Download or read book Laron Syndrome from Man to Mouse written by and published by . This book was released on 2011 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Laron Syndrome From Man to Mouse written by Zvi Laron and published by Springer Science & Business Media. This book was released on 2010-11-25 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.
Download or read book Growth Hormone Resistance written by Martin O. Savage and published by . This book was released on 1996 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examining growth hormone resistance, this text includes coverage of such topics as: growth hormone receptor signalling; metabolic actions of growth hormone - direct and indirect; and IGF bioactivity and its modification in growth hormone resistance in childhood.
Download or read book Textbook of Energy Balance Neuropeptide Hormones and Neuroendocrine Function written by Eduardo A. Nillni and published by Springer. This book was released on 2018-07-20 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. The textbook includes an examination the history of the evolution of human society from a thin to the obese phenotype and, within that context, how modern society habits and industrial food production did not respect the evolutionary trait resulting in changes in the energy balance set point. It provides a novel conceptualization of the problem of obesity when considering the biochemistry of peptide hormones and entertaining novel ideas on multiple approaches to the problems of energy balance, as well as demonstrates and explains why alterations in pro-hormone processing are paramount to understand metabolic disease. This text is excellent material for teaching graduate and medical school courses, as well as a valuable resource for researchers in biochemistry, cell, and molecular biology, neuroscientists, physician endocrinologists, and nutritionists.
Download or read book Murine Models Energy Balance and Cancer written by Nathan A. Berger and published by Springer. This book was released on 2015-06-19 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
Download or read book The Growth Plate written by Irving M. Shapiro and published by IOS Press. This book was released on 2002 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.
Download or read book Insulin like Growth Factors and Cancer written by Derek LeRoith and published by Springer Science & Business Media. This book was released on 2011-09-18 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.
Download or read book Encyclopedia of Biomedical Gerontology written by and published by Academic Press. This book was released on 2019-11-20 with total page 1656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Biomedical Gerontology, Three Volume Set presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years
Download or read book The Molecular Genetics of Aging written by Siegfried Hekimi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.
Download or read book Stem Cells written by Mariusz Z. Ratajczak and published by Springer Nature. This book was released on 2020-01-02 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.
Download or read book The Growth Hormone Insulin Like Growth Factor Axis during Development written by Isabel Varela-Nieto and published by Springer Science & Business Media. This book was released on 2005-12-17 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.
Download or read book Mendelian Inheritance in Man written by Victor A. McKusick and published by JHU Press. This book was released on 1998-06-29 with total page 1728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The twelfth edition of this classic reference work includes: - More than 2,000 new entries - A total of more than 9,000 entries - New features and enhancement of the familiar old features - Mapping information on more than 4,000 genes of known function - Information on specific point mutations responsible for more than 700 genetic disorders or neoplasms Mendelian Inheritance in Man (MIM) is a genetic knowledgebase that serves clinical medicine and biomedical research, including the Human Genome Project. It aims to be comprehensive (not only complete, but also collated, integrated, and interpreted), authoritative (not only accurate but also sound in its interpretations and judgements), and timely (not only up-to-date but also historically dimensioned). From a review of the eleventh edition, Reproductive Toxicology: "Even the convenience of computer-based forms of MIM cannot eliminate the need for MIM in book form. The preface provides a wonderful synopsis of human genetics. The information contained in this text serves as a concise review for those with a genetics background." From a review of the tenth edition, New England Journal of Medicine: " Victor McKusick] has been for all these years the shepherd of the development of the field of clinical genetics]. Perhaps his most important pragmatic achievement has been the 10 editions of Mendelian Inheritance in Man, which rapidly became and has remained the principal source of information on inherited diseases for all clinical geneticists. "In addition to the erudite entries in the books, the references given with each description represent a magnificent bibliography of clinical genetics. With McKusick's leadership and continued interest in gene mapping, the book also rep-resents an important compen-dium of the location of genes on specific chromosomes. "The book is a magnificent security blanket for the clinical geneticist and should be in the libraries not only of these specialists, but also of all others who see patients with diseases that have genetic components."
Download or read book Lessons from Laron Syndrome LS 1966 1992 written by Zvi Laron and published by Karger Medical and Scientific Publishers. This book was released on 1993-01-01 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laron Syndrome (LS) is a disease characterized by resistance to growth hormone (GH) and caused by molecular defects of the GH receptor, leading to a deficiency of insulin-like growth factor-1 (IGF-1) and a significant impairment of growth. The syndrome is a unique human model of a peptide hormone receptor defect and GH-IGF-1 interaction. It offers the opportunity to study the consequences of long-term IGF-1 deficiency and the role of IGF-1 in growth and metabolism. With the recent biosynthesis of IGF-1 and the initiation of IGF-1 therapy, a whole new world of basic biological interactions is opening up. This volume brings together leading researchers in genetics, endocrinology, pediatrics, biochemistry, physiology and pharmacology to summarize what is now known about LS, and to discuss the lessons learned from studying and treating this disease since its initial description in 1966. Special features include the demography of LS, and the first data on the long-term IGF-1 treatment of a large group of patients.
Download or read book Growth Hormone Deficiency in Adults written by Jens O. L. Jørgensen and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.
Download or read book Advances in Integrative Dermatology written by Katlein França and published by John Wiley & Sons. This book was released on 2019-01-18 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative overview of contemporary approaches to integrative skin health The popularity of integrative medical treatment of skin disorders has increased significantly in recent years—requiring practicing clinicians to keep pace with continuingdevelopments in dermatological research and methods. Advances in Integrative Dermatology offers a comprehensive survey of this dynamic field, providing up-to-date information on both preventative and therapeutic approaches to skin health. Combining clinical medicine with complimentary treatment plans, integrative dermatology provides an innovative perspective to individual patient care. This essential text explores new research in areas including the effects of stress and pollution on the skin, the importance of high-quality sleep, complementary methods of averting skin conditions, and more. Recognizing the impact skin disorders have on physiological, psychological, and emotional health, editors Katlein França and Torello Lotti illustrate key components of inclusive skin health strategies, such as therapeutic diets and nutritional supplements, topical botanicals, and other complementary therapies. Filling a significant gap in current literature on integrative dermatology, this valuable resource: Answers the common questions asked by patients in real-world dermatology practices Addresses pervasive misconceptions of integrative dermatological methods and principles with evidence-based review of current practices Examines contemporary research in the diagnosis and treatment of dermatological disorders Presents comprehensive treatment options for a wide range of conditions such as rosacea, melanoma, and psoriasis Advances in Integrative Dermatology is an indispensable volume for physicians seeking to incorporate holistic techniques into their practices, expand their knowledge of integrative medicine, and provide the best possible care for their patients.
Download or read book Growth Hormone in Adults written by Anders Juul and published by Cambridge University Press. This book was released on 2000-04-27 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.
Download or read book Alopecias Practical Evaluation and Management written by D. Ioannides and published by Karger Medical and Scientific Publishers. This book was released on 2015-02-26 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hair is subject to either intrinsic (i.e. physiological) aging or extrinsic (i.e. premature) aging that can be attributed to external factors. The intrinsic factors can be associated with genetic mechanisms and are subject to individual variations, whereas external factors include ultraviolet radiation, air pollution, smoking, and possibly nutrition. Leading experts have contributed to this book which offers a practical approach to the evaluation and management of various forms of alopecia, including their pathogenesis, the diagnostic procedures involved, medical treatments, and nutritional issues. A completely new surgical technique for hair transplantation that leaves behind sufficient follicle unit tissue to regenerate hairs is also described. Being comprehensive and easy-to-read, this book should be very useful for dermatologists who wish to diagnose and treat their patients with hair problems more effectively.
