Download or read book Evolution by Gene Duplication written by Susumu Ohno and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is said that "necessity is the mother of invention". To be sure, wheels and pulleys were invented out of necessity by the tenacious minds of upright citi zens. Looking at the history of mankind, however, one has to add that "Ieisure is the mother of cultural improvement". Man's creative genius flourished only when his mind, freed from the worry of daily toils, was permitted to entertain apparently useless thoughts. In the same manner, one might say with regard to evolution that "natural selection mere(y tnodifted, while redundanry created". Natural selection has been extremely effective in policing alleHe mutations which arise in already existing gene loci. Because of natural selection, organisms have been able to adapt to changing environments, and by adaptive radiation many new species were created from a common ancestral form. Y et, being an effective policeman, natural selection is extremely conservative by nature. Had evolution been entirely dependent upon natural selection, from a bacterium only numerous forms of bacteria would have emerged. The creation of metazoans, vertebrates and finally mammals from unicellular organisms would have been quite impos sible, for such big leaps in evolution required the creation of new gene loci with previously nonexistent functions. Only the cistron which became redun dant was able to escape from the relentless pressure of natural selection, and by escaping, it accumulated formerly forbidden mutations to emerge as a new gene locus.
Download or read book Viral Genome Replication written by Craig E. Cameron and published by Springer Science & Business Media. This book was released on 2009-05-28 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive review of viral genome replication strategies, emphasizing not only pathways and regulation but also the structure-function, mechanism, and inhibition of proteins and enzymes required for this process.
Download or read book The Regulation of DNA Replication and Transcription written by Mirko Beljanski and published by Demos Medical Publishing. This book was released on 2013-03-26 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Regulation of DNA Replication and Transcription explores basic processes of DNA replication and transcription in an effort to identify the mechanisms responsible for the release of genetic information and its role in the regulation of cellular events. Concerned with discovering the fundamental concept that might integrate and explain the wide range of existing lines of evidence, the author reports and interprets the results of experiments conducted in an impressive range of biological systems. Focused on complex mechanisms at the biochemical level, these studies allow analysis of the pathways involved when cells, organs and animal systems react to various trigger molecules derived from both living cells and exogenous sources. These include hormones, RNA, RNA fragments, alkaloids, actinomycin D, and phorbol esters, as well as chemical carcinogens and drugs. Comnining the results of these studies with his own extensive work in this field, the author is able to formulate a uniquely integrative biochemical model for the gene expression, demonstrating that both biological and chemically synthesized molecules can trigger the differential release of information from the DNA and thus influence cell transformation. Apart from its academic significance, the model offers high potential assistance in the search for ways to induce or control the expression of certain genes and, moreover, to promote differentiation of given cells in vitro as well as in situ. "
Download or read book DNA Replication Controls Volume 1 written by Eishi Noguchi and published by MDPI. This book was released on 2018-04-27 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "DNA Replication Controls" that was published in Genes
Download or read book Duplicate written by Harris Dickson Shortle and published by Tate Publishing. This book was released on 2009-08 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'No man in Louisiana would have believed the fearless advocate John Laronde might be panicked by a snapshot. But it had taken him quite by surprise. It had come so suddenly.' Everything was going along as normal for John Laronde. Now a prominent attorney in Louisiana, he was certain he and Ruth had left the past in the past. But when a series of photographs revealing his past, all mysteriously marked Duplicate, turn up in stacks of mail awaiting him in his office, he suddenly realizes that someone out there knows the secret only he and Ruth should know. And even stranger, the snapshots have been mailed from different cities and on different dates, a clue the sender has followed their trail from New York City to Louisiana. Suddenly John and Ruth's stable life is thrown into chaos as the sender begins taking diabolical delight in tormenting them. When a murder shocks them all, an entire community will be shaken with a truth hidden for twenty-six years.
Download or read book Library Literature written by and published by . This book was released on 1927 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: "An index to library and information science".
Download or read book Links Between Recombination and Replication written by Proceedings of the National Academy of Sciences and published by National Academies Press. This book was released on 2002-09-18 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a sea change in how we view genetic recombination. When germ cells are produced in higher organisms, genetic recombination assures the proper segregation of like chromosomes. In the course of that process, called meiosis, recombination not only assures segregation of one chromosome of each type to progeny germ cells, but also further shuffles the genetic deck, contributing to the unique inheritance of individuals. In a nutshell, that is the classical view of recombination. We have also known for many years that in bacteria recombination plays a role in horizontal gene transfer and in replication itself, the latter by establishing some of the replication forks that are the structural scaffolds for copying DNA. In recent years, however, we have become increasingly aware that replication, which normally starts without any help from recombination, is a vulnerable process that frequently leads to broken DNA. The enzymes of recombination play a vital role in the repair of those breaks. The recombination enzymes can function via several different pathways that mediate the repair of breaks, as well as restoration of replication forks that are stalled by other kinds of damage to DNA. Thus, to the classical view of recombination as an engine of inheritance we must add the view of recombination as a vital housekeeping function that repairs breaks suffered in the course of replication. We have also known for many years that genomic instability--including mutations, chromosomal rearrangements, and aneuploidy--is a hallmark of cancer cells. Although genomic instability has many contributing causes, including faulty replication, there are many indications that recombination, faulty or not, contributes to genome instability and cancer as well. The (Nas colloquium) Links Between Recombination and Replication: Vital Roles of Recombination was convened to broaden awareness of this evolving area of research. Papers generated by this colloquium are published here. To encourage the desired interactions of specialists, we invited some contributions that deal only with recombination or replication in addition to contributions on the central thesis of functional links between recombination and replication. To aid the nonspecialist and specialist alike, we open the set of papers with a historical overview by Michael Cox and we close the set with a commentary on the meeting and the field by Andrei Kuzminov.
Download or read book Genotype to Phenotype written by J. J. Goodship and published by Garland Science. This book was released on 2003-12-16 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition builds on the success of the first by reviewing the increased understanding of the mechanisms of gene action in humans, focusing particularly on those derived from the study of genetic diseases. It deals mainly with the fundamental aspects of gene arrangement and expression rather than mutation. As well as updating and revising material from the first edition, it covers methods of exploring gene function and contains a range of chapters on specific systems which raise issues of special interest such as imprinting or homologous genes within clusters.
Download or read book The Chancellor s Roll Or Duplicate of the Great Pipe Roll of the Third Year of King John written by Great Britain. Exchequer and published by . This book was released on 1833 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Acts Passed by the General Assembly of the State of Louisiana written by Louisiana and published by . This book was released on 1921 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes extra sessions.
Download or read book DNA Replication written by Hisao Masai and published by Springer. This book was released on 2018-01-22 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.
Download or read book Illinois Waterway Duplicate Locks written by and published by . This book was released on 1974 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Duplicate Letters written by and published by . This book was released on 1822 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Corpus Juris written by William Mack and published by . This book was released on 1920 with total page 1300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book DNA Replication and the Cell Cycle written by Ellen Fanning and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provided here is an easily accessible introduction to the mechanisms of DNA replication, regulation and the biochemistry of cell cycle control. An overview of this rapidly developing field is presented to orient the reader, followed by a series of contributions by leading researchers summarizing recent results on selected topics, such as protein phosporylation, tumor suppressor genes, and signal transduction in prokaryotic and eucaryotic systems. The reader will gain an overview of our current understanding of DNA replication and the cell cycle, and a selection of useful recent references for further reading.
Download or read book Nuclear Genome Stability DNA Replication Telomere Maintenance and DNA Repair written by Maria Isabel Nogueira Cano and published by Frontiers Media SA. This book was released on 2022-03-09 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt:
