Download or read book Linear DNA linked Nanoparticle Building Blocks nBLOCKs for Modular Self assembly of Nanostructures written by Jakob Thomas Hockman and published by . This book was released on 2017 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Controlling the shapes and sizes of nanomaterials often enables controlling their properties for certain applications. The most promising methods for controlling the shapes and sizes of nanostructures use base-pairing between complementary DNA strands to self-assemble nanostructures from DNA and nanoparticles. DNA Brick-based self-assembly is a particularly useful method for creating DNA nanostructures. It offers a large amount of control over the final shapes and sizes because it uses building blocks that are anisotropic and have predictable geometry. However, this control has not been extended to the self-assembly of nanostructures from nanoparticles. Applying DNA Brick based self-assembly to the self-assembly of nanostructures from nanoparticles would require DNA-linked nanoparticles that are anisotropic and have predictable geometry. To this end, Solidworks models were used to study the interactions between DNA Bricks so that detailed information could be gained about their mode of self-assembly. This information was used to generate Solidworks models of DNA-linked nanoparticle building blocks (nBLOCKs) that can be used for DNA Brick-based self-assembly. These nBLOCKs could be created by attaching a single 43 base pair (bp) long DNA strand to gold nanoparticles using the anisotropic monofunctionalization technique. However, accomplishing this feat would require improving the efficiency of the anisotropic monofunctionalization method first. Attempts to improve all three steps of the anisotropic monofunctionalization technique yielded mixed results. The efficiency of the first step, binding DNA to a solid support, was improved by implementing the photocleavable (PC) biotin – streptavidin interaction. UV-Vis absorbance spectroscopy revealed that the PC biotinylated DNA strands became bound to streptavidin-coated magnetic beads with nearly 100% efficiency. However, the second and third steps, binding gold nanoparticles (AuNPs) to DNA and cleaving DNA-linked AuNPs from the beads, still suffer from low yields. The efficiency of the second step was incrementally improved from 3% to 25% by tuning the reaction conditions. The third step was carried out at a maximum of 10% efficiency. The method was successfully used to generate nBLOCKs but the overall yield was less than 5%. Explanations of and possible solutions to the low-yield are suggested for future experiments.
Download or read book International Conference on Innovative Computing and Communications written by Deepak Gupta and published by Springer. This book was released on 2020-10-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes high-quality research papers presented at the Third International Conference on Innovative Computing and Communication (ICICC 2020), which is held at the Shaheed Sukhdev College of Business Studies, University of Delhi, Delhi, India, on 21–23 February, 2020. Introducing the innovative works of scientists, professors, research scholars, students and industrial experts in the field of computing and communication, the book promotes the transformation of fundamental research into institutional and industrialized research and the conversion of applied exploration into real-time applications.
Download or read book Frontiers and Progress of Current Soft Matter Research written by Xiang-Yang Liu and published by Springer. This book was released on 2021-12-16 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers some fundamental aspects and frontiers in non-equilibrium physics and soft matter research. Apart from the basic knowledge on nonlinear statistic physics, dynamics, computer simulations, and main approaches and emerging systems in soft matter research, particular attention is devoted to new conceptual flexible functional materials and the enriching areas, such as silk meso-molecular materials, molecular gels, liquid crystals, flexible electronics and new types of catalysis, etc. One of the main characteristics of this book is to start with the structure formation dynamics and the correlation between the structures and macroscopic performance. This lays down the foundation for the mesoscopic materials design and functionalization. The book is intended for upper undergraduate students, graduate students, and researchers who are interested in soft matter researches. As one of main references, the basic principles and technologies of computer simulations and experimental methods adopted in soft matter research are also explained. Illustrations and tables are included in this book to improve the readability, and examples and exercises are added to help understanding.
Download or read book Metal Catalysts in Olefin Polymerization written by Zhibin Guan and published by Springer Science & Business Media. This book was released on 2009-03-31 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyolefin is a major industry that is important for our economy and impacts every aspect of our lives. The discovery of new transition metal-based catalysts is one of the driving forces for the further advancement of this field. Whereas the classical heterogeneous Ziegler-Natta catalysts and homogeneous early transition metal metallocene catalysts remain the workhorses of the polyolefin industry, in roughly the last decade, tremendous progress has been made in developing non-metallocene-based olefin polymerization catalysts. Particularly, the discovery of late transition metal-based olefin polymerization catalysts heralds a new era for this field. These late transition metal complexes not only exhibit high activities rivaling their early metal counterparts, but more importantly they offer unique properties for polymer architectural control and copolymerization with polar olefins. In this book, the most recent major breakthroughs in the development of new olefin polymerization catalysts, including early metal metallocene and non-metallocene complexes and late transition metal complexes, are discussed by leading experts. The authors highlight the most important discoveries in catalysts and their applications in designing new polyolefin-based functional materials.
Download or read book Statistical Mechanics of Chain Molecules written by Paul J. Flory and published by Hanser Gardner Publications. This book was released on 1989-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nanomaterials for Drug Delivery and Therapy written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2019-03-14 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomaterials for Drug Delivery and Therapy presents recent advances in the field of nanobiomaterials and their important applications in drug delivery, therapy and engineering. The book offers pharmaceutical perspectives, exploring the development of nanobiomaterials and their interaction with the human body. Chapters show how nanomaterials are used in treatments, including neurology, dentistry and cancer therapy. Authored by a range of contributors from global institutions, this book offers a broad, international perspective on how nanotechnology-based advances are leading to novel drug delivery and treatment solutions. It is a valuable research resource that will help both practicing medics and researchers in pharmaceutical science and nanomedicine learn more on how nanotechnology is improving treatments. - Assesses the opportunities and challenges of nanotechnology-based drug delivery systems - Explores how nanotechnology is being used to create more efficient drug delivery systems - Discusses which nanomaterials make the best drug carriers
Download or read book Biosensors written by Donald G. Buerk and published by CRC Press. This book was released on 2014-07-22 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introductory text covers in detail the technology and applications of biosensors in their many forms. It provides an extensive survey of the basic principles, functions and applications of different categories of biosensors. The presentation is concise, systematic and well illustrated. Numerous schematics illustrate design and function.This bo
Download or read book Handbook of Fibrous Materials 2 Volumes written by Jinlian Hu and published by John Wiley & Sons. This book was released on 2020-06-22 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a leading expert in the field with contributions from experienced researchers in fibers and textiles, this handbook reviews the current state of fibrous materials and provides a broad overview of their use in research and development. Volume One focuses on the classes of fibers, their production and characterization, while the second volume concentrates on their applications, including emerging ones in the areas of energy, environmental science and healthcare. Unparalleled knowledge of high relevance to academia and industry.
Download or read book Giant Molecules written by A. I?U. Grosberg and published by World Scientific. This book was released on 2011 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: ?? Giant molecules are important in our everyday life. But, as pointed out by the authors, they are also associated with a culture. What Bach did with the harpsichord, Kuhn and Flory did with polymers. We owe a lot of thanks to those who now make this music accessible ??Pierre-Gilles de GennesNobel Prize laureate in Physics(Foreword for the 1st Edition, March 1996)This book describes the basic facts, concepts and ideas of polymer physics in simple, yet scientifically accurate, terms. In both scientific and historic contexts, the book shows how the subject of polymers is fascinating, as it is behind most of the wonders of living cell machinery as well as most of the newly developed materials. No mathematics is used in the book beyond modest high school algebra and a bit of freshman calculus, yet very sophisticated concepts are introduced and explained, ranging from scaling and reptations to protein folding and evolution. The new edition includes an extended section on polymer preparation methods, discusses knots formed by molecular filaments, and presents new and updated materials on such contemporary topics as single molecule experiments with DNA or polymer properties of proteins and their roles in biological evolution.
Download or read book Sequence Controlled Polymers written by Jean-François Lutz and published by John Wiley & Sons. This book was released on 2018-04-09 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a leading authority in the field, the first book on this important and emerging topic provides an overview of the latest trends in sequence-controlled polymers. Following a brief introduction, the book goes on to discuss various synthetic approaches to sequence-controlled polymers, including template polymerization, genetic engineering and solid-phase chemistry. Moreover, monomer sequence regulation in classical polymerization techniques such as step-growth polymerization, living ionic polymerizations and controlled radical polymerizations are explained, before concluding with a look at the future for sequence-controlled polymers. With its unique coverage of this interdisciplinary field, the text will prove invaluable to polymer and environmental chemists, as well as biochemists and bioengineers.
Download or read book Sustainable Nanoscale Engineering written by Gyorgy Szekely and published by Elsevier. This book was released on 2019-09-18 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sustainable Nanoscale Engineering: From Materials Design to Chemical Processing presents the latest on the design of nanoscale materials and their applications in sustainable chemical production processes. The newest achievements of materials science, in particular nanomaterials, opened new opportunities for chemical engineers to design more efficient, safe, compact and environmentally benign processes. These materials include metal-organic frameworks, graphene, membranes, imprinted polymers, polymers of intrinsic microporosity, nanoparticles, and nanofilms, to name a few. Topics discussed include gas separation, CO2 sequestration, continuous processes, waste valorization, catalytic processes, bioengineering, pharmaceutical manufacturing, supercritical CO2 technology, sustainable energy, molecular imprinting, graphene, nature inspired chemical engineering, desalination, and more. - Describes new, efficient and environmentally accepted processes for nanomaterials design - Includes a large array of materials, such as metal-organic frameworks, graphene, imprinted polymers, and more - Explores the contribution of these materials in the development of sustainable chemical processes
Download or read book Recent Developments in Polymer Macro Micro and Nano Blends written by P.M. Visakh and published by Woodhead Publishing. This book was released on 2016-08-24 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Developments in Polymer Macro, Micro and Nano Blends: Preparation and Characterisation discusses the various types of techniques that are currently used for the characterization of polymer-based macro, micro, and nano blends. It summarizes recent technical research accomplishments, emphasizing a broad range of characterization methods. In addition, the book discusses preparation methods and applications for various types of polymer-based macro, micro, and nano blends. Chapters include thermoplastic-based polymer & nano blends, applications of rubber based and thermoplastic blends, micro/nanostructures polymer blends containing block copolymers, advances in polymer-inorganic hybrids as membrane materials, synthesis of polymer/inorganic hybrids through heterophase polymerizations, nanoporous polymer foams from nanostructured polymer blends, and natural polymeric biodegradable nano blends for protein delivery. - Describes the techniques pertaining to a kind (or small number) of blends, showing specific examples of their applications - Covers micro, macro, and nano polymer blends - Contains contributions from leading experts in the field
Download or read book Coarse grained Simulations of the Self assembly of DNA linked Gold Nanoparticle Building Blocks written by Charles Armistead and published by . This book was released on 2016 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The self-assembly of nanoparticles (NPs) of varying shape, size, and composition for the purpose of constructing useful nanoassemblies with tailored properties remains challenging. Although progress has been made to design anisotropic building blocks that exhibit the required control for the precise placement of various NPs within a defined arrangement, there still exists obstacles in the technology to maximize the programmability in the self-assembly of NP building blocks. Currently, the self-assembly of nanostructures involves much experimental trial and error. Computational modeling is a possible approach that could be utilized to facilitate the purposeful design of the self-assembly of NP building blocks into a desired nanostructure. In this report, a coarse-grained model of NP building blocks based on an effective anisotropic mono-functionalization approach, which has shown the ability to construct six building block configurations, was used to simulate various nanoassemblies. The purpose of the study was to validate the model's ability to simulate the self-assembly of the NP building blocks into nanostructures previously produced experimentally. The model can be programmed to designate up to six oligonucleotides attached to the surface of a Au NP building block, with a modifiable length and nucleotide sequence. The model successfully simulated the self-assembly of Au NP building blocks into a number of previously produced nanostructures and demonstrated the ability to produce visualizations of self-assembly as well as calculate interparticle distances and angles to be used for the comparison with the previous experimental data for validation of the model. Also, the model was used to simulate nanoassemblies which had not been produced experimentally for its further validation. The simulations showed the capability of the model to use specific NP building blocks and self-assemble. The coarse-grained NP building block model shows promise as a tool to complement the purposeful experimental design of functional nanostructures.
Download or read book International Conference on Innovative Computing and Communications written by Ashish Khanna and published by Springer Nature. This book was released on 2021-08-17 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes high-quality research papers presented at the Fourth International Conference on Innovative Computing and Communication (ICICC 2021), which is held at the Shaheed Sukhdev College of Business Studies, University of Delhi, Delhi, India, on February 20–21, 2021. Introducing the innovative works of scientists, professors, research scholars, students and industrial experts in the field of computing and communication, the book promotes the transformation of fundamental research into institutional and industrialized research and the conversion of applied exploration into real-time applications.
Download or read book Nanoparticles for Biomedical Applications written by Eun Ji Chung and published by Elsevier. This book was released on 2019-11-19 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticles for Biomedical Applications: Fundamental Concepts, Biological Interactions and Clinical Applications brings into one place information on the design and biomedical applications of different classes of nanoparticles. While aspects are dealt with in individual journal articles, there is not one source that covers this area comprehensively. This book fills this gap in the literature. - Outlines an in-depth review of biomedical applications of a variety of nanoparticle classes - Discusses the major techniques for designing nanoparticles for use in biomedicine - Explores safety and regulatory aspects for the use of nanoparticles in biomedicine
Download or read book Stimuli responsive Drug Delivery Systems written by Amit Singh and published by Royal Society of Chemistry. This book was released on 2018-07-09 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials. Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.
Download or read book Innovative Computing written by Chao-Tung Yang and published by Springer. This book was released on 2021-10-11 with total page 1954 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers peer-reviewed proceedings of the 3rd International Conference on Innovative Computing (IC 2020). This book aims to provide an open forum for discussing recent advances and emerging trends in information technology, science, and engineering. Themes within the scope of the conference include Communication Networks, Business Intelligence and Knowledge Management, Web Intelligence, and any related fields that depend on the development of information technology. The respective contributions presented here cover a wide range of topics, from databases and data mining, networking and communications, the web and Internet of Things, to embedded systems, soft computing, social network analysis, security and privacy, optical communication, and ubiquitous/pervasive computing. Readers such as students, researchers, and industry professionals in the fields of cloud computing, Internet of Things, machine learning, information security, multimedia systems, and information technology benefit from this comprehensive overview of the latest advances in information technology. The book can also benefit young investigators looking to start a new research program.
