Download or read book Marine Microbial Diversity as a Source of Bioactive Natural Products written by Didier Stien and published by MDPI. This book was released on 2020-06-17 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: A trillion different microbial species have been evolving for some 3.5 billion years, producing ever more complex active secondary metabolites. The sea is a cauldron of a great diversity of useful and valuable compounds. This Special Issue focused on studies of marine microbe natural products for discovering compounds useful to humankind. Papers were collected that provide up-to-date information regarding the characterization of marine microbes’ metabolic diversity and the evaluation of the therapeutic potential of marine microbes’ metabolites. Most of the articles in this book deal with marine fungi, biological and chemical diversity, and their active metabolites. This may be a sign that marine fungi have been under studied to date and are perceived by many researchers as an important source of discovery in this field. A best practices guide for the isolation of marine fungi from different matrixes and their conservation is also presented. The comparison of the phylogenetic and metabolomic profiles of microalgae from different lineages provides novel insights into the potential of chemotaxonomy in marine phytoplankton, showing a good overlap of phylogenetic and chemotaxonomic signals.
Download or read book Marine Microbial Diversity as a Source of Bioactive Natural Products written by Didier Stien and published by . This book was released on 2020 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: A trillion different microbial species have been evolving for some 3.5 billion years, producing ever more complex active secondary metabolites. The sea is a cauldron of a great diversity of useful and valuable compounds. This Special Issue focused on studies of marine microbe natural products for discovering compounds useful to humankind. Papers were collected that provide up-to-date information regarding the characterization of marine microbes' metabolic diversity and the evaluation of the therapeutic potential of marine microbes' metabolites. Most of the articles in this book deal with marine fungi, biological and chemical diversity, and their active metabolites. This may be a sign that marine fungi have been under studied to date and are perceived by many researchers as an important source of discovery in this field. A best practices guide for the isolation of marine fungi from different matrixes and their conservation is also presented. The comparison of the phylogenetic and metabolomic profiles of microalgae from different lineages provides novel insights into the potential of chemotaxonomy in marine phytoplankton, showing a good overlap of phylogenetic and chemotaxonomic signals.
Download or read book Marine Microbial Diversity as Source of Bioactive Compounds written by Khaled A. Shaaban and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 70% of the Earth's surface is covered by oceans and seas, which are massively complex and consist of diverse assemblages of life forms. Marine bacteria, fungi, and other microorganisms develop unique metabolic and physiological capabilities that enable them to survive in extreme habitats and to produce compounds that might not be produced by their terrestrial counterparts. In the last few decades, the systematic investigations of marine/marine-derived microorganisms as sources of novel biologically active agents has exponentially increased. This Special Issue will focus on aspects relating to new bioactive metabolites from marine microorganisms including the isolation, taxonomy, and/or dereplication of microorganisms and the corresponding isolation, structure elucidation, biosynthesis, and/or biological activities of the new compounds. Comprehensive topical review articles relating to marine metabolites will also be considered.
Download or read book YOUMARES 9 the Oceans Our Research Our Future written by Simon Jungblut and published by Springer Nature. This book was released on 2020-01-01 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book summarizes peer-reviewed articles and the abstracts of oral and poster presentations given during the YOUMARES 9 conference which took place in Oldenburg, Germany, in September 2018. The aims of this book are to summarize state-of-the-art knowledge in marine sciences and to inspire scientists of all career stages in the development of further research. These conferences are organized by and for young marine researchers. Qualified early-career researchers, who moderated topical sessions during the conference, contributed literature reviews on specific topics within their research field. .
Download or read book Marine Microorganisms written by Leo M.L. Nollet and published by CRC Press. This book was released on 2016-09-19 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: The marine environment covers 70% of the earth’s surface and accounts for 98% of the potentially habitable space. The bioactives from marine microorganisms include antibiotic compounds, polysaccharides, inhibitors, enzymes, peptides, and pigments. These are used in various fields of biology that range from nutraceuticals to cosmeceuticals. Recent scientific investigations have revealed that marine microbial compounds exhibit various beneficial biological effects, such as anti-inflammatory, anti-cancer, anti-HIV, anti-hypertensive, and anti-diabetic. Marine Microorganisms: Extraction and Analysis of Bioactive Compounds sheds light on the extraction, clean-up, and detection methods of major compounds from marine organisms. The book includes information on the different classes of marine microorganisms and the different bioactives that can be extracted from bacteria, fungi and microalgae. Divided into 7 chapters, the book covers bioactive marine natural products, such as marine microbes, seaweeds, and marine sponges as potential sources of drug discovery, and focuses on analysis methods of the biocomponents from marine microorganisms. A useful reference tool for researchers and students, this book provides current knowledge about isolation and analysis methods of the bioactives and provides insight into the various bioactives of marine microbes toward nutraceutical and pharmaceutical development.
Download or read book Marine Ecosystems A Unique Source of Valuable Bioactive Compounds written by Hassan A.H. Ibrahim and published by Bentham Science Publishers. This book was released on 2023-11-06 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference highlights the significance of marine ecosystems, encompassing seaweed beds, seagrasses, coral reefs, mangroves, estuaries, and protected areas, as a remarkable gateway to overcoming healthcare challenges and unlocking a rich trove of bioactive compounds for drug discovery. One of the key highlights of this book is its exploration of the development of marine bio-drugs, a field that demands collaboration among scientists from both academic and industrial fronts. The editors also include a prospective review on marine environments, emphasizing the necessity for big data, collective knowledge sharing, financial support, and streamlined administrative processes, all of which contribute to enhancing innovation in the drug discovery process. Another feature includes reference lists that allow researchers to explore topics of interest in depth. With twelve comprehensive chapters, this book extensively covers marine ecosystem biodiversity, productivity, protected areas, and the intricate interplay of biotic and abiotic factors that shape these ecosystems. Readers will learn about important bioactive compounds within marine organisms and how to use this knowledge to outline a strategy for bio-drug discovery. The book caters to a diverse audience of researchers, students, ecologists, microbiologists, pharmacologists, and biotechnologists who are engaged in studying the dynamic components of marine environments. By providing the latest insights and strategies in the realm of bio-drug discovery from marine resources, this book serves as an invaluable resource for scholars and professionals seeking to tap into the potential of these unique ecosystems.
Download or read book Marine Microbiology written by Se-Kwon Kim and published by John Wiley & Sons. This book was released on 2013-06-21 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deliberately breaking with the classical biology-centered description of marine organisms and their products, this reference emphasizes microbial technology over basic biology, setting it apart from its predecessors. As such, it systematically covers the technology behind high-value compounds for use as pharmaceuticals, nutraceuticals or cosmetics, from prospecting to production issues. Following a definition of the field, the book goes on to address all industrially important aspects of marine microbial biotechnology. The first main part contains a description of the major production organisms, from archaebacteria to cyanobacteria to algae and symbionts, including their genetic engineering. The remaining four parts look at commercially important compounds produced by these microorganisms together with their applications. Throughout, the emphasis is on technological considerations, and the future potential of these organisms or compound classes is discussed. A valuable and forward-looking resource for innovative biotechnologists in industry as well as in academia.
Download or read book The Marine Microbiome written by Lucas J. Stal and published by Springer. This book was released on 2016-06-03 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the state-of-the-art concerning the ‘marine microbiome’ and its uses in biotechnology. The first part discusses the diversity and ecology of marine microorganisms and viruses, including all three domains of life: Bacteria, Archaea, and Eukarya. It discusses whether marine microorganisms exist and, if so, why they might be unique. The second part presents selected marine habitats, their inhabitants and how they influence biogeochemical cycles, while the third discusses the utilization of marine microbial resources, including legal aspects, dissemination, and public awareness. The marine microbiome is the total of microorganisms and viruses in the ocean and seas and in any connected environment, including the seafloor and marine animals and plants. The diversity of microbial life remains unquantified and largely unknown, and could represent a hidden treasure for human society. Accordingly, this book is also intended to connect academics and industry, providing essential information for microbiologists from both fields.
Download or read book Bioactive Natural Products from the Red Sea written by Mostafa Rateb and published by MDPI. This book was released on 2021-09-08 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the recent advances in natural product chemistry and biodiversity in the Red Sea. All previous marine natural products isolated from different Red Sea organisms and microbes were collected in a comprehensive review. Additionally, newly discovered marine natural products and their biological activities are described.
Download or read book Natural Products from Marine Microorganisms written by Xian-Wen Yang and published by Frontiers Media SA. This book was released on 2020-01-22 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products continue to serve as sources for the development of new medicines. There is currently a revival of interest in the discovery of bioactive compounds with new chemical structures from natural sources, largely due to the fact that synthetic libraries have not yielded the expected number of developmental candidates in the pharmaceutical industry during the last decade. In addition, the emergence of clinically relevant pathogens that are becoming increasingly resistant to currently used medicines strengthens the notion that natural product research is urgently required. Considering the fact that almost 10% of bioactive compounds are of microbial origin, and that marine microorganisms are relatively poorly studied compared to their terrestrial relatives, marine microorganisms are regarded as the most potential-laden resource for drug discovery.
Download or read book Natural Product Genomics and Metabolomics of Marine Bacteria written by and published by . This book was released on 2022-02-24 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Marine Microbial Diversity written by Jennie C. Hunter-Cevera and published by . This book was released on 2005 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine microbes are uniquely important to life as we know it. Since life most likely began in the oceans, marine microorganisms are the closest living descendants of the original forms of life. They are also major pillars of the biosphere. Their unique metabolisms allow marine microbes to carry out many steps of the biogeochemical cycles that other organisms are unable to complete. The smooth functioning of these cycles is necessary for life to continue on earth. Early marine microorganisms also helped create the conditions under which subsequent life developed. More than two billion years ago, the generation of oxygen by photosynthetic marine microorganisms helped shape the chemical environment in which plants, animals, and all other life forms have evolved. A great deal of research on the biogeography of marine microorganisms has been carried out, but many unknowns persist, and more work is needed to elucidate and understand their complexity. It is now known that microorganisms live in every corner of the oceans. Their habitats are diverse and include open water, sediment, bodies of marine macro- and microorganisms, estuaries, and hydrothermal vents. By studying these habitats, scientists have developed a limited ability to predict the composition of marine microbial communities. It has also been found that some marine microbes have more cosmopolitan distributions than others. Recent work has found that most of the ecological principles that apply to larger organisms can also be applied to microorganisms, including marine microbes, but there are exceptions. Almost every ecophysiological parameter in the oceans is thought to have an impact on the diversity of microbial communities. Most of the direct interactions marine microorganisms have with larger organisms fall into one of two broad categories: symbiosis or pathogenesis. Beneficial microbial symbioses have enabled many invertebrate species to take advantage of habitats that would otherwise be unavailable to them. Invertebrates in these relationships may also enjoy the benefits of bioactive compounds microbes may produce to prevent bio-fouling or to ward off predators. Marine viruses are found in surprisingly high numbers in seawater, but it is likely that these populations are in equilibrium with their host populations. The metabolic diversity of marine microorganisms allows them to assume many roles in the biogeochemical cycles that other organisms cannot complete. Marine microbes are also able to adapt to the many extreme environments in the oceans. As humans continue to alter the environment, climate change will inevitably impact marine microbial communities and the biogeochemical cycles in which they participate, but the exact nature of these impacts cannot yet be predicted. Human health relies on a number of critical equilibria that marine microorganisms broker, including the balance between viruses and their hosts in the oceans, the balances that keep harmful algal blooms in check, the processes that control nutrient concentrations in marine waters, and others. The metabolic capabilities of marine microbes can be put to work in any number of biotechnology applications, including the manufacture of industrial products and energy production. Marine microbes are sources of novel bioactive compounds that may have application as pharmaceuticals. Potential applications for marine microorganisms in ameliorating environmental degradation also exist. Innovative approaches in research, education, and training are critical for moving the field of marine microbiology forward. Modern research in this field should embrace the new tools of genomics and metagenomics, but not to the exclusion of other methods of discovery. Education and training in marine microbiology needs to be multidisciplinary. Arrangements that expose graduate students and postdoctoral scientists to laboratories that do work outside the students' immediate fields of focus should be encouraged.
Download or read book Bioactive Marine Natural Products written by Dewan S. Bhakuni and published by Springer Science & Business Media. This book was released on 2006-06-30 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included. Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R and D divisions of pharmaceutical companies. Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.
Download or read book Drugs from the Sea written by Nobuhiro Fusetani and published by Karger Medical and Scientific Publishers. This book was released on 2000-01-01 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book consists of three parts: discovery, development and production of drugs from marine organisms. Marine bacteria, fungi, microalgae, sponges and opisthobranch mollusks have attracted much attention as sources of potential drugs, which is described in the first part. A pain-killing drug developed from the venom of a cone shell is a recent highlight of marine natural product research; the interesting story of its discovery is provided. The second part features an anticancer drug with a novel mode of action which was originally isolated from a songe and a potential antiosteoporotic drug of a hexacoral origin. But the most serious problem for development of drugs from the sea remains supply. Two possible solutions, production by fermentation and by aquaculture, are described in the third part. Identification and culture of symbiotic bacteria which are responsible for the production of bioactive sponge metabolites are the main objectives for many researchers.
Download or read book Biodiversity of Marine Microbes written by Savvas Genitsaris and published by MDPI. This book was released on 2021-08-31 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book entitled “Biodiversity of Marine Microbes” aims at highlighting the significance of marine microbes as primary producers, their contribution in complex ecological processes and their roles in biogeochemical cycles and ecosystem functioning. The book includes five research papers covering the diversity and composition of marine microbial communities representing all three domains of life in various marine environments, including coastal eutrophic areas, ice waters, and lagoons. One paper examines the diversity and succession of bacterial and archaeal communities from coastal waters in mesocosm experiments. The combination of classical tools with novel technological advances implemented in the methods of the papers offered an opportunity to answer fundamental questions and shed light on the complex and diverse life of marine microbes.
Download or read book Microbial Secondary Metabolites Recent Developments and Technological Challenges written by Bhim Pratap Singh and published by Frontiers Media SA. This book was released on 2019-08-02 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on microbes plays an essential role in the improvement of biotechnological and biomedical areas. It has turned into a subject of expanding significance as new organisms and their related biomolecules are being characterized for several applications in health and agriculture. Microbial biomolecules confer the ability of microbes to cope with a range of adverse conditions. However, these biomolecules have several advantages over the plant origin, which makes them a suitable target in drug discovery and development. The reasons could be that microbial sources can be genetically engineered to enhance the production of desired natural production by large-scale fermentation. The interaction between microbes and their biotic and abiotic environment is fundamental to numerous processes taking place in the biosphere. The natural environments and hosts of these microorganisms are extremely diverse being reflected by the fact that microbes are widespread and occur in nearly every biological community on Earth. This metabolic versatility makes microbes interesting objects for a range of economically important biotechnological applications. Most of the biotechniques are established but inefficient genetic engineering strategies are still a bottleneck for selected microbe producing industrial scale biomolecules. Therefore, untapped microbial biodiversity and related metablomics, give a noteworthy wellspring of biologicals for the advancement of meds, immunizations, enhanced plants and for other natural applications. The present eBook volume contains articles on microbial secondary metabolites, microbial biosynthetic potential including biosynthetic gene expression, and metagenomics obtained from microorganism isolated unique from habitats like marine sources, endophytes, thermal springs, deserts, etc.
Download or read book A Comprehensive Analysis of the Microbial Diversity Associated with Eunicea Fusca and Related Plexauridae Octorals and the Isolation of New Natural Products from Selected Associated Bacteria written by Rebecca Emily Pike and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine invertebrates, including octocorals, are a prolific source of marine natural products (MNPs) and are also known to host diverse microbial communities. It is well-established that marine microbes are producers of bioactive secondary metabolites. Accordingly, it is hypothesized that bioactive metabolites extracted from some marine invertebrates may actually be produced by associated microbes rather than the invertebrate host. This research aimed to characterize the microbial community of E. fusca and related Plexauridae octocorals and to discover novel, bioactive compounds biosynthesized by associated microorganisms. E. fusca was the main focus of this study because its microbial community has not been thoroughly characterized, and it is the sole source of the potent anti-inflammatory diterpenes fuscol, eunicol, and the fuscosides. Investigations of the unexplored E. fusca microbial community could therefore lead to the discovery of novel MNPs from unexplored microbes, as well as provide insights into the biosynthetic source of these diterpenes. The microbiome of Floridian and Bahamian E. fusca and related Plexauridae octocorals collected in June 2009 were characterized using culture-independent (454-pyrosequencing, denaturing gradient gel electrophoresis, cloning, and species-specific primers) and -dependent (dilution plating) methods. The culture-independent analysis revealed that E. fusca hosted a geographically-heterogeneous bacterial community, where Endozoicomonas relatives dominated the Florida sites, and Mycoplasma relatives dominated at The Bahamas sites. There were, however, a few stable bacterial associates found in all E. fusca at all sites, including relatives of the Endozoicomonas, Mycoplasma, and Oceanospirillales, suggesting that these bacteria may be critical to holobiont functioning, and differences in environmental conditions at the locations may affect the dominant community member. E. fusca's bacterial community also differed from that of closely-related Plexauridae octocorals and the surrounding seawater. All octocorals contained the same clade of dinoflagellate, Symbiodinium B1/B184. However, the fungal and archaeal communities were not consistent between Plexauridae species or location. In the culture-dependent study, 137 unique bacteria and 11 unique fungi were cultured from the Plexauridae octocorals; 31 of the isolated bacteria were putative novel species based on 16S rDNA analysis (
