Download or read book Linear Dichroism and Circular Dichroism written by Bengt Nordén and published by Royal Society of Chemistry. This book was released on 2019-05-02 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to optical anisotropy (linear dichroism, LD) and optical activity (circular dichroism, CD) as techniques for the study of structures and interactions of molecules in solution. The book covers the use of these techniques for both small and large molecular systems with particular emphasis being placed on proteins and nucleic acids. CD is a well-established technique and this book aims to explain how it can be used simply and effectively for new entrants to the field as well as covering more advanced techniques for experts. LD is often seen as a rather exotic method intended only for experienced spectroscopists. This book demonstrates that it is an approach with real utility that may be used by both students and scientists from graduate level onwards to give simple answers, which are not available from any other technique, to structural and kinetic questions. Much of the emphasis is on flow orientation of samples in solution phase. The book first describes the techniques and the information they can provide; it then goes on to give specific details on how to actually implement them, including a wide range of examples showing how LD and CD can help with * protein and nucleic acid secondary structure elucidation; * analysis of the formation and rearrangements of fibrous proteins and membrane proteins; * identification of the absolute configuration of small molecules; * determination of the orientation of small molecules in anisotropic media; * assignment of transition moment polarizations; * investigation of binding strengths and geometries of ligand-macromolecule complexes; * 3-D structure determination from LD, molecular replacement and MD modeling. The advantages of combined LD/CD studies are also outlined with examples of DNA/drug complexes and protein insertion into membranes. Taken together the book represents a comprehensive text on the theory and application of LD and CD in the chemical and biological sciences.
Download or read book Circular Dichroism and Linear Dichroism written by Alison Rodger and published by Oxford University Press, USA. This book was released on 1997 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to all those who wish to use the complementary spectroscopic techniques of optical activity (circular dichroism, CD) and optical anisotropy (linear dichroism, LD) for the study of the structure of molecules and interactions between molecules in solution. It emphasizes these techniques and how to use them for both low and high molecular weight molecules. The book begins by describing the principles behind CD and LD and how these techniques can be used in the laboratory without using advanced maths or quantum mechanics. The next chapters describe how both techniques may be applied to the study of biological macromolecules and give a detailed description of how they may be used on small molecules to investigate molecular and electronic structure. The final part contains theoretical derivations of all the equations required for the applications described previously. Specific molecular examples are used to illustrate concepts and to show the reader how to use the techniques in chemical and biological systems. Circular Dichroism and Linear Dichroism is an easy guide to what a prospective user of CD needs to know and explains how LD is not merely an exotic technique only to be practiced by experienced spectroscopists, but may be routinely and usefully employed as an aid to molecular structure determination.
Download or read book Magnetic Circular Dichroism Spectroscopy written by W. Roy Mason and published by John Wiley & Sons. This book was released on 2007-07-09 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a technical guide for chemists and spectroscopists, and presents a concise description of magnetic circular dichroism (MCD) spectroscopy and how it has advanced the interpretation of molecular electronic spectra. Provides a practical guide to utilizing MCD spectroscopy for chemists starting in the field Written by an expert with over twenty years of experience in the field Helps the reader to visualize the optical spectroscopic effects presented by MCD measurements Includes practical considerations for experimental MCD measurements based on the author's experience Written as a general discussion of the subject matter, with illustrative examples provided and discussed in the case studies to show the breadth of application of MCD measurements.
Download or read book Modern Techniques for Circular Dichroism and Synchrotron Radiation Circular Dichroism Spectroscopy written by Bonnie Ann Wallace and published by IOS Press. This book was released on 2009 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents an account of circular dichroism (CD) spectroscopy and its application to structural biology. This book covers the methods of synchrotron radiation circular dichroism (SRCD) and linear dichroism (LD).
Download or read book Linear Dichroism Spectroscopy written by Bengt Nordén and published by Lund University Press. This book was released on 1977 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spectroscopy of Polymers written by J.L. Koenig and published by Elsevier. This book was released on 1999-09-16 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised and updated Second Edition of the best-selling reference/text is essential reading for students and scientists who seek a thorough and practical introduction to the field of polymer spectroscopy. Eleven chapters cover the fundamental aspects and experimental applications of the primary spectroscopic methods. The advantages and disadvantages of the various techniques for particular polymer systems are also discussed. The goal of the author is not to make the reader an expert in the field, but rather to provide enough information about the different spectroscopic methods that the reader can determine how the available techniques can be used to solve a particular polymer problem. This Second Edition contains new and updated information on techniques in IR and NMR, as well as an all-new chapter on Mass Spectrometry.
Download or read book Chiroptical Spectroscopy written by Prasad L. Polavarapu and published by CRC Press. This book was released on 2016-10-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details chiroptical spectroscopic methods: electronic circular dichroism (ECD), optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational Raman optical activity (VROA). For each technique, the text presents experimental methods for measurements and theoretical methods for analyzing the experimental data. It also includes a set of experiments that can be adopted for undergraduate teaching laboratories. Each chapter is written in an easy-to-follow format for novice readers, with necessary theoretical formalism in appendices for advanced readers.
Download or read book X Ray Absorption and X Ray Emission Spectroscopy 2 Volume Set written by Jeroen A. van Bokhoven and published by John Wiley & Sons. This book was released on 2016-03-21 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-Ray Absorption and X-ray Emission Spectroscopy: Theory and Applications During the last two decades, remarkable and often spectacular progress has been made in the methodological and instrumental aspects of x-ray absorption and emission spectroscopy. This progress includes considerable technological improvements in the design and production of detectors especially with the development and expansion of large-scale synchrotron reactors All this has resulted in improved analytical performance and new applications, as well as in the perspective of a dramatic enhancement in the potential of x-ray based analysis techniques for the near future. This comprehensive two-volume treatise features articles that explain the phenomena and describe examples of X-ray absorption and emission applications in several fields, including chemistry, biochemistry, catalysis, amorphous and liquid systems, synchrotron radiation, and surface phenomena. Contributors explain the underlying theory, how to set up X-ray absorption experiments, and how to analyze the details of the resulting spectra. X-Ray Absorption and X-ray Emission Spectroscopy: Theory and Applications: Combines the theory, instrumentation and applications of x-ray absorption and emission spectroscopies which offer unique diagnostics to study almost any object in the Universe. Is the go-to reference book in the subject for all researchers across multi-disciplines since intense beams from modern sources have revolutionized x-ray science in recent years Is relevant to students, postdocurates and researchers working on x-rays and related synchrotron sources and applications in materials, physics, medicine, environment/geology, and biomedical materials
Download or read book Vacuum Ultraviolet Spectroscopy written by James A. Samson and published by Academic Press. This book was released on 2000-12-21 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Techniques of Vacuum Ultraviolet Spectroscopy was first published in 1967. In the three decades since, the techniques associated with vacuum ultraviolet spectroscopy have been greatly expanded. Originally published as two volumes in the serial "Experimental Methods in the Physical Sciences," Vacuum Ultraviolet Spectroscopy combines in one paperback volume information on the many advances in vacuum ultraviolet (VUV) research. In addition, the book provides students and researchers with concise reviews of the important aspects of designing experiments in the VUV region.This is the only comprehensive treatise describing the use of synchrotron and other light sources for research, along with the new technologies in optical elements, multilayers, mirror coatings, soft x-ray zone plates, VUV detectors, interferometric spectrometers, and subjects such as spectromicroscopy, lithography, and photon-induced fluorescence. Vacuum Ultraviolet Spectroscopy is an ideal handbook both for the beginner and for the experienced researcher in any field requiring the use of VUV radiation. Key Features* Detailed review of synchrotron radiation sources including undulators and wigglers* Comprehensive outline of monochromator design* Concise review of optics theory for multilayers, spectrometers, and zone plates* Information about other important VUV sources such as laser produced plasmas and Electron Beam Ion Trap (EBIT) sources* Applications such as spectromicroscopy, lithography, and fluorescence
Download or read book Circular Dichroism and Magnetic Circular Dichroism Spectroscopy for Organic Chemists written by Nagao Kobayashi and published by Royal Society of Chemistry. This book was released on 2011-11-10 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: CD and MCD spectroscopy can provide key information about the conformations and electronic states of chromophore containing molecules. However, the theory has remained too challenging and inaccessible for many organic chemists and biochemists and only a few researchers have carried out detailed quantitative analyses of their spectral data. This is not surprising as people who excel at spectroscopic theory usually lack the skills set required to design and synthesise the molecules that would be most appropriate for describing and explaining the theory of CD and MCD spectroscopy. Most of the books that have been written on the subject have, therefore, been based on very dense sets of mathematical equations. This timely book rectifies that situation by summarizing the relationship between the different types of spectra and by describing in detail the qualitative and quantitative methods which can readily be used to analyse CD and MCD spectral data. During the last decade the authors have successfully synthesized several molecules to illustrate key points related to the theory of CD and MCD spectroscopy, resulting in this definitive book providing key practical knowledge in a readily accessible style. It is aimed primarily at organic chemists and biochemists and is required reading for researchers active in the field. In the introduction, the book describes the types of information that can be derived from CD and MCD spectroscopy. After a detailed explanation of the theory of electronic absorption spectroscopy, it then provides practical in depth examples of the various analytical methods that can be carried out with CD and MCD spectral data. This makes the theory of these techniques much more accessible for researchers who do not specialise in physical chemistry. The book concludes by briefly summarizing the key mathematical expressions associated with each technique.
Download or read book Drug DNA Interactions written by Kazuo Nakamoto and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
Download or read book Protein Ligand Interactions written by Mark A. Williams and published by Humana. This book was released on 2016-11-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are the cell’s workers, their messengers and overseers. In these roles, proteins specifically bind small molecules, nucleic acid and other protein partners. Cellular systems are closely regulated and biologically significant changes in populations of particular protein complexes correspond to very small variations of their thermodynamics or kinetics of reaction. Interfering with the interactions of proteins is the dominant strategy in the development of new pharmaceuticals. Protein Ligand Interactions: Methods and Applications, Second Edition provides a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins. From the initial discovery of natural substrates or potential drug leads, to the detailed quantitative understanding of the mechanism of interaction, all stages of the research process are covered with a focus on those techniques that are, or are anticipated to become, widely accessible and performable with mainstream commercial instrumentation. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Protein Ligand Interactions: Methods and Applications, Second Edition serves as an ideal guide for researchers new to the field of biophysical characterization of protein interactions – whether they are beginning graduate students or experts in allied areas of molecular cell biology, microbiology, pharmacology, medicinal chemistry or structural biology.
Download or read book Biochemical Spectroscopy written by Kenneth Sauer and published by Academic Press. This book was released on 1995-02-16 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes spectroscopic methods for the characterization of macromolecules. Methods span the electromagnetic spectrum from X-ray to microwaves. It focuses on the types of information that can be derived: how measurements are made; state of the art apparatus; data acquisition, analysis, and interpretation; casebook examples; and new developments and future directions. Key Features * Ultraviolet and Visible Spectroscopy, including * Absorption and Circular Dichroism * Transient Absorption and Kinetics * Linear Dichroism and Fluorescence * Vibrational Spectroscopy * Magnetic Resonance Spectroscopy * X-Ray Spectroscopy
Download or read book Vibrational Optical Activity written by Laurence A. Nafie and published by John Wiley & Sons. This book was released on 2011-07-12 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book stands as the only comprehensive introduction to vibrational optical activity (VOA) and is the first single book that serves as a complete reference for this relatively new, but increasingly important area of molecular spectroscopy. Key features: A single-source reference on this topic that introduces, describes the background and foundation of this area of spectroscopy. Serves as a guide on how to use it to carry out applications with relevant problem solving. Depth and breadth of the subject is presented in a logical, complete and progressive fashion. Although intended as an introductory text, this book provides in depth coverage of this topic relevant to both students and professionals by taking the reader from basic theory through to practical and instrumental approaches.
Download or read book Ord and Cd in Chemistry and Biochemistry written by Pierre Crabbe and published by Elsevier. This book was released on 2012-12-02 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: ORD and CD in Chemistry and Biochemistry: An Introduction essentially presents the necessary foreword and theoretical foundation for the useful application of optical rotatory dispersion (ORD) and circular dichroism (CD) to certain common chemical problems. This book emphasizes the precision of ORD and CD data in terms of stereochemical information. The book begins with some historical references and a concise review of basic principles on stereochemistry. It further delves onto the phenomena of optical activity. Also included are the definitions and units commonly used in ORD and CD. The book also discusses optical properties of polymers, organometallic, and inorganic derivatives; and some of the aspects of magnetic optical rotator dispersion (MORD) and magnetic circular dichroism (MCD). A table that presents wavelength range of the Cotton effects of most chromophoric groupings concludes the book. This monograph is a helpful reference to students as well as professionals from both chemistry and biochemistry fields of science.
Download or read book Photosynthetic Excitons written by Herbert van Amerongen and published by World Scientific. This book was released on 2000 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excitons are considered as the basic concept used by describing the spectral properties of photosynthetic pigment-protein complexes and excitation dynamics in photosynthetic light-harvesting antenna and reaction centers. Following the recently obtained structures of a variety of photosynthetic pigment-protein complexes from plants and bacteria our interest in understanding the relation between structure, function and spectroscopy has strongly increased. These data demonstrate a short interpigment distance (of the order of 1 nm or even smaller) and/or a highly symmetric (ring-like) arrangement of pigment molecules in peripheral light-harvesting complexes of photosynthetic bacteria. Books which were devoted to the exciton problem so far mainly considered the spectral properties of molecular crystals. However, the small size of these pigment aggregates in the pigment-protein complexes as well as the role of the protein, which is responsible for the structural arrangement of the complex, clearly will have a dramatic influence on the pigment spectra and exciton dynamics. All these aspects of the problem are considered in this book. Exciton theory is mainly considered for small molecular aggregates (dimers, ring-like structures etc.). Together with the theoretical description of the classical conceptual approach, which mainly deals with polarization properties of the absorption and fluorescence spectra, the nonlinear femtosecond spectroscopy which is widely used for investigations now is also discussed. A large part of the book demonstrates the excitonic effects in a multitude of photosynthetic pigment-protein complexes and how we can understand these properties on the basis of the exciton concept.
Download or read book Vibrational Spectroscopy of Polymers written by Neil J. Everall and published by John Wiley & Sons. This book was released on 2007-06-05 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, measurements using vibrational spectroscopy techniques for both the chemical and physical characteristics of polymers are described, alongside chapters covering spectra-structure correlations and spectra calculation. Special chapters deal with composites and conducting polymers, while others discuss the role of vibrational spectroscopy in understanding polymer weathering and degradation, and determining the optical, dielectric and solar and thermal properties of polymers. Dichroism measurement methods, important in understanding product performance, are covered, as well as practical methods for determining molecular orientation; linear, biaxial and trichroic determinations for polymers, as are dynamic measurement systems.
