Download or read book Kidney Inflammation Injury and Regeneration written by Patrick C. Baer and published by MDPI. This book was released on 2020-04-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.
Download or read book Kidney Inflammation Injury and Regeneration written by Patrick C. Baer and published by . This book was released on 2020 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.
Download or read book Kidney Inflammation Injury and Regeneration 2020 written by Patrick C. Baer and published by . This book was released on 2021 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function--in both the short- and long-term--is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles.
Download or read book Kidney Inflammation Injury and Regeneration 2020 written by Patrick C Baer and published by Mdpi AG. This book was released on 2021-11-23 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function-in both the short- and long-term-is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles.
Download or read book Acute Kidney Injury and Regenerative Medicine written by Yoshio Terada and published by Springer Nature. This book was released on 2020-05-14 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis.Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.
Download or read book Cardiorenal Syndromes in Critical Care written by C. Ronco and published by Karger Medical and Scientific Publishers. This book was released on 2010-05-04 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Critical care nephrology is an emerging multidisciplinary science in which the competences of different specialists are merged to provide a unified diagnostic and therapeutic approach to the critically ill patient. The volume at hand places great emphasis on cardiorenal syndromes and the multidisciplinary collaboration between cardiology and nephrology. Several contributions describe the cardiorenal syndrome in its different varieties and subtypes and report the results from the most recent Acute Dialysis Quality Initiative Consensus Conference, as well as proposing new diagnostic approaches based on early biomarkers of AKI. Other papers discuss advances in technology for renal replacement therapy and multiple organ support therapy. Moreover, special emphasis is placed on the potential role of extracorporeal therapies in patients affected by H1N1 influenza, and a summary of the most recent trials in the field is included.Containing the proceedings of the 2010 International Vicenza Course on Critical Care Nephrology, this publication is a state-of-the-art appraisal of today’s technology and current issues related to cardiorenal syndromes.
Download or read book Inflammation 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.
Download or read book Regenerative Nephrology written by Michael S. Goligorsky and published by Academic Press. This book was released on 2010-11-26 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney
Download or read book Recent advances on renoprotection and kidney regeneration written by Vladimir T. Todorov and published by Frontiers Media SA. This book was released on 2023-05-25 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Kidney Protection written by Vijay Lapsia and published by Oxford University Press. This book was released on 2019-02-15 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney disease affects approximately ten percent of the population worldwide, with more than 2.6 million individuals estimated to be receiving renal replacement therapy. Chronic kidney disease (CKD) is fast becoming a major public health issue, with increasing incidence and death rates throughout the world. Many strategies have been proposed to reduce the growing burden of kidney disease; but while early identification and improved access to renal replacement therapies and transplantation are important, they are unlikely to solve this enormous problem. Efforts focused on primary prevention, protection, and slowing the progression of kidney disease are needed as well. Renal protection is a vital and critical component of protecting the kidneys, promoting recovery, and preventing further renal loss, yet observational data suggests that awareness of renal protection remains low and the concept of renal protection under-recognized.. Kidney Protection: A Practical Guide to Preserving Renal Function in Acute and Chronic Disease is a clinically focused review that aims to address this awareness and knowledge gap. It assembles clinically pertinent information in a concise and lucid format with the goal of helping the clinician protect the kidneys, whether in the ICU, perioperative, or out-patient setting. The authors' interdisciplinary approach is inclusive of nephrology, urology, critical care, anesthesia, and emergency medicine. Chapters review understanding kidney disease, general concepts in protecting renal function, patient selection, assessment, pharmacologic issues, and kidney protection in systemic illness. The latest evidence-based practical guidelines for optimal renal outcomes are also included.
Download or read book Oxford Handbook of Nephrology and Hypertension written by Simon Steddon and published by Oxford University Press. This book was released on 2014-03 with total page 1002 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the Oxford Textbook of Clinical Nephrology and companion to the Oxford Handbook of Dialysis, this handbook provides clear information and practical advice about the day-to-day management of patients with renal disease.
Download or read book Kidney Transplantation Bioengineering and Regeneration written by Giuseppe Orlando and published by Academic Press. This book was released on 2017-06-08 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function
Download or read book Kidney Diseases Molecular Mechanisms and Clinical Assessment written by Jordan Bryan and published by States Academic Press. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are situated on the right and left sides of the retroperitoneal space. The kidneys are essential for the body's basic physiological activities. Kidney dysfunction disrupts these physiological activities and can result in a variety of diseases. A range of immunological, toxic and ischemic insults can harm kidney cells. This results in inflammation and cell death, which in turn leads to organ damage or complete failure. The damage to renal cells and the subsequent cellular regeneration processes are both influenced by inflammation. However, chronic inflammation can lead to renal fibrosis. The kidneys have the ability to regenerate after injury and can recover completely based on the type of renal lesions. The therapeutic intervention options facilitating the regeneration process are limited to fluid management and extracorporeal kidney support. This book unravels the recent studies on kidney diseases. It attempts to understand the molecular mechanisms and clinical assessment of these diseases. This book will help new researchers by foregrounding their knowledge in this area of study.
Download or read book Acute Kidney Injury Basic Research and Clinical Practice written by X. Ding and published by Karger Medical and Scientific Publishers. This book was released on 2018-01-23 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute Kidney Injury (AKI) is a complex syndrome that is prevalent among hospitalized patients. In recent years, occurrence of AKI events has risen due to a growing susceptibility of fragile and elderly subjects and an increase in the use of complex procedures such as cardiovascular surgery and imaging techniques. Exposure to potentially nephrotoxic drugs, such as new chemotherapeutic agents, is also proving to be a cause of AKI. This book summarizes recent advances in various settings. A reappraisal of current definitions and staging classifications for AKI in the literature is followed by a description of new criteria for identifying patients at risk and characterizing early kidney damage by using biomarkers. Other important topics include the sequelae of AKI and AKI in special populations such as children, the elderly, and those with cancer. The effects of AKI and its consequences on healthcare expenditures are also addressed from several perspectives. AKI management requires the cooperation of different specialists to optimize outcomes. This book is thus a perfect tool not only for nephrologists, but for every specialist involved in the complicated endeavor of improving patient care.
Download or read book Toxicology of the Kidney written by Jerry B. Hook and published by CRC Press. This book was released on 1993-06-30 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition provides a synthesis of recent research on the mechanisms of chemically-induced kidney injury. The text includes a review of current concepts of clinical nephrotoxicity and renal failure, and mechanisms of specific classes of nephrotoxic drugs and environmental chemicals.
Download or read book Nephrology and Public Health Worldwide written by G.B. Silva Junior and published by Karger Medical and Scientific Publishers. This book was released on 2021-11-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.
Download or read book Clinical Regenerative Medicine in Urology written by Bup Wan Kim and published by Springer. This book was released on 2017-09-14 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multidisciplinary book provides up-to-date information on clinical approaches that combine stem or progenitor cells, biomaterials and scaffolds, growth factors, and other bioactive agents in order to offer improved treatment of urologic disorders including lower urinary tract dysfunction, urinary incontinence, neurogenic bladder, and erectile dysfunction. In providing clinicians and researchers with a broad perspective on the development of regenerative medicine technologies, it will assist in the dissemination of both regenerative medicine principles and a variety of exciting therapeutic options. After an opening section addressing current developments and future perspectives in tissue engineering and regenerative medicine, fundamentals such as cell technologies, biomaterials, bioreactors, bioprinting, and decellularization are covered in detail. The remainder of the book is devoted to the description and evaluation of a range of cell and tissue applications, with individual chapters focusing on the kidney, bladder, urethra, urethral sphincter, and penis and testis.
