Download or read book Mechanisms of Transcriptional Control in Phosphate responsive Signaling Pathway of Saccharomyces Cerevisiae written by Xu Zhou and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of gene expression is essential for many biological processes. Binding of transcription factors to DNA is a key regulatory step in the control of gene expression. It is commonly observed that DNA sequences with high affinity for transcription factors occur more frequently in the genome than the instances of genes bound or regulated by these factors. However, the mechanism by which transcription factors selectively identify and regulate these genes was unclear. I utilized the transcriptional control of the phosphate-responsive signaling pathway (PHO) in Saccharomyces cerevisiae as a model system to address this problem.
Download or read book Mechanisms of Transcriptional Control in Phosphate responsive Signaling Pathway of Saccharomyces Cerevisiae written by Xu Zhou (Biochemist) and published by . This book was released on with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Analysis of Nutrient responsive Signal Transduction Pathways in Saccharomyces Cerevisiae written by Jonathan M. Raser and published by . This book was released on 2005 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organisms and their component cells exist in a dynamic and unpredictable environment. Many of these environmental changes are potentially harmful or lethal. It is therefore unsurprising that cells are capable of adaptation to many of these potentially harmful environmental conditions. This adaptation requires both the ability to gather information about the environment, and the ability to convert the information gathered into the appropriate cellular response. Cells have developed specific signal transduction pathways that respond to a specific environmental stimulus and effect a specific, corresponding cellular response. Such signal transduction pathways are quantitative, in that cells do not simply display binary information processing but are capable of more subtle interpretation of different magnitudes of a particular stimulus. In particular, many signaling pathways enable adaptation to changing levels of environmental nutrients by control of cellular gene expression. We employed the single-cell eukaryote Saccharomyces cerevisiae as a model to study several facets of nutrient-responsive signal transduction in a quantitative manner. In the following text, we present our study of the sources of heterogeneity in gene expression in a population of genetically identical cells. In addition, we review recent advances in understanding of heterogeneity or noise in gene expression. Also, we present work characterizing the zinc-responsive signaling pathway in a quantitative manner, and studies uncovering the presence of positive feedback in the phosphate-responsive (PHO) signaling pathway.
Download or read book Yeast Stress Responses written by Stefan Hohmann and published by Springer Science & Business Media. This book was released on 2007-10-23 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every cell has developed mechanisms to respond to changes in its environment and to adapt its growth and metabolism to unfavorable conditions. The unicellular eukaryote yeast has long proven as a particularly useful model system for the analysis of cellular stress responses, and the completion of the yeast genome sequence has only added to its power This volume comprehensively reviews both the basic features of the yeast genral stress response and the specific adapations to different stress types (nutrient depletion, osmotic and heat shock as well as salt and oxidative stress). It includes the latest findings in the field and discusses the implications for the analysis of stress response mechanisms in higher eukaryotes as well.
Download or read book Mycorrhizal Symbiosis written by Sally E. Smith and published by Academic Press. This book was released on 2010-07-26 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The roots of most plants are colonized by symbiotic fungi to form mycorrhiza, which play a critical role in the capture of nutrients from the soil and therefore in plant nutrition. Mycorrhizal Symbiosis is recognized as the definitive work in this area. Since the last edition was published there have been major advances in the field, particularly in the area of molecular biology, and the new edition has been fully revised and updated to incorporate these exciting new developments. - Over 50% new material - Includes expanded color plate section - Covers all aspects of mycorrhiza - Presents new taxonomy - Discusses the impact of proteomics and genomics on research in this area
Download or read book Methods in Yeast Genetics written by David C. Amberg and published by CSHL Press. This book was released on 2005 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Methods in Yeast Genetics" is a course that has been offered annually at Cold Spring Harbor for the last 30 years. This provides a set of teaching experiments along with the protocols and recipes for the standard techniques and reagents used in the study of yeast biology.
Download or read book Yeast Membrane Transport written by José Ramos and published by Springer. This book was released on 2015-12-31 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume reviews the recent progress in our understanding of membrane transport in yeast including both Saccharomyces cerevisiae and non-conventional yeasts. The articles provide a summary of the key transport processes and put these in a systems biology context of cellular regulation, signal reception and homeostasis. After a general introduction, readers will find review articles covering the mechanisms and regulation of transport for various substrates ranging from diverse nutrients to cations, water and protons. These articles are complemented by a chapter on extremophilic yeast, a chapter on the mathematical modelling of ion transport and two chapters on the role of transport in pathogenic yeasts and antifungal drug resistance. Each article provides both a general overview of the main transport characteristics of a specific substrate or group of substrates and the unique details that only an expert working in the field is able to transmit to the reader. Researchers and students of the topic will find this book to be a useful resource for membrane transport in yeast collecting information in one complete volume, which is otherwise scattered across many papers. This might also be interesting for scientists investigating other species in order to compare transport mechanisms with known functions in yeast with the cells on which they work.
Download or read book Systems Biology written by Lilia Alberghina and published by Springer Science & Business Media. This book was released on 2007-10-04 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: For life to be understood and disease to become manageable, the wealth of postgenomic data now needs to be made dynamic. This development requires systems biology, integrating computational models for cells and organisms in health and disease; quantitative experiments (high-throughput, genome-wide, living cell, in silico); and new concepts and principles concerning interactions. This book defines the new field of systems biology and discusses the most efficient experimental and computational strategies. The benefits for industry, such as the new network-based drug-target design validation, and testing, are also presented.
Download or read book Molecular Mechanisms Controlling Transmembrane Transport written by Eckhard Boles and published by Springer Science & Business Media. This book was released on 2004-06-16 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: All living cells are strictly separated from their surroundings by a membranous lipid bilayer. Into these membranes a variety of transport proteins are embedded that ensure the uptake and secretion of various molecules and ions. In order to respond properly to a changing nutrient supply or demand, as well as to external stress factors, cells must be able to adapt both amount and activity of the corresponding transporters. This book provides readers with state-of-the-art knowledge on the various regulatory mechanisms that control transmembrane transporter expression, activity and their subcellular localisation.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signaling in Plants written by František Baluška and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive monograph on all emerging topics in plant signaling. The book addresses diverse aspects of signaling at all levels of plant organization. Emphasis is placed on the integrative aspects of signaling.
Download or read book Nutrient Induced Responses in Eukaryotic Cells written by Joris Winderickx and published by Springer Science & Business Media. This book was released on 2004-03-29 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells of all living organisms have the ability to respond to altered nutritional conditions. They have developed mechanisms to sense nutrient availability and to produce appropriate responses, which involve changes in gene expression and the production or degradation of certain enzymes and other proteins. In recent years, the understanding of nutrient-induced signal transduction has greatly advanced and the emerging picture is that nutrient signalling mechanisms evolved early in evolution. This book provides a detailed presentation and comparison of the key nutritional regulatory mechanisms in lower as well as higher eukaryotes, written by recognised experts in this expanding field.
Download or read book The Molecular Biology of Schizosaccharomyces pombe written by Richard Egel and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fission yeast Schizosaccharomyces pombe is the favoured tool of many productive research groups throughout the world, serving as a useful model for fundamental principles and mechanisms, such as genome organization, differential gene regulation, cell-cycle control, signal transduction, or cellular morphogenesis. This book collates the current state of knowledge derived from molecular studies in this simple eukaryotic microorganism. The entire sequence of its genome has been completed, emphasizing the comparative value and model status of this yeast. The individual chapters, highlighting up-to-date views on prominent aspects of molecular organization, were written by active research scientists, presenting the results of their investigations to other workers in neighbouring fields. This book intends to serve the fission yeast community as a handy source of reference for years to come. It will also be of particular value to the ever-increasing number of researchers starting to look into fission yeast affairs for comparative reasons from other platforms of molecular genetics and cell biology.
Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Download or read book Phosphate in Microorganisms written by Annamaria Torriani-Gorini and published by Amer Society for Microbiology. This book was released on 1994-01 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of phosphate metabolism and transport. The phosphotransferase system. Polyphosphates and phosphates reserves. Phospholipids. Protein export and folding. Signal transduction and phosphoproteins. Structure/function relationships.
Download or read book The Plausibility of Life written by Marc W. Kirschner and published by Yale University Press. This book was released on 2005-10-19 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two biologists tackle the unresolved question in the field of evolution: how have living organisms on Earth developed with such variety and complexity? In the 150 years since Darwin, the field of evolutionary biology has left a glaring gap in understanding how animals developed their astounding variety and complexity. The standard answer has been that small genetic mutations accumulate over time to produce wondrous innovations such as eyes and wings. Drawing on cutting-edge research across the spectrum of modern biology, Marc Kirschner and John Gerhart demonstrate how this stock answer is woefully inadequate. Rather they offer an original solution to the longstanding puzzle of how small random genetic change can be converted into complex, useful innovations. In a new theory they call “facilitated variation,” Kirschner and Gerhart elevate the individual organism from a passive target of natural selection to a central player in the 3-billion-year history of evolution. In clear, accessible language, the authors invite every reader to contemplate daring new ideas about evolution. By closing the major gap in Darwin’s theory Kirschner and Gerhart also provide a timely scientific rebuttal to modern critics of evolution who champion “intelligent design.” “Makes for informative and enjoyable reading, and the issues the authors raise are worthy of attention.”—American Scientist “Thought-provoking and lucidly written…The Plausibility of Life will help readers understand not just the plausibility of evolution, but its remarkable, inventive powers.”—Sean Carroll, author of Endless Forms Most Beautiful: The New Science of Evo Devo
Download or read book Plant Signaling Molecules written by M. Iqbal R. Khan and published by Woodhead Publishing. This book was released on 2019-03-15 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Signaling Molecule: Role and Regulation under Stressful Environments explores tolerance mechanisms mediated by signaling molecules in plants for achieving sustainability under changing environmental conditions. Including a wide range of potential molecules, from primary to secondary metabolites, the book presents the status and future prospects of the role and regulation of signaling molecules at physiological, biochemical, molecular and structural level under abiotic stress tolerance. This book is designed to enhance the mechanistic understanding of signaling molecules and will be an important resource for plant biologists in developing stress tolerant crops to achieve sustainability under changing environmental conditions. - Focuses on plant biology under stress conditions - Provides a compendium of knowledge related to plant adaptation, physiology, biochemistry and molecular responses - Identifies treatments that enhance plant tolerance to abiotic stresses - Illustrates specific physiological pathways that are considered key points for plant adaptation or tolerance to abiotic stresses
