Download or read book Mechanical Testing for the Biomechanics Engineer written by Marnie M. Saunders and published by Springer Nature. This book was released on 2022-06-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanical testing is a useful tool in the field of biomechanics. Classic biomechanics employs mechanical testing for a variety of purposes. For instance, testing may be used to determine the mechanical properties of bone under a variety of loading modes and various conditions including age and disease state. In addition, testing may be used to assess fracture fixation procedures to justify clinical approaches. Mechanical testing may also be used to test implants and biomaterials to determine mechanical strength and appropriateness for clinical purposes. While the information from a mechanical test will vary, there are basics that need to be understood to properly conduct mechanical testing. This book will attempt to provide the reader not only with the basic theory of conducting mechanical testing, but will also focus on providing practical insights and examples.

Download or read book Mechanical Testing for the Biomechanics Engineer written by Marnie M. Saunders and published by Morgan & Claypool Publishers. This book was released on 2014-12-01 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanical testing is a useful tool in the field of biomechanics. Classic biomechanics employs mechanical testing for a variety of purposes. For instance, testing may be used to determine the mechanical properties of bone under a variety of loading modes and various conditions including age and disease state. In addition, testing may be used to assess fracture fixation procedures to justify clinical approaches. Mechanical testing may also be used to test implants and biomaterials to determine mechanical strength and appropriateness for clinical purposes. While the information from a mechanical test will vary, there are basics that need to be understood to properly conduct mechanical testing. This book will attempt to provide the reader not only with the basic theory of conducting mechanical testing, but will also focus on providing practical insights and examples. Table of Contents: Preface / Fundamentals / Accuracy and Measurement Tools / Design / Testing Machine Design and Fabrication / Fixture Design and Applications / Additional Considerations in a Biomechanics Test / Laboratory Examples and Additional Equations / Appendices: Practical Orthopedic Biomechanics Problems / Bibliography / Author Biography

Download or read book Experimental Methods in Orthopaedic Biomechanics written by Radovan Zdero and published by Academic Press. This book was released on 2016-10-14 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Methods in Orthopaedic Biomechanics is the first book in the field that focuses on the practicalities of performing a large variety of in-vitro laboratory experiments. Explanations are thorough, informative, and feature standard lab equipment to enable biomedical engineers to advance from a 'trial and error' approach to an efficient system recommended by experienced leaders. This is an ideal tool for biomedical engineers or biomechanics professors in their teaching, as well as for those studying and carrying out lab assignments and projects in the field. The experienced authors have established a standard that researchers can test against in order to explain the strengths and weaknesses of testing approaches. - Provides step-by-step guidance to help with in-vitro experiments in orthopaedic biomechanics - Presents a DIY manual that is fully equipped with illustrations, practical tips, quiz questions, and much more - Includes input from field experts who combine their real-world experience to provide invaluable insights for all those in the field

Download or read book Design Development and Optimization of Bio Mechatronic Engineering Products written by Kumar, Kaushik and published by IGI Global. This book was released on 2019-03-15 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanical engineering is involved with creating and producing a variety of products in everyday use, from environmentally safe plastics to various foods, fabrics, and medicines. A combination of engineering and biology, it is a fast-growing field with many new and exciting opportunities in genetic engineering and biotechnology. However, research surrounding biomechanical applications is scattered and often restricted, leading to the need for a comprehensive publication of the recent advances and developments in this emerging field. Design, Development, and Optimization of Bio-Mechatronic Engineering Products provides pivotal research on the application of combining mechanical engineering with human biological systems in order to develop bio-mechatronic products like pacemakers, artificial kidney replacements, artificial hearts, and new joints or limbs to better and more accurately monitor and advance human health. While highlighting topics such as orthotic devices, inter-electrode gap, and biomaterial applications, this publication explores producing artificial material to work in sync with the human body. This book is ideally designed for engineers, health professionals, technology developers, researchers, academicians, and students.

Download or read book Computerized Analysis of Mammographic Images for Detection and Characterization of Breast Cancer written by Arianna Mencattini and published by Springer Nature. This book was released on 2022-05-31 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification and interpretation of the signs of breast cancer in mammographic images from screening programs can be very difficult due to the subtle and diversified appearance of breast disease. This book presents new image processing and pattern recognition techniques for computer-aided detection and diagnosis of breast cancer in its various forms. The main goals are: (1) the identification of bilateral asymmetry as an early sign of breast disease which is not detectable by other existing approaches; and (2) the detection and classification of masses and regions of architectural distortion, as benign lesions or malignant tumors, in a unified framework that does not require accurate extraction of the contours of the lesions. The innovative aspects of the work include the design and validation of landmarking algorithms, automatic Tabár masking procedures, and various feature descriptors for quantification of similarity and for contour independent classification of mammographic lesions. Characterization of breast tissue patterns is achieved by means of multidirectional Gabor filters. For the classification tasks, pattern recognition strategies, including Fisher linear discriminant analysis, Bayesian classifiers, support vector machines, and neural networks are applied using automatic selection of features and cross-validation techniques. Computer-aided detection of bilateral asymmetry resulted in accuracy up to 0.94, with sensitivity and specificity of 1 and 0.88, respectively. Computer-aided diagnosis of automatically detected lesions provided sensitivity of detection of malignant tumors in the range of [0.70, 0.81] at a range of falsely detected tumors of [0.82, 3.47] per image. The techniques presented in this work are effective in detecting and characterizing various mammographic signs of breast disease.

Download or read book Spatiotemporal Modeling of Influenza written by William E. Schiesser and published by Springer Nature. This book was released on 2022-05-31 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has a two-fold purpose: (1) An introduction to the computer-based modeling of influenza, a continuing major worldwide communicable disease. (2) The use of (1) as an illustration of a methodology for the computer-based modeling of communicable diseases. For the purposes of (1) and (2), a basic influenza model is formulated as a system of partial differential equations (PDEs) that define the spatiotemporal evolution of four populations: susceptibles, untreated and treated infecteds, and recovereds. The requirements of a well-posed PDE model are considered, including the initial and boundary conditions. The terms of the PDEs are explained. The computer implementation of the model is illustrated with a detailed line-by-line explanation of a system of routines in R (a quality, open-source scientific computing system that is readily available from the Internet). The R routines demonstrate the straightforward numerical solution of a system of nonlinear PDEs by the method of lines (MOL), an established general algorithm for PDEs. The presentation of the PDE modeling methodology is introductory with a minumum of formal mathematics (no theorems and proofs), and with emphasis on example applications. The intent of the book is to assist in the initial understanding and use of PDE mathematical modeling of communicable diseases, and the explanation and interpretation of the computed model solutions, as illustrated with the influenza model.

Download or read book Models of Horizontal Eye Movements written by Alireza Ghahari and published by Springer Nature. This book was released on 2022-06-01 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book series is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. In Part 1, early models of saccades and smooth pursuit are presented. A number of oculomotor plant models are described here beginning with the Westheimer model published in 1954, and up through our 1995 model involving a 4th order oculomotor plant model. In Part 2, a 2009 version of a state-of-the-art model is presented for horizontal saccades that is 3rd-order and linear, and controlled by a physiologically based time-optimal neural network. Part 3 describes a model of the saccade system, focusing on the neural network. It presents a neural network model of biophysical neurons in the midbrain for controlling oculomotor muscles during horizontal human saccades. In this book, a multiscale model of the saccade system is presented, focusing on a multiscale neural network and muscle fiber model. Chapter 1 presents a comprehensive model for the control of horizontal saccades using a muscle fiber model for the lateral and medial rectus muscles. The importance of this model is that each muscle fiber has a separate neural input. This model is robust and accounts for the neural activity for both large and small saccades. The muscle fiber model consists of serial sequences of muscle fibers in parallel with other serial sequences of muscle fibers. Each muscle fiber is described by a parallel combination of a linear length tension element, viscous element, and active-state tension generator. Chapter 2 presents a biophysically realistic neural network model in the midbrain to drive a muscle fiber oculomotor plant during horizontal monkey saccades. Neural circuitry, including omnipause neuron, premotor excitatory and inhibitory burst neurons, long lead burst neuron, tonic neuron, interneuron, abducens nucleus, and oculomotor nucleus, is developed to examine saccade dynamics. The time-optimal control mechanism demonstrates how the neural commands are encoded in the downstream saccadic pathway by realization of agonist and antagonist controller models. Consequently, each agonist muscle fiber is stimulated by an agonist neuron, while an antagonist muscle fiber is unstimulated by a pause and step from the antagonist neuron. It is concluded that the neural network is constrained by a minimum duration of the agonist pulse, and that the most dominant factor in determining the saccade magnitude is the number of active neurons for the small saccades. For the large saccades, however, the duration of agonist burst firing significantly affects the control of saccades. The proposed saccadic circuitry establishes a complete model of saccade generation since it not only includes the neural circuits at both the premotor and motor stages of the saccade generator, but it also uses a time-optimal controller to yield the desired saccade magnitude. Table of Contents: Acknowledgments / A New Linear Muscle Fiber Model for Neural Control of Saccades\footnotemark / A Physiological Neural Controller of a Muscle Fiber Oculomotor Plant in Horizontal Monkey Saccades\footnotemark / References / Authors' Biographies

Download or read book Eco and Ground Bio Engineering The Use of Vegetation to Improve Slope Stability written by A. Stokes and published by Springer Science & Business Media. This book was released on 2007-04-10 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together papers from geotechnical and civil engineers, biologists, ecologists and foresters. They discuss current problems in slope stability research and how to address them using ground bio- and eco-engineering techniques. Coverage presents studies by scientists and practitioners on slope instability, erosion, soil hydrology, mountain ecology, land use and restoration and how to mitigate these problems using vegetation.

Download or read book Insights and Innovations in Structural Engineering Mechanics and Computation written by Alphose Zingoni and published by CRC Press. This book was released on 2016-11-25 with total page 2223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insights and Innovations in Structural Engineering, Mechanics and Computation comprises 360 papers that were presented at the Sixth International Conference on Structural Engineering, Mechanics and Computation (SEMC 2016, Cape Town, South Africa, 5-7 September 2016). The papers reflect the broad scope of the SEMC conferences, and cover a wide range of engineering structures (buildings, bridges, towers, roofs, foundations, offshore structures, tunnels, dams, vessels, vehicles and machinery) and engineering materials (steel, aluminium, concrete, masonry, timber, glass, polymers, composites, laminates, smart materials).

Download or read book Reference Manual on Scientific Evidence written by National Research Council and published by National Academies Press. This book was released on 2011-10-26 with total page 1034 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Reference Manual on Scientific Evidence, Third Edition, assists judges in managing cases involving complex scientific and technical evidence by describing the basic tenets of key scientific fields from which legal evidence is typically derived and by providing examples of cases in which that evidence has been used. First published in 1994 by the Federal Judicial Center, the Reference Manual on Scientific Evidence has been relied upon in the legal and academic communities and is often cited by various courts and others. Judges faced with disputes over the admissibility of scientific and technical evidence refer to the manual to help them better understand and evaluate the relevance, reliability and usefulness of the evidence being proffered. The manual is not intended to tell judges what is good science and what is not. Instead, it serves to help judges identify issues on which experts are likely to differ and to guide the inquiry of the court in seeking an informed resolution of the conflict. The core of the manual consists of a series of chapters (reference guides) on various scientific topics, each authored by an expert in that field. The topics have been chosen by an oversight committee because of their complexity and frequency in litigation. Each chapter is intended to provide a general overview of the topic in lay terms, identifying issues that will be useful to judges and others in the legal profession. They are written for a non-technical audience and are not intended as exhaustive presentations of the topic. Rather, the chapters seek to provide judges with the basic information in an area of science, to allow them to have an informed conversation with the experts and attorneys.

Download or read book Forensic Biomechanics and Human Injury written by Harold Franck and published by CRC Press. This book was released on 2015-12-18 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forensic Biomechanics and Human Injury: Criminal and Civil Applications An Engineering Approach provides a concise, comprehensive overview of human anatomy and the biomechanical factors involved in human injury. It describes the methodologies used to compute the various forces, stresses, and energies required to injure the human body.The book cov

Download or read book Exosomes and MicroRNAs in Biomedical Science written by Hamed Mirzaei and published by Morgan & Claypool Publishers. This book was released on 2022-04-21 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth of the tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.

Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Download or read book Functional Imaging and Modeling of the Heart written by Dimitris N. Metaxas and published by Springer Science & Business Media. This book was released on 2011-05-10 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the proceedings of the 6th International Conference on Functional Imaging and Modeling of the Heart, held in New York City, NY, USA in May 2011. The 24 revised full papers presented together with 29 revised poster papers were carefully reviewed and selected from about 120 initial submissions. The contributions feature current research and development efforts in the fields of cardiovascular modeling, physiology, and image-based analysis, at a range of scales and imaging methods. Topics addresses are such as imaging, signal and image processing, applied mathematics, biomedical engineering and computer science; biologically oriented fields such as cardiac physiology and biology; as well as clinical issues such as cardiology, radiology and surgery, with a common interest in the heart.

Download or read book Emerging Trends in Immunomodulatory Nanomaterials Toward Cancer Therapy written by Anubhab Mukherjee and published by Springer Nature. This book was released on 2022-05-31 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, immunomodulatory nanomaterials have gained immense attention due to their involvement in the modulation of the body’s immune response to cancer therapy. This book highlights various immunomodulatory nanomaterials (including organic, polymer, inorganic, liposomes, viral, and protein nanoparticles) and their role in cancer therapy. Additionally, the mechanism of immunomodulation is reviewed in detail. Finally, the challenges of these therapies and their future outlook are discussed. We believe this book will be helpful to a broad community including students, researchers, educators, and industrialists.

Download or read book Nanotechnology for Bioengineers written by Wujie Zhang and published by Springer Nature. This book was released on 2022-05-31 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is an interdisciplinary field that is rapidly evolving and expanding. Significant advancements have been made in nanotechnology-related disciplines in the past few decades and continued growth and progression in the field are anticipated. Moreover, nanotechnology, omnipresent in innovation, has been applied to resolve critical challenges in nearly every field, especially those related to biological technologies and processes. This book, used as either a textbook for a short course or a reference book, provides state-of-the-art analysis of essential topics in nanotechnology for bioengineers studying and working in biotechnology, chemical/biochemical, pharmaceutical, biomedical, and other related fields. The book topics range from introduction to nanotechnology and nanofabrication to applications of nanotechnology in various biological fields. This book not only intends to introduce bioengineers to the amazing world of nanotechnology, but also inspires them to use nanotechnology to address some of the world's biggest challenges.

Download or read book Fast Quantitative Magnetic Resonance Imaging written by Guido Buonincontri and published by Springer Nature. This book was released on 2022-05-31 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among medical imaging modalities, magnetic resonance imaging (MRI) stands out for its excellent soft-tissue contrast, anatomical detail, and high sensitivity for disease detection. However, as proven by the continuous and vast effort to develop new MRI techniques, limitations and open challenges remain. The primary source of contrast in MRI images are the various relaxation parameters associated with the nuclear magnetic resonance (NMR) phenomena upon which MRI is based. Although it is possible to quantify these relaxation parameters (qMRI) they are rarely used in the clinic, and radiological interpretation of images is primarily based upon images that are relaxation time weighted. The clinical adoption of qMRI is mainly limited by the long acquisition times required to quantify each relaxation parameter as well as questions around their accuracy and reliability. More specifically, the main limitations of qMRI methods have been the difficulty in dealing with the high inter-parameter correlations and a high sensitivity to MRI system imperfections. Recently, new methods for rapid qMRI have been proposed. The multi-parametric models at the heart of these techniques have the main advantage of accounting for the correlations between the parameters of interest as well as system imperfections. This holistic view on the MR signal makes it possible to regress many individual parameters at once, potentially with a higher accuracy. Novel, accurate techniques promise a fast estimation of relevant MRI quantities, including but not limited to longitudinal (T1) and transverse (T2) relaxation times. Among these emerging methods, MR Fingerprinting (MRF), synthetic MR (syMRI or MAGIC), and T1‒T2 Shuffling are making their way into the clinical world at a very fast pace. However, the main underlying assumptions and algorithms used are sometimes different from those found in the conventional MRI literature, and can be elusive at times. In this book, we take the opportunity to study and describe the main assumptions, theoretical background, and methods that are the basis of these emerging techniques. Quantitative transient state imaging provides an incredible, transformative opportunity for MRI. There is huge potential to further extend the physics, in conjunction with the underlying physiology, toward a better theoretical description of the underlying models, their application, and evaluation to improve the assessment of disease and treatment efficacy.