Download or read book Kinetic Logic A Boolean Approach to the Analysis of Complex Regulatory Systems written by R. Thomas and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: The E M B 0 course on "Formal Analysis of Genetic Regulation" A course entitled "Formal analysis of Genetic Regulation" was held at the University of Brussels from 6 to 16 September 1977 under the auspices of EMBO (European Molecular Biology Organization). As indicated by the title of the book (but not explicitly enough by the title of the course), the main emphasis was put on a dynamic analysis of systems using logical methods, that is, methods in which functions and variables take only a limited number of values - typically two. In this respect, this course was complementary to an EMBO course using continuous methods which was held some months later in Israel by Prof. Segel. People from four very different laboratories took an active part in teaching our course in Brussels : Drs Anne LEUSSLER and Philippe VAN HAM, from the Laboratory of Prof. Jean FLORINE (Laboratoire des Systemes logiques et numeriques, Faculte des Sciences appliquees, Universite Libre de Bruxelles). Dr Stuart KAUFFMAN (Dept. of Biochemistry and Biophysics, School of Medicine, Philadelphia). Prof. Gregoire NICOLlS (Service de Biophysique Theorique, Faculte des Sciences, Universite Libre de Bruxelles) and his temporary coworker Dr David RIGNEY (presently at the Center for Statistical Mechanics and Thermodynamics of the University of Texas at Austin, Texas).
Download or read book Reason Regulation and Realism written by Clifford Alan Hooker and published by SUNY Press. This book was released on 1995-01-01 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book develops a new naturalist theory of reason and scientific knowledge from a synthesis of philosophy and the new sciences of complex adaptive systems. In particular, the theory of partially self-organizing regulatory systems is now emerging as central to all the life and social sciences, and this book shows how these ideas can be used to illuminate and satisfyingly reconstruct our basic philosophical concepts and principles. Evolutionary epistemology provides a unifying subject for the book. It is taken as proposing some important commonality between cognitive biological and cognitive epistemic processes. Here, that commonality is found by embedding both in a common model of complex adaptive system dynamics. New reconstructions are offered on the theories of Jean Piaget, Karl Popper, and Nicholas Rescher which show how their ideas are more deeply illuminated from this perspective in contrast to the formal rationalist interpretations standard among philosophers and scientists.
Download or read book Images of Biologically Active Structures in the Immune System written by Hilary Koprowski and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diversity of antigen-binding structures of antibody molecules is so vast that every conceivable antigen can be bound by an antibody molecule within the immune system. This is true even for the antigen binding sites of antibodies called idiotypes, which are bound by complementary bind ing sites of other antibodies called anti-idiotypes. Thus, anti-idiotypes are structural homologues of antigens. These idiotypic-anti-idiotypic interactions constitute a network within the immune system. Since one lymphocyte produces only one type of antibody molecule, this network is in fact a network of cells. We expect that the network is functional: the appearance of antigen will disturb the equilibrium of the network at the point where it competes with the anti idiotypic lymphocyte for binding to the idiotypic lympho cyte. It has been known for quite some time that anti idiotypic antibody can be used to prime the immune system for memory to an antigen that it has never seen. This phe nomenon is now being explored for possible use in immuni zation against viruses, bacteria, parasites and tumors as well as for the modulation of autoimmunity. The ability of anti-idiotypes to mimic, both antigenically and function ally, the corresponding biologically active molecules seen by an idiotypic antibody was first demonstrated for the hormone insulin and is now being observed in many other systems. The papers assembled in this volume· bring the reader to the cutting edge of the potential practical applica tions of the network theory of the immune system.
Download or read book Design Computing and Cognition 10 written by John S. Gero and published by Springer Science & Business Media. This book was released on 2011-02-22 with total page 733 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the refereed and revised papers of the Fourth International Conference on Design Computing and Cognition (DCC'10), held in Stuttgart, Germany. The material in this book represents the state-of-the-art research and developments in design computing and design cognition. The papers are grouped under the following nine headings, describing both advances in theory and application and demonstrating the depth and breadth of design computing and design cognition: Design Cognition; Framework Models in Design; Design Creativity; Lines, Planes, Shape and Space in Design; Decision-Making Processes in Design; Knowledge and Learning in Design; Using Design Cognition; Collaborative/Collective Design; and Design Generation. This book is of particular interest to researchers, developers and users of advanced computation in design across all disciplines and to those who need to gain better understanding of designing.
Download or read book Rhythms in Biology and Other Fields of Application written by M. Cosnard and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disordered Systems and Biological Organization written by E. Bienenstock and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NATO workshop on Disordered Systems and Biological Organization was attended, in march 1985, by 65 scientists representing a large variety of fields: Mathematics, Computer Science, Physics and Biology. It was the purpose of this interdisciplinary workshop to shed light on the conceptual connections existing between fields of research apparently as different as: automata theory, combinatorial optimization, spin glasses and modeling of biological systems, all of them concerned with the global organization of complex systems, locally interconnected. Common to many contributions to this volume is the underlying analogy between biological systems and spin glasses: they share the same properties of stability and diversity. This is the case for instance of primary sequences of biopo Iymers I ike proteins and nucleic acids considered as the result of mutation-selection processes [P. W. Anderson, 1983] or of evolving biological species [G. Weisbuch, 1984]. Some of the most striking aspects of our cognitive apparatus, involved In learning and recognttlon [J. Hopfield, 19821, can also be described in terms of stability and diversity in a suitable configuration space. These interpretations and preoccupations merge with those of theoretical biologists like S. Kauffman [1969] (genetic networks) and of mathematicians of automata theory: the dynamics of networks of automata can be interpreted in terms of organization of a system in multiple possible attractors. The present introduction outlInes the relationships between the contributions presented at the workshop and brIefly discusses each paper in its particular scientific context.
Download or read book written by 国立国会図書館 (Japan) and published by . This book was released on 1972 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Feedback written by Rene Thomas and published by CRC Press. This book was released on 2024-11-01 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clearly explaining the logical analysis of biological control phenomena, Biological Feedback answers questions concerning everything from regulation to logic. This rare monograph presents a formal methodology for analyzing the dynamic behavior of complex systems. The easy-to-read text describes a simple logical formalization called "kinetic logic". The reader discovers how this method is used to predict all possible patterns of behavior of which a system is capable. It includes specific conditions required for each pattern. It also explains how to modify an incorrect model in order to account for the observed behavior. The authors give special attention to the two basic types of simple feedback loops: positive and negative. This volume is filled with easy-to-use tables, providing quick reference throughout the book. The subject matter is of great interest to everyone working in molecular genetics and developmental biology. Researchers, immunologists, physical chemists, physicists, electrical engineers, economists, and mathematicians will find this unique text to be an informative, indispensable resource.
Download or read book AI IA 2009 Emergent Perspectives in Artificial Intelligence written by Roberto Serra and published by Springer. This book was released on 2009-11-17 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 11th International Conference of the Italian Association for Artificial Intelligence, AI*IA 2009, held in Reggio Emilia, Italy, in December 2009. The 50 revised full papers presented together with 3 invited talks were carefully reviewed and selected from 83 submissions. The papers are organized in topical sections on knowledge representation and reasoning, machine learning, evolutionary computation, search, natural language processing, multi-agent systems and application.
Download or read book Math and Bio 2010 written by Lynn Arthur Steen and published by MAA. This book was released on 2005 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Math and bio 2010 grew out of 'Meeting the Challenges: Education across the Biological, Mathematical and Computer Sciences,' a joint project of the Mathematical Association of America (MAA), the National Science Foundation Division of Undergraduate Education (NSF DUE), the National Institute of General Medical Sciences (NIGMS), the American Association for the Advancement of Science (AAAS), and the American Society for Microbiology (ASM)."--Foreword, p. vi
Download or read book Predictability and Nonlinear Modelling in Natural Sciences and Economics written by J. Grasman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: Researchers in the natural sciences are faced with problems that require a novel approach to improve the quality of forecasts of processes that are sensitive to environmental conditions. Nonlinearity of a system may significantly complicate the predictability of future states: a small variation of parameters can dramatically change the dynamics, while sensitive dependence of the initial state may severely limit the predictability horizon. Uncertainties also play a role. This volume addresses such problems by using tools from chaos theory and systems theory, adapted for the analysis of problems in the environmental sciences. Sensitive dependence on the initial state (chaos) and the parameters are analyzed using methods such as Lyapunov exponents and Monte Carlo simulation. Uncertainty in the structure and the values of parameters of a model is studied in relation to processes that depend on the environmental conditions. These methods also apply to biology and economics. For research workers at universities and (semi)governmental institutes for the environment, agriculture, ecology, meteorology and water management, and theoretical economists.
Download or read book Analysis of Neural Networks written by U. an der Heiden and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this work is a unified and general treatment of activity in neural networks from a mathematical pOint of view. Possible applications of the theory presented are indica ted throughout the text. However, they are not explored in de tail for two reasons : first, the universal character of n- ral activity in nearly all animals requires some type of a general approach~ secondly, the mathematical perspicuity would suffer if too many experimental details and empirical peculiarities were interspersed among the mathematical investigation. A guide to many applications is supplied by the references concerning a variety of specific issues. Of course the theory does not aim at covering all individual problems. Moreover there are other approaches to neural network theory (see e.g. Poggio-Torre, 1978) based on the different lev els at which the nervous system may be viewed. The theory is a deterministic one reflecting the average be havior of neurons or neuron pools. In this respect the essay is written in the spirit of the work of Cowan, Feldman, and Wilson (see sect. 2.2). The networks are described by systems of nonlinear integral equations. Therefore the paper can also be read as a course in nonlinear system theory. The interpretation of the elements as neurons is not a necessary one. However, for vividness the mathematical results are often expressed in neurophysiological terms, such as excitation, inhibition, membrane potentials, and impulse frequencies. The nonlinearities are essential constituents of the theory.
Download or read book Theoretical Immunology Part One written by Alan S. Perelson and published by CRC Press. This book was released on 2018-03-05 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomena in different ways, the Sante Fe Institute and the Theoretical Division of Los Alamos National Laboratory cosponsored a workshop entitled "Theoretical Immunology". The workshop focused on themes spanning the field of immunology, with emphasis on areas where the theorists have made the most progress. This book covers the discussions a that workshop on the topics of immune surveillance, mathematical models of HIV infection, complexities of antigen-antibody systems, immune suppression and tolerance, and idiotypie networks. In each of these areas there is reason to believe that advances can be made either through interactions among experimentalists and theorists or through the critical look experimentalists and theorists will bring to bear upon one another's work.
Download or read book Stochastic Transport Processes in Discrete Biological Systems written by Eckart Frehland and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: These notes are in part based on a course for advanced students in the applications of stochastic processes held in 1978 at the University of Konstanz. These notes contain the results of re cent studies on the stochastic description of ion transport through biological membranes. In particular, they serve as an introduction to an unified theory of fluctuations in complex biological transport systems. We emphasize that the subject of this volume is not to introduce the mathematics of stochastic processes but to present a field of theoretical biophysics in which stochastic methods are important. In the last years the study of membrane noise has become an important method in biophysics. Valuable information on the ion transport mechanisms in membranes can be obtained from noise analysis. A number of different processes such as the opening and closing of ion channels have been shown to be sources of the measured current or voltage fluctuations. Bio logical 'transport systems can be complex. For example, the transport process can be coupled to other processes such as chemical reactions and take place in discontinuous structures of molecular dimensions. Furthermore, since there are strong electric fields or high concentration gradients across biological membranes ion transport processes of biological relevance are mostly processes far from equilibrium. For these reasons the development of new theoretical concepts has been necessary. The concept of transport in discrete systems has turned out to be more appropriate than continuum models.
Download or read book Systems Theory in Immunology written by C. Bruni and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume collects the contributions presented at the "Working Conference on System Theory in Immunology", held in Rome, May 1978. The aim of the Conference was to bring together immunologists on one side and experts in system theory and applied mathematics on the other, in order to identify problems of common interest and to establish a network of joint effort toward their solution. The methodologies of system theory for processing experimental data and for describing dynamical phenomena could indeed contribute significantly to the under standing of basic immunological facts. Conversely, the complexity of experimental results and of interpretative models should stimulate mathematicians to formulate new problems and to design appropriate procedures of analysis. The multitude of scientific publications in theoretical biology, appeared in recent years, confirms this trend and calls for extensive interaction between mat- matics and immunology. The material of this volume is divided into five sections, along the scheme of the Conference program.
Download or read book A Primer in Mathematical Models in Biology written by Lee A. Segel and published by SIAM. This book was released on 2013-05-09 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: A textbook on mathematical modelling techniques with powerful applications to biology, combining theoretical exposition with exercises and examples.
Download or read book Topics in Geophysical Fluid Dynamics Atmospheric Dynamics Dynamo Theory and Climate Dynamics written by M. Ghil and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vigorous stirring of a cup of tea gives rise, as we all know, to interesting fluid dynamical phenomena, some of which are very hard to explain. In this book our "cup of tea" contains the currents of the Earth's atmosphere, oceans, mantle, and fluid core. Our goal is to under stand the basic physical processes which are most important in describing what we observe, directly or indirectly, in these complex systems. While in many respects our understanding is measured by the ability to predict, the focus here will be on relatively simple models which can aid our physical intuition by suggesting useful mathematical methods of investiga tion. These elementary models can be viewed as part of a hierarchy of models of increasing complexity, moving toward those which might be use fully predictive. The discussion in this book will deal primarily with the Earth. Interplanetary probes of Venus, Mars, Jupiter and Saturn have revealed many exciting phenomena which bear on geophysical fluid dynamics. They have also enabled us to see the effect of changing the values of certain parameters, such as gravity and rotation rate, on geophysical flows. On the other hand, satellite observations of our own planet on a daily and hourly basis have turned it into a unique laboratory for the study of fluid motions on a scale never dreamt of before: the motion of cyclones can be observed via satellite just as wing tip vortices are studied in a wind tunnel.
