Download or read book Proteins Structure Function and Genetics written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents information on "Proteins: Structure, Function, and Genetics," a journal published by Wiley-Liss, Inc., a subsidiary of John Wiley and Sons, Inc. Posts contact information via street address, telephone and fax numbers, and e-mail. Lists editorial board members and includes information on submissions, copyright, and abstracting and indexing services. The journal publishes original reports of significant experimental and analytic research in all areas of protein research. Links to tables of contents and to related societies and professional organizations.
Download or read book Protein Structure Function Relationship written by Z.H. Zaidi and published by Springer. This book was released on 1996-10-31 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although many pursue understanding of the relationship between protein structure and function for the thrill of pure science, the pay-off in a much broader sense is the ability to manipulate the Earth's chemistry and biology to improve the quality of life for mankind. Immediately goals of this area of research include identification of the life-supporting functions of proteins, and the fundamental forces that facilitate these functions. Upon reaching these goals, we shall have the understanding to direct and the tools required to implement changes that will dramatically improve the quality of life. For example, under standing the chemical mechanism of diseases will facilitate development of new therapeutic drugs. Likewise, understanding of chemical mechanisms of plant growth will be used with biotechnology to improve food production under adverse climatic conditions. The challenge to understand details of protein structure/function relationships is enormous and requires an international effort for success. To direct the chemistry and biology of our environment in a positive sense will require efforts from bright, imaginative scientists located throughout the world. Although the emergence of FAX, e-mail, and the World Wide Web has revolutionized international communication, there remains a need for scientists located in distant parts of the world to occasionally meet face to face.
Download or read book Molecular Genetic Approaches to Protein Structure and Function written by James A. Spudich and published by Wiley-Liss. This book was released on 1989-12-14 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This compilation of twenty reviews by well-known researchers presents current genetic and molecular genetic approaches to the study of protein structure and function both in vitro and in vivo. The approaches described here are applicable to the study of most proteins involved in cell and developmental biology. The collection focuses on cell motility and other cytoskeleton-mediated events, which are complex cell biological phenomena that are being explored with these techniques. Reviews are grouped into sections according to questions commonly asked by investigators new to genetics and molecular genetics.
Download or read book Impact of Genetic Variation on Structure and Function of Proteins written by and published by . This book was released on 2017 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protein Data Bank (PDB; http://wwpdb.org) was established in 1971 as the first open access digital data resource in biology with seven protein structures as its initial holdings. The global PDB archive now contains more than 124,000 experimentally determined atomic level 3D structures of biological macromolecules, all of which are freely accessible via the Internet. Knowledge of the 3D structure of a gene product is beneficial for understanding its function and its role in disease. The main theme of this thesis is to improve our knowledge of this relationship between genes and proteins. First, we manually review the existing knowledge of how changes in 3D protein structure are related to diseases. Second, we analyze novel datasets of genetic information and prioritize single nucleotide variation for further analysis, using protein level annotations. Of particular interest in the PDB archive are protein structures for which 3D structures of both wild type and genetic variants have been determined, thereby revealing atomic-level structural differences. In the first part of this thesis, we present a systematic review of these cases. We observe a wide range of possible structural and functional changes at the protein caused by single point mutations, including changes in enzyme activity, aggregation, structural stability, binding and dissociation, some in the context of large biological assemblies. An increasing number of software methods are available that attempt to predict the consequences of genetic variation data. Our results show that the range of possible consequences is much larger than is often assumed and also a comprehensive understanding of three-dimensional structure, dynamics, and biophysics will be required to develop better tools that can make accurate predictions about the consequences of genetic changes manifested at the atomic level in protein and RNA gene products. In the second part of this thesis, we are developing a bioinformatics pipeline by which we can achieve fast and accurate annotation for large variation databases using information derived from protein sequences and 3D structures.
Download or read book Genetic Databases written by and published by Academic Press. This book was released on 1999-09-01 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computer access is the only way to retrieve up-to-date sequences and this book shows researchers puzzled by the maze of URLs, sites, and searches how to use internet technology to find and analyze genetic data. The book describes the different types of databases, how to use a specific database to find a sequence that you need, and how to analyze the data to compare it with your own work. The content also covers sequence phenotype, mutation, and genetic linkage databases; simple repetitive DNA sequences; gene feature identification; and prediction of structure and function of proteins from sequence information. This book will be invaluable to those starting a career in life sciences research as well as to established researchers wishing to make full use of available resources. - Describes a wide range of databases: DNA, RNA, protein, pathways, and gene expression - Enables readers to access the information they need from databases on the web - Includes a directory of URLs for easy reference - Invaluable for those starting a career in life sciences research and also for established researchers wishing to make full use of available resources
Download or read book Innovations in Applied Artificial Intelligence written by Bob Orchard and published by Springer Science & Business Media. This book was released on 2004-05-07 with total page 1293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 17th International Conference on Industrial and Engineering Applications of Artificial Intelligence and Expert Systems, IEA/AIE 2004, held in Ottawa, Canada, in May 2004. The 129 revised full papers presented were carefully reviewed and selected from 208 submissions. The papers are organized in topical sections on neural networks, bioinformatics, data mining, general applications, autonomous agents, intelligent systems, knowledge processing and NLP, intelligent user interfaces, evolutionary computing, fuzzy logic, human-roboter interaction, computer vision and image processing, machine learning and case-based reasoning, heuristic search, security, Internet applications, planning and scheduling, constraint satisfaction, e-learning, expert systems, applications to design, machine learning, and image processing.
Download or read book Publications of the National Institute of Standards and Technology Catalog written by National Institute of Standards and Technology (U.S.) and published by . This book was released on 1990 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Publications written by United States. National Bureau of Standards and published by . This book was released on 1989 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Publications of the National Institute of Standards and Technology 1988 Catalog written by Rebecca J. Pardee and published by . This book was released on 1989 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ulrich s International Periodicals Directory written by Carolyn Farquhar Ulrich and published by . This book was released on 1998 with total page 2242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure Expression From proteins to ribosomes written by Mukti H. Sarma and published by Adenine Press, Incorporated. This book was released on 1988 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Use of Services for Family Planning and Infertility United States 1982 written by Gerry E. Hendershot and published by . This book was released on 1988 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 1982 statistics on the use of family planning and infertility services presented in this report are preliminary results from Cycle III of the National Survey of Family Growth (NSFG), conducted by the National Center for Health Statistics. Data were collected through personal interviews with a multistage area probability sample of 7969 women aged 15-44. A detailed series of questions was asked to obtain relatively complete estimates of the extent and type of family planning services received. Statistics on family planning services are limited to women who were able to conceive 3 years before the interview date. Overall, 79% of currently mrried nonsterile women reported using some type of family planning service during the previous 3 years. There were no statistically significant differences between white (79%), black (75%) or Hispanic (77%) wives, or between the 2 income groups. The 1982 survey questions were more comprehensive than those of earlier cycles of the survey. The annual rate of visits for family planning services in 1982 was 1077 visits /1000 women. Teenagers had the highest annual visit rate (1581/1000) of any age group for all sources of family planning services combined. Visit rates declined sharply with age from 1447 at ages 15-24 to 479 at ages 35-44. Similar declines with age also were found in the visit rates for white and black women separately. Nevertheless, the annual visit rate for black women (1334/1000) was significantly higher than that for white women (1033). The highest overall visit rate was for black women 15-19 years of age (1867/1000). Nearly 2/3 of all family planning visits were to private medical sources. Teenagers of all races had higher family planning service visit rates to clinics than to private medical sources, as did black women age 15-24. White women age 20 and older had higher visit rates to private medical services than to clinics. Never married women had higher visit rates to clinics than currently or formerly married women. Data were also collected in 1982 on use of medical services for infertility by women who had difficulty in conceiving or carrying a pregnancy to term. About 1 million ever married women had 1 or more infertility visits in the 12 months before the interview. During the 3 years before interview, about 1.9 million women had infertility visits. For all ever married women, as well as for white and black women separately, infertility services were more likely to be secured from private medical sources than from clinics. The survey design, reliability of the estimates and the terms used are explained in the technical notes.
Download or read book Ulrich s Periodicals Directory written by and published by . This book was released on 2003 with total page 2748 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structural Aspects Of Protein Synthesis 2nd Edition written by Anders Liljas and published by World Scientific. This book was released on 2013-06-06 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases.Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation.There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system.
Download or read book U S Government Research Development Reports written by and published by . This book was released on 1969-10 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Library Information Sciences written by and published by . This book was released on 1989 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular Organelles and the Extracellular Matrix written by Edward Bittar and published by Elsevier. This book was released on 1996-01-04 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is in two parts. The first contains the remaining chapters on cellular organelles and several chapters relating to organelle disorders. An account of mitochondriopathis is given in the chapter on the mitochondrion rather than in a separate one. The subject matter of this part of the volume shows quite clearly that the interdisciplinary approach to the study of organelles has shed considerable light on the nature of the mechanisms underlying the etiology and pathobiology of many of these disorders. As an example, mutations in the genes encoding integral membrane proteins are found to lead to disturbances in peroxisome assembly. It is also interesting and significant that mistargeting of protein is now thought to be another cause. It will be revealing to see whether mistargeting is the result of mutations in the genes encoding chaperones.The second part of the volume is concerned with the extracellular matrix. It sets out to show that a vast body of new knowledge of the extracellular matrix is available to us. Take for example the integrin family of cell adhesion receptors. It turns out that integrins play a key role not only in adhesion but also in coupling signals to the nucleus via the cytoskeleton. As for fibronectins, they seem to link the matrix with the cytoskeleton by interacting with integrins.Collagen molecules are dealt with in the last two chapters. The boundaries of collagen in disease are defined by drawing a clear line of demarcation between systemic connective tissue disorders (e.g., scleroderma), better known as autoimmune diseases, and the heritable, and the heritable diseases such as osteogenesis imperfect and the Marfan syndrome. This classification takes into account a second group of acquired disorders of collagen forming tissues in which regional fibrosis is the hallmark. Liver cirrhosis and pulmonary fibrosis are prime examples.The decision to place Volumes 2 and 3 before those dealing with cell chemistry was not easily made. It was based on the view that most students will have had an undergraduate course in biochemistry of cell biology or both courses, and that they could go to Volumes 4-7 in which the subject of cell chemistry is covered, and then return to Volumes 2 and 3.
