Download or read book Therapeutic Progress in Oncology written by Jacques Barbet and published by John Wiley & Sons. This book was released on 2020-02-19 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: The combined effects of population growth and aging have led to an increase in the number of cancers. Preventing, diagnosing, treating and curing cancer are therefore, more than ever, imperatives facing medicine especially to continue the decrease in cancers mortality rates and to improve the quality of survival. Over time, the classic modes of treatment (surgery, external beam radiotherapy, chemotherapy) have become more refined and efficient. From the beginning of this century, new therapeutic options have been developed: targeted cancer therapy, targeted radionuclide therapy and immunologic therapies based on monoclonal antibodies, cellular therapy and vaccinations. Artificial intelligence and machine learning are also being introduced to the field of oncology. Starting with the basic scientific principles relevant to oncology, this book explains and makes these concepts and innovations accessible to a wide audience especially in the interest of patients. It also contributes to the oncological field of 4P medicine with 4P standing for predictive, preventive, personalized and participative.
Download or read book Toxines et cancer written by GOUDEY-PERRIÈRE Françoise and published by Lavoisier. This book was released on 2006-11-26 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: De tout temps, l'homme a eu conscience de l'intérêt thérapeutique des toxines. Certaines toxines végétales depuis longtemps utilisées figurent encore dans la pharmacopée actuelle. Viennent s'y ajouter depuis peu des toxines microbiennes. Cependant le maniement des toxines natives ou à peine modifiées reste délicat tant est faible la marge entre les effets toxiques et l'efficacité thérapeutique. Comment, dans une perspective médicale, canaliser la puissance d'action et l'efficacité d'une toxine ? Connaître sa structure, comprendre son mécanisme d'action n'est pas suffisant : il faut aussi identifier sa cible privilégiée, autrement dit un récepteur cellulaire, faute de quoi l'entreprise apparemment chimérique d'un détournement de sa puissance et de sa spécificité reste aveugle. Ce cap est franchi, depuis un certain nombre d'années, et le développement des recherches sur les toxines axées sur la thérapeutique est devenu foisonnant. Voyez telle ou telle toxine protéique ternaire, avec ses trois domaines, de fixation sur un récepteur membranaire, de translocation qui lui permet de franchir la membrane cellulaire, et d'activité enzymatique qui va alors pouvoir s'exercer dans la cellule. Qu'on parvienne à dissocier chacun de ces trois domaines en leur conservant leurs propriétés, et des possibilités nouvelles d'utilisation thérapeutique vont s'ouvrir, presque à l'infini semble-t-il. Car chacun d'entre eux pourra être couplé à une molécule active bien ciblée, et leur efficacité sera même améliorée pour peu qu'on parvienne à conjuguer leur action. Qu'un récepteur, qu'une molécule, propres au métabolisme ou à la physiologie d'une cellule cancéreuse soient identifiés, et des toxines conjuguées à un ligand de ce récepteur, de cette molécule (ce peut être un anticorps) bloqueront les canaux ioniques ou exerceront leur effet cytolytique sur cette seule cellule, sans nuire aux cellules saines. Nous voilà dégagés de l'utopie, le contenu de cet ouvrage le prouve abondamment. Et même si la concrétisation des promesses reste délicate, le champ d'action est si vaste initialement qu'il ne saurait rester improductif : il ne l'est d'ailleurs déjà plus.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1983 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Treatment of Ovarian Cancer written by A. P. Bardos and published by Nova Publishers. This book was released on 2005 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume presents the latest research on therapies for ovarian cancer. Ovarian cancer is cancer that begins in the cells that constitute the ovaries, including surface epithelial cells, germ cells, and the sex cord-stromal cells. Cancer cells that metastasize from other organ sites to the ovary (most commonly breast or colon cancers) are not then considered ovarian cancer. According to the American Cancer Society, ovarian cancer accounts for 4 percent of all cancers among women and ranks fifth as a cause of their deaths from cancer. The American Cancer Society statistics for ovarian cancer estimate that there will be 25,400 new cases and 14,300 deaths in 2003. The death rate for this disease has not changed much in the last 50 years. Unfortunately, almost 70 percent of women with the common epithelial ovarian cancer are not diagnosed until the disease is advanced in stage -- i.e., has spread to the upper abdomen (stage III) or beyond (stage IV). The 5-year survival rate for these women is only 15 to 20 percent, whereas the 5-year survival rate for stage I disease patients approaches 90 percent and for stage II disease patients approaches 70 percent. Ovarian tumors are named according to the type of cells the tumor started from and whether the tumor is benign or cancerous. The three main types of ovarian tumors are: Epithelial Tumors, Germ Cell Tumors and Stromal Tumors.
Download or read book Bulletin written by International Union against Cancer and published by . This book was released on 1978 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunoreceptor Tyrosine based Inhibition Motifs written by Marc Daeron and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research and with exciting potential clinical applications. The present volume contains 15 reviews written by authors who all made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties. It constitutes the first synthesis ever published that is specifically devoted to this emerging topic.
Download or read book Targeted Therapies in Oncology Second Edition written by Giuseppe Giaccone and published by CRC Press. This book was released on 2013-10-21 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.
Download or read book ACB written by and published by . This book was released on 1987 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues for 1950-51 include Acta Anaesthesiologica Belgica, 1-2 Année.
Download or read book Chimeric Antigen Receptor T Cells written by Kamilla Swiech and published by Humana. This book was released on 2020-11-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes.
Download or read book Cancer Pain written by Eduardo D. Bruera and published by Cambridge University Press. This book was released on 2010 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of the widely praised book by Drs Eduardo D. Bruera and Russell K. Portenoy on all aspects of cancer pain.
Download or read book Regional Forum on the Impact of Emerging Technologies on the Law of Intellectual Property for African and Arab Countries written by and published by . This book was released on 1990 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fluorine Magnetic Resonance Imaging written by Ulrich Flogel and published by CRC Press. This book was released on 2016-10-26 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.
Download or read book Multiple Sclerosis 2 written by W. Ian McDonald and published by Butterworth-Heinemann. This book was released on 2003 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This practical resource encompasses the newest essential information on multiple sclerosis-focusing on those areas where progress has been made in research, bringing about new concepts of patient management"--Back cover.
Download or read book Antibody Engineering written by Benny K. C. Lo and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hybridoma technology by Köhler and Milstein in 1975, a phenomenal number of mo- clonal antibodies have been generated against a diverse array of targets. Some of these have become indispensable reagents in biomedical research, while others were developed for novel therapeutic applications. The attractiveness of an- bodies in this regard is obvious—high target specificity, adaptability to a wide range of disease states, and the potential ability to direct the host’s immune s- tem for a therapeutic response. The initial excitement in finding Paul Ehrlich’s “magic bullet,” however, was met with widespread disappointment when it was demonstrated that murine antibodies frequently elicit the human anti-murine an- body (HAMA) response, thus rendering them ineffective and potentially unsafe in humans. Despite this setback, advances in recombinant DNA techniques over the last 15–20 years have empowered the engineering of recombinant antibodies with desired characteristics, including properties to avoid HAMA. The ability to p- duce bulk quantities of recombinant proteins from bacterial fermentation also fueled the design of numerous creative antibody constructs. To date, the United States Food and Drug Administration has approved more than 10 recombinant antibodies for human use, and hundreds more are in the development pipeline. The recent explosion in genomic and proteomic information appears ready to deliver many more disease targets amenable to antibody-based therapy.
Download or read book Clinical Pediatric Oncology written by Wataru Walter Sutow and published by . This book was released on 1984 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Targeted Therapies for Solid Tumors written by Antonio Russo and published by Humana. This book was released on 2016-10-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.
Download or read book Souvenirs D un Physiologiste written by Charles Richet and published by Hassell Street Press. This book was released on 2021-09-09 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
