Download or read book Local Immunosuppression of Organ Transplants written by Scott A. Gruber and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time a complete review of the research work done over the past 30 years by leading investigators around the world in targeting immunosuppressants to both solid-organ and cellular transplants is available in a single volume. One section consists of studies conducted in rat allograft models using osmotic minipumps for delivery of a variety of immunosuppressants. The book will be of great benefit to researchers in the fields of transplant immunology, pharmacology and drug delivery and targeting, particularly those involved in drug development.
Download or read book Local Immunosuppression of Organ Transplants written by Scott A. Gruber and published by Springer. This book was released on 2013-11-13 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time a complete review of the research work done over the past 30 years by leading investigators around the world in targeting immunosuppressants to both solid-organ and cellular transplants is available in a single volume. One section consists of studies conducted in rat allograft models using osmotic minipumps for delivery of a variety of immunosuppressants. The book will be of great benefit to researchers in the fields of transplant immunology, pharmacology and drug delivery and targeting, particularly those involved in drug development.
Download or read book Current and Future Immunosuppressive Therapies Following Transplantation written by Giuseppe Remuzzi and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides a comprehensive and state-of-the-art summary of current and future immunosuppressive strategies in transplantation, with emphasis on the basic science mechanisms and clinical applicability of these strategies. The uniqueness of this book is the inclusion of up-to-date information on the basic mechanisms of actions of the immunosuppressive drugs as well as a summary of the clinical trials data and the potential use of these drugs in clinical organ transplantation. In addition to describing the various immunosuppressive strategies, the book has three special features, including immunosuppression in xenotransplantation, gene therapy approaches, and transplantation tolerance. A group of outstanding investigators have been assembled to write the chapters. The book is intended for the transplant professional and the specialist who wants to stay abreast of the current status of immunosuppression in organ transplantation. The book is also useful for basic scientists who work in the field of transplantation immunology.
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Report to the Secretary and the Congress on Immunosuppressive Therapies written by United States. Task Force on Organ Transplantation and published by . This book was released on 1985 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Personalized Immunosuppression in Transplantation written by Michael Oellerich and published by Elsevier. This book was released on 2015-08-08 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. - Focuses on the personalized management of immunosuppression therapy in individual transplant patients - Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology - Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients - Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use - Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy
Download or read book Transplantation Immunology written by Philip Hornick and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading clinicians and scientists in solid organ transplantation review the current status of the field and describe cutting-edge techniques for detecting the immune response to the allografted organ. The authors present the latest techniques for HLA typing, detecting HLA antibodies, and monitoring T-cell response, and examine more specialized methods utilizing proteomics, laser dissection microscopy, and real-time polymerase chain reaction. The area of tolerance induction and reprogramming of the immune system is also covered, along with a discussion of up-to-date methods of organ preservation, of today's optimal immunosuppressive drug regimens, as well as the difficulty of mimicking chronic rejection in experimental models. Introductory chapters provide a theoretical update on current practices in renal, liver, islet, and lung transplantation and on the pathways of antigen presentation and chronic rejection.
Download or read book Immunosuppression under Trial written by Pierre Cochat and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunosuppression in solid organ transplantation is currently experiencing a worldwide revival since new drugs are now available and others are under development. In order to contribute to the design of future strategies, a critical approach of surrogate endpoints is given and long-term side effects are analysed, together with the impact of non-compliance, quality-of-life and economical parameters. In this book, international specialists have set up the scientific rationale and provided new bases for further immunosuppressive strategies.
Download or read book Current Immunosuppressive Therapy in Organ Transplantation written by Huifang Chen and published by . This book was released on 2015 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ transplantation has revolutionized the treatment for end-stage organ failure. Immunosuppression is still a major approach currently used in the prevention and treatment of allograft rejection. Both editors Dr. Chen and Dr. Qian have been contributing to preclinical evaluation of immunosuppressants for more than 25 years in North America. Experts from the United States, Canada, the United Kingdom, China, Japan, Germany, Sweden, Hungary and Brazil contributed 23 chapters to this book, providing details of immunological basis in transplantation. They also describe six classes of immunosuppressive agents (calcineurin inhibitors, mTOR inhibitors, JAK-STAT inhibitors, antiproliferative agents, costimulation blockers and corticosteroids), as well as ischemia/reperfusion injury treated agents. Additionally, the new development of cell therapy in the induction of transplant tolerance is introduced. This book provides many important references for the research direction of novel immunosuppressants. Readers that will find this book useful include transplant physicians, surgeons, nurses, immunologists, pharmacologists, pharmacists, medical students, residents and trainees in transplantation.
Download or read book Immunosuppression in Organ Transplantation written by Hellenic Transplantation Society and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Living Donor Organ Transplantation written by Rainer Gruessner and published by McGraw Hill Professional. This book was released on 2007-12-21 with total page 855 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, technique-oriented guide to abdominal organ transplantation A Doody's Core Title for 2011! Valuable to the seasoned and novice transplant surgeon as well as the multidisciplinary team that tends to both the living donor and the recipient of abdominal organs, Living Organ Donor Transplantation puts the entire discipline in perspective while guiding you step-by-step through the most common organ transplant surgeries. Organized into four cohesive parts and featuring numerous surgical illustrations, this sourcebook delivers an incisive look at every key consideration for general surgeons who perform transplantations, from patient selection to recipient workup and outcomes, and emphasizes the most humanitarian approaches. Features: The first A-to-Z, operation-oriented guide to the field of living donor organ transplantation Unparalleled examination of a wide spectrum of solid organ transplantation procedures (liver, pancreas, kidney, intestine), with accompanying chapters on the history of the procedure, the donor, the recipient, and cost analysis Skill-building coverage of techniques that explains adequate pretransplant workup and posttransplant care Chapters on cultural differences, ethical and legal issues, social issues, current financial incentives, and the illegal organ trade Up-to-date survey of the future possibilities of organ transplantation, covering new immunosuppressive protocols, xenotransplantation, gene therapy, organogenesis and therapeutic cloning, and more Reflections from pioneers in the field
Download or read book Skin Cancer after Organ Transplantation written by Eggert Stockfleth and published by Springer. This book was released on 2010-12-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ transplantation has been performed for almost 40 years with steadily increasing success regarding long-time survival of the graft, as well as quality of life for the patient. However, graft tolerance only can be achieved via induction and maintenance of an impaired immunological surveillance. An increase of skin cancers as a consequence of the lowered cellular immunoresponse seems to parallel the overall increased long-time survival rate of organ transplant recipients. Against the background of chronic immunosuppression known risk factors like the amount of sun exposure prior and post transplantation, oncogenic viruses as well as the genetic background, and place of residence (latitude) are strongly related with the increased skin cancer incidence. The increasing incidence of non-melanoma skin cancer, paralleling a prolonged survival of patients after organ transplantation, represents a significant reason for morbidity and long-term morbidity in organ transplant recipients worldwide. The incidence of non-melanoma skin cancer in liver-, kidney- and heart transplant recipients varies from 1.5 to 22 %, 2 to 24 % and 6 to 34 % after 5 years post transplant. Ultraviolet radiation as well as immunosuppressive therapy are crucial risk-factors regarding the induction and progression of skin cancer. Ultraviolet radiation is related to the induction of DNA damage, as well as interference with Langerhans cell antigen presentation and a Th1 – Th2 shift induced via a release of IL-10. Whereas the overall duration of immunosuppression and the cumulative dosage applied are relevant parameters in the evaluation of an increased tumor risk, individual differences between specific immunosuppressive agents remain unclear. The workup of genetic as well as other unclear phenomenon like the reverse BCC/SCC ratio might shed some further light into the genesis and immunology of the non-melanoma skin cancer in general.
Download or read book Minimization of Immunosuppression in Organ Transplantation written by Raffaello Cortesini and published by . This book was released on 2008 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Selective Immunosuppression in Organ Transplantation written by Theodoor Jacques Marie Ruers and published by . This book was released on 1989 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oxford Textbook of Fundamentals of Surgery written by William E. G. Thomas and published by Oxford University Press. This book was released on 2016 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: A definitive, accessible, and reliable resource which provides a solid foundation of the knowledge and basic science needed to hone all of the core surgical skills used in surgical settings. Presented in a clear and accessible way it addresses the cross-specialty aspects of surgery applicable to all trainees.
Download or read book Anesthesia for Transplant Surgery written by Jayashree Sood and published by JP Medical Ltd. This book was released on 2014-04-30 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides clinicians with the most recent developments in anaesthesia for transplant surgery. Beginning with the history and ethics of the procedure, the following chapters discuss anaesthetic techniques for transplant surgery of different organs in the body. The importance of history taking, thorough clinical examination, invention of the artificial respirator and controversies surrounding brain death, are discussed in depth. This useful manual includes more than 110 clinical photographs and illustrations to enhance learning. Key points Provides clinicians with recent developments in anaesthesia for transplant surgery Covers techniques for transplant surgery of different organs in body Emphasis on importance of history taking and thorough clinical examination Includes more than 110 clinical photographs and illustrations
Download or read book Immunosuppression in Organ Transplantation written by and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
