Download or read book Iron III Cobalt III and Copper II Complexes with Carboxamide Ligands that Assist Characterization of Metal Peroxide Intermediates written by John Murray Rowland and published by . This book was released on 2002 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2002 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Synthesis and Characterization of Cobalt III Iron II and Iron III Catechol Complexes written by Peter A. Wicklund and published by . This book was released on 1976 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book American Doctoral Dissertations written by and published by . This book was released on 2001 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Syntheses and Physical Properties of Complexes of Iron III Copper II and Cobalt III with Hetero donor Schiff base Ligands written by Nawal K. Al-Rasby and published by . This book was released on 2003 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Characterization of Cobalt II Nickel II and Copper II Complexes with 3 3 bis p X benzoylacetoneiminato bis trimethylene amine Ligands written by Yu-Ying Chen and published by . This book was released on 1979 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cobalt III Complexes Containing Analogues of Bioactive Anticancer Compounds written by Meet Mistry and published by . This book was released on 2016 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of cisplatin as a potent anticancer agent, transition metal complexes have played a significant role in the development of new anticancer compounds. The anticancer potential of cobalt complexes has been extensively studied over the last three decades, and much time has been devoted to understanding their mechanisms of action. After understanding the Co(III)/Co(II) reduction activation mechanism, several Co(III) complexes of bioactive anticancer agents have been investigated as potential hypoxia activated prodrugs. Furthermore, after the initial use of nitrogen mustard, several bioactive compounds and their analogues have been investigated as ligands to develop hypoxia activated Co(III) complexes. This thesis describes syntheses and characterisation of Co(III) complexes that have been designed using structural analogues of bioactive anticancer compounds. Chapter 1 gives an overview of the prodrug strategy in cancer therapy, prodrug design using a trigger and an effector unit, and different mechanisms for prodrug activation. Several examples of Co(III) complexes are given, which have been investigated as potential prodrugs to target tumour hypoxia. There are three different parts to this research. Chapters 2, 3 and 4 describe the syntheses and characterisation of Co(III) complexes designed using ligands, which are structural analogues of bioactive anticancer compounds. Chapter 2 describes syntheses of dipeptide analogues of bortezomib, a proteasome inhibitor that is currently being used for the treatment for multiple myeloma. The Co(III)-dipeptide complexes were also analysed for their possible use as hypoxia activated prodrugs in Chapter 2. Chapter 3 includes the continuation to the previous investigation by Ware et al. on Co(III)-cyclen complex using 8-hydroxyquinoline (8HQ) as a model cytotoxin. Efforts were made to establish a synthetic route to introduce a porphyrin derivative into prodrug design, with the aim of improving tumour cell targeting properties of the prodrug complex. Chapter 4 describes syntheses of two polypyridyl carboxamide ligands, PDPA and MID(AMP)2, and syntheses of their Co(III) complexes. PDPA and MID(AMP)2, are structural analogues of PMAH, Py3PH2, which are carboxamide ligands containing a similar metal-binding domain as bleomycins. The experimental procedures are detailed in Chapter 5.
Download or read book Cobalt III Copper II and Nicker II Coordination Compounds as Cations in Polyborate Chemistry written by Mohammed Abdulredha Altahan and published by . This book was released on 2017 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the synthesis and characterization of a number of polyborate compounds containing transition metal complex cations; most of these compounds contain 6-membered B3O3 boroxole rings within their structures.A total of twenty-six transition metal complex polyborate salts are reported: one contains the triborate monoanion, [B3O3(OH)4]-, three contain the tetraborate dianion [B4O5(OH)4]2-, twelve contain the pentaborate anion, [B5O6(OH)4]-, three contain the hexaborate dianion, [B6O7(OH)6]2- and five contain heptaborate anions (three of which are [B7O9(OH)5]2-, and two are [B7O9(OH)6]3-). Additionally, two compounds contain two isolated polyborate anion species (octaborate dianion [B8O10(OH)6]2- with pentaborate anion [B5O6(OH)4]-, and triborate anion [B3O3(OH)4]- with [B5O6(OH)4]-). The crystal structures of fifteen salts containing these polyborate anions are reported: [Co(en)3][B5O6(OH)4][B8O10(OH)6]∙5H2O (6), [Co(NH3)6]2[B4O5(OH)4]3∙11H2O (9), s-fac-[Co(dien)2][B7O9(OH)6]∙9H2O (11), [Co(diNOsar)]2[B3O3(OH)4]Cl5∙4.75H2O (12), [Cu(en)2][B5O6(OH)4]2∙2H2O (20), [Cu(pn)2{B5O6(OH)4}][B5O6(OH)4]∙4H2O (22), [Cu(TMEDA){B6O7(OH)6}]∙6H2O (23), [Cu(dac)2(H2O)2][Cu(dac)2][B7O9(OH)5]2∙4H2O (24), [Cu(N,N-dmen)2(H2O)][B5O6(OH)4]2·3H2O (27), [Cu(N,N-dmen){B6O7(OH)6}]·4H2O (28), [Ni(en){B6O7(OH)6}(H2O)2]∙H2O (37), [Ni(AEN)][B5O6(OH)4]∙H2O (38), [Ni(dac)2(H2O-)2][Ni(dac)2][B7O9(OH)5]2∙4H2O (39), [Ni(hn)2][B5O6(OH)4]2 (40), and s-fac-[Ni(dien)2][B5O6(OH)4]2 (41). All the synthesized compounds reported were characterized using spectroscopic (IR, multi-element NMR) and analytical (melting point, elemental analysis, magnetic susceptibility, thermal analysis, powder X-ray diffraction) techniques.The solid-state structures of transition metal complex polyborate salts all display multiple cation-anion H-bond interactions and these undoubtedly play a major role in the energetics of engineering these structures. For example, in compound [Co(NH3)6]2[B4O5(OH)4]3∙11H2O (9), fourteen of the 18 amino hydrogen atoms of the [Co(NH3)6]3+ cation are involved in secondary coordination to anions via H-bonds.Two unique polyborate anions, [B8O10(OH)6)]2- and [B7O9(OH)6]3- have been prepared and characterized in [Co(en)3][B5O6(OH)4][B8O10(OH)6]∙5H2O (6) and s-fac-[Co(dien)2][B7O9(OH)6]∙9H2O (11), respectively.viiThe reaction of transition metal complex cations with boric acid in different ratiosproduced polyborate compounds with different polyborate anions e.g. reaction of [Cu(en)2]2+with boric acid in 1:10 and 1:5 ratios produce polyborate compounds with pentaborate(1-) andtetraborate(2-) anions, respectively.New polyborate anion structural architectures are identified in this thesis: (i) thepentaborate(1-) anion in [Cu(pn)2{B5O6(OH)4}][B5O6(OH)4]∙4H2O (22) acts as a monodentateligand coordinated to the Cu(II) cation, (ii) the hexaborate(2-) anion in[Cu(TMEDA){B6O7(OH)6}]∙6H2O (23) and [Cu(N,N-dmen){B6O7(OH)6}]·4H2O (28)coordinates as a tridentate ligand with the Cu(II) cations, and (iii) the hexaborate(2-) anion in[Ni(en){B6O7(OH)6}(H2O)2]∙H2O (37) coordinates as a bidentate ligand with the Ni(II) cation.This is the first time that such coordination mode (i) and (iii) have been observed.
Download or read book Cobalt III Complexes as Hypoxia Selective Cytotoxins written by Helen Rosemary Palmer and published by . This book was released on 1997 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis Characterization and Aquation Reactions of Cobalt III Complexes Containing Monodentate Ligands written by Noel John Farrier and published by . This book was released on 1969 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Preparation and Characterization of Cobalt II and Cobalt III Complexes written by 陳彥彤 and published by . This book was released on 2012 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Preparation Characterization and Kinetic Studies on Cobalt III Complexes with a Sulfur Containing Flexible Linear Pentadentate Ligand written by Thomas Andrew Jackman and published by . This book was released on 1976 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metal centered and Ligand centered Autoxidations Involving U peroxo bridged Cobalt Dioxygen Complexes written by Carl James Raleigh and published by . This book was released on 1984 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Coordination and Organometallic Diamido donor Iron and Cobalt Complexes written by Zohreh Moatazedi and published by . This book was released on 2013 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structures, reactivity and magnetic properties of high-spin iron and cobalt complexes of diamido donor ligands were investigated. Unusual multinuclear Fe(II) and Co(II) complexes with the basic dinuclear unit M2X2[[superscript{tBu}]NON] (X= Br, M= Fe (1), Co (2); X= Cl, M= Fe (3), Co (4)), ([[superscript{tBu}]NON]2−= [Me3CN(SiMe2)]2O2−) were synthesized and characterized. The reduction reaction of 3 with KC8 and addition of CO and dmpe (Me2P(CH2)2PMe2) generated {Fe2[[superscript{tBu}]NON]}2 and, with dmpe also FeCl2(dmpe)2. However, the addition of 1,3-bis-(2,4,6-trimethylphenyl)imidazol-2-ylidene (NHC) carbene to 3 resulted in the new {[NHC]FeCl2}2. Alkyl for halide metathesis via the reaction of LiCH2SiMe3 in 1-4 generated rare high-spin alkyl/halide {[[superscript{tBu}]NON]M2X(CH2SiMe3)2}2 (8-11) complexes and unusual high-spin dialkyl iron and cobalt complexes of the form {M2(CH2SiMe3)2[[superscript{tBu}]NON]} (M = Fe (6) and Co (7)); reaction with MeLi to form the dimethyl analogue was not successful, while addition of one equivalent of methyl reagent per dinuclear unit in 3 and 4 resulted in {Fe2Br(Me)[[superscript{tBu}]NON]}2 and {Co2Cl(Me)[[superscript{tBu}]NON]}2. Neither 6 nor 7 act as polymerization catalysts for ethylene; addition of B(C6F5)3 as a cocatalyst was found to further hinder any activity of 6 and 7 by the formation of {Co2(C6F5)2[[superscript{tBu}]NON]} and {Fe2Cl(C6F5)[[superscript{tBu}]NON]}2. Upon exposing 6 to excess CO, a rare dicarbamoyl trinuclear iron complex was obtained, which results from CO binding, isocarbonyl binding and Fe-C and Fe-N CO insertions. Attempts towards obtaining high oxidation state iron and cobalt complexes showed that the [NON] ligand did not support such systems. Addition of benzyl bromide to {Fe[[superscript{Me3Ph}]NON]}2 resulted in {FeBr[[superscript{Me3Ph}]NON]}2 and reaction of {FeCl[[superscript{tBu}]NON]}2 with dmpe led to a rare tetrahedral iron(III) complex {FeCl[[superscript{tBu}]NON]}2([mu]-Me2PCH2CH2PMe2). To overcome potential difficulties with limited Si-N bond stabilities, carbon-backbone diamido {M[[superscript{iPr}]NN'N]}2 and {M[[superscript{iPr}]NO'N]}2 (M= Fe, Co) [MeN((CH2)2N−iPr)2] ([[superscript{iPr}]NO'N]2−) and [O((CH2)2N−iPr)2] ([[superscript{iPr}]NN'N]2−) were synthesized, characterized and compared with similar diamido complexes.
Download or read book Some Cyanide bridged Cobalt III iron II Complexes written by James Albert Meitner and published by . This book was released on 1968 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modern Syntheses of Cobalt III Complexes written by M. Shibata and published by Springer. This book was released on 2013-10-03 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electronic Structure Electrochemical Properties and Mechanism of the Autoxidation Reaction of Cobalt Dioxygen Complexes Containing 2 2 bipyridine 1 10 phenanthroline 2 2 6 2 terpyridine and Several of the Dimethyl Substituted Ligands written by Eric Cary Niederhoffer and published by . This book was released on 1983 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
