Download or read book Mathematical Models for Cell Rearrangement written by George D. Mostow and published by . This book was released on 1975-01-01 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mathematical Models of Cell Based Morphogenesis written by Hisao Honda and published by Springer Nature. This book was released on 2022-06-27 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the shape formation of living organisms using mathematical models. Genes are deeply related to the shape of living organisms, and elucidation of a pathway of shape formation from genes is one of the fundamental problems in biology. Mathematical cell models are indispensable tools to elucidate this problem. The book introduces two mathematical cell models, the cell center model and the vertex model, with their applications. The cell center model is applied to elucidate the formation of neat cell arrangements in epidermis, cell patterns consisting of heterogeneous-sized cells, capillary networks, and the branching patterns of blood vessels. The vertex model is applied to elucidate the wound healing mechanisms of the epithelium and ordered pattern formation involving apoptosis. Pattern formation with differential cell adhesion is also described. The vertex model is then extended from a two-dimensional (2D) to a three-dimensional (3D) model. A cell aggregate involving a large cavity is described to explain the development of the mammalian blastocyst or the formation of an epithelial vesicle. Epithelial tissues and the polarity formation process of the epithelium are also explained. The vertex model also recapitulates active remodeling of tissues and describes the twisting of tissue that contributes to understanding the cardiac loop formation of the embryonic tube. The book showcases that mathematical cell models are indispensable tools to understand the shape formation of living organisms. Successful contribution of the mathematical cell models means that the remodeling of collective cells is self-construction. Examining the successive iterations of self-constructions leads to understanding the remarkable and mysterious morphogenesis that occurs during the development of living organisms. The intended readers of this book are not only theoretical or mathematical biologists, but also experimental and general biologists, including undergraduate and postgraduate students who are interested in the relationship between genes and morphogenesis.
Download or read book Mathematical Models of the Cell and Cell Associated Objects written by Viktor V. Ivanov and published by Elsevier. This book was released on 2006-05-10 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives the reader a survey of hundreds results in the field of the cell and cell associated objects modeling. Applications to modeling in the areas of AIDS, cancers and life longevity are investigated in this book. - Introduces and proves fundamental properties of evolutionary systems on optimal distribution of their various resources on their internal and external functions - Gives detailed analysis of applications to modeling AIDS, cancers, and life longevity - Introducing and grounding the respective numerical algorithms and software - Detailed analysis of hundreds of scientific works in the field of mathematical modeling of the cell and cell associated objects
Download or read book Mathematical Models in Molecular Cellular Biology written by Lee A. Segel and published by CUP Archive. This book was released on 1980 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in theoretical biology is rapidly growing and this 1981 book attempts to make the theory more accessible to experimentalists. Its primary purpose is to demonstrate to experimental molecular and cellular biologists the possible usefulness of mathematical models. Biologists with a basic command of calculus should be able to learn from the book what assumptions are implied by various types of equations, to understand in broad outline a number of major theoretical concepts, and to be aware of some of the difficulties connected with analytical and numerical solutions of mathematical problems. Thus they should be able to appreciate the significance of theoretical papers in their fields and to communicate usefully with theoreticians in the course of their work.
Download or read book Mathematical Modelling of Cellular Rearrangements During Embryonic Development written by Khoren Ponsin and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cell death by apoptosis plays a key role in several developmental processes such as tissue sculpting and homeostasis. During embryonic development of the urogenital system in mice, apoptosis plays a crucial role in removing a temporal structure called the Common Nephric Duct (CND), a necessary step to connect the ureter to the bladder epithelium. Evidence suggests that apoptotic cell removal generates pulling forces necessary for tissue rearrangement. Non-professional phagocytosis of apoptotic cells by neighbouring epithelial cells (referred to as non-professional efferocytosis) was observed during CND elimination. In this process, epithelial cells programmed to die are engulfed and subsequently phagocytosed by neighboring cells. This entire process involves five different stages of apoptosis, a cell drift and an apoptotic gradient along the CND. We develop a novel multiscale mathematical model that couples the different stages of efferocytosis and the cell types involved (e.g., apoptotic, phagocyte and engulfed) with the cellular drift equation system (advection) equation to provide spatiotemporal insights about this process.} We use the apoptotic gradient along the CND, the stationary distribution of cells in the different stages and the maintenance of a uniform diameter of the duct to parameterize the model. Using experimental data and boundary conditions, we adapt the model to different physiological conditions, including in vivo wild types, ex vivo non-treated embryos and ex vivo treated embryos. The mathematical model is then employed to perform tasks that are difficult or not possible to be conducted experimentally. With this approach, we quantify the dwell time at each stage of efferocytosis and dissect the relative contribution of efferocytosis, cell extrusion and proliferation individually and in combination to CND shortening/elongation continuously over time. We finally examine the effects of Blebbistatin treatment on CND dynamics and determine the role of actomyosin during CND elimination. Our results suggest that there is significant CND shortening forces in the absence of actomyosin activity, an interesting outcome of this modeling study in view of the generally recognized belief that morphogenetic forces are largely driven primarily by actomyosin activity. Indeed, this work provides an evidence that efferocytosis and actomyosin drive the CND elimination throughout time (i.e., not only at certain time points). It also provides a mathematical spatiotemporal framework for how cellular rearrangement could occur during embryonic development in the CND"--
Download or read book A mathematical modeling framework to simulate and analyze cell type transitions written by Daniella Schittler and published by Logos Verlag Berlin GmbH. This book was released on 2015-03-20 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The quantitative understanding of changes in cell types, referred to as cell type transitions, is fundamental to advance fields such as stem cell research, immunology, and cancer therapies. This thesis provides a mathematical modeling framework to simulate and analyze cell type transitions. The novel methodological approaches and models presented here address diverse levels which are essential in this context: Gene regulatory network models represent the cell type-determining gene expression dynamics. Here, a novel construction method for gene regulatory network models is introduced, which allows to transfer results from generic low-dimensional to realistic high-dimensional gene regulatory network models. For populations of cells, a generalized model class is proposed that accounts for multiple cell types, division numbers, and the full label distribution. Analysis and solution methods are presented for this new model class, which cover common cell population experiments and allow to exploit the full information from data. The modeling and analysis methods presented here connect formerly isolated approaches, and thereby contribute to a holistic framework for the quantitative understanding of cell type transitions.
Download or read book Simple Mathematical Models of Gene Regulatory Dynamics written by Michael C. Mackey and published by Springer. This book was released on 2016-11-09 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a short and self-contained introduction to the field of mathematical modeling of gene-networks in bacteria. As an entry point to the field, we focus on the analysis of simple gene-network dynamics. The notes commence with an introduction to the deterministic modeling of gene-networks, with extensive reference to applicable results coming from dynamical systems theory. The second part of the notes treats extensively several approaches to the study of gene-network dynamics in the presence of noise—either arising from low numbers of molecules involved, or due to noise external to the regulatory process. The third and final part of the notes gives a detailed treatment of three well studied and concrete examples of gene-network dynamics by considering the lactose operon, the tryptophan operon, and the lysis-lysogeny switch. The notes contain an index for easy location of particular topics as well as an extensive bibliography of the current literature. The target audience of these notes are mainly graduates students and young researchers with a solid mathematical background (calculus, ordinary differential equations, and probability theory at a minimum), as well as with basic notions of biochemistry, cell biology, and molecular biology. They are meant to serve as a readable and brief entry point into a field that is currently highly active, and will allow the reader to grasp the current state of research and so prepare them for defining and tackling new research problems.
Download or read book Modeling Cellular Systems written by Frederik Graw and published by Springer. This book was released on 2017-05-08 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume comprises research articles and reviews on topics connected to the mathematical modeling of cellular systems. These contributions cover signaling pathways, stochastic effects, cell motility and mechanics, pattern formation processes, as well as multi-scale approaches. All authors attended the workshop on "Modeling Cellular Systems" which took place in Heidelberg in October 2014. The target audience primarily comprises researchers and experts in the field, but the book may also be beneficial for graduate students.
Download or read book Mathematical Models for Biological Pattern Formation written by Philip K. Maini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 121st IMA volume, entitled MATHEMATICAL MODELS FOR BIOLOGICAL PATTERN FORMATION is the first of a new series called FRONTIERS IN APPLICATION OF MATHEMATICS. The FRONTIERS volumes are motivated by IMA pro grams and workshops, but are specially planned and written to provide an entree to and assessment of exciting new areas for the application of mathematical tools and analysis. The emphasis in FRONTIERS volumes is on surveys, exposition and outlook, to attract more mathematicians and other scientists to the study of these areas and to focus efforts on the most important issues, rather than papers on the most recent research results aimed at an audience of specialists. The present volume of peer-reviewed papers grew out of the 1998-99 IMA program on "Mathematics in Biology," in particular the Fall 1998 em phasis on "Theoretical Problems in Developmental Biology and Immunol ogy." During that period there were two workshops on Pattern Formation and Morphogenesis, organized by Professors Murray, Maini and Othmer. James Murray was one of the principal organizers for the entire year pro gram. I am very grateful to James Murray for providing an introduction, and to Philip Maini and Hans Othmer for their excellent work in planning and preparing this first FRONTIERS volume. I also take this opportunity to thank the National Science Foundation, whose financial support of the IMA made the Mathematics in Biology pro gram possible.
Download or read book Mathematical Modeling for Genes to Collective Cell Dynamics written by Tetsuji Tokihiro and published by Springer Nature. This book was released on 2022-02-23 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the dynamics of biological cells and their mathematical modeling. The topics cover the dynamics of RNA polymerases in transcription, construction of vascular networks in angiogenesis, and synchronization of cardiomyocytes. Statistical analysis of single cell dynamics and classification of proteins by mathematical modeling are also presented. The book provides the most up-to-date information on both experimental results and mathematical models that can be used to analyze cellular dynamics. Novel experimental results and approaches to understand them will be appealing to the readers. Each chapter contains 1) an introductory description of the phenomenon, 2) explanations about the mathematical technique to analyze it, 3) new experimental results, 4) mathematical modeling and its application to the phenomenon. Elementary introductions for the biological phenomenon and mathematical approach to them are especially useful for beginners. The importance of collaboration between mathematics and biological sciences has been increasing and providing new outcomes. This book gives good examples of the fruitful collaboration between mathematics and biological sciences.
Download or read book Mathematical Models and Methods for Living Systems written by Luigi Preziosi and published by Springer. This book was released on 2016-11-09 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of these lecture notes is to give an introduction to several mathematical models and methods that can be used to describe the behaviour of living systems. This emerging field of application intrinsically requires the handling of phenomena occurring at different spatial scales and hence the use of multiscale methods.Modelling and simulating the mechanisms that cells use to move, self-organise and develop in tissues is not only fundamental to an understanding of embryonic development, but is also relevant in tissue engineering and in other environmental and industrial processes involving the growth and homeostasis of biological systems. Growth and organization processes are also important in many tissue degeneration and regeneration processes, such as tumour growth, tissue vascularization, heart and muscle functionality, and cardio-vascular diseases.
Download or read book Cell Movement written by Magdalena Stolarska and published by Springer. This book was released on 2018-11-22 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a collection of original research articles and review articles that describe novel mathematical modeling techniques and the application of those techniques to models of cell motility in a variety of contexts. The aim is to highlight some of the recent mathematical work geared at understanding the coordination of intracellular processes involved in the movement of cells. This collection will benefit researchers interested in cell motility as well graduate students taking a topics course in this area.
Download or read book A Primer in Mathematical Models in Biology written by Lee A. Segel and published by SIAM. This book was released on 2013-01-01 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook introduces differential equations, biological applications, and simulations and emphasizes molecular events (biochemistry and enzyme kinetics), excitable systems (neural signals), and small protein and genetic circuits. A Primer on Mathematical Models in Biology will appeal to readers because it grew out of a course that the popular and highly respected applied mathematician Lee Segel taught at the Weizmann Institute and it represents his unique perspective; combines clear and useful mathematical methods with applications that illustrate the power of such tools; and includes many exercises in reasoning, modeling, and simulations.
Download or read book Network based Mathematical Modeling in Cell and Developmental Biology written by Susan Mertins and published by Frontiers Media SA. This book was released on 2024-08-22 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vast amount of knowledge in Cell Signaling gathered through reductionist efforts and omics technology is poised to approach a Systems Biology understanding of precise representations of cell structure and function and predictions at multi-scale levels despite the complexity. Super-resolution microscopy and single cell analysis are also providing opportunities to explore both spatial and temporal landscapes. Notably, many basic biological processes have been studied capturing mechanistic detail with the goal to understand cellular proliferation and differentiation, gene regulation, morphogenesis, metabolism, and cell-cell communication. Similarly, at the intracellular level, addressing functions such as self-assembly, phase separation, and transport is leading to insights not readily understood as linear pathways. Therefore, network-based mathematical modeling, delineating dynamic biochemical reactions through ordinary and partial differential equations, promises to discover emergent biological properties not heretofore expected.
Download or read book Tutorials in Mathematical Biosciences III written by Avner Friedman and published by Springer. This book was released on 2005-11-23 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume introduces some basic mathematical models for cell cycle, proliferation, cancer, and cancer therapy. Chapter 1 gives an overview of the modeling of the cell division cycle. Chapter 2 describes how tumor secretes growth factors to form new blood vessels in its vicinity, which provide it with nutrients it needs in order to grow. Chapter 3 explores the process that enables the tumor to invade the neighboring tissue. Chapter 4 models the interaction between a tumor and the immune system. Chapter 5 is concerned with chemotherapy; it uses concepts from control theory to minimize obstacles arising from drug resistance and from cell cycle dynamics. Finally, Chapter 6 reviews mathematical results for various cancer models.
Download or read book Non Local Cell Adhesion Models written by Andreas Buttenschön and published by Springer Nature. This book was released on 2021-06-09 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph considers the mathematical modeling of cellular adhesion, a key interaction force in cell biology. While deeply grounded in the biological application of cell adhesion and tissue formation, this monograph focuses on the mathematical analysis of non-local adhesion models. The novel aspect is the non-local term (an integral operator), which accounts for forces generated by long ranged cell interactions. The analysis of non-local models has started only recently, and it has become a vibrant area of applied mathematics. This monograph contributes a systematic analysis of steady states and their bifurcation structure, combining global bifurcation results pioneered by Rabinowitz, equivariant bifurcation theory, and the symmetries of the non-local term. These methods allow readers to analyze and understand cell adhesion on a deep level.
Download or read book Mathematical Modelling written by Murray S. Klamkin and published by SIAM. This book was released on 1987-01-01 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for classroom use, this book contains short, self-contained mathematical models of problems in the physical, mathematical, and biological sciences first published in the Classroom Notes section of the SIAM Review from 1975-1985. The problems provide an ideal way to make complex subject matter more accessible to the student through the use of concrete applications. Each section has extensive supplementary references provided by the editor from his years of experience with mathematical modelling.
