Download or read book Hot Melt Extrusion written by Dennis Douroumis and published by John Wiley & Sons. This book was released on 2012-04-24 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations and regulatory issues. Topics covered include: principles and die design of single screw extrusion twin screw extrusion techniques and practices in the laboratory and on production scale HME developments for the pharmaceutical industry solubility parameters for prediction of drug/polymer miscibility in HME formulations the influence of plasticizers in HME applications of polymethacrylate polymers in HME HME of ethylcellulose, hypromellose, and polyethylene oxide bioadhesion properties of polymeric films produced by HME taste masking using HME clinical studies, bioavailability and pharmacokinetics of HME products injection moulding and HME processing for pharmaceutical materials laminar dispersive & distributive mixing with dissolution and applications to HME technological considerations related to scale-up of HME processes devices and implant systems by HME an FDA perspective on HME product and process understanding improved process understanding and control of an HME process with near-infrared spectroscopy Hot-Melt Extrusion: Pharmaceutical Applications is an essential multidisciplinary guide to the emerging pharmaceutical uses of this processing technology for researchers in academia and industry working in drug formulation and delivery, pharmaceutical engineering and processing, and polymers and materials science. This is the first book from our brand new series Advances in Pharmaceutical Technology. Find out more about the series here.

Download or read book Melt Extrusion written by Michael A. Repka and published by Springer Science & Business Media. This book was released on 2013-10-11 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with the basic principles and fundamentals of extrusion technology and a detailed description of the practical applications of a variety of extrusion processes, including various pharma grade extruders. In addition, the downstream production of films, pellets and tablets, for example, for oral and other delivery routes, are presented and discussed utilizing melt extrusion. This book is the first of its kind that discusses extensively the well-developed science of extrusion technology as applied to pharmaceutical drug product development and manufacturing. By covering a wide range of relevant topics, the text brings together all technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements. As extrusion technology continues to be refined further, usage of extruder systems and the array of applications will continue to expand, but the core technologies will remain the same.

Download or read book Practical Guide to Hot Melt Extrusion written by Mohammed Maniruzzaman and published by Smithers Rapra. This book was released on 2015-07-22 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few decades, hot-melt extrusion (HME) techniques have been shown to exhibit remarkable potential for the manufacture of various pharmaceutical products. HME is an emerging processing technology used primarily for the manufacture of pharmaceutical solid dispersions, combining the advantages of a solvent-free process with fewer production steps making it suitable for easy to scale-up and continuous manufacturing applications. A single unit HME based operation, employing heat and mechanical shear, has displayed a significant potential to retain the stability even of thermo-labile therapeutics e.g., proteins. HME has now explicitly been established from a quality-by-design viewpoint for in-line data monitoring as per the recent guidelines issued by the US Food and Drugs Administration (FDA).This book will focus primarily on the foregoing subject areas and will be of significant interest to a broad/interdisciplinary readership across the industries and academia for, (but not limited to) the following reasons:- Emerging HME processes and applications for multiple drug delivery.- Solid-state engineering, solubility enhancement, controlled release, taste masking and sustained release case studies from a continuous manufacturing view-point.- Means to explore the potential of continuous manufacture of co-crystals for promoting solvent free production methods.- Scale-up case study and issue considerations and studies on the regulatory guidelines (FDA) for continuous manufacturing involving emerging HME techniques.

Download or read book Pharmaceutical Extrusion Technology written by Isaac Ghebre-Selassie and published by CRC Press. This book was released on 2003-05-14 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Extrusion Technology is the only resource to provide in-depth descriptions and analyses of the key parameters of extruders and extrusion processes. The book highlights the applicability of melt extrusion in pharmaceutical drug development and product manufacturing, including controlled release, dissolution rate and bioavailability enhancement, and granulation technology. It brings together the technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements and details extruder hardware and controls, process definition and troubleshooting of single and twin screw extrusion processes, and more.

Download or read book Pharmaceutical Extrusion Technology written by Isaac Ghebre-Sellassie and published by CRC Press. This book was released on 2018-03-05 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion. Now it is expanded and improved, just like the usage of extrusion has expanded, improved and evolved into an accepted manufacturing technology to continuously mix active pharmaceutical ingredients with excipients for a myriad of traditional and novel dosage forms. Pharmaceutical Extrusion Technology, Second Edition reflects how this has spawned numerous research activities, in addition to hardware and process advancements. It offers new authors, expanded chapters and contains all the extrusion related technical information necessary for the development, manufacturing, and marketing of pharmaceutical dosage forms. Key Features: Reviews how extrusion has become an accepted technology to continuously mix active pharmaceutical ingredients with excipients Focuses on equipment and process technology Explains various extrusion system configurations as a manufacturing methodology for a variety of dosage forms Presents new opportunities available only via extrusion and future trends Includes contributions of experts from the process and equipment fields

Download or read book Reactive Extrusion written by Günter Beyer and published by John Wiley & Sons. This book was released on 2018-01-03 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive overview of reactive extrusion technology for over a decade combines the views of contributors from both academia and industry who share their experiences and highlight possible applications and markets. They also provide updated information on the underlying chemical and physical concepts, summarizing recent developments in terms of the material and machinery used. As a result, readers will find here a compilation of potential applications for reactive extrusion to access new and cost-effective polymeric materials, while using existing compounding machines.

Download or read book Extrusion Processing Technology written by Jean-Marie Bouvier and published by John Wiley & Sons. This book was released on 2014-06-23 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extrusion is the operation of forming and shaping a molten or dough-like material by forcing it through a restriction, or die. It is applied and used in many batch and continuous processes. However, extrusion processing technology relies more on continuous process operations which use screw extruders to handle many process functions such as the transport and compression of particulate components, melting of polymers, mixing of viscous media, heat processing of polymeric and biopolymeric materials, product texturization and shaping, defibering and chemical impregnation of fibrous materials, reactive extrusion, and fractionation of solid-liquid systems. Extrusion processing technology is highly complex, and in-depth descriptions and discussions are required in order to provide a complete understanding and analysis of this area: this book aims to provide readers with these analyses and discussions. Extrusion Processing Technology: Food and Non-Food Biomaterials provides an overview of extrusion processing technology and its established and emerging industrial applications. Potency of process intensification and sustainable processing is also discussed and illustrated. The book aims to span the gap between the principles of extrusion science and the practical knowledge of operational engineers and technicians. The authors bring their research and industrial experience in extrusion processing technology to provide a comprehensive, technical yet readable volume that will appeal to readers from both academic and practical backgrounds. This book is primarily aimed at scientists and engineers engaged in industry, research, and teaching activities related to the extrusion processing of foods (especially cereals, snacks, textured and fibrated proteins, functional ingredients, and instant powders), feeds (especially aquafeeds and petfoods), bioplastics and plastics, biosourced chemicals, paper pulp, and biofuels. It will also be of interest to students of food science, food engineering, and chemical engineering. Also available Formulation Engineering of Foods Edited by J.E. Norton, P.J. Fryer and I.T. Norton ISBN 978-0-470-67290-7 Food and Industrial Bioproducts and Bioprocessing Edited by N.T. Dunford ISBN 978-0-8138-2105-4 Handbook of Food Process Design Edited by J. Ahmed and M.S. Rahman ISBN 978-1-4443-3011-3

Download or read book Bio based Polymers and Nanocomposites written by Muhammed Lamin Sanyang and published by Springer. This book was released on 2019-02-05 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the various types of polymer and nanocomposites that can be derived from biorenewable resources. It covers various aspects of biobased polymers and nanocomposites, including preparation, processing, properties, and performance, and the latest advances in these materials. It also includes recent findings from leading researchers in academia and industry, government, and private research laboratories around the globe, providing the latest information on biobased polymers and nanocomposites. Offering an overview of the entire production process, it guides readers through all stages, from the raw source materials, processing and property characterization to application performance. This book is suitable for professionals and researchers seeking in-depth practical information as well as the fundamental science behind this. It also serves as a point of reference for undergraduate and graduate students, as well as postdoctoral researchers working in the area of polymer and composites with a special emphasis on biobased materials.

Download or read book Burger s Medicinal Chemistry Drug Discovery and Development 8 Volume Set written by and published by John Wiley & Sons. This book was released on 2021-04-20 with total page 6057 pages. Available in PDF, EPUB and Kindle. Book excerpt: Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.

Download or read book Melt Rheology and Its Role in Plastics Processing written by K. Wissbrun and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to fulfill a dual role. On the one hand it provides a description of the rheological behavior of molten poly mers. On the other, it presents the role of rheology in melt processing operations. The account of rheology emphasises the underlying principles and presents results, but not detailed deriva tions of equations. The processing operations are described qualita tively, and wherever possible the role of rheology is discussed quantitatively. Little emphasis is given to non-rheological aspects of processes, for example, the design of machinery. The audience for which the book is intended is also dual in It includes scientists and engineers whose work in the nature. plastics industry requires some knowledge of aspects of rheology. Examples are the polymer synthetic chemist who is concerned with how a change in molecular weight will affect the melt viscosity and the extrusion engineer who needs to know the effects of a change in molecular weight distribution that might result from thermal degra dation. The audience also includes post-graduate students in polymer science and engineering who wish to acquire a more extensive background in rheology and perhaps become specialists in this area. Especially for the latter audience, references are given to more detailed accounts of specialized topics, such as constitutive relations and process simulations. Thus, the book could serve as a textbook for a graduate level course in polymer rheology, and it has been used for this purpose.

Download or read book Polymer Melt Fracture written by Rudy Koopmans and published by CRC Press. This book was released on 2010-08-03 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continually growing plastics market consists of more than 250 million tons of product annually, making the recurring problem of polymer melt fracture an acute issue in the extrusion of these materials. Presenting a pictorial library of the different forms of melt fracture and real industrial extrusion melt fracture phenomena, Polymer Melt Fract

Download or read book Advances and Challenges in Pharmaceutical Technology written by Amit Kumar Nayak and published by Academic Press. This book was released on 2021-02-09 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances and Challenges in Pharmaceutical Technology: Materials, Process Development and Drug Delivery Strategies examines recent advancements in pharmaceutical technology. The book discusses common formulation strategies, including the use of tools for statistical formulation optimization, Quality by design (QbD), process analytical technology, and the uses of various pharmaceutical biomaterials, including natural polymers, synthetic polymers, modified natural polymers, bioceramics, and other bioinorganics. In addition, the book covers rapid advancements in the field by providing a thorough understanding of pharmaceutical processes, formulation developments, explorations, and exploitation of various pharmaceutical biomaterials to formulate pharmaceutical dosage forms. - Provides extensive information and analysis on recent advancements in the field of pharmaceutical technology - Includes contributions from global leaders and experts in academia, industry and regulatory agencies - Uses high quality illustrations, flow charts and tables to explain concepts and text to readers, along with practical examples and research case studies

Download or read book Extrusion written by Harold F. Giles Jr and published by William Andrew. This book was released on 2013-09-21 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Extrusion is designed to aid operators, engineers, and managers in extrusion processing in quickly answering practical day-to-day questions. The first part of the book provides the fundamental principles, for operators and engineers, of polymeric materials extrusion processing in single and twin screw extruders. The next section covers advanced topics including troubleshooting, auxiliary equipment, and coextrusion for operators, engineers, and managers. The final part provides applications case studies in key areas for engineers such as compounding, blown film, extrusion blow molding, coating, foam, and reprocessing. This practical guide to extrusion brings together both equipment and materials processing aspects. It covers basic and advanced topics, for reference and training, in thermoplastics processing in the extruder. Detailed reference data are provided on such important operating conditions as temperatures, start-up procedures, shear rates, pressure drops, and safety. - A practical guide to the selection, design and optimization of extrusion processes and equipment - Designed to improve production efficiency and product quality - Focuses on practical fault analysis and troubleshooting techniques

Download or read book Fluoroplastics Volume 2 written by Sina Ebnesajjad and published by William Andrew. This book was released on 2015-07-30 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluoroplastics, Volume 2: Melt Processible Fluoropolymers - The Definitive User's Guide and Data Book compiles the working knowledge of the polymer chemistry and physics of melt processible fluoropolymers with detailed descriptions of commercial processing methods, material properties, fabrication and handling information, technologies, and applications, also including history, market statistics, and safety and recycling aspects. Both volumes of Fluoroplastics contain a large amount of specific property data useful for users to readily compare different materials and align material structure with end use applications. Volume Two concentrates on melt-processible fluoropolymers used across a broad range of industries, including automotive, aerospace, electronic, food, beverage, oil/gas, and medical devices. This new edition is a thoroughly updated and significantly expanded revision covering new technologies and applications, and addressing the changes that have taken place in the fluoropolymer markets. - Exceptionally broad and comprehensive coverage of melt processible fluoropolymers processing and applications - Provides a practical approach, written by long-standing authorities in the fluoropolymers industry - Thoroughly updated and significantly expanded revision covering new technologies and applications, and addressing the changes that have taken place in the fluoropolymer markets

Download or read book Thermoforming of Single and Multilayer Laminates written by Syed Ali Ashter and published by William Andrew. This book was released on 2013-11-07 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thermoforming of Single and Multilayer Laminates explains the fundamentals of lamination and plastics thermoforming technologies along with current and new developments. It focuses on properties and thermoforming mechanics of plastic films and in particular single and multilayered laminates, including barrier films. For environmental and economic reasons, laminates are becoming increasingly important as a replacement for solid sheets and paint finishes in many industries, including transportation, packaging, and construction. Yet the processes of film formability during the extensive deformation and elevated temperatures experienced in conventional processing technologies, such as thermoforming, are poorly understood by most engineers. This book covers production processes, such as extrusion, calendaring, and casting, as well as mechanical and impact testing methods. It also describes how testing protocols developed for metals can be leveraged for plastic films and laminates, and includes a thorough discussion on methods for performing optical strain analysis. Applications in transportation vehicles and packaging, including packaging for food, medical and electronics applications, sports equipment, and household appliances, are discussed. Safety, recycling and environmental aspects of thermoforming and its products complete the book. First comprehensive source of information and hands-on guide for the thermoforming of multilayered laminates Covers applications across such sectors as automotive, packaging, home goods, and construction Introduces new testing methods leveraging protocols used for metals

Download or read book Carbon Based Nanofillers and Their Rubber Nanocomposites written by Srinivasarao Yaragalla and published by Elsevier. This book was released on 2019-02-06 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-Based Nanofillers and their Rubber Nanocomposites: Fundamentals and Applications provides the synthetic routes, characterization, structural properties and effect of nano fillers on rubber nanocomposites. The synthesis and characterization of all carbon-based fillers is discussed, along with their morphological, thermal, mechanical, dynamic mechanical, and rheological properties. The book also covers the theory, modeling, and simulation aspects of these nanocomposites and their various applications. Users will find a valuable reference source for graduates and post graduates, engineers, research scholars, polymer engineers, polymer technologists, and those working in the biomedical field. - Reviews rubber nanocomposites, specifically carbon-associated nanomaterials (nanocarbon black, graphite, graphene, carbon nanotubes, fullerenes, diamond) - Presents the synthesis and characterization of carbon based nanocomposites - Relates the structure of these nanocomposites to their function as rubber additives and their many applications

Download or read book Discovering and Developing Molecules with Optimal Drug Like Properties written by Allen C Templeton and published by Springer. This book was released on 2014-10-31 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.