Download or read book Jak Stat Signaling From Basics to Disease written by Thomas Decker and published by Springer Science & Business Media. This book was released on 2012-06-06 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.
Download or read book Jak Stat Signaling written by and published by Springer. This book was released on 2012-08-31 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book JAK STAT Pathway in Disease written by Jr., Richard H. Bell and published by CRC Press. This book was released on 2009-06-11 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current understanding of the biological roles of the signal transducer and activator of transcription (STAT) proteins and their dysregulation in diseases. STAT proteins were named after their role as signal transducers and activators of transcription. STAT proteins are highly conserved among species, thus reflecting the importance
Download or read book JAK STAT Signaling in Diseases written by Ritobrata Goswami and published by CRC Press. This book was released on 2020-02-28 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.
Download or read book The Jak Stat Pathway in Hematopoiesis and Disease written by Alister C. Ward and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book for the first time comprehensively surveys the research investigating the Jak-Stat pathway and its role in normal blood development as well as its perturbation in disease. It draws on the expertise of world-renowned medical researchers to take the reader from basic biology through to recent therapeutic advances.
Download or read book JAK STAT Signaling in Development and Disease written by Christine J. Watson and published by . This book was released on 2008 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Jak Stat Pathway in Hematopoiesis and Disease written by Alister C. Ward and published by Eurekah.Com Incorporated. This book was released on 2002 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signal Transducers and Activators of Transcription STATs written by P. Sehgal and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only fully comprehensive reference for STAT proteins and their biology, this book describes the current state of ongoing research in this broad area, and looks toward the future to try to predict the discoveries that lie ahead.
Download or read book Encyclopedia of Exercise Medicine in Health and Disease written by Frank C. Mooren and published by Springer. This book was released on 2012-04-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Exercise Medicine is intelligently structured, easy accessible and user-friendly: A-Z format, clear, concise language and uniform essay structure as well as extensive cross references between keywords and related articles enables efficient searches in a user-friendly manner both for experts and newcomers. It is intended to be a comprehensive up-to-date data base on the adaptation of the human body to exercise and on the therapeutic use of exercise with up to 2,000 keywords. It covers all aspects within the full range of modern exercise medicine of each particular scientific discipline (cancer, parasitology, aging, etc.). This includes information on methodological approaches to measuring the principle components of motor fitness, and practical aspects of their enhancement by trainings regimes as well as by nutrition and the application of drugs. Such a wide range of entries, all written by leading experts in their respective fields, will therefore address both the basic/clinical scientist as well as the practitioner. Moreover, the Encyclopedia of Exercise Medicine is aimed at people in related fields, health care professionals, physiotherapists, trainers, students, informed athletes and interested laypersons. It is available both in print and as a fully searchable and hyperlinked electronic online edition.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book JAK STAT Pathway in Disease written by Richard H. Bell, Jr. and published by CRC Press. This book was released on 2005-11-08 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Performing a surgical operation must be one of the most complex motor tasks undertaken by humans. To the student rotating on a third-year clerkship, or to the resident beginning a surgical career, the complexity can no doubt be daunting. It is the goal of this handbook to try to bring some degree of order to the complexity, focusing on many of the common operations in general, plastic, thoracic, and vascular surgery, and in organ transplantation. We have done so by dividing each procedure into specific and well-defined steps.
Download or read book Adipose Tissue in Health and Disease written by Todd Leff and published by John Wiley & Sons. This book was released on 2010-03-19 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.
Download or read book JAKs and STATs from a Clinical Perspective Loss of function Mutations Gain of function Mutations and Their Multidimensional Consequences written by Nils Ott and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT signaling pathway appears to be straightforward. However, on closer examination, the factors influencing the JAK/STAT signaling activity, such as cytokine diversity, receptor profile, overlapping JAK and STAT specificity among non-redundant functions of the JAK/STAT complexes, positive regulators (e.g., cooperating transcription factors), and negative regulators (e.g., SOCS, PIAS, PTP), demonstrate the complexity of the pathway's architecture, which can be quickly disturbed by mutations. The JAK/STAT signaling pathway has been, and still is, subject of basic research and offers an enormous potential for the development of new methods of personalized medicine and thus the translation of basic molecular research into clinical practice beyond the use of JAK inhibitors. Gain-of-function and loss-of-function mutations in the three immunologically particularly relevant signal transducers STAT1, STAT3, and STAT6 as well as JAK1 and JAK3 present themselves through individual phenotypic clinical pictures. The established, traditional paradigm of loss-of-function mutations leading to immunodeficiency and gain-of-function mutation leading to autoimmunity breaks down and a more differentiated picture of disease patterns evolve. This review is intended to provide an overview of these specific syndromes from a clinical perspective and to summarize current findings on pathomechanism, symptoms, immunological features, and therapeutic options of STAT1, STAT3, STAT6, JAK1, and JAK3 loss-of-function and gain-of-function diseases
Download or read book Hormone Signaling written by Vincent Goffin and published by Springer Science & Business Media. This book was released on 2002-03-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.
Download or read book Genetics of Animal Health and Disease in Livestock written by Bianca Castiglioni and published by MDPI. This book was released on 2021-06-02 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wood surface attributes can be established by examining its several different physical or chemical properties. Differences in the wood surfaces occur between the manufacturing and post-treatment processes as well. Understanding how their unique anisotropic molecular organization, chemical linkages, branching, and other molecular features govern micro- and macroscale accessibility is essential for coating and complex modification processes. It is therefore important for scientific as well as practical reasons to qualify and quantify the effects of wood surface treatments and modifications. Challenges still exist to fully understanding the effect of the numerous applied chemicals and the wide range of treatment processes on wood surfaces.
Download or read book Fundamentals of Inflammation written by Charles N. Serhan and published by Cambridge University Press. This book was released on 2010-04-26 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.
Download or read book Intracellular Signal Transduction The JAK STAT Pathway written by Andrew F. Wilks and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first one written about the JAK/STAT pathway. The JAK (Janus Kinase) Protein tyrosine kinases are novel phosphotransferases absolutely required for cellular signalling downstream of non-catalytic cytokine receptors (amongst others). These molecules are components in pathways utilising the STAT (Signal Transducers and Activators of Transcription) transcription factors. The basic components of the JAK/STAT pathway are covered in detail, and the centre piece of the book is a guided tour of the pathway itself. An interesting addition to the book is the chapter on the use of Drosophila melanogaster as a genetic system to probe the pathway at the whole organism level. The book is targeted to researchers who have an interest in intracellular signalling.
