Download or read book Medicinal Plants in Gastrointestinal Cancers and Tumor Microenvironments written by Qingmin Sun and published by Frontiers Media SA. This book was released on 2022-09-13 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers written by Ganji Purnachandra Nagaraju and published by Springer Nature. This book was released on 2020-10-07 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.

Download or read book Chinese Herbal Medicine written by Leon I. Hammer and published by Thieme. This book was released on 2012-12-05 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: A treasure trove of information for practitioners of Chinese medicine, this book gathers the herbal formulas of master practitioner Dr. John H. F. Shen for the first time. Not only does it incorporate the experience of Dr. Leon Hammer, who studied directly with Dr. Shen for nearly three decades, but it also presents the stimulus, rationale, and thinking behind many of the formulas. The result is a unique compendium of diseases spanning infancy to old age, with expert analysis and commentary by the authors, and the clinically tested herbal formulas used to treat each condition. Special Features Logically organized in two sections: the first by standard medical systems ranging from cardiovascular to respiratory; and the second by life cycle progression and developmental milestones Offers valuable insights on the etiology, symptoms, pathogenesis, and clinical signs of each disease Combines pulse diagnosis with herbal medicine for superior therapeutic outcomes Builds on the prominent Ding-Menghe lineage in Chinese medicine, dating back to the early 1600s Offering a window into the mind and practice of one of the greatest innovators in Chinese medicine, and integrating the knowledge and expertise of two foremost modern practitioners, this book is the only complete source available on Dr. Shens herbal heritage. It is essential reading for all Chinese medicine practitioners, herbalists, and other medical professionals prescribing herbs.

Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

Download or read book The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease written by Bharat B. Aggarwal and published by Springer Science & Business Media. This book was released on 2007-08-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Download or read book Veterinary Herbal Medicine written by Susan G. Wynn and published by Elsevier Health Sciences. This book was released on 2006-11-29 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: This full-color reference offers practical, evidence-based guidance on using more than 120 medicinal plants, including how to formulate herbal remedies to treat common disease conditions. A body-systems based review explores herbal medicine in context, offering information on toxicology, drug interactions, quality control, and other key topics. More than 120 herbal monographs provide quick access to information on the historical use of the herb in humans and animals, supporting studies, and dosing information. Includes special dosing, pharmacokinetics, and regulatory considerations when using herbs for horses and farm animals. Expanded pharmacology and toxicology chapters provide thorough information on the chemical basis of herbal medicine. Explores the evolutionary relationship between plants and mammals, which is the basis for understanding the unique physiologic effects of herbs. Includes a body systems review of herbal remedies for common disease conditions in both large and small animals. Discusses special considerations for the scientific research of herbs, including complex and individualized interventions that may require special design and nontraditional outcome goals.

Download or read book Nutraceuticals and Cancer written by Fazlul H. Sarkar and published by Springer Science & Business Media. This book was released on 2011-11-22 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.

Download or read book Herbal Medicines for Gastrointestinal and Hepatic Diseases Novel Pharmacological and Toxicological approaches Volume I 2nd edition written by Muhammad Hasnat, and published by Frontiers Media SA. This book was released on 2023-07-21 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of a series with: Herbal Medicines for Gastrointestinal and Hepatic Diseases - Novel Pharmacological and Toxicological approaches, Volume II Ethnopharmacology deals with the exchange of knowledge about people's use of herbal medicines and their pharmacological effects. The information related to therapeutic agents of plant origin and their toxic effects was preserved by oral tradition as well as recorded in materia medica. Many drugs that are now available on the market have been developed from this valuable information. Today, scientists that specialize in medicinal chemistry use these existing herbal drugs to develop and produce more therapeutically active agents with less toxic side effects. The gastrointestinal tract (GIT) is a multi-organ system, consisting of bacteria, and digestive enzymes that have the capacity of degrading food and other molecules. Diseases associated with this organ system include peptic ulcer, inflammatory bowel disease, gastric cancer to name a few. The liver receives seventy percent of its blood supply from the GIT via the hepatic portal vein. The disruption in the gut–liver axis is associated with liver diseases including alcohol-associated liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), and autoimmune liver disease (AILD). NAFLD can cause non-alcoholic steatohepatitis, which can develop into liver cirrhosis through inflammation and fibrosis. Liver cirrhosis is categorized as an end-stage of chronic liver disease, which impairs innate immunity-related genes. Growing evidence from preclinical studies proposes that the gut–liver axis leads to targeted therapeutic modalities for various liver injuries. Therefore, therapeutic treatment of these conditions is essential to prevent progression to these more harmful late-stage diseases.

Download or read book Diagnostics in Chinese Medicine written by Jiaxu Chen and published by PMPH-USA. This book was released on 2011-12-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acting as a bridge between the basic theory of Chinese medicine (CM) and various clinical subjects, Diagnostics in Chinese Medicine can be regarded as a core subject in understanding the concept of CM. Based on the national textbooks of CM in China, Diagnostics in Chinese Medicine is written combined with the National Standard and Quality Course given by Professor Chen Jiaxu at Beijing University of CM. According to Professor Chen’s long-standing high academic profile and clinical practice, figures and tables are presented clearly to intensify understanding and comprehension. We are sorry that the DVD content are not included.

Download or read book Oxford Textbook of Oncology written by David J. Kerr and published by Oxford University Press. This book was released on 2016-01-28 with total page 2837 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written and edited by internationally recognised leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Download or read book Adverse Effects of Herbal Drugs written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book series gives a comprehensive overview of the adverse effects of botanical medicines. It provides introductory information on Botany, Chemistry, Pharmacology and Uses, followed by an Adverse Reaction Profile subdivided according to organ and function. The third contribution to the series gives important information about eighteen specific medicinal herbs and important plant constituents. The herbs and constituents have been selected for several reasons, such as a prominent place in phytotherapy, clinical expectations about therapeutic potential and recent concern about a serious adverse reaction. The World Health Organization Regional Office for Europe (Copenhagen) has supported the book in the form of an acknowledgement that has been prepared by this Office.

Download or read book Integrative Veterinary Medicine written by Mushtaq A. Memon and published by John Wiley & Sons. This book was released on 2023-05-31 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrative Veterinary Medicine Practical guide integrating holistic modalities into Western veterinary practice to help with patient treatment Integrative Veterinary Medicine provides a clinically oriented, evidence-based guide to integrating complementary and conventional therapies into veterinary practice. Covering acupuncture, manual therapies, botanical and herbal medicine, integrative nutrition, and physical rehabilitation, the book draws information on these modalities together into a single resource. Rooted in evidence-based medicine, it demonstrates how to use these modalities in veterinary practice. The book begins by discussing the basic concepts of integrative veterinary medicine, then examines each modality in detail. A companion website offers video clips showing acupuncture techniques. In Integrative Veterinary Medicine, readers can expect to find detailed information on topics such as: Anatomy and physiology of acupuncture with relation to soft tissue and neurologic concepts, and traditional Chinese theory of acupuncture (Yin and Yang, Five Element Theory, and The Meridians) Veterinary manipulative therapy (neurology, biomechanics, and available evidence), and massage therapy and myofascial principles Origins and major systems of herbal therapy with selected evidence-based interventions and adverse events, herb-drug interactions, supplement evaluation, and regulation Trends in nutrition, such as raw diets, home-prepared diets, grain-free diets, owner perception, and current marketing Covering common modalities across all species in one volume, Integrative Veterinary Medicine is an essential reference for any veterinary practitioner wishing to use integrative techniques in their practices, as well as veterinary students, academics, and researchers involved in programs of study related to integrative veterinary medicine.

Download or read book Harnessing Medicinal Plants in Cancer Prevention and Treatment written by Roy, Arpita and published by IGI Global. This book was released on 2024-03-11 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a world grappling with the relentless impact of cancer, claiming nearly 10 million lives in 2020 alone, the pursuit of effective prevention and treatment methods is more crucial than ever. Harnessing Medicinal Plants in Cancer Prevention and Treatment delves into promising medicinal plants, exploring their potential in the prevention and treatment of various types of cancer. Acknowledging the limitations and risks associated with synthetic medicines, the book emphasizes the significance of traditional medicine, revealing that approximately 80% of the global population relies on plant-based remedies for primary health care. Within these pages, readers will find a comprehensive exploration of diverse medicinal plants and their active compounds, unraveling their mode of action against cancer. The content spans continents, from the phytochemical and biological properties of anticancer medicinal plants in India to the role of Chinese and Thai plants in cancer prevention and treatment. Each chapter meticulously examines specific plants or compounds, such as the renowned Curcuma longa, or the intriguing Momordica charantia, providing an in-depth analysis of their anticancer properties. This book elucidates the multifaceted role of plant-derived compounds in various cancer types, addressing their efficacy and safety profiles. The book is rich with insights into the potential of bioactive compounds to serve as lead candidates in drug discovery, highlighting the importance of plants in developing effective anticancer agents. This book is an invaluable resource for a diverse audience, including biotechnologists, plant biologists, pharmacologists, and cancer-related researchers.

Download or read book Rising stars in microbiome in health and disease 2022 written by Ping Li and published by Frontiers Media SA. This book was released on 2023-05-25 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Aggregation Induced Emission AIE written by Jianwei Xu and published by Elsevier. This book was released on 2022-04-17 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aggregation-Induced Emission (AIE): A Practical Guide introduces readers to the topic, guiding them through fundamental concepts and the latest advances in applications. The book covers concepts, principles and working mechanisms of AIE in AIE-active luminogens, with different classes of AIE luminogens reviewed, including polymers, three-dimensional frameworks (MOFs and COFs) and supramolecular gels. Special focus is given to the structure-property relationship, structural design strategies, targeted properties and application performance. The book provides readers with a deep understanding, not only on the fundamental principles of AIE, but more importantly, on how AIE luminogens and AIE properties can be incorporated in material development. Provides the fundamental principles, design and synthesis strategies of aggregation induced emission materials Reviews the most relevant applications in materials design for stimuli-responsive materials, biomedical applications, chemo-sensing and optoelectronics Emphasizes structural design and its connection to aggregation induced emission properties, also exploring the structure-property relationship

Download or read book Gastrointestinal Cancer Immunotherapy from Drug Resistance Mechanisms to Overcoming Strategies written by Xiaofang Che and published by Frontiers Media SA. This book was released on 2023-06-15 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrointestinal (GI) cancers, including gastric cancer, colon cancer, liver cancer, esophageal cancer, and pancreatic cancer, seriously threaten the health of human beings worldwide with a high rate of morbidity and mortality. The clinical successes achieved with immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 and CTLA-4 have opened a new cancer therapy era and brought new hope to cancer patients. However, the overall response rate (ORR) of ICI monotherapy in the non-selective population is only about 20%, in which some patients subsequently develop immunotherapy resistance. Moreover, the remaining 70-80% of patients displayed primary resistance to ICIs, and a few patients even experienced hyper progression disease (HPD). Although PD-L1 expression, mismatch repair deficient (MMRd), high tumor mutational burden (TMB-H) , high homologous recombination deficiency (HRD), and tumor infiltrated immune cells (TILs) are known as effective biomarkers for immunotherapy, growing studies have reported that ICIs could not improve the OS of all patients with PD-L1 expression higher than 50%, and the ORR of MSI-H patients was only about 60%, whereas some patients with low PD-L1 expression or MSS could still benefit from immunotherapy, indicating the complexity of ICI resistance. Therefore, it is of great importance and significance to explore the prediction biomarkers for primary or acquired immunotherapy resistance and elucidate their underlying molecular mechanisms and develop reversal strategies. Due to the multiple steps of the cancer immune cycle and complex immune microenvironment, any disorders of immune cell infiltration or T cell activation, such as lack of antigens and/or their presentation, lack of response to antigen presentation, and T cell priming, could contribute to ICI resistance. The combination with anti-angiogenesis therapy, radiotherapy, chemotherapy, and other ICIs has improved the efficacy of ICI therapy to some extent in the clinic. Although numerous studies related to ICI resistance were reported in GI cancers, due to the strong spatial/temporal heterogeneity and the complex immune microenvironment in different kinds of GI cancers and different individuals, many questions about ICI resistance and reversal strategies remain unsolved. The aim of this Research Topic is to provide a forum to exhibit the latest research achievement related to the exploration of biomarkers for immunotherapy resistance including HPD and the underlying molecular mechanisms, as well as the development of reversal strategies in GI cancers. We hope this Research Topic will lead to a better understanding of precision cancer immunotherapy and provide useful clues for clinical application to benefit more GI cancer patients with immunotherapy.

Download or read book Juzen taiho to Shi Quan Da Bu Tang written by Haruki Yamada and published by CRC Press. This book was released on 2005-04-29 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kampo is a traditional Japanese herbal medicine that takes a holistic approach to healing. Since Kampo is currently being used for the treatment of a wide range of diseases with many reports of clinical effectiveness, it is playing an increasingly important role in Japan's modern-day health care. Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Applications presents a concise overview of the important Kampo formula of Juzen-taiho-to. The book describes the therapeutic indications and traditional uses of Juzen-taiho-to, followed by its taxonomy, cultivation, quality assurance, and chemical constituents and pharmacological actions of raw plant material as the component herbs. Experts in the field discuss up-to-date findings and topics associated with the pharmacology and clinical application of Juzen-taiho-to, including its important immunomodulating, anti-tumor, and anti-metastatic properties, toxicology and side effects, and other related formulations. Today, Kampo medicine is steadily gaining acceptance by Japan's national health insurance system, the medical community, and contemporary society. This book provides a comprehensive review of Juzen-taiho-to and demonstrates how Kampo and other herbal medicines are becoming the popular, practical, and preferred treatments of tomorrow.