Download or read book Ketamine written by Bita Moghaddam and published by MIT Press. This book was released on 2021-02-16 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emergence of ketamine--previously known as a combat anesthetic and club drug--as a treatment for depression. Ketamine, approved in 2019 by the Food and Drug Administration for the treatment of depression, has been touted by scientists and media reports as something approaching a miracle cure. This volume in the MIT Press Essential Knowledge series chronicles the ascent of a drug that has been around for fifty years--in previous incarnations, a Vietnam-era combat anesthetic and a popular club drug--that has now been reinvented as a treatment for depression. Bita Moghaddam, a leading researcher in neuropharmacology, explains the scientific history and the biology of ketamine, its clinical use, and its recently discovered antidepressant effects, for the nonspecialist reader.

Download or read book Ketamine written by and published by . This book was released on 2020 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants. --

Download or read book The Little Book of Ketamine written by Kit Kelly and published by Ronin Publishing. This book was released on 2001-07-15 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ketamine, also called K, Special K, and Kit Kat, causes bizarre experiences unlike any other psychedelic drug. The Little Book of Ketamine describes the recreational and spiritual use of Ketamine, including: What K is, how it is made, and how it is used; How K affects the brain; Hallucinations, near-death and out-of-body experiences; Spiritual enlightenment through K and afterlife experiences; Dosages, administration, and safety precautions; Accounts of K-Trips by experienced users; How it feels to go to K-Land; Ketamine and the law. The Little Book of Ketamine reviews the history of Ketamine from its discovery to its use in night clubs and raves, as well as describing extraordinary stories of Ketamine's effects while being mindful of what is myth and what is reality. "Ketamine is a very odd and intriguing entheogen, outpacing all others in sheer range of experience and utter strangeness. It unlocks powers so intense and improbable it is hard to believe such a substance could even exist." —James Kent TRP

Download or read book Modern Anesthetics written by Jürgen Schüttler and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.

Download or read book Ketamine for Treatment Resistant Depression written by Sanjay J. Mathew and published by Springer. This book was released on 2016-11-25 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research.

Download or read book Ketamine for Treatment Resistant Depression written by Gustavo H. Vazquez and published by Academic Press. This book was released on 2020-09-16 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. - Provides efficacy research on ketamine as a treatment for depression - Identifies best practices for clinical use, both long-term and acute - Discusses the molecular mechanisms and neurobiology of action

Download or read book Ketamine written by Karl Jansen and published by . This book was released on 2001-01-01 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.

Download or read book Ketamine for Depression written by Dr. Stephen J. Hyde and published by Xlibris Corporation. This book was released on 2015-09-04 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the unacceptably high rates of suffering, disability and premature death experienced by people with treatment-resistant depression and the surprisingly low rates of problems arising from the use of ketamine to treat the disorder, this is a therapy that all patients and their doctors should be discussing. This book summarises the research that has been carried out into ketamine for the treatment of depression over the past 15 years and, most importantly, describes different ways of using ketamine that are both practical and cost–effective. Currently most ketamine therapy is given intravenously in specialised clinics at considerable expense, but the author has successfully treated patients with low-dose sublingual ketamine and his patients have been able to safely take this at home. Profits from the sales of this book will assist further research into the use of ketamine for the treatment of depression.

Download or read book Ketamine Infusions written by Berkley Jones and published by . This book was released on 2020-03-25 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the 2nd Edition of a Patients guide to Ketamine Infusions. We have added over 40 pages of new content of what you should know prior to getting your infusions. Ketamine is an old anesthetic drug developed in the 1960's. Over the past 20 years researchers began to figure out that Ketamine is much more versatile than simply being used for anesthesia. It can also be used to treat different kinds of Chronic Pain such as the pain from CRPS, Neuropathic Pain, and Small Fiber Neuropathy to name a few. Researchers have also discovered that Ketamine can significantly improve one's mood and are using it to treat Depression, Anxiety, OCD, PTSD, and certain types of Bipolar illness.Are you considering getting Ketamine to treat your Chronic Pain or Mental Health issues? Have you started looking into where to go and who can treat you? Are you wondering what to expect during Ketamine treatments?This book will guide you with everything from choosing your provider, to what to expect during your infusion experience, and how to get the best results from your infusions.This book was written with the input of physicians and patients from around the world and was accumulated with data amassed over the last 20 years.If you are considering infusions reading this book should be your first step before making the call to your local infusion clinic.

Download or read book The Ketamine Papers written by Phil Wolfson and published by . This book was released on 2016-11 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ketamine Papers opens the door to a broad understanding of this medicine's growing use in psychiatry and its decades of history providing transformative personal experiences. Now gaining increasing recognition as a promising approach to the treatment of depression, posttraumatic stress disorder (PTSD), and other psychological conditions, ketamine therapies offer new hope for patients and clinicians alike. With multiple routes of administration and practices ranging from anesthesia to psychotherapy, ketamine medicine is a diverse and rapidly growing field. The Ketamine Papers clarifies the issues and is an inspiring introduction to this powerful tool for healing and transformation--from its early use in the 1960s to its emerging role in the treatment of depression, suicidality, and other conditions. This comprehensive volume is the ideal introduction for patients and clinicians alike, and for anyone interested in the therapeutic and transformative healing power of this revolutionary medicine.

Download or read book Ketamine written by David T. Yew and published by CRC Press. This book was released on 2015-03-16 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing use of ketamine as a recreational drug in Asia, Europe, and America is a great burden on society at large, leading to aspirational strain, unemployment, and crime. These societal effects have led to growing interest among researchers and clinicians in ketamine's effects on various systems of the body. Ketamine: Use and Abuse reviews the

Download or read book Suicide COVID 19 and Ketamine written by Johnathan Edwards and published by . This book was released on 2021-08-15 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why a book about suicide, COVID-19, and Ketamine? These delicate topics are more inter-related than you might think. The World Health Organization (WHO) estimates that each year 800,000 people die from suicide. But have you wondered about the long-term unintended consequences of COVID-19? The deluge of mental-health problems like depression, suicide, and drug overdoses resulting from the pandemic. Depression, suicide and drug overdoses have been a problem since long before the pandemic. But COVID-19 has made the situation worse: it is more of a crisis than a pandemic. Lockdowns have fueled a litany of tragedies: suicides, drug overdoses, heightened crime, starvation, financial ruin, and much more. Adolescent and adult mental illness have skyrocketed during the crisis, and the tsunami of post-traumatic stress, depression, and suicides will follow. The mental-health consequences will persist long after the COVID-19 pandemic ends. Because of the lockdowns, we expect millions of people will die of hunger and postponed medical treatments, a potential outcome that, unfortunately, has developed less notice. The result is a "perfect storm" of suicides and drug overdose deaths. Mental-health practitioners are employing everything, including telemedicine, to help people battle this threat. Suicide is subtle, and the decision to take your own life is often impulsive. The treatment of suicide and depression is complex, with current medications taking weeks or months to work. When a loved one commits suicide, they leave many unanswered questions. Constant thoughts of "what" and "why," permeate the minds of those left behind. We do not have many effective treatments for suicide. But there is one drug that can often stop suicide in its tracks: ketamine. Few are aware that this decades-old anesthetic and party drug might save your loved one's or even your life. Our goal is to convince you ketamine is a legitimate path to treat mental disorders. Simply said, ketamine works. If your loved one was suicidal, would you suggest trying ketamine? Or use it yourself?

Download or read book Rapid Acting Antidepressants written by and published by Academic Press. This book was released on 2020-06-29 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Download or read book Compounded Topical Pain Creams written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-21 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is both a symptom and a disease. It manifests in multiple forms and its treatment is complex. Physical, social, economic, and emotional consequences of pain can impair an individual's overall health, well-being, productivity, and relationships in myriad ways. The impact of pain at a population level is vast and, while estimates differ, the Centers for Disease Control and Prevention reported that 50 million U.S. adults are living in pain. In terms of pain's global impact, estimates suggest the problem affects approximately 1 in 5 adults across the world, with nearly 1 in 10 adults newly diagnosed with chronic pain each year. In recent years, the issues surrounding the complexity of pain management have contributed to increased demand for alternative strategies for treating pain. One such strategy is to expand use of topical pain medicationsâ€"medications applied to intact skin. This nonoral route of administration for pain medication has the potential benefit, in theory, of local activity and fewer systemic side effects. Compounding is an age-old pharmaceutical practice of combining, mixing, or adjusting ingredients to create a tailored medication to meet the needs of a patient. The aim of compounding, historically, has been to provide patients with access to therapeutic alternatives that are safe and effective, especially for people with clinical needs that cannot otherwise be met by commercially available FDA-approved drugs. Compounded Topical Pain Creams explores issues regarding the safety and effectiveness of the ingredients in these pain creams. This report analyzes the available scientific data relating to the ingredients used in compounded topical pain creams and offers recommendations regarding the treatment of patients.

Download or read book Davis s Drug Guide for Rehabilitation Professionals written by Charles D. Ciccone and published by F.A. Davis. This book was released on 2013-03-21 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-of-a-kind guide specifically for rehabilitation specialists! A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. Organized alphabetically by generic name, over 800 drug monographs offer the most up-to-date information on drug indications, therapeutic effects, potential adverse reactions, and much more! A list of implications for physical therapy at the end of each monograph helps you provide the best possible care for your patients. It’s the perfect companion to Pharmacology in Rehabilitation, 4th Edition!

Download or read book Anaesthesia Pain Intensive Care and Emergency Medicine A P I C E written by A. Gullo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous update in critical care medicine is a real challenge due to the growing dimensions of its contents; these elements are the result of new research acquisitions, and of those clinical situations where the physician is able to intervene at a given moment, with the use of effective prevention techniques. They are also the result of new technologies able to define complex sub-clinical diagnostic aspects; lastly, they are the result of effective therapeutic techniques available, and of treatment strategies able to influence radically and positively the patient's clinical course. Critical care medicine is playing a key role in the most advanced environments, as it represents a cross-sectional field of action, involving several specialties, such as anesthesiology, general medicine, surgery, pediatrics.