Download or read book Lipid Rafts and Caveolae written by Christopher J. Fielding and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail. Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include: Historical background Distinct structures and functions Structural basis Signaling Viral entry and virion budding Cholesterol transport Caveolins Lipid shells Cell polarity and intracellular trafficking Cancer cells Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lipid Domains written by and published by Academic Press. This book was released on 2015-06-08 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. - Written by leading experts - Contains original material, both textual and illustrative, that should become a very relevant reference material - The material is presented in a very comprehensive manner - Both researchers in the field and general readers should find relevant and up-to-date information
Download or read book Membrane Microdomain Signaling written by Mark P. Mattson and published by Springer Science & Business Media. This book was released on 2007-10-27 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.
Download or read book Targeting Lipid Rafts as a Strategy against Infection and Cancer written by Giulio Preta and published by Frontiers Media SA. This book was released on 2021-10-22 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Membrane Dynamics and Domains written by Peter J. Quinn and published by Springer Science & Business Media. This book was released on 2004-07-02 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fluid-mosaic model of membrane structure formulated by Singer and Nicolson in the early 1970s has proven to be a durable concept in terms of the principles governing the organization of the constituent lipids and proteins. During the past 30 or so years a great deal of information has accumulated on the composition of various cell membranes and how this is related to the dif ferent functions that membranes perform. Nevertheless, the task of explaining particular functions at the molecular level has been hampered by lack of struc tural detail at the atomic level. The reason for this is primarily the difficulty of crystallizing membrane proteins which require strategies that differ from those used to crystallize soluble proteins. The unique exception is bacteriorhodopsin of the purple membrane of Halobacterium halobium which is interpolated into a membrane that is neither fluid nor in a mosaic configuration. To date only 50 or so membrane proteins have been characterised to atomic resolution by diffraction methods, in contrast to the vast data accumulated on soluble proteins. Another factor that has been difficult to explain is the reason why the lipid compliment of membranes is often extremely complex. Many hundreds of different molecular species of lipid can be identified in some membranes. Remarkably, the particular composition of each membrane appears to be main tained within relatively narrow limits and its identity distinguished from other morphologically-distinct membranes.
Download or read book Lipid Rafts written by Dan Sillence and published by Nova Science Publishers. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, the surface of cells was viewed as a homogeneous fluid lipid casing. However, it is now understood that the surface of cells is not homogeneous but instead contains domains selectively enriched in particular lipids and proteins. Although it is still not completely clear how these lipid platforms are formed, their existence provides a basis for the organisation of many cell processes. One possibility is that microdomain formation relies on lipid phase separation in the plane of the bilayer -- 'lipid raft' hypothesis. Lipid rafts are compelling since they provide spontaneous organisation for signal transduction as well as intracellular sorting and targeting. What are the functions of these domains? Do they rely on specific interactions and how do they change in response to cell signalling processes? Do they help in the understanding of cell signalling and immune function and how may they be disrupted in disease processes such as neurodegeneration?
Download or read book An Introduction to Biological Membranes written by William Stillwell and published by Newnes. This book was released on 2013-04-20 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Biological Membranes: From Bilayers to Rafts covers many aspects of membrane structure/function that bridges membrane biophysics and cell biology. Offering cohesive, foundational information, this publication is valuable for advanced undergraduate students, graduate students and membranologists who seek a broad overview of membrane science. - Brings together different facets of membrane research in a universally understandable manner - Emphasis on the historical development of the field - Topics include membrane sugars, membrane models, membrane isolation methods, and membrane transport
Download or read book Lipid Rafts written by Thomas J. McIntosh and published by Humana Press. This book was released on 2010-10-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many unanswered questions concerning the composition, structure, and dynamics of lateral microdomains (rafts) in biological membranes. Thus, sophisticated techniques have been used to study intact cell membranes as well as model systems composed of specific lipids and proteins thought to be in rafts. Using biochemical, biophysical, and computational methods, "Lipid Rafts" provides the most up-to-date information on the subject.
Download or read book B Cell Receptor Signaling written by Tomohiro Kurosaki and published by Springer. This book was released on 2015-12-26 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Download or read book Lipid Rafts written by Erhard Bieberich and published by . This book was released on 2021 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lipid Rafts written by Thomas Nils and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid rafts are nanometer-sized subdomains of the plasma membrane containing higher concentrations of cholesterol, phosphatidylinositols, and sphingolipids. In Lipid Rafts: Properties and Role in Signaling, the authors summarize their observations that receptor preassembly is required for biological function; the interaction between receptor chains requires both the presence of Jak1 and their co-nanolocalization within lipid raft; a sequence-supported structural analysis of Janus kinases that suggests a significant influence of phospholipids on Janus kinase function; and critical observations made by others. The authors go on to discuss the way in which some studies have pointed out the relative contribution of microdomain lipid raft abnormalities to the pathophysiology of cardiovascular disease or cancer, and examples of substances known to affect lateral membrane organization in cells are discussed as potential therapeutics. A mini-review is included which summarizes the present data behind the relevance of lipid raft membrane domains in neuronal survival and death, with a particular emphasis in age-related neurodegenerative diseases. Furthermore, the emerging importance of the lipid matrix in alpha-synuclein protein configurations in synucleopathies will also be discussed. Lastly, the authors attempt to understand the molecular background of low-solubility of neuronal membrane to non-ionic detergent and find that phosphatidylserine prepared from brain showed insolubility to Triton X-100 at 4℃. Additionally, it was found that some lipid-derived molecules increased the solubility of neuronal DRM to non-ionic detergents.
Download or read book Physics of Biological Membranes written by Patricia Bassereau and published by Springer. This book was released on 2018-12-30 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book mainly focuses on key aspects of biomembranes that have emerged over the past 15 years. It covers static and dynamic descriptions, as well as modeling for membrane organization and shape at the local and global (at the cell level) scale. It also discusses several new developments in non-equilibrium aspects that have not yet been covered elsewhere. Biological membranes are the seat of interactions between cells and the rest of the world, and internally, they are at the core of complex dynamic reorganizations and chemical reactions. Despite the long tradition of membrane research in biophysics, the physics of cell membranes as well as of biomimetic or synthetic membranes is a rapidly developing field. Though successful books have already been published on this topic over the past decades, none include the most recent advances. Additionally, in this domain, the traditional distinction between biological and physical approaches tends to blur. This book gathers the most recent advances in this area, and will benefit biologists and physicists alike.
Download or read book Caveolae and Lipid Rafts Roles in Signal Transduction and the Pathogenesis of Human Disease written by Edward Bittar and published by Elsevier Science. This book was released on 2005-07-20 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.
Download or read book Plant Lipids written by Denis J. Murphy and published by John Wiley & Sons. This book was released on 2009-02-12 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: New research tools have revealed many surprising aspects of thedynamic nature of lipids and their participation in processes suchas recognition, intra- and inter-cellular signalling, deterrenceand defence against pathogens, membrane trafficking and proteinfunction. This is in addition to new information on the moreestablished roles of plant lipids as structural components ofmembranes and as long-term storage products. Plant lipids are alsoincreasingly being seen as sources of a new generation ofenvironmentally friendly, biodegradable and renewable industrialproducts, including biopolymers and high grade lubricants. This volume provides a broad overview of plant lipid researchand its many applications, linking the various disciplines andproviding an interesting and wide-ranging perspective on thisfast-moving field. Extensive lists of references are provided,totalling well over two thousand non-redundant citations andoffering a point of entry to the detailed literature. This is a book for researchers and professionals in plantbiochemistry, molecular biology, biotechnology and genetics, inboth the academic and industrial sectors.
Download or read book Caveolae and Lipid Rafts Roles in Signal Transduction and the Pathogenesis of Human Disease written by Edward Bittar and published by Elsevier. This book was released on 2005-10-07 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.
Download or read book Lipid Rafts written by Thomas J. McIntosh and published by Humana Press. This book was released on 2007-07-06 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many unanswered questions concerning the composition, structure, and dynamics of lateral microdomains (rafts) in biological membranes. Thus, sophisticated techniques have been used to study intact cell membranes as well as model systems composed of specific lipids and proteins thought to be in rafts. Using biochemical, biophysical, and computational methods, "Lipid Rafts" provides the most up-to-date information on the subject.
