Download or read book The Biology of Early Influences written by Richard L. Hyson and published by Springer Science & Business Media. This book was released on 2007-08-20 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The underlying theme of this book the role of experience in the development of the nervous system. It is now widely acknowledged that there are a variety of organi- environment interactions that guide the development of the nervous system. The popular press has also picked up on this theme and parents are being advised to enrich their child's sensory experience as early as possible. The importance of experience in development is so well accepted that it has begun to dictate public policy. In 1997, the President and First Lady hosted "The White House Conference on Early Childhood Development and Learning: What New Research on the Brain Tells Us About Our Youngest Children. " Along with this conference came a reemphasis on programs directed at enriching the en- ronment of America's youth. In some cases laws have been passed to assure enhanced early experience. In Georgia, the former governor proposed sending newborn children home from the hospital with classical music CDs. This received some praise, but was also ridiculed by others who felt the policy was not justified by the available scientific evidence. Here in Florida, enhanced "brain development activities" are mandated for sta- funded child care facilities. Chapter 402. 25 of the 1998 State of Florida Statues reads (emphasis added): Infants and toddlers in state-funded education and care programs; brain development activities.
Download or read book Root Biology written by Bhoopander Giri and published by Springer. This book was released on 2018-05-01 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book ‘Root Biology’ written by experts in the field, covers latest research on cellular, genetic, physiological and ecological developmental facets of root growth as well as the interaction of root with an array of microbes whether for the establishment of symbiosis, increasing plant growth or protecting plant from pathogens/attackers. Plant roots provide an excellent model to study physiological, developmental and metabolic processes at a system level. Root system architecture - an excellent creation of nature, is closely interconnected with the availability of soil nutrients. Several strategies including biotechnological interventions are gaining interest and importance for sustainable food production and enhanced resource acquisition. Such strategies have largely focused on root traits for efficient utilization of soil resources. The biotechnological application of root biology is expected to promote the production of food while maintaining ecologically and economically sustainable production systems. With a fortune of information on technical and experimental aspects useful in the laboratory, this extensive book is a valuable resource for researchers, academician and students in the broad field of microbiology, plant and fungal biology.
Download or read book Gene Expression in Crop Plants written by Robert D. Warmbrodt and published by . This book was released on 1991 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nutritional Epigenomics written by and published by Academic Press. This book was released on 2019-07-20 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition's role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet's role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. - Empowers the reader to employ nutritional epigenomics approaches in their own research - Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease - Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies
Download or read book Advances in Metallic Biomaterials written by Mitsuo Niinomi and published by Springer. This book was released on 2015-06-17 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews fundamental advances in the use of metallic biomaterials to reconstruct hard tissues and blood vessels. It also covers the latest advances in representative metallic biomaterials, such as stainless steels, Co-Cr alloys, titanium and its alloys, zirconium, tantalum and niobium based alloys. In addition, the latest findings on corrosion, cytotoxic and allergic problems caused by metallic biomaterials are introduced. The book offers a valuable reference source for researchers, graduate students and clinicians working in the fields of materials, surgery, dentistry, and mechanics. Mitsuo Niinomi, PhD, D.D.Sc., is a Professor at the Institute for Materials Research, Tohoku University, Japan. Takayuki Narushima, PhD, is a Professor at the Department of Materials Processing, Tohoku University, Japan. Masaaki Nakai, PhD, is an Associate Professor at the Institute for Materials Research, Tohoku University, Japan.
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by Michelle A. Rudek and published by Springer Science & Business Media. This book was released on 2014-01-10 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Download or read book Transcriptional Regulation by Neuronal Activity written by Serena Dudek and published by Springer Science & Business Media. This book was released on 2007-11-24 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of gene transcription by neuronal activity is evident in a large number of neuronal processes ranging from neural development and refinement of neuronal connections to learning and response to injury. In the field of activity-dependent gene expression, rapid progress is being made that can impact these, and many other areas of neuroscience. This book offers an up-to-date picture of the field.
Download or read book Principles and Practice of Endocrinology and Metabolism written by Kenneth L. Becker and published by Lippincott Williams & Wilkins. This book was released on 2001 with total page 2500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established as the foremost text in the field, Principles and Practice of Endocrinology and Metabolism is now in its thoroughly revised, updated Third Edition. This practical, clinically relevant, and comprehensive text covers the entire field of endocrinology and metabolism, including the diffuse endocrine system; morphology and physiology; diagnosis and treatment of endocrine diseases; endocrinology of the female; hormones and cancer; and much more. The Third Edition contains new chapters reflecting the latest advances and features expanded coverage of genetics and the endocrinology of sepsis. More than 1,400 illustrations complement the text. A drug formulary appears at the back of the book.
Download or read book Sustained Energy for Enhanced Human Functions and Activity written by Debasis Bagchi and published by Academic Press. This book was released on 2017-08-07 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sustained Energy for Enhanced Human Functions and Activity addresses the basic mechanistic aspects of energy metabolisms, the chemistry, biochemistry and pharmacology of a variety of botanical ingredients, micronutrients, antioxidants, amino acids, selected complexes, and other nutracueticals which have demonstrated a boost in and the sustainability of functional energy. The role of exercise and physical activity is also discussed, and the conclusion addresses paradigm shifts in the field and envisions the future. Intended for researchers and industry professionals, the book is as an essential reference on the impact of proper nutrient balance on sustained energy. - Serves as a comprehensive reference on natural products that can boost and sustain energy - Encompasses information on diverse energy ingredients and their potential role in optimal health and sustained energy - Conceptualizes the key features in diverse nutraceuticals that can boost sustained energy and well-being - Presents the intricate mechanistic aspects and balance between optimal and sustained energy - Addresses the pathophysiology and mechanistic insight of diverse nutraceuticals and functional foods that can help in maintaining optimal health and sustain functional energy
Download or read book Cellular Bioenergetics Role of Coupled Creatine Kinases written by Valdur A. Saks and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the information on the functional role, structure and molecular biology of creatine kinase is scattered in several hundreds of publications. The editors of this volume invited all authors who are most active at present in experimental research on creatine kinases to summarize their work and make the information easily available to a wider scientific audience, especially to young investigators who are entering this field. Since the functional role of coupled creatine kinases is directly related to the phenomenon of compartmentation and structural organization of metabolic networks, we also invited experts in the related areas to contribute to the volume. Almost all invited authors responded enthusiastically and the results of this collective work are presented here. For biochemists, biophysicists, physiologists, and medical research workers.
Download or read book Quick Bibliography Series written by and published by . This book was released on 1976 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Thermodynamics Kinetics and Microphysics of Clouds written by Vitaly I. Khvorostyanov and published by Cambridge University Press. This book was released on 2014-08-25 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book advances understanding of cloud microphysics and provides a unified theoretical foundation for modeling cloud processes, for researchers and advanced students.
Download or read book NK Cell Based Cancer Immunotherapy written by Francisco Borrego and published by Frontiers Media SA. This book was released on 2016-09-08 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.
Download or read book Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds written by Evandro Fei Fang and published by Springer Science & Business Media. This book was released on 2013-02-26 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern unhealthy diet and lifestyle in conjunction with pathogens, environmental carcinogens and multiple other risk factors increase humans’ susceptibility to different diseases exemplified by elevated levels of cancers, cardiovascular and communicable diseases. Screening of potential drugs from medicinal plants and animals provides a promising strategy for the alleviation of the impact of these diseases. Components with potential medicinal applications include RIPs, RNases, lectins, protease inhibitors and numerous small compounds. These compounds have shown both preventive and therapeutic effects for humans. This book is a compilation of articles written by internationally renowned experts exploring the different uses of medicinal compounds in human therapeutics. Here we provide a comprehensive outlook on both qualitative and quantitative studies focusing on medicinal plants and animals, and establishing a link between laboratory research discovery and clinical applications.
Download or read book Plant Roots written by Tom Beeckman and published by CRC Press. This book was released on 2024-08-30 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following its predecessors, Plant Roots: The Hidden Half, Fifth Edition is thoroughly updated and reports the major changes that have taken place in root research since the last edition published over 10 years ago. Considered a widely acclaimed book in the field of plant sciences, this edition includes a broad array of topics reflecting progress being made in the subdomains of root biology, featuring chapters on modern topics, while retained chapters are fully updated to demonstrate significant developments made in our understanding of root biology and in fast-evolving research methodologies and techniques. It reviews all root-related processes, from the evolution of roots in past eras to single-cell genomics, allowing readers to grasp an overall view of the state-of-the-art research in this field. Among the 104 contributors to this book are seasoned experts in the field, as well as uprising specialists who have already made a distinguished mark in scientific literature. All of the chapters are extensively referenced featuring specific information on any topic related to the biology of the hidden half of plants. Featuring full color illustrations throughout, this handbook is an essential source of information for both expert and novice root scientists.
Download or read book Travaux scientifiques de Fran ois Jacob written by François Jacob and published by Odile Jacob. This book was released on 2002 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comptes rendus de l Acad mie des sciences written by and published by . This book was released on 2001 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
