disease has globally risen mainly due to a prevalent hepatitis C virus (HCV) infection rate and an epidemic of obesity. It is estimated by the year 2030, 2.2 billion people around the world will be overweight and 1.1 billion people will be obese. Diabetes and obesity are the main risk factors for the development of the metabolic syndrome and in the liver of non-alcoholic fatty liver disease (NAFLD) which could progress to non-alcoholic fatty steatohepatitis (NASH) related cirrhosis and liver malignancy. At present there is not effective therapy for NASH besides loss of weight and exercise. Furthermore, optimal management of HCC with curative intent includes resection or liver transplantation. Nevertheless, these therapies are limited because the degree of liver dysfunction or the medical conditions at the time of diagnosis and the scarcity of available liver grafts. The role of cellular lipid management and metabolism in human health and disease is taking a center stage. The present overview articulates the current pathophysiology of fatty liver disease under the aging processes, potential biological markers of liver disease diagnosis and progression and future therapies.

Download or read book Biomarkers in Liver Disease written by Victor R. Preedy and published by Springer. This book was released on 2017-07-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Download or read book Metabolomics and Its Impact on Health and Diseases written by Veronica Ghini and published by Springer Nature. This book was released on 2023-03-03 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the Handbook of Experimental Pharmacology, which celebrated its 100th anniversary in 2019, addresses the rapidly growing and evolving field of metabolomics. It has been compiled and designed to broaden and enrich your understanding as well as simplify a complicated picture of the diverse field of metabolomics. This is accomplished by chapters from experts in the field on basic principles as well as reviews and updates of analytical techniques. The variety and different perspectives of the NMR approaches are described in the chapters By David Wishart, Daniel Raftery and Ryan McKay, while mass spectrometry advances are covered by Charles R. Evans and Stefan Kempa. This book also reflects the state of the art in the application of metabolomics to cell biology (Marta Cascante and Ulrich Guenther) and chapters that share insights into the application of metabolomics in various diseases (Paola Turano and Claudio Luchinat, Rachel S. Kelly and Jessica Lasky-Su, Paige Lacy, and Angela Rogers. Relationships of metabolomics with drugs are highlighted by Robert Verpoorte (natural products drug discovery), by Oscar Millet and by Turano and Luchinat (perspectives in precision medicine) and by Daniel L. Hertz (drug-induced peripheral neuropathy). From the above list of diverse topics, we believe this book has interdisciplinary appeal and scholars with an interest in the role of metabolomics in achieving precision medicine will find it of particular or special interest.

Download or read book Metabolomics written by Ute Roessner and published by IntechOpen. This book was released on 2012-02-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolomics is a rapidly emerging field in life sciences, which aims to identify and quantify metabolites in a biological system. Analytical chemistry is combined with sophisticated informatics and statistics tools to determine and understand metabolic changes upon genetic or environmental perturbations. Together with other 'omics analyses, such as genomics and proteomics, metabolomics plays an important role in functional genomics and systems biology studies in any biological science. This book will provide the reader with summaries of the state-of-the-art of technologies and methodologies, especially in the data analysis and interpretation approaches, as well as give insights into exciting applications of metabolomics in human health studies, safety assessments, and plant and microbial research.

Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.

Download or read book Mass Spectrometry Based Metabolomics in Clinical and Herbal Medicines written by Aihua Zhang and published by John Wiley & Sons. This book was released on 2021-08-20 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.

Download or read book Obesity Fatty Liver and Liver Cancer written by Jun Yu and published by Springer. This book was released on 2018-06-28 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers a state-of-the-art illustration of recent discoveries concerning obesity-related fatty liver diseases and liver cancer. The contents are extensive and comprehensive. It brings important topics in the field all together under one umbrella, from epidemiology and etiology, molecular pathogenesis, cellular biology, epigenetics, immunology, microbiology, animal models to therapeutic approaches and treatments. All the book contributors are leading experts in the field. It will appeal to researchers, clinicians and graduate students in obesity, fatty liver diseases, GI/Liver cancer field. It may also yield benefits for pharmaceutical companies with regard to drug discovery.