Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1964 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Download or read book Leukotrienes and Prostacyclin written by F. Berti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1971 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Download or read book Information Resources in Toxicology written by P.J. Bert Hakkinen and published by Elsevier. This book was released on 2000-01-10 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information Resources in Toxicology, Third Edition is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources--books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the Third Edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added.This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists. - Serves as an all-in-one resource for toxicology information - New edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reports - Updated to include the latest internet and electronic sources, e-mail addresses, etc. - Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects

Download or read book Central Nervous System written by E. Genazzani and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the Symposium "Metabolic Regulation and Functional Activity in the Central Nervous System" which was held on September 16 and 17, 1972, at Saint Vincent (Aosta)/Italy, and was sponsored by the Accademia di Medicina di Torino with the scientific cooperation of the Istituto di Farmacologia, Universita di Torino, and the Pharmakologisches Institut der Freien Universitat Berlin. Its purpose was to give a greater number of scientists from different countries an opportunity to report their latest results under a heading concerning general relationships between metabolism and function. We quite deliberately refrained from pursuing the partly heterogenous subjects into details. Thus, the organizers hoped to be able to interest a greater circle of readers for the manifold subjects from various fields dealing with the investigation of metabolic processes in the central nervous system. The discussion remarks to the lectures could not be considered for printing. The Accademia di Medicina di Torino and all others concerned do not only thank Dr. R. Di Carlo and other members of the Istituto di Farmacologia, Universita di Torino, for the excellent work they performed in preparing this Symposium, but also the Amministrazione Regionale della Valle di Aosta and SIT A V di Saint-Vincent for their generous support and their kind hospitality which made the stay at Saint-Vincent most agreeable for all participants.

Download or read book Serotonin written by Paul M. Vanhoutte and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents the proceedings ofthe invited lectures ofthe first International Symposium on "Serotonin from Cell Biology to Pharmacology and Therapeutics" which was held in Florence on March 29 -Aprill, 1989. This meeting, held under the co-sponsorship of the Serotonin Club and the Fondazione Giovanni Lorenzini, represents the first attempt to bring together scientists fascinated by the complexity of the action of 5-hydroxytryptamine throughout the body and in various species. Hence this volume provides the reader with the unique overview of the sources, effects, receptors, physiological actions and pathological role of Serotonin. As such it will be of interest not only to the person devoting herorhis research efforts to the study of 5-hydroxytryptamine but also to all scholars and even clinicians wanting to know how the powerful monoamine can modulate cellular functions. To accelerate the publication of these proceedings the Editors and the publishers have selected the camera ready format and have avoided a lengthy refereeing process. Hence the scientific content of, and the opinions expressed in the chapters are the sole responsibility of the authors. The Editors Milan and Houston The Editors want to thank Mrs. H. Liepman and her staff at Kluwer for the prompt and efficient handling of the manuscripts.

Download or read book Neurotransmitter Release the Neuromuscular Junction written by Francesco Clementi and published by Elsevier. This book was released on 2012-12-02 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotransmitter Release: The Neuromuscular Junction is a collection of papers presented at a small meeting organized in the University of Milan to honor Bruno Ceccarelli. Ceccarelli was particularly interested in the structure and functioning of the neuromuscular junction and spent the rest of his career characterizing the process of neurotransmitter release, and eventually providing the strongest available support for the widely accepted ""vesicle hypothesis"" of neurotransmitter release. The meeting was intended to gather as many scientists who had been directly in touch with Bruno as possible and to discuss together problems of Bruno's interest. Organized into 20 chapters, the book first discusses the organelles of distinct secretory pathways involved in distinct types of neuronal signaling, such as synapsins, synaptophysin , and synaptobrevin. It then examines the role of coated vesicles, acetylcholine compartments, and potassium and calcium channels on neurotransmission processes. Other topics considered are the regeneration of nerve-evoked neurotransmission; the single-channel recordings of KNa in avian sensory neurons; the modulation of voltage-dependent calcium currents in identified snail neurons; and the agonistic/antagonistic action of calcium channel in mammalian peripheral neurons. Cross-talks between receptors coupled to calcium currents and between different intracellular signaling are provided in the last chapters of the book. These chapters also look into the relevance of lipoxygenase metabolites of arachidonic acid to cell-to-cell communication in the central nervous system. This book is an invaluable source for scientists, researchers, and students who are interested in basic neurology.

Download or read book Receptors in the Nervous System written by Abel Lajtha and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 683 pages. Available in PDF, EPUB and Kindle. Book excerpt: A major advance in the biological sciences in the past decade has been the biochemical identification of cell membrane receptors. The existence of re ceptor substances on the surface of cells that recognize and bind to extracellular molecules was proposed at the beginning of the century by the pharmacologist and immunologist Paul Ehrlich and the physiologist J. N. Langley. Since then, receptors have been found to play an important role in numerous physiological and pathological processes. Over the years many attempts have been made to physically isolate and chemically characterize receptors, but because of the receptors' extremely low concentration and membrane localization, these ef forts have met with limited success. Yet, despite the failure to characterize receptor substances, the concept of the presence of such molecules has had considerable heuristic value. Using pharmacological, physiological, and im munologic approaches, researchers have identified several specific receptors, e. g. , a-and ~-adrenergic, nicotinic and muscarinic cholinergic, and histami nergic. With the characterization of various types of receptors on cell mem branes, many drugs were developed that proved to be experimentally and ther apeutically useful. It was only in the early 1970s that methods for the specific measurement, chemical characterization, and physical isolation of cell membrane receptors were developed. These advances were made possible by the availability of ligands with high specific radioactivity that retained their biological activity and of experimental procedures that differentiated between specific and non specific binding of ligands.

Download or read book New Trends in Pharmacokinetics written by Aldo Rescigno and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last decade or so has witnessed tremendous progress in methodology in the field of drug development in general and pharmacokinetics in particular. Clinical pharmacokinetics is using new tools for probing into the "black box" once being ac cessible only partly through experimental techniques and, mostly through mathemati cal and computer means. Development of computerized scanning, positron emission tomography (PET), stereoselectivity and other techniques are now enabling investi gators to have better pictures of the systems they are studying. Mathematical models through computer simulation and statistical estimation, mostly due to easy access be cause of inexpensive yet powerful personal computers, are enabling us to investigate ultrastructures and their functional connectivity in more detail. As a consequence, new hypotheses are being formed and tested in various related fields. In clinical pharmacokinetics, mostly due to mathematical modeling, more accurate interspecies scaling of pharmacokinetic parameters and dosimetry can be done now-a-days. The concept of "a human is a bigger rat" does not necessarily fly as a consequence. Pharmacokinetic concepts are becoming powerful tools in meaningful carcinogenic and toxic risk extrapolation of different chemicals in humans. New dose delivery designs are being formulated using pharmacokinetic techniques for different pharmaceutical compounds. Investigations continue in the academia, research institutions, pharmaceutical, biotechnological, and agricultural industries in developmental and physiological aspects of different chemicals for the benefit of mankind. The idea of a school on "New Trends in Pharmacokinetics", from which the present pUblication was made possible, took shape over almost a year.

Download or read book Fat Soluble Vitamins written by Peter J. Quinn and published by Springer Science & Business Media. This book was released on 1998-09-30 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject for a volume on the fat-soluble vitamins needs no justification considering the importance of this group of nutrients and the rate of expan sion of our knowledge of its role in cell biology, genetics, and disease. The level of our understanding has clearly moved from knowing what fat soluble vitamins do to how they perform their functions. Hand in hand with a knowledge of their molecular mechanisms of action is the recognition that vitamins are used sparingly, and regeneration processes operate in certain cases to recycle vitamins from their metabolites. We have divided the volume into alphabetical sections beginning with vitamin A and the carotenoids through vitamins D, E, F, and K, and ending with coenzyme Q. The contributors are all acknowledged experts in their particular fields and have made significant contributions to published research results. All have worked assiduously to deliver the product of their labors on a restricted time scale and to provide the most up-to date information on their respective topics. We are truly grateful for their indulgence.

Download or read book Nitric Oxide Part F written by and published by Academic Press. This book was released on 2011-09-02 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery that nitrogen monoxide or nitric oxide (NO)is a biologically produced free radical has revolutionized our thinking about physiological and pathological processes. This discovery has ignited enormous interest in the scientific community. When generated at low levels, NO is a signaling molecule, but at high concentration, NO is a cytotoxic molecule. The physiological and pathological processes of NO production and metabolism and its targets, currently areas of intensive research, have important pharmacologic implications for health and disease.

Download or read book Dopaminergic Systems and their Regulation written by G.N. Woodruff and published by Springer. This book was released on 2016-01-15 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book ICRDB Cancergram written by and published by . This book was released on 1986 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cholinergic Mechanisms From Molecular Biology to Clinical Significance written by J. Klein and published by Elsevier. This book was released on 1996-12-18 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a comprehensive update and overview of the field of cholinergic transmission as presented by some thirty distinguished investigators who were recruited for their task from Germany, Great Britain, Canada, USA, Sweden, Israel, France and Italy. Exciting new discoveries, described in this volume, are due to recent methodological breakthroughs. These discoveries throw new light on many areas of cholinergic mechanisms.

Download or read book Vitamin A and Retinoids An Update of Biological Aspects and Clinical Applications written by Maria A. Livrea and published by Birkhäuser. This book was released on 2012-12-06 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolic pathways during oncogenesis. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on the clinical efficiency of retinoids in skin disorders and cancer. The book presents recent findings on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. It also offers a survey of the molecular and cell biochemistry of retinoids. Basic researchers in biochemistry, pharmacology and cell biology as well as clinicians will find this book very informative and up-to-date. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on clinical efficiency of retinoids in skin disorders and cancer. Basic researchers in biochemistry, pharmacology, cell biology, and clinicians will find this book very informative and up-to-date. The chapters, organized in six sections, are contributed by leading scientists who have been working in the retinoid field for decades. Their experience and competence is aknowledged worldwide.

Download or read book Advances in Dopamine Research written by M. Kohsaka and published by Elsevier. This book was released on 2013-10-22 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Dopamine Research documents the proceedings of a satellite symposium to the 8th International Congress of Pharmacology held in Okayama, Japan, July 1981. The importance of dopamine in brain function is reflected in this volume book by the chapters on the neurochemical, behavioral, neuroanatomical, and electrophysiological aspects of dopamine in the central nervous system. Dopamine receptor agonists and antagonists enjoy widespread use in the treatment of various brain disorders. A comprehensive account of research on the actions and mechanisms of action of drugs which affect central dopaminergic pathways is included in this volume. Also presented are accounts of the importance of dopamine and dopamine receptors in the periphery. It is hoped that this volume will be of interest to neuroscientists and pharmacologists, and indeed to all who are interested in clinical and scientific aspects of dopamine and other neurotransmitters.

Download or read book Modulation of Synaptic Transmission and Plasticity in Nervous Systems written by Georg Hertting and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on a workshop "Modulation of Synaptic Transmission and Plasticity in Nervous Systems" held in n Ciocco, Castelvecchio, Pascoli, Italy, from September 8th to 13th, 1987. The purpose of the meeting was to bring together scientists working on plasticity in nervous systems on different levels. The contributions can be subgrouped into six fields of research: 1) Presynaptic Modulation of Chemical Neurotransmission 2) Postsynaptic Signal Transduction 3) Modulation of Synaptic Transmission and Plasticity in the Hippocampus 4) Modulation of Neuromuscular Transmission 5) Molecular and Cellular Analysis of Conditioning in Marine Snails 6) Analysis of Learning and Memory in Insects Understanding how nervous systems and in particular our brain processes and stores information has been a major challenge in science for centuries and will remain for some time to come. Not until recently neurobiologists agreed to seek plasticity of behavior primarily in the modulation of the properties of synapses between nerve cells. This is to be understood within the context provided by a neural circuitry. An important stimulus came from the work on the marine snail Aplysia, where learning processes can be described as a modulation of transmitter release, traced back to a complete chain of molecular events in an identified neuron. Learning became a topic of molecular biology. Three systems appear particularly promising for this approach: insects, in particular Drosophila, marine snails and the mammalian hippocampal tissue. Our views on neurotransmission have rapidly changed.