Download or read book Lysophospholipid Receptors written by Jerold Chun and published by John Wiley & Sons. This book was released on 2013-02-06 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current state of the science supporting new research in lysophospholipids The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling. Lysophospholipid Receptors is divided into three sections: Receptors and other possible effectors Enzymes Physiology and pathophysiology Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics. Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.

Download or read book Lysophospholipid Receptors Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lysophospholipid Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Lysophospholipid Receptors in a compact format. The editors have built Lysophospholipid Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Lysophospholipid Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Lysophospholipid Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Lysophospholipid Signaling Through Their G Protein coupled Receptors written by Linnea M. Baudhuin and published by . This book was released on 2002 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Distribution of Lysophospholipid Receptors in the Embryonic Neonatal and Adult Mouse Brain written by Christine McGiffert and published by . This book was released on 2004 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lysophospholipids and Eicosanoids in Biology and Pathophysiology written by Edward J. Goetzl and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cellular-wide activities of the lipid mediators have made them intrinsic to research on such prevalent cell-based pathologies as obesity, cell immunity, and neural degeneration. The influence of the lyphospholipids and eicosanoid families, especially LPA and S1P, needs to be defined for the progress of research on these important cancer and cardiovascular diseases. These papers and posters focus on lipid biochemistry and eicosanoid generation, and highlight findings on their roles in nuclear signaling, in cellular proliferation, differentiation, and in cell apoptosis and transformation. Participants reviews of the psychological effects of the lipids in the nervous, immune and cardiovascular systems lead directly to a statement of pharmaceutical approaches with small molecule agonists and antagonists that could offer direct results for these critical public health problems.

Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Download or read book Lysophospholipid Receptors and Effects in Breast Cancer written by and published by . This book was released on 2002 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are widely-distributed stimuli of cellular growth and functions, which are generated enzymatically from precursors in membranes of activated normal cells and at much higher levels from many types of cancers. A subfamily of 0 protein-coupled receptors encoded by endothelial differentiation genes (Edg Rs) bind and transduce cellular signals from LPA (Edg-2, -4, -7) and S1P (Edg-l, -3,-S, -6, and -8). Human breast cancer cells (BCCs) express principally Edg-3, less Edg-4, very low levels of Edg-2 and Edg-5, and no Edg-1, -6,-? or -8. BCCs have much higher levels of Edg-3 S1P Rs than normal human breast epithelial cells. These Edg Rs mediate proliferation of BCCs directly by signaling growth-related immediate-early genes, through a distinctive set of transcription factors, and indirectly by increasing BCCs secretion of several autocrine protein growth factors. Delivery of LPA to BCCs by specific plasma protein carriers, such as gelsolin, and novel mechanisms for regulation of expression of Edg-3 Rs also may distinguish mechanisms of action of SIP and LPA in BCCs from those in normal breast epithelial cells. Detection of elevated levels of Edg-3 Rs and splice variants of Edg-3 Rs may become a diagnostic index of breast cancer and Edg R- directed antagonists may suppress growth and dissemination of breast cancers.

Download or read book Lysophosphatidate Signaling written by Marcel E. Durieux and published by Springer. This book was released on 1995 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses the varied cellular effects of lysophosphatidate (LPA) and the molecular biology of its signaling pathway to the extent that it has been dissected thus far. Covers the structural properties and metabolic role of LPA; smooth muscle; mitogenic effects and Ca2 release; antimitogenesis; blood; morphology; cytoskeleton; non-mammals; receptors and membrane G proteins; cAMP; intracellular signaling; and sphingosine-1- phosphate. Annotation copyright by Book News, Inc., Portland, OR

Download or read book Genomic and Functional Characterization of Lysophospholipid Receptor Genes written by James John Achilles Contos and published by . This book was released on 1999 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-02-06 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including S1P, neuregulin, Notch, erythropoietin, Rho-ROCK, mTOR, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field

Download or read book Druggable Lipid Signaling Pathways written by Yasuyuki Kihara and published by Springer. This book was released on 2021-09-22 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, became the first FDA-approved medicine as an orally bioavailable drug for treating relapsing forms of multiple sclerosis (MS). In addition to fingolimod, other drugs targeting lipid GPCRs had been developed such as latanoprost (prostaglandin F2a analogue, used for ocular hypertension and glaucoma), epoprostenol and treprostinil (prostaglandin I2 analogue, used for pulmonary arterial hypertension), montelukast and pranlukast (cysteinyl leukotriene receptor antagonist, used for asthma and allergies), etc. Novel drugs are also expected like lysophosphatidic acid (LPA) receptor antagonist for treatment of pulmonary fibrosis. Drug development targeting lipid signalling pathways are backdated to more than a century, when aspirin was synthesized and selling by Bayer, while the basic mechanism of aspirin's effects (block prostanoid synthesis by inhibiting cyclooxygenases) had not been discovered until 1970s. Nowadays, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprophen are commonly used as antipyretic analgesics and available readily over-the-counter oral drugs. Both upstream and downstream enzymes, such as phospholipase A2s and prostaglandin E synthases, respectively, are also potential therapeutic targets for inflammatory diseases. Recent studies of lipid metabolism expand the lipid biology field from pro-inflammatory lipid mediators to anti-inflammatory epoxy fatty acids (epoxyeicosatrienoic acids), and also omega-3 fatty acid-derived pro-resolving lipid mediators (lipoxin, resolvin, and neuroprotectin). These bioactive lipids, their metabolic pathways and receptors are of great interest in developing next-generation anti-inflammatory and pro-resolving drugs for a wide variety of diseases including. This book summarizes not only historical overview of lipid signaling pathways but also provides summary of cutting-edge studies that may provide some hints of novel “druggable” lipid signaling targets.

Download or read book Cannabinoids and Their Receptors written by and published by Academic Press. This book was released on 2017-07-24 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cannabinoids and Their Receptors, Volume 593, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This updated volume includes comprehensive chapters on a variety of topics, including Real time cAMP signaling in response to CB1 activation, CB1 signaling in mitochondria, Lipidomics of cannabinoid systems, Studying endocannabinoid transport, Metabolic profiling of CB1 neutral antagonists, Approaches to assess biased signaling at the CB1 receptor, and the Development of CB1 allosteric modulators. Continues the legacy of this premier serial with a new and updated release Covers research cannabinoids and their receptors

Download or read book Reviews of Physiology Biochemistry and Pharmacology 160 written by Susan G Amara and published by Springer Science & Business Media. This book was released on 2008-05-15 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews of Physiology, Biochemistry and Pharmacology Volume 160 2008 V. di Marzo: Endocannabinoids: Synthesis and Degradation R. Rivera and J. Chun: Biological Effects of Lysophospholipids S.J. O'Meara, K. Rodgers, and C. Godson: Lipoxins: Update and Impact of Endogenous Pro-Resolution Lipid Mediators R.K.P. Benninger, M. Hao, and D. Piston: Multi-photon Excitation Imaging of Dynamic Processes in Living Cells and Tissues G. Schmitz and M. Grandl: Lipid Homeostasis in Macrophages - Implications for Atherosclerosis.

Download or read book In Vitro and in Vivo Pharmacologic Evaluation of Novel Lysophospholipid Analogs as Anticancer Agents written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Lysophospholipids are phospholipid growth factors that promote tumor cell proliferation, survival, and invasion by binding to a family of G protein-coupled receptors. Due to their involvement in cancer progression and overexpression of their receptors in cancer, novel agents that inhibit molecules in the lysophospholipid signal transduction pathways hold promise as potential chemotherapeutic agents. Prostate cancer presents a unique disease model to study the role of lysophospholipid growth factor signaling pathways. Different human prostate cancer cell lines represent a wide range of clinically relevant prostate tumor types demonstrating various stages of the disease, different sites of metastasis, and differences in androgen dependence for cell growth. Moreover, these cell lines demonstrate differential expression and activity profiles of the LPL receptors and downstream mediators including PTEN lipid phosphatase and AKT and MAPK. Three classes of lysophospholipid analogs were synthesized and tested in prostate cancer cell lines and a negative control cell line that lacks lysophospholipid receptors. Active serine amide derivatives showed potency similar to that of 5-fluorouracil, but they also affected growth of the negative control cell line. Thiazolidinone analogs were equipotent to serine amides with improved selectivity. Thiazolidine analogs were the most potent and selective of all three groups of lysophospholipid analogs examined. Further, thiazolidine analogs almost completely inhibited AKT phosphorylation, consequently inducing apoptosis. However, these analogs failed to interact directly with lysophosphatidic acid receptors as proven by absence of inhibitory action on lysophosphatidic acid-driven calcium mobilization. Two thiazolidine analogs were chosen for assessment of in vivo anticancer activity. Daily intraperitoneal doses of these analogs significantly delayed PC-3 xenograft tumor growth, validating the importance of LPL receptor and/or downstream signal transduction pathways in growth and progression of prostate tumors. Thiazolidine analogs also enhanced bicalutamide activity in vitro by 2- to 30-fold in both androgen-dependent and androgen-independent prostate cancer cell lines. In conclusion, lysophospholipid signal transduction pathways can be exploited to provide a novel modality for prostate cancer treatment. Identification of target proteins and improvement of intrinsic activity, selectivity profile, and pharmacokinetic properties will hopefully lead to an increase in the in vivo efficacy of this series of lysophospholipid analogs.

Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-10-29 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Download or read book Druggable Lipid Signaling Pathways written by Yasuyuki Kihara and published by Springer Nature. This book was released on 2020-09-07 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, became the first FDA-approved medicine as an orally bioavailable drug for treating relapsing forms of multiple sclerosis (MS). In addition to fingolimod, other drugs targeting lipid GPCRs had been developed such as latanoprost (prostaglandin F2a analogue, used for ocular hypertension and glaucoma), epoprostenol and treprostinil (prostaglandin I2 analogue, used for pulmonary arterial hypertension), montelukast and pranlukast (cysteinyl leukotriene receptor antagonist, used for asthma and allergies), etc. Novel drugs are also expected like lysophosphatidic acid (LPA) receptor antagonist for treatment of pulmonary fibrosis. Drug development targeting lipid signalling pathways are backdated to more than a century, when aspirin was synthesized and selling by Bayer, while the basic mechanism of aspirin's effects (block prostanoid synthesis by inhibiting cyclooxygenases) had not been discovered until 1970s. Nowadays, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprophen are commonly used as antipyretic analgesics and available readily over-the-counter oral drugs. Both upstream and downstream enzymes, such as phospholipase A2s and prostaglandin E synthases, respectively, are also potential therapeutic targets for inflammatory diseases. Recent studies of lipid metabolism expand the lipid biology field from pro-inflammatory lipid mediators to anti-inflammatory epoxy fatty acids (epoxyeicosatrienoic acids), and also omega-3 fatty acid-derived pro-resolving lipid mediators (lipoxin, resolvin, and neuroprotectin). These bioactive lipids, their metabolic pathways and receptors are of great interest in developing next-generation anti-inflammatory and pro-resolving drugs for a wide variety of diseases including. This book summarizes not only historical overview of lipid signaling pathways but also provides summary of cutting-edge studies that may provide some hints of novel “druggable” lipid signaling targets.