Download or read book Maternal fetal Toxicology written by Gideon Koren and published by Marcel Dekker. This book was released on 1994 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: For health professionals who are asked by women and their families to provide answers on potential reproductive effects of xenobiotics and radiation, this volume presents the approaches and clinical tools developed by the multidisciplinary team at the Motherisk Clinic in Toronto to inform, counsel, and follow up pregnant women exposed to drugs, chemicals, or radiation in pregnancy. This revised and expanded edition adds several novel aspects, such as the maternal-fetal toxicology of medicinal plants, developmental risk assessment, and biological markers of intrauterine exposure to drugs of abuse. This edition also includes clinical cases at the beginning of most chapters, with answers at the end. Annotation c. by Book News, Inc., Portland, Or.

Download or read book Maternal fetal Toxicology written by Gideon Koren and published by . This book was released on 1990 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Developmental and Reproductive Toxicology written by Ronald D. Hood and published by CRC Press. This book was released on 2005-08-30 with total page 1164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers e

Download or read book Biologic Markers in Reproductive Toxicology written by National Research Council (U.S.). Subcommittee on Reproductive and Neurodevelopmental Toxicology and published by Routledge. This book was released on 1989 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Clinical Pharmacology During Pregnancy written by Donald Mattison and published by Academic Press. This book was released on 2012-12-05 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems, as well as essential content on dosing and efficacy. Written in a clear and practical manner, this reference provides easily accessible information and clinical guidance on how best to treat women with medications during pregnancy.

Download or read book Developmental Toxicology written by CaroleAKimmel and published by CRC Press. This book was released on 1994-06-30 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of this highly regarded work provides a state-of-the-art review of developmental toxicology from basic science, clinical, epidemiological, and regulatory perspectives. This new edition highlights the latest approaches to understanding the mechanisms of developmental toxicity, testing pharmaceutical and environmental agents, and interpreting developmental toxicity data.; The contributors demonstrate how new information on molecular embryology and cell biology is being applied to problems in developmental toxicology. Chapters describe the effects of toxic exposure on the functional development of various organs, examine the relationship between maternal and developmental toxicity, and discuss current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the use of mathematical and statistical techniques in data interpretation, as well as to the regulatory aspects of testing and risk assessment. Other chapters focus on pre- and post conceptional clinical care and on genetic factors in clinical developmental toxicology.

Download or read book Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards written by K.S. Khera and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (!LSI) is a scientific foundation that addresses critical health and safety issues of national and international con cern. ILSI promotes international cooperation by providing the mechanism for scientists from government, industry, and universities to work together on cooperative programs to generate and disseminate scientific data. The mem bers and trustees of the institute believe that questions regarding health and safety are best resolved when scientists can examine and discuss issues as an independent body separate from the political pressures of individual countries and the economic concerns of individual companies. Frequently, meaningful assessment of the risk of a test substance is hindered by the inherent inconsistencies in the system. The development and refine ment of methods and systems to evaluate the safety of chemicals have evolved in a rapid and largely unplanned fashion. Attempts to improve the system have mainly been directed toward broad general concerns, with little attention being given to specific problems or issues. A failure to resolve these problems has frequently resulted in increased testing costs and complications in the assessment and extrapolation of the results to humans. Publicity surrounding toxicologic issues makes it difficult for governments to deal effectively with these problems. In response to these difficulties, ILSI has assembled highly qualified and renowned scientists from research institutes, universities, government, and industry with relevant scientific knowledge and expertise regarding the issues that complicate risk assessment procedures.

Download or read book Developmental and Reproductive Toxicology written by Ali S. Faqi and published by Humana. This book was released on 2018-06-15 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working in this vital field of study./div

Download or read book Drinking Water and Health written by National Research Council and published by National Academies Press. This book was released on 1986-02-01 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.

Download or read book Placental Toxicology written by B. V. Rama Sastry and published by CRC Press. This book was released on 1995-02-24 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time in a single volume, placental and fetal consequences of exposure of pregnant women to drugs, environmental chemicals, and infections, such as HIV, are discussed. Topics include: The art of in

Download or read book Placental Toxicology written by B. V. Rama Sastry and published by CRC Press. This book was released on 1995-02-24 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placental Toxicology examines placental transfer and toxicology of drugs and environmental agents to placenta, as well as to fetus. For the first time in a single volume, placental and fetal consequences of exposure of pregnant women to drugs, environmental chemicals, and infections, such as HIV, are discussed. Topics include: The art of in vitro perfusion of human placenta Abuse of alcohol, nicotine, morphine, and cocaine during pregnancy, their placental transfer and fetal growth retardation Placental transfer and fetal toxicities of environmental insecticides Placental hormones and fetal well-being Placental transfer of HIV and treatment of pregnant women with anti-HIV drugs

Download or read book Toxicology and the Maternal fetal Environment written by Teresa Dodd-Butera and published by . This book was released on 2008 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placental function is paramount to maintaining optimum conditions both in utero and for long term fetal development. Glutathione-S-transferases (GSTs) play a role in the placenta by protecting the fetus from toxicants and oxidative stress. A soluble form of GST, GST pi (GSTP1), accounts for a significant amount of placental GST enzyme activity. Previous studies indicate that the Ile105Val polymorphism in GSTP1 affects susceptibility to pathologic conditions of pregnancy such as preeclampsia and recurrent pregnancy loss. GSTP1 also detoxifies environmental carcinogens such as polyaromatic hydrocarbons (PAHs). This study investigates the relationship between placental levels of GST pi, enzyme activity, and genetic polymorphisms of biotransformation enzymes CYP1A1 exon 7, GSTP1, GSTM1; and PAH-DNA adduct measurements. Maternal venous and umbilical cord blood and placental tissue were collected from 54 consenting obstetric patients from Tijuana, Baja California (BC), Mexico (maternal age mean 25.8, range 16--39 years). Placental GST pi levels were measured via Western blots; GST activity was measured against CDNB; and genetic polymorphisms were assessed by PCR and restriction enzyme digestion. Relative adduct levels were obtained by 32P-postlabeling. A 30-fold variation in enzyme activity was found and activity ranged from 21--623 nmol/min/ml. Activity and levels of GSTPi were modestly correlated (r = 0.359, p = 0.13). No difference was found in placental GSTPi activity associated with the GSTP1 Ile105/Ile105 genotype vs. the Val105/Val105 genotype. An increased activity was however observed in placental supernatant from GSTP1 Ile105 positive mother/baby pairs that were concordant for GST mu negative genotype vs. pairs with GST mu positive genotype, though numbers were very small (n = 6 vs. n = 31, p = 0.024); median PAH-DNA adduct measurements were 10.4 RAL x 109 nucleotides. Placental variability in levels and activity of the protective enzyme GST pi can be substantial between Hispanic women. GST pi levels and genetic variation at GSTP1 ile105val does not appear to explain variability in placental enzyme activity and PAH-DNA adduct measurements. Further studies are necessary to elucidate the impact of placental biotransformation enzymes on pregnancies which are more at risk from endogenous and environmental toxicants.

Download or read book Clinical Pharmacology During Pregnancy written by Donald Mattison and published by Academic Press. This book was released on 2021-09-24 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. This update includes substantially expanded sections on the ethics of pharmacological research in pregnancy and physiologic changes, along with new sections on patient reported outcomes in pregnancy, delivery and postnatal care, and the use of pharmacokinetic and pharmacodynamic approaches to estimate maternal, placental and fetal dosing. The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are also covered, as are research issues, including clinical trial design and ethical considerations. Uses an evidence-based approach for therapeutics during pregnancy Presents a summary of specific medications by indication, including up-to-date information on dosing and efficacy in pregnancy for the given indication Includes significant new sections on physiologic changes and the ethics of pharmacological research in pregnancy

Download or read book The Health Effects of Cannabis and Cannabinoids written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-03-31 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.

Download or read book Teratogenesis and Reproductive Toxicology written by E.M. Johnson and published by Springer. This book was released on 1983-05-01 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The resolution of links between exposure to components of our complex environmental and causation of reproductive effects in the population constitutes an important problem in the field of toxicology. The focus of this volume is developmental toxicology, which represents one aspect of reproductive toxicology dealing with the study of adverse effects on the developing conceptus. Developmental toxicology, which includes teratogenesis as one of its manifesta tions, provides a fertile field for research in several basic and clinical disciplines; this field also receives input from several disoiplines such as developmental and molecu lar biology, pathology, pharmacology and toxicology, pediatrics and neonatology, and epidemiology. More recently we h~ve seen an emergence of interest in other fields such as perinatal physiology and postnatal behavior which have now become incorporated into the mainstream of research in this discipline. The present volume is an effort to provide a sampling of concepts currently under active investigation in several of the above fields. The authors have endeavored to provide up-to-date in formation on the following topics: detection and analysis of potential hazards to the conceptus in the workplace, pharmacokinetic aspects of the maternal/placental! fetal complex and its relationship to human birth defects, and probable mechanisms of teratogenesis as uncovered in certain well-defined situations. Also included are summaries of newer investigations on the emerging field of postnatal functional evaluations, i. e. , adverse effects on adult activities resultant from in utero exposure to toxic substances.

Download or read book Drug Therapy During Pregnancy written by Tom K. A. B. Eskes and published by Elsevier. This book was released on 2013-10-22 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Therapy During Pregnancy is a collection of papers dealing with the risks and benefits of drug treatment for both mother and fetus. One paper notes that the total use of medication during pregnancy in the Netherlands has decreased from 82.7 % to 71.7 %. The paper also points out the lack of a relationship between the number or type of congenital anomalies and the use of medication. Another paper assesses fetal drug exposure in two ways: firstly, through the physicochemical characteristics of the drug and the way it is handled by the mother in order to estimate placental passage and fetal exposure. Secondly, through the utilization of pharmacokinetic models estimating the probable time course of drug concentrations in the feto-maternal unit. One paper investigates the effects of hypertension during pregnancy, in which the etiology of hypertension, a group of disorders with one common abnormality, remains unsolved with a clinical diagnosis that is not always accurate. Treatment differs widely depending on the type: chronic hypertension, albuminuric hypertension, and hypertensive crises during pregnancy. One paper suggests that to prove any environmental exposure to a particular substance affecting pregnancy, the exact timing of exposure must be established, large samples are necessary, possibly on a national or international scale. The paper cites as example the four-year documentation period of the 50% to 80% incidence of malformations due to thalidomide. General medicine practitioners, obstetricians, gynecologists, and researchers dealing with pharmacology, pharmocokinetics, toxicology, or embryology will find the collection valuable.

Download or read book Reproductive and Developmental Toxicology written by Ramesh C Gupta and published by Academic Press. This book was released on 2022-02-11 with total page 1558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more