Download or read book Membrane Potential Imaging in the Nervous System written by Marco Canepari and published by Springer Science & Business Media. This book was released on 2010-10-19 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is structured in five sections, each containing several chapters written by experts and major contributors to particular topics. The volume starts with a historical perspective and fundamental principles of membrane potential imaging and continues to cover the measurement of membrane potential signals from dendrites and axons of individual neurons, measurements of the activity of many neurons with single cell resolution, monitoring of population signals from the nervous system, and concludes with the overview of new approaches to voltage-imaging. The book is targeted at all scientists interested in this mature but also rapidly expanding imaging approach.
Download or read book Membrane Potential Imaging in the Nervous System and Heart written by Marco Canepari and published by Springer. This book was released on 2015-08-03 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses membrane potential imaging in the nervous system and in the heart and modern optical recording technology. Additionally, it covers organic and genetically-encoded voltage-sensitive dyes; membrane potential imaging from individual neurons, brain slices, and brains in vivo; optical imaging of cardiac tissue and arrhythmias; bio-photonics modelling. This is an expanded and fully-updated second edition, reflecting all the recent advances in this field. Twenty chapters, all authored by leading names in the field, are cohesively structured into four sections. The opening section focuses on the history and principles of membrane potential imaging and lends context to the following sections, which examine applications in single neurons, networks, large neuronal populations and the heart. Topics discussed include population membrane potential signals in development of the vertebrate nervous system, use of membrane potential imaging from dendrites and axons, and depth-resolved optical imaging of cardiac activation and repolarization. The final section discusses the potential – and limitations – for new developments in the field, including new technology such as non-linear optics, advanced microscope designs and genetically encoded voltage sensors. Membrane Potential Imaging in the Nervous System and Heart is ideal for neurologists, electro physiologists, cardiologists and those who are interested in the applications and the future of membrane potential imaging.
Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ligand and Electronically Induced Activation Patterns in Myenteric Neuronal Networks written by Raf Bisschops and published by Leuven University Press. This book was released on 2005 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrointestinal motility regulated by hormonal, myogenic and neuronal mechanisms. The neuronal control consists of two elements: on the one hand the extrinsic innervation by para- and ortho-sympathetic nerve fibres and on the other hand intrinsic intrinsic innervation by the enteric nervous system (ENS). The myenteric plexus as part of the ENS, is to a great extent involved in the control of gastrointestinal motility. The guinea-pig myenteric plexus has been the subject of intense research over the last three decades, resulting in a better understanding of gastrointestinal physiology and motility. The ENS comprises a large diversity of neurons. Current classification schemes of enteric neurons are mainly based on the data obtained from classical electrophysical experiments, immunohistochemistry and retrograde labeling techniques. Electrophysiological recordings give real-time information concerning the electrical activity of one impaled myenteric neuron (S/AH type neurons), but this information is mostly limited to a single neuron. Immunohistochemical staining for different neurotransmitters or different functionally relevant proteins provides information about an activity due to intrinsic technical limitations of fixation techniques.
Download or read book Cellular and Molecular Neurophysiology written by Constance Hammond and published by Elsevier. This book was released on 2024-06-03 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Neurophysiology, Fifth Edition is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in graduate-level courses on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field. The new edition contains new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction, and a section containing exercises for further learning. This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. Authoritative foundational coverage of basic cellular and molecular neurophysiology Includes new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction Provides fifteen appendices that describe how neurobiological techniques are interspersed in the text Presents enhanced coverage of new methodologies and experimental techniques
Download or read book Anatomy Physiology written by Lindsay Biga and published by . This book was released on 2019-09-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A version of the OpenStax text
Download or read book Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants written by Yvonne Will and published by John Wiley & Sons. This book was released on 2018-03-23 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria
Download or read book Properties of Membranes and Diseases of the Nervous System written by American Neurological Association and published by . This book was released on 1962 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Exploration of Cortical Function written by M. Stetter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploration of Cortical Function summarizes recent research efforts aiming at the revelation of cortical population coding and signal processing strategies. Topics include optical detection techniques of population activity in the sub-millimeter range, advanced methods for the statistical analysis of these data, and biologically inspired neuronal modeling techniques for population activities in the frameworks of optimal coding, statistical learning theory, and mean-field recurrent networks. Exploration of Cortical Function is unique in that it covers one complete branch of population-based brain research ranging from techniques for data acquisition over data analysis up to modeling techniques for the quantification of functional principles. The volume covers an area which is of great current interest to researchers working on cerebral cortex. The combination of models and image analysis techniques to examine the activity of large cohorts of neurons is especially intriguing and prone to considerable error and debate.
Download or read book Imaging in Neuroscience and Development written by Rafael Yuste and published by CSHL Press. This book was released on 2005 with total page 813 pages. Available in PDF, EPUB and Kindle. Book excerpt: As imaging studies have continued to expand in scope and sophistication, this new edition of the highly successful and well–received Imaging Neurons: A Laboratory Manualhas expanded to include development, with over twenty new chapters on such topics as MRI microscopy, imaging early developmental events, and labeling single neurons. Chapters on FRET, FCS/ICS, FRAP, hyperresolution microscopy, single molecule imaging, imaging with quantum dots, and imaging gene expression are included. With over forty full chapters, the manual also includes over forty sections of protocols for imaging techniques.
Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Download or read book In Vivo Optical Imaging of Brain Function written by Ron Frostig and published by CRC Press. This book was released on 2002-05-15 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major advantage of in vivo optical techniques is the ability to study many levels of function of the CNS that are inaccessible by other methods. This rapidly expanding field is multidisciplinary in nature and findings have thus far been scattered throughout the literature. In Vivo Optical Imaging of Brain Function reviews the wide varie
Download or read book Environmental Neurotoxicology written by National Research Council and published by National Academies Press. This book was released on 1992-02-01 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
Download or read book Diffusion Magnetic Resonance Imaging of Central Nervous System Diseases written by Qing Wang and published by . This book was released on 2011 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffusion magnetic resonance imaging (MRI) is a noninvasive imaging modality widely used to probe the microstructure of central nervous system (CNS). Studies have demonstrated that progression of the CNS pathology may increase or decrease apparent diffusion coefficient (ADC) measured by diffusion MRI, and the axial and radial diffusivities derived from diffusion tensor imaging (DTI) have shown promises to separate axonal injury from myelin damage. Recently, diffusion MRI was also used to predict functional outcome in various CNS diseases. In this dissertation, diffusion MRI was first employed to image the normal retinal cell structure. The retinal cell pathology of retina degeneration-1 (rd1) mice was then evaluated by diffusion MRI and found that the photoreceptor cell death induced retinal vascular leakage causes increased inner retinal ADC in living rd1 mice. To further investigate the unknown relationship between DTI-derived biomarkers of axonal injury and myelin damage and changes in functional behavior of white matter tracts, in vitro electrophysiological recordings of compound action potential (CAP) were conducted to evaluate the function of mouse optic nerves after transient retinal ischemia. The correlation between CAP measurements and DTI injury markers was established. In this dissertation, a novel diffusion MRI method, diffusion basis spectrum imaging (DBSI), was employed to detect and quantify neuro-inflammation as well as coexisting axon/myelin damage in a single setting. Our findings suggest that diffusion MRI is a promising noninvasive tool in investigating the structure, function and pathology of CNS.
Download or read book The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals A Clinical Perspective written by William C Klingensmith III and published by Springer. This book was released on 2016-04-06 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the mathematics and biology of the biodistribution of radiopharmaceuticals following their introduction into the body, but does so primarily from a clinical perspective – from the point of view of image interpretation and any associated image-derived quantification. All of the equations included in the book relate directly to the biodistribution of radiopharmaceuticals and are clinically useful, either conceptually or because of their value in quantifying a biological parameter, e.g., renal clearance. In particular, the more complex equations are not meant to be solved but instead are intended to provide a conceptual basis for the analysis of clinical images, especially those that are unusual and/or difficult to interpret. The efficacy of every diagnostic and therapeutic nuclear medicine procedure is critically dependent on the biodistribution of the radiopharmaceutical in question over time. This book will enable the reader to gain a sound understanding of the relevant mathematics and biology, and the clinical orientation ensures that it will be of value in enhancing clinical practice.
Download or read book Characterizing Cardiac Electrophysiology during Radiofrequency Ablation An Integrative Ex vivo In silico and In vivo Approach written by Pollnow, Stefan and published by KIT Scientific Publishing. This book was released on 2019-04-23 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
