Download or read book Le remodelage ventriculaire gauche inverse au cours de l insuffisance cardiaque written by Arthur Cescau and published by . This book was released on 2015 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Le remodelage ventriculaire gauche au cours de l’insuffisance cardiaque à fraction d’éjection ventriculaire gauche altérée est le phénomène définissant les modifications anatomiques, tissulaires et cellulaires au cours de l’évolution de la maladie. Il s’agit le plus souvent d’un remodelage associé à un pronostic péjoratif. Le remodelage inverse est moins fréquent et est associé à un pronostic plus favorable. Néanmoins, les données concernant ce phénomène sont peu nombreuses. Ce travail avait pour but de caractériser le remodelage inverse dans une cohorte monocentrique de 196 patients insuffisants cardiaques avec FE VG altérée, inclus entre 2008 et 2010 et ayant eu au moins deux échocardiographies espacées de 3 à 18 mois et un suivi clinique d’au moins 3 ans. Le remodelage inverse était défini par une diminution d’au moins 10% du diamètre télédiastolique VG et par une augmentation d’au moins 10 points de la FEVG. Un remodelage inverse a été observé chez 21 patients (10,7%). Les facteurs associés à sa survenue étaient l’obésité (OR=3,6), le caractère de novo de l’insuffisance cardiaque (OR=0,19) et une FE VG initiale plus basse (OR=0,95). En analyse multivariée le remodelage inverse avait par ailleurs un impact positif sur la survie sans transplantation cardiaque (HR = 0,22 IC95% 0,06-0.95, p=0,04). De façon paradoxale, l’obésité semble donc associée au remodelage inverse dans l’insuffisance cardiaque à FEVG altérée, ce qui nécessite confirmation dans d’autres cohortes et d’en comprendre les mécanismes. De façon plus attendue, ce remodelage inverse a également une valeur pronostique positive.

Download or read book D synchronisation et physiopathologie du remodelage ventriculaire gauche dans l insuffisance cardiaque written by Aymeric Menet and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'objectif de ce travail était de mieux appréhender les mécanismes impliqués dans la réponse à la resynchronisation biventriculaire en insistant sur la caractérisation écho-cardiographique du substrat éligible à un traitement par resynchronisation cardiaque (TRC). Afin de valider dans notre cohorte les critères de réponse au TRC, nous avons évalué l'impact pronostic au long cours de l'amélioration du strain longitudinal du ventricule gauche (VG), de la fraction d'éjection VG et des volumes VG 6 à 9 mois après un TRC. L'amélioration du volume télésystolique du VG (remodelage inverse) semble être le marqueur le plus pertinent du pronostic au long cours après TRC. De plus, l'insuffisance mitrale secondaire significative persistante malgré un TRC semble être un facteur pronostic important indépendant du remodelage VG. Nous avons démontré qu'il existe un certain degré de désynchronisation mécanique (fondé sur la mesure des délais entre paroi) dans les insuffisances cardiaques à fraction d'éjection préservée qui est semblable aux insuffisances cardiaques à fraction d'éjection basse à QRS fins et supérieur aux témoins hypertendus. Cependant, les paramètres de désynchronisation échographiques considérés comme les substrats de la réponse au TRC (fondés sur la contraction type bloc de branche gauche) ne sont que très rarement retrouvés chez ces patients. Ces paramètres sont fréquemment présents dans les insuffisances cardiaques à fraction d'éjection basse avec un QRS large et une indication de TRC. Le strain longitudinal du septum interventriculaire permet de caractériser 3 patterns de contraction septale eux même prédicteurs du remodelage inverse, des hospitalisations pour insuffisance cardiaque, de la mortalité cardiovasculaire et de la mortalité toute cause après un TRC. L'élargissement de la largeur du QRS après un TRC est quant à elle un prédicteur de l'absence de remodelage inverse, et d'un excès de mortalité cardiovasculaire et toute cause après un TRC. L'association d'un pattern de contraction septal peu prédicteur de réponse au TRC et d'un élargissement du QRS après le TRC permet d'identifier des patients avec une probabilité de réponse très faible au TRC.

Download or read book Resynchronisation cardiaque et remodelage inverse du ventricule gauche written by Emmanuelle Lescaroux and published by . This book was released on 2015 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: La resynchronisation cardiaque est un traitement efficace chez l'insuffisant cardiaque à FEVG altérée avec un bloc de branche gauche. Mais 30% des patients sont dit non répondeurs, il n'est pas possible de les identifier avant l'implantation du dispositif. L'étude ProBioHF a pour objectif d'identifier des marqueurs biologiques pronostics de l'évolution de l'insuffisance cardiaque après la resynchronisation. Les données cliniques de cette étude sont analysées pour quantifier le phénomène de remodelage inverse, son incidence sur le pronostic et rechercher des facteurs prédictifs cliniques de l'évolution. 31% de patients n'ont pas de signe de remodelage inverse, 20.6% sont super répondeurs. Les patients présentant un remodelage inverse sont moins symptomatiques. En analyse univariée : la cardiopathie ischémique, une durée plus longue d'évolution de la maladie et une FEVG plus altérée au moment de l'implantation du défibrillateur multisite sont des facteurs prédictifs d'une non réponse à la resynchronisation.

Download or read book Innovations in Information and Communication Technologies IICT 2020 written by Pradeep Kumar Singh and published by Springer Nature. This book was released on 2021-07-15 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book is comprised of original research that focuses on technological advancements for effective teaching with an emphasis on learning outcomes, ICT trends in higher education, sustainable developments and digital ecosystem in education, management and industries. The contents of the book are classified as; (i) Emerging ICT Trends in Education, Management and Innovations (ii) Digital Technologies for advancements in education, management and IT (iii) Emerging Technologies for Industries and Education, and (iv) ICT Technologies for Intelligent Applications. The book represents a useful tool for academics, researchers, industry professionals and policymakers to share and learn about the latest teaching and learning practices supported by ICT. It also covers innovative concepts applied in education, management and industries using ICT tools.

Download or read book Pathogenesis of Idiopathic Scoliosis written by Masafumi Machida and published by Springer. This book was released on 2018-02-23 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS.

Download or read book Development of the Cardiac Conduction System written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2005-01-21 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues. The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood. This book draws together contributions from an international and interdisciplinary group of experts working on both basic and clinical aspects of cardiac development. It features reviews of the structure and function of the developing PCS, discussion of the molecular and cellular mechanisms regulating embryological development of this system and studies on the fundamental basis of PCS pathology. The book also considers how novel therapeutic interventions based on understanding of the developmental biology of cardiac pacemaking and conduction tissues might ultimately impact on clinical medicine.

Download or read book Exercise and Physical Activity for Older Adults written by Danielle R. Bouchard and published by Human Kinetics. This book was released on 2020-04-23 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Go beyond aging theories and examine the physiological and physical impacts of aging. Exercise and Physical Activity for Older Adults takes a close look at the physical implications of the aging process and how health, physical activity, and exercise interact in aging adults. With an international team of contributors composed of leading experts from across the field of gerontology, Exercise and Physical Activity for Older Adults delivers comprehensive, interdisciplinary coverage of the physical aging process and its effects on movement and exercise. Research on the physiological and physical implications of aging is presented, focusing on study outcomes and their practical application in optimizing healthy aging. Presented in an integrated and cohesive manner, this text is organized into four parts. Part I covers the theoretical foundations of biological aging, the implications of aging theories on medical research, and the social and economic impacts of demographic shifts due to population aging and global population size. Part II addresses age-related changes to the musculoskeletal, cardiovascular, pulmonary, and endocrine systems. Part III covers the physical effects of aging on other dimensions of life, including balance, motor control, and physical functions. Part IV focuses on exercise and older adults, taking an in-depth look at exercise measurements and the main barriers to regular exercise. One full chapter is devoted to recommendations for optimizing health for the general public, while another chapter is focused on performance by elite older athletes who exercise beyond functional fitness. Chapter objectives, end-of-chapter summaries, and review questions highlight key concepts and promote learning retention. Behavior Check sidebars look at the impacts of aging on behavior, how behavior affects physical health and activity, and how changes in behavior can improve everyday living. Functional Fitness Checkup sidebars focus on the performance of daily movements that are vital for older adults who want to maintain their physical independence. Putting It Into Practice elements provide examples of real-life application of the concepts presented, facilitating a practical understanding of how to use the content to benefit clients. A definitive resource for students and health care professionals who study physical aging, conduct clinical research, or work with older adults as clients and patients, Exercise and Physical Activity for Older Adults helps readers understand the aging process and its effects on movement, exercise, and other dimensions of life.

Download or read book Surgical Neuroangiography written by Alejandro Berenstein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Volume 5 of Surgical Neuroangiography we will discuss indications and approaches for endovascular treatment of disorders affecting the spine and spinal cord circulations. Our approach is similar to those discussed in volume 2 and 4, it requires integration of knowledge concerning functional vascular anatomy, lesion angioarchitecture, and the relationship between normal and pathological circulations. In AVMs these features are considered as they relate to the clinical presen tation, progression, and natural history of the lesion. All these factors must then be combined with an understanding of technical capabilities to for mulate a pretherapeutic plan designed to favorably affect the long term out come in the individual patient. Endovascular surgery of spinal cord AVMs has become the treatment of choice, while microsurgery is reserved for those cases where embolization fails. Endovascular surgery may be the sole form of treatment, or may be combined with other therapeutic modalities including surgery, chemothera py, or radiation in cases of neoplasms, or may be palliative, to decrease pain or spinal cord compression. As in all other areas a multidisciplinary ap proach is essential for decision making to best accomplish the desired ob jectives.

Download or read book Fatty Acid and Lipotoxicity in Obesity and Diabetes written by Novartis Foundation and published by John Wiley & Sons. This book was released on 2007 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

Download or read book Cognitive Aging written by Institute of Medicine and published by National Academies Press. This book was released on 2015-07-21 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: For most Americans, staying "mentally sharp" as they age is a very high priority. Declines in memory and decision-making abilities may trigger fears of Alzheimer's disease or other neurodegenerative diseases. However, cognitive aging is a natural process that can have both positive and negative effects on cognitive function in older adults - effects that vary widely among individuals. At this point in time, when the older population is rapidly growing in the United States and across the globe, it is important to examine what is known about cognitive aging and to identify and promote actions that individuals, organizations, communities, and society can take to help older adults maintain and improve their cognitive health. Cognitive Aging assesses the public health dimensions of cognitive aging with an emphasis on definitions and terminology, epidemiology and surveillance, prevention and intervention, education of health professionals, and public awareness and education. This report makes specific recommendations for individuals to reduce the risks of cognitive decline with aging. Aging is inevitable, but there are actions that can be taken by individuals, families, communities, and society that may help to prevent or ameliorate the impact of aging on the brain, understand more about its impact, and help older adults live more fully and independent lives. Cognitive aging is not just an individual or a family or a health care system challenge. It is an issue that affects the fabric of society and requires actions by many and varied stakeholders. Cognitive Aging offers clear steps that individuals, families, communities, health care providers and systems, financial organizations, community groups, public health agencies, and others can take to promote cognitive health and to help older adults live fuller and more independent lives. Ultimately, this report calls for a societal commitment to cognitive aging as a public health issue that requires prompt action across many sectors.

Download or read book Emerging Therapeutic Approaches for Cystic Fibrosis written by Miquéias Lopes-Pacheco and published by Frontiers Media SA. This book was released on 2020-01-27 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Diuretics in Heart Failure written by Lawrence E. Ramsey and published by . This book was released on 1985 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Endurance Handbook written by Philip Maffetone and published by Simon and Schuster. This book was released on 2015-06-09 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Are you a triathlete, runner, cyclist, swimmer, cross-country skier, or other athlete seeking greater endurance? The Endurance Handbook teaches athletes how to stay healthy, achieve optimal athletic potential, and be injury-free for many productive years. Dr. Philip Maffetone’s approach to endurance offers a truly “individualized” outlook and unique system that he has refined over three decades of training and treating athletes, ranging from world champions to weekend warriors. Maffetone’s training and racing philosophy emphasizes building a strong aerobic base for increased fat burning, weight loss, sustained energy, and a healthy immune system. Good nutrition and stress reduction are also key to this common-sense, big-picture approach. Dr. Maffetone also dispels many of the commonly held myths that linger in participatory sports—and which adversely impact performance—and explains the “truths” about endurance, such as: The need to train slower to race faster will enable your aerobic system to improve endurance Why expensive running shoes can actually cause foot and leg injuries The fact that refined carbohydrates actually reduce endurance energy and disrupt hormone balance How overtraining can be avoided in its earliest stages And much more! If you are looking to increase your endurance and maximize your athletic potential, The Endurance Handbook is your one-stop guide to training and racing effectively. Skyhorse Publishing, as well as our Sports Publishing imprint, is proud to publish a broad range of books for readers interested in sports—books about baseball, pro football, college football, pro and college basketball, hockey, or soccer, we have a book about your sport or your team. In addition to books on popular team sports, we also publish books for a wide variety of athletes and sports enthusiasts, including books on running, cycling, horseback riding, swimming, tennis, martial arts, golf, camping, hiking, aviation, boating, and so much more. While not every title we publish becomes a New York Times bestseller or a national bestseller, we are committed to publishing books on subjects that are sometimes overlooked by other publishers and to authors whose work might not otherwise find a home.

Download or read book Curable written by Travis Christofferson and published by Chelsea Green Publishing. This book was released on 2019-09-27 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Journalist and healthcare advocate Christofferson looks at medicine through a magnifying glass and asks an important question: What if the roots of the current U.S. healthcare crisis are psychological and systemic, perpetuated not just by corporate influence and the powers that be, but by citizens?

Download or read book Clinical Chronopharmacology written by Alain Reinberg and published by CRC Press. This book was released on 1990-07 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Periodical and predictable changes in biological susceptibility and response to a large variety of chemical agents, including drugs and food, have been documented since the early 1970s. This book provides a survey of clinically-documented research in chronopharmacology.

Download or read book Live Young Forever written by Jack LaLanne and published by Robert Kennedy Publishing. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only has LaLanne been the figurehead of fitness forever, at an active, strong, and healthy 95 years old, he has definitively proven that his methods work. Here, he explains how to keep going strong, stay trim and healthy, and more.

Download or read book An Introduction to Differential Manifolds written by Jacques Lafontaine and published by Springer. This book was released on 2015-07-29 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an introduction to differential manifolds. It gives solid preliminaries for more advanced topics: Riemannian manifolds, differential topology, Lie theory. It presupposes little background: the reader is only expected to master basic differential calculus, and a little point-set topology. The book covers the main topics of differential geometry: manifolds, tangent space, vector fields, differential forms, Lie groups, and a few more sophisticated topics such as de Rham cohomology, degree theory and the Gauss-Bonnet theorem for surfaces. Its ambition is to give solid foundations. In particular, the introduction of “abstract” notions such as manifolds or differential forms is motivated via questions and examples from mathematics or theoretical physics. More than 150 exercises, some of them easy and classical, some others more sophisticated, will help the beginner as well as the more expert reader. Solutions are provided for most of them. The book should be of interest to various readers: undergraduate and graduate students for a first contact to differential manifolds, mathematicians from other fields and physicists who wish to acquire some feeling about this beautiful theory. The original French text Introduction aux variétés différentielles has been a best-seller in its category in France for many years. Jacques Lafontaine was successively assistant Professor at Paris Diderot University and Professor at the University of Montpellier, where he is presently emeritus. His main research interests are Riemannian and pseudo-Riemannian geometry, including some aspects of mathematical relativity. Besides his personal research articles, he was involved in several textbooks and research monographs.