Download or read book Mechanisms and Models in Rheumatoid Arthritis written by B. Henderson and published by Academic Press. This book was released on 1995-03-16 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this disease in an effort to test hypotheses about putative pathological mechanisms and to investigate the effect of novel therapeutic agents. A major section of this book covers these experimental models in great detail from their development through to reviews of the most recent information on each model.Mechanisms and Models in Rheumatoid Arthritis brings together a group of eminent researchers from the fields of clinical rheumatology, pathology, experimental pathology, immunology, connective tissue biochemistry, microbiology, pharmacology and developmental biology to describe the current views of the cellular and humoral mechanisms that drive the pathology of rheumatoid arthritis and experimental models of rheumatoid arthritis.Key Features:* The book is divided into five sections:* The clinical spectrum, aetiopathogenesis, the role of microbial superantigens in pathology and the present and future therapies for rheumatoid arthritis* The pathology of rheumatoid arthritis, the development and role of synovial pannus and the use of immunohistochemistry in defining synovial pathology* Cell populations involved in synovitis with chapters on synovial cells, chondrocytes, bone cells, leukocytes and leukocyte trafficking* Mediators, with coverage of: cytokines and cytokine inhibitors, growth factors, free radicals and inflammatory lipid mediators, neuropeptides and proteases* Current studies on experimental models of rheumatoid arthritis
Download or read book Arthritis written by H. Deicher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid arthritis is a common disease, an estimated 1. 5% of the population being under medical treatment for it in European countries and elsewhere. However, to date the origin of this chronic inflammatory disorder has not been elucidated. Evidence for the involvement of microbial agents is still tenuous, the rea son for the defective control of inflammation is still unknown, and the disease all too of ten progresses to crippling stages despite long-term treatment. As T. McKeown recently stated with regard to rheumatoid arthritis, "not enough is even known to indicate which is the more promising approach, and the pru dent course is to investigate both origins and mechanisms". While working on animal model diseases as well as on aspects of rheumatoid arthritis and related disorders in man, the members of the Special Research Area on patho physiology of rheumatoid inflammation in man and. animals (Sonderforschungsbereich 54 "Pa thomechanismen der rheumatoiden Entztindung bei Mensch und Tier"; maintained by the Deut sche Forschungsgemeinschaft) at the Veterinary and Medical Schools, Hannover, have been guided by the concept that by studying clinically and morphologically similar diseases in several species, mutually stimulating results might lead to improved knowledge of the pathophysio logy of rheumatoid arthritis. In particular, from working with model diseases in animals new approaches to the etiology of rheumatoid arthritis might be derived, while detailed knowledge of pathogenetic processes in rheu matoid arthritis could further research in chronic stages of pertinent animal diseases
Download or read book Tolerance Mechanisms in Collagen induced Arthritis written by Alexandra Bäcklund and published by . This book was released on 2005 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Behaviorally Conditioned Immunosuppression in a Model of Rheumatoid Arthritis in Rats written by Laura Lückemann and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rheumatoid Arthritis written by J. J. Goronzy and published by Karger Medical and Scientific Publishers. This book was released on 2001-01-01 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, the third volume of the new series 'Current Directions in Autoimmunity', is the first one to exclusively focus on one disease. Written by experts in genetics and immunobiology, the articles reflect the complexity and multiple facets of the disease process but also show their convergence to a better understanding of pathogenetic mechanisms and the evolving clinical applications. The models and concepts described in this volume have implications for studies of other inflammatory diseases and are of interest not only for clinical and basic scientists devoted to the study of rheumatoid arthritis but for investigators of autoimmune diseases in general.
Download or read book Analysis of the Mechanisms of Immune Gene Therapy in a Murine Model for Rheumatoid Arthritis written by Hanna Stina Dreja and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rheumatoid Arthritis written by Reem Hamdy A. Mohammed and published by BoD – Books on Demand. This book was released on 2020-11-19 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid Arthritis - Other Perspectives towards Better Practice sheds light on the disease process of rheumatoid arthritis as well as the disease’s related comorbidities. Chapters cover such topics as immune-pathogenic theories, classification criteria, available composite measures of disease assessment, and latest available therapeutic approaches.
Download or read book Early Rheumatoid Arthritis written by Paul Emery and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.
Download or read book Mechanisms of MHC class II Restricted Presentation of Aggrecan in an Animal Model of Rheumatoid Arthritis written by Katie Lowes and published by . This book was released on 2006 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rheumatoid Arthritis Pathogenetic Mechanisms and Consequences in Therapeutics written by Werner Müller (Prof., Dr. med.) and published by Academic Press. This book was released on 1971 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms of Arsenic Trioxide in an in Vitro Model of Rheumatoid Arthritis Synoviocyte written by Wai-Han Law and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Molecular Mechanisms of Arsenic Trioxide in an in Vitro Model of Rheumatoid Arthritis Synoviocyte" by Wai-han, Law, 羅慧嫺, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4150853 Subjects: Arsenic compounds Rheumatoid arthritis - Molecular aspects
Download or read book Polymyositis and Dermatomyositis written by Marinos C. Dalakas and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.
Download or read book Mechanisms of Autoimmunity in Rheumatoid Arthritis written by Cindy Lees and published by . This book was released on 1997 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pathogenesis Mechanism and Cardiovascular Risk Factors for Arteriosclerosis in Rheumatoid Arthritis written by Alberto López de Guzmán and published by Nova Novinka. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is well established that in auto-immune diseases there is a chronic systemic inflammatory process that predominantly affects the joints. This has a significant negative impact on the quality of life of patients and considerable socio-economic costs. In addition, in recent years a decline in life expectancy has been observed, either due to the complications of the disease itself or as a consequence of the treatments used. The most important predictors of mortality are the presence of a rheumatoid factor, the results of the Health Assessment Questionnaire (HAQ) and extra-articular manifestations. This book examines the prognostic factors and the causes of death, using rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) as models of auto-immune diseases.
Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Download or read book Molecular Mechanisms of Arsenic Trioxide in an in Vitro Model of Rheumatoid Arthritis Synoviocyte written by Wai-han Law (M. Phil.) and published by . This book was released on 2008 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book T Cells in Arthritis written by P. Miossec and published by Springer Science & Business Media. This book was released on 1998-07-21 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempted to incorporate the most recent data. Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA. While each of the editors and authors has his/her own bias (as will be clear by reading the respective chapters), our hope is that the readers will enjoy a complete and balanced view of the critical questions and experiments. This is not just an intellectual exercise since the direction of future therapeutic interventions depends heavily on how one interprets the pathogenesis of RA and the contribution of T cells.
