Download or read book Liver Biopsy Evaluation written by Gary C. Kanel and published by . This book was released on 2000 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introducing a highly illustrated microscope-side liver pathology reference. The text lists the presenting symptom and then follows through the process to arrive at a diagnosis. Divided into three sections, this reference provides an introduction to liver biopsy evaluation that includes basic morphologic information. This is a step-by-step guide to evaluation. The second section covers histological features seen under a microscope and lists potential diagnoses. The third section lists all liver diseases and includes the pathologic characteristics and clinical/laboratory features of each.
Download or read book Liver Biopsy Interpretation written by Peter Joseph Scheuer and published by . This book was released on 1973 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Scheuer s Liver Biopsy Interpretation written by Jay H. Lefkowitch and published by Elsevier Health Sciences. This book was released on 2020-03-28 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trusted for more than 50 years by pathologists in practice and in training, Scheuer’s Liver Biopsy Interpretation is a well-organized, superbly illustrated guide designed to help solve diagnostic problems at the microscope. Authored by renowned expert Dr. Jay Lefkowitch and reflecting the extensive experience of the late Dr. Peter Scheuer, this practical text contains technical tips, diagnostic clues, and pearls on all aspects of liver pathology diagnosis, including acute and chronic hepatitis, biliary tract diseases, childhood disorders, and hepatic neoplasms – as well as ancillary topics such as biopsy assessment, laboratory techniques, normal liver histology, and transplantation. Throughout the text, histopathologic features are correlated with clinical features, molecular genetics, and immunohistochemistry to provide a practical account of how pathology impacts the diagnosis and management of liver disease. Covers key topics such as genomic alterations in liver tumours, diagnosis of acute liver allograft rejection, scoring systems for non-alcoholic fatty liver disease, and discussions of immunohistochemical features wherever relevant. Presents the latest information on next generation sequencing and drug-induced liver injury, including adverse reactions to new biologics and alternative medicines to help both the clinician and pathologist avoid diagnostic errors. Features many new illustrations, including over 300 large, full-color and fully annotated photomicrographs that illustrate a wide range of pathologic appearances and help identify each diagnostic entity under discussion. Offers coverage of cytopathology in the assessment of liver tumors to provide further clinical clues to diagnosis. Provides basic overview of major histopathologic diagnostic problems in paediatric liver biopsy, including biliary atresia and several types of progressive familial intrahepatic cholestasis Provides new and updated algorithms, tables and images highlighting key features of each diagnostic entity – ideal as a concise review during sign out or for studying and board preparation.
Download or read book Liver Biopsy written by Nobumi Tagaya and published by BoD – Books on Demand. This book was released on 2012-11-21 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver biopsy is a procedure that involves obtaining a small piece of liver tissue, which is then analyzed in the laboratory. Liver biopsy may be used to evaluate a mass seen on images, diagnose unexplained liver diseases or abnormal liver function tests, and to determine the severity of the liver disease including hepatitis, fibrosis, and steatosis. Liver biopsy is an invasive procedure, and its complications are rare but potentially lethal. Therefore, it is necessary to perform liver biopsy safely from clinical aspect and to take specimen steadily from a pathological one. I hope this book addresses the future aspects of liver biopsy including role, indication, technique and evaluation. Furthermore, this book introduces new non-invasive alternatives including elastography and computer analysis of liver fibrosis.
Download or read book The Non Invasive Liver Biopsy written by Mikael Forsgren and published by Linköping University Electronic Press. This book was released on 2017-04-19 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The liver is one of the largest organs within the human body and it handles many vital tasks such as nutrient processing, toxin removal, and synthesis of important proteins. The number of people suffering from chronic liver disease is on the rise, likely due to the present ‘western’ lifestyle. As disease develops in the liver there are pathophysiological manifestations within the liver parenchyma that are both common and important to monitor. These manifestations include inflammation, fatty infiltration (steatosis), excessive scar tissue formation (fibrosis and cirrhosis), and iron loading. Importantly, as the disease progresses there is concurrent loss of liver function. Furthermore, postoperative liver function insufficiency is an important concern when planning surgical treatment of the liver, because it is associated with both morbidity and mortality. Liver function can also be hampered due to drug-induced injuries, an important aspect to consider in drug-development. Currently, an invasive liver needle biopsy is required to determine the aetiology and to stage or grade the pathophysiological manifestations. There are important limitations with the biopsy, which include, risk of serious complications, mortality, morbidity, inter- and intra-observer variability, sampling error, and sampling variability. Cleary, it would be beneficial to be able investigate the pathophysiological manifestations accurately, non-invasively, and on regional level. Current available laboratory liver function blood panels are typically insufficient and often only indicate damage at a late stage. Thus, it would be beneficial to have access to biomarkers that are both sensitive and responds to early changes in liver function in both clinical settings and for the pharmaceutical industry and regulatory agencies. The main aim of this thesis was to develop and evaluate methods that can be used for a ‘non-invasive liver biopsy’ using magnetic resonance (MR). We also aimed to develop sensitive methods for measure liver function based on gadoxetate-enhanced MR imaging (MRI). The presented work is primarily based on a prospective study on c. 100 patients suffering from chronic liver disease of varying aetiologies recruited due to elevated liver enzyme levels, without clear signs of decompensated cirrhosis. Our results show that the commonly used liver fat cut-off for diagnosing steatosis should be lowered from 5% to 3% when using MR proton-density fat fraction (PDFF). We also show that MR elastography (MRE) is superior in staging fibrosis. Finally we presented a framework for quantifying liver function based on gadoxetate-enhanced MRI. The method is based on clinical images and a clinical approved contrast agent (gadoxetate). The framework consists of; state-of the-art image reconstruction and correction methods, a mathematical model, and a precise model parametrization method. The model was developed and validated on healthy subjects. Thereafter the model was found applicable on the chronic liver disease cohort as well as validated using gadoxetate levels in biopsy samples and blood samples. The liver function parameters correlated with clinical markers for liver function and liver fibrosis (used as a surrogate marker for liver function). In summary, it should be possible to perform a non-invasive liver biopsy using: MRI-PDFF for liver fat and iron loading, MRE for liver fibrosis and possibly also inflammation, and measure liver function using the presented framework for analysing gadoxetate-enhanced MRI. With the exception of an MREtransducer no additional hardware is required on the MR scanner. The liver function method is likely to be useful both in a clinical setting and in pharmaceutical trials.
Download or read book Liver Biopsy in Modern Medicine written by Yoshiaki Mizuguchi and published by BoD – Books on Demand. This book was released on 2011-10-10 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver biopsy, first performed by Paul Ehrlich in 1883, remains an important diagnostic procedure for the management of hepatobiliary disorders and the candidate/donated organ for transplantation. The book "Liver biopsy in Modern Medicine" comprises 21 chapters covering the various aspects of the biopsy procedure in detail and provides an up-to-date insightful coverage to the recent advances in the management of the various disorders with liver biospy. This book will keep up with cutting edge understanding of liver biopsy to many clinicians, physicians, scientists, pharmaceutics, engineers and other experts in a wide variety of different disciplines.
Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Download or read book Cholestatic Liver Disease written by Elizabeth J. Carey and published by Springer. This book was released on 2014-07-18 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition, there have been advances in both the diagnosis and the management of many of the cholestatic liver diseases. Cholestatic Liver Disease, Second Edition thoroughly updates the topics previously addressed, such as primary biliary cirrhosis, primary sclerosing cholangitis and cholestatic variants of drug hepatotoxicity and viral disease. New treatments, such as the development of the farnesoid X receptor agonists for the treatment of PBC, are highlighted. Current guidelines and areas of uncertainty are also covered. Additionally, new chapters have been added to reflect the changing landscape of cholestatic liver disease. Cholestatic Liver Disease, Second Edition is a concise yet comprehensive summary of the current status of the field and is of value to clinicians and researchers interested in patients with cholestatic liver disease provide that will help to guide patient management and stimulate investigative efforts.
Download or read book Liver Pathology for Clinicians written by Maura O'Neil and published by Springer. This book was released on 2015-09-09 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first volume in a new Springer series, Pathology for Clinicians, which aims to assist clinicians in their daily decision making by providing reliable, clearly presented information on current techniques in pathology, their uses and indications, clinical–pathologic correlations, and the significance of pathologic diagnoses. Liver Pathology for Clinicians first discusses key technical aspects of liver biopsy, including the use of special stains and immunohistochemistry. Detailed guidance is provided on both common and uncommon indications for liver biopsy, including repeat or serial biopsies, and on the choice of procedure. The role of liver biopsy in the contexts of transplantation and systemic disease is also clearly explained. Clinical-pathologic correlations are presented with the aid of high-quality illustrations.
Download or read book MacSween s Pathology of the Liver E Book written by Alastair D. Burt and published by Elsevier Health Sciences. This book was released on 2017-05-22 with total page 1067 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its first publication more than 35 years ago, MacSween’s Pathology of the Liver, by Drs. Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hübscher, has established itself as the definitive reference on liver pathology. The 7th Edition continues the tradition of excellence with more than 1,000 high-quality illustrations, coverage of the new and emerging diagnostic applications and techniques that pathologists must be familiar with, an up-to-date review of drug-induced injury, and much more. A must-have for every surgical pathologist, MacSween’s remains the most authoritative and comprehensive book in its field. Provides comprehensive, state-of-the-art coverage of all malignant and benign hepatobiliary disorders from an international "who’s who" in the field. Helps you quickly recognize the wide variety of liver appearances that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. Features 1,000+ full-color illustrations that provide a complete visual guide to each tumor or tumor-like lesion and assist in the recognition and diagnosis of any tissue sample you’re likely to encounter. Incorporates relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the tools required to master the latest breakthroughs in diagnostic technology. Includes an updated chapter on mechanisms of liver disease, including coverage of regression and remodeling of disease and new information on next generation sequencing; an up-to-date review of drug-induced injury, including the effects of herbal and alternative medicines. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Download or read book Interventional Radiology Procedures in Biopsy and Drainage written by Debra A. Gervais and published by Springer Science & Business Media. This book was released on 2010-11-02 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Techniques in Interventional Radiology series of handbooks describes in detail the various interventional radiology procedures and therapies that are in current practice. The series comprises four titles, which in turn cover procedures in angioplasty and stenting, transcatheter embolization and therapy, biopsy and drainage and ablation. Forthcoming are volumes on pediatric interventional radiology and neurointerventional radiology. Each book is laid out in bullet point format, so that the desired information can be located quickly and easily. Interventional radiologists at all stages, from trainees through to specialists, will find this book a valuable asset for their practice. Interventional Radiology Procedures in Biopsy and Drainage presents the full array of operations using these techniques. The book is split into two sections – one dedicated to biopsy procedures and the other to drainage procedures. Dr. Debra Gervais is Director of Pediatric Imaging and Associate Director of Abdominal Imaging and Intervention at Massachusetts General Hospital, Boston, Massachusetts, USA. Dr. Tarun Sabharwal is a Consultant Interventional Radiologist at Guy’s and St Thomas’ Hospital, London, UK.
Download or read book Scheuer s Liver Biopsy Interpretation E Book written by Jay H. Lefkowitch and published by Elsevier Health Sciences. This book was released on 2010-08-03 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over 40 years Scheuer’s Liver Biopsy Interpretation has been an invaluable resource for the pathologist in practice and in training in helping to solve diagnostic problems at the microscope. Lavishly illustrated in full color throughout it covers all aspects of liver pathology from the normal, the hepatidities, childhood disease and neoplasms. Copious technical tips and diagnostic 'pearls' reflect the extensive experience and insight of the late Peter Scheuer and Jay Lefkowitch.. Throughout the text histopathologic features are correlated with clinical features to provide a practical account of how pathology impacts the diagnosis and management of liver disease. Well written, complete and concise quick reference.Helps the practicing and trainee pathologist solve diagnostic problems at the microscope. High quality color images complement the text throughout.Provides the user with a complete visual guide to each entity and assists in the recognition and diagnosis of any tissue sample under the microscope. Practical tips and “hands on advice from two of the world’s leading experts in liver pathology. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens. Glossary of frequently used terms and descriptions used in the pathology report contained at the end of the book. Useful quick reference for trainee pathologists and clinical hepatologists who may be unfamiliar with many of the terms and descriptions. Will assist in the writing and reading of a pathology report. A selection of a few general reading references at the end of each chapter.Directs the trainee or practitioner to the most relevant and authoritative sources of further information and study. A brand new chapter: "Practical Principles in Biopsy Assessment". Focus is on interpretation rather than a mere listing of pathological changes. The initial overview of the biopsy specimen provides critical clues to diagnosis and a highly illustrated guide to ddx will be of enormous help in avoiding diagnostic errors. Expanded coverage throughout, especially of liver tumours, pediatric fatty liver disease, neonatal cholestasis. Keeps the user apprised of the key areas of growth and development in diagnosis and interpretation. Histopathology correlated with molecular genetics and immunohistochemistry whenever clinically relevant. Keeps the user up-to-date with all of the latest tools for performing a complete and accurate diagnosis. Many new high-quality colour illustrations. Helps the user identify a wide variety of pathologic lesions. Text and images available online via Expert Consult.
Download or read book Diagnosis of Liver Disease written by Etsuko Hashimoto and published by Springer. This book was released on 2019-07-18 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book guides practitioners in the assessment of patients with a liver problem. The emphasis is on the role of macro- and microscopic pathology in elucidating pathogenesis as well as identifying confounding features of image findings that may lead to a more elaborate differential diagnosis. If appropriate, the role of light and electron microscopic examination, along with the role of specific stains and molecular techniques, is illustrated. In addition, the concept of each liver disease is summarized briefly and its up-to-data is provided, and unresolved problems in diagnosis, treatment, and pathogenesis are clearly described.The approach in this book is a practical one with a focus on the evaluation of illustrative cases, simultaneously demonstrating cross-sectional images (ultrasonography, computed tomography, magnetic resonance imaging, and angiography), pathological findings, and peritoneoscopic images. The diagnosis and therapy are summed up in helpful tables, and association of clinical manifestations with image analysis and pathological findings is shown to be important in differential diagnosis and treatment. With the authors comprising internationally renowned experts, this book will serve as a useful source of information for medical students, physicians, internists, hepatologists, gastroenterologists, radiologists, and pathologists worldwide.
Download or read book Liver Pathology An Issue of Gastroenterology Clinics of North America E Book written by Jay H. Lefkowitch and published by Elsevier Health Sciences. This book was released on 2017-06-28 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Lefkowitch has created a primer on liver pathology for the gastroenterologist that provides depth of clinical coverage in an area not typically covered in depth for gastroenterologists. This issue will provide state-of-the-art reviews in the areas of NAFLD, liver biopsy, liver pathology, hepatitis, and genomics. Articles are specifically devoted to IgG4-related disease and the liver; current concepts in pediatric NAFLD; evaluation of the pediatric liver biopsy; hepatocellular adenomas: morphology and genomics; drug-induced liver injury: the hepatic pathologist’s approach; liver pathology in alpha-1-antitrypsin deficiency; immunohistochemistry in the diagnosis of hepatocellular carcinoma; HIV infection, antiretroviral therapy and liver pathology; autoimmune hepatitis overlap syndromes and liver pathology; current perspectives on the pathology of hepatocellular carcinoma and its variants; hepatitis E virus and the liver: clinical settings and liver pathology; hepatic progenitor cells; and cholangiocarcinoma: current genomics and pathology, to name a few.
Download or read book Biopsy Interpretation of the Liver written by Stephen A. Geller and published by Lippincott Williams & Wilkins. This book was released on 2004 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the Biopsy Interpretation Series offers clear guidelines to help readers recognize and diagnose a full spectrum of liver disorders with speed, confidence, and accuracy. It begins with the basics—technical considerations, liver anatomy, and examination methods—then provides essential guidelines for recognizing and assessing specific hepatic conditions, such as hepatitis, toxic liver disease, bile duct disorders, and cirrhosis. Coverage also includes a timely discussion on liver transplantation...and speculations on the future of the liver biopsy. A bound-in CD-ROM contains over 500 full-color images.
Download or read book Liver Biopsy written by Nobumi Tagaya and published by IntechOpen. This book was released on 2012-11-21 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver biopsy is a procedure that involves obtaining a small piece of liver tissue, which is then analyzed in the laboratory. Liver biopsy may be used to evaluate a mass seen on images, diagnose unexplained liver diseases or abnormal liver function tests, and to determine the severity of the liver disease including hepatitis, fibrosis, and steatosis. Liver biopsy is an invasive procedure, and its complications are rare but potentially lethal. Therefore, it is necessary to perform liver biopsy safely from clinical aspect and to take specimen steadily from a pathological one. I hope this book addresses the future aspects of liver biopsy including role, indication, technique and evaluation. Furthermore, this book introduces new non-invasive alternatives including elastography and computer analysis of liver fibrosis.
Download or read book Ultrasound Elastography written by Monica Lupsor-Platon and published by BoD – Books on Demand. This book was released on 2020-03-04 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elastography, the science of creating noninvasive images of mechanical characteristics of tissues, has been rapidly evolving in recent years. The advantage of this technique resides in the ability to rapidly detect and quantify the changes in the stiffness of soft tissues resulting from specific pathological or physiological processes. Ultrasound elastography is nowadays applied especially on the liver and breast, but the technique has been increasingly used for other tissues including the thyroid, lymph nodes, spleen, pancreas, gastrointestinal tract, kidney, prostate, and the musculoskeletal and vascular systems. This book presents some of the applications of strain and shear-wave ultrasound elastography in hepatic, pancreatic, breast, and musculoskeletal conditions.
