Download or read book Ir Genes written by Carl W. Pierce and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.
Download or read book Regulation of the Immune Response written by Pearay L. Ogra and published by S. Karger AG (Switzerland). This book was released on 1983 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ir Genes and Ia Antigens written by Hugh Mcdevitt and published by Elsevier. This book was released on 2012-12-02 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ir Genes and Ia Antigens features papers that were presented at the Third Ir Gene Workshop held in Asilomar, California, December 13-16, 1976. The book is organized into seven parts that correspond to the seven sessions held during the workshop. The first session focused on the definition of the I-E and I-C subregions, and the mapping and cellular expression of complementing Ir genes. The second session included papers on the expression of gene products of the I region. The third session covered two major areas: (1) the biochemical characterization and primary structure of la antigens; and (2) the possible carbohydrate nature of la antigenic determinant. The studies presented in the fourth session focused on the role of I-region gene products in cellular interactions. The fifth session discussed the "recognition" functions controlled by the I region of the major histocompatibility complex (MHC). The sixth session featured papers on la-containing T cell factors. Finally, the seventh session examined the properties of T-cell antigen receptors.
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Handbook of Immune Response Genes written by Tak W. Mak and published by Springer Science & Business Media. This book was released on 2007-07-27 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of immunology encompasses a vast and ever-growing body of information that in some way or other incorporates most areas of medical biological research. As the body of information in the medical sciences continues to increase its rate of expansion, one of the greatest challenges to investigators will be to integrate this information in a manner that is intellectually fruitful and productive. Considering the intended scope of this text, we could not pretend to have gone too far toward achieving such an integration--and considering the pace of change, in its very best form a measured approximation of such lofty goals might be the most we could hope for. Nevertheless, in these pages we have sought to produce a collection of information that is at once concise and up-to-date regarding areas where important developments are impacting on the way we understand the vertebrate immune system. In addition, although the information is geared toward advanced study, we have discussed some basic elements and concepts that we hope make the text a useful resource for both the immunologist and the nonspecialist. The intention is to provide the researcher, clinician, or advanced undergraduate student with a brief ov- view of specific components of the immune system, and to provide a place from which to begin further detailed study if necessary. To this end, we made every effort to supply extensive referencing--although limitations in space prevented exhaustive or complete referencing in some cases.
Download or read book IR Genes written by Carl W Pierce and published by . This book was released on 1983-03-21 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Immune Gene Expression written by Marc Feldmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book encompasses the proceedings of a conference held at Trinity College, Oxford on September 21-25, 1985 organized by a committee comprised of Drs. M. Crumpton, M. Feldmann, A. McMichael, and E. Simpson, and advised by many friends and colleagues. The immune response gene workshops that took place were based on the need to understand why certain experimental animal strains were high responders and others were low responders. It was assumed that identification of the immune response (Ir) genes and definition of their products would explain high and low responder status. Research in the ensuing years has identified the Ir gene products involved in antibody responses as the la antigens, or MHC Class II antigens. These proteins are now well defined as members of the immunoglobulin gene superfamily, and their domain structure is known. Epitopes have been defined by multiple mono clonal antibodies and regions of hypervariability identified. Their genes have been identified and cloned. The basic observation of high and low responsive ness to antigen is still not understood in mechanistic terms, however, at either the cellular or molecular level. This is because the rate of progress in immune regulation has been far slower than in the molecular biology of the MHC Class II antigens. This is not surprising, since immune regulation is a very complex field at the crossroads of many disciplines.
Download or read book Ir Genes and T Lymphocytes written by and published by . This book was released on 1978 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetic Control of Immune Responsiveness written by Hugh Mcdevitt and published by Academic Press. This book was released on 2012-12-02 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Control of Immune Responsiveness: Relationship to Disease Susceptibility documents the proceedings of an international conference held at Brook Lodge, Augusta, Michigan, May 8-10, 1972. It brings together the detailed experimental evidence on the mechanism of action of specific immune response genes, and shows how the two major classes of immune response genes affect our understanding of basic immunology and antibody formation on the one hand, and of host factors determining disease susceptibility on the other. The book is organized into seven parts that correspond to the seven sessions of the conference. Part I presents a session on how the study of the genetic control of immune responses in guinea pigs and mice has contributed to the development of T cell immunology. Part II presents a session on genetic fine structure of the major (H-2) histocompatibility complex in the mouse. Part III presents a session dealing with the association between the production of homogeneous antibody, or of idiotypic antibody, and immunoglobulin allotypes. Part IV presents a session on the relationship between histocompatibility-linked and allotype-linked immune response genes and antigen-specific receptors on T and B cells. Part V presents a session on animal models of multigenic control of susceptibility to disease. Part VI presents a session on the associations between HL-A type and specific disease entities. Finally, Part VII provides a commentary on the ideas and concepts emerging from the three days of free-ranging discussion.
Download or read book Ir Genes and la Antigens written by Ir Gene Workshop and published by . This book was released on 1978 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunology and Evolution of Infectious Disease written by Steven A. Frank and published by Princeton University Press. This book was released on 2002-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
Download or read book The Genetic Landscape of Diabetes written by Laura Dean and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics of the Immune Response written by Erna Moller and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 55th Nobel Symposium entitled "Genetics of the Immune Response" took place in Saltsjobaden, Sweden, June 15 - 17, 1982. The topic was selected for several reasons, such as the rapid progress in the genetic analysis of immunoglobulin and MHC genes and the elucidation of the mechanism of switch to different immunoglobulin classes and subclasses. The genetic advances formed a basis for discussions of problems relating to regulation of T cell subsets, mechanisms of activation and regulation of B cell differentiation and an analysis of the network hypothesis. The format of the symposium was arranged so as to include two sessions in the morning and two in the afternoon. Each session was introduced by one speaker, followed by free discussion. The intro ductory lectures are included in the proceedings. The participants summarized their contributions to the discussion in written form. In addi tion to the closed sessions, there was one open session at the Karolinska Institute with lectures by Drs. L. Hood, C. Milstein, D. Baltimore, J. Klein and B. Benacerraf, which are not included in these procee din gs. The symposium was sponsored by the Nobel Foundation and its Nobel Symposium Committee through grants from the Tercentenary Fund of the Bank of Sweden and the Knut & Alice Wallenberg Foundation. The Swedish Medical Research Council, the Swedish Cancer Society and the Swedish Ministry of Education and Cultural Affairs also made contri butions.
Download or read book Mean Genes written by Terry Burnham and published by Basic Books. This book was released on 2012-10-02 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Short, sassy, and bold, Mean Genes uses a Darwinian lens to examine the issues that most deeply affect our lives: body image, money, addiction, violence, and the endless search for happiness, love, and fidelity. But Burnham and Phelan don't simply describe the connections between our genes and our behavior; they also outline steps that we can take to tame our primal instincts and so improve the quality of our lives. Why do we want (and do) so many things that are bad for us? We vow to lose those extra five pounds, put more money in the bank, and mend neglected relationships, but our attempts often end in failure. Mean Genes reveals that struggles for self-improvement are, in fact, battles against our own genes -- genes that helped our cavewoman and caveman ancestors flourish but that are selfish and out of place in the modern world. Why do we like junk food more than fruit? Why is the road to romance so rocky? Why is happiness so elusive? What drives us into debt? An investigation into the biological nature of temptation and the struggle for control, Mean Genes answers these and other fundamental questions about human nature while giving us an edge to lead more satisfying lives.
Download or read book Immunogenetics and Immunodeficiency written by B. Benacerraf and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification of the genes which determine biological phenomena, and the study of the control they exert on these phenomena, has proven to be the most successful approach to a detailed understanding of their mechanism. The greatest advances in molecular biology have relied upon the application of the methodology of genetics to the elucidation of the fundamental processes of life at the cellular level. The same statement may be made concerning our understanding of im munological phenomena. The genetic approach has again proven extremely productive and has permitted us to identify many fundamental questions in im munobiology and to resolve some of them successfully. Among the problems with which the young discipline of immunogenetics has been concerned are the structural genes of the immunoglobulin chains. These genes have been iden tified by their control of allotypic antigenic determinants on the constant seg ment of H chains of different classes, on the constant segments of L chains and on both the constant and variable regions of rabbit H chains. These studies have provided the first evidence for the control of a single polypeptide chain by two distinct structural genes. Much has been learned concerning the genes coding the C and V regions of immunoglobulin chains (a) from the study of the inheritance of allotypic and idiotypic determinants on these chains discussed by Kunkel and Kindt and (b) from the analysis of the amino acid sequence in immunoglobulin chains from individual myeloma proteins and abnormal paraproteins, discussed by Frangione.
Download or read book Immunoglobulin Genes written by Tasuku Honjo and published by Elsevier. This book was released on 1995-09-27 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immunoglobulin gene complex is responsible for generating an extraordinarily wide range of antibodies, each possessing a unique antigen specificity. The Second Edition of Immunoglobulin Genes brings the reader up to date with the rapid progress in our understanding of this system. Firmly established as the definitive book on the topic, it provides a fully comprehensive account of the organization, function, rearrangement and expression of these and related genes. Since the publication of the first edition, the work has been extensively revised and updated to cover new research data on human immunoglobulin genes as well as mammalian and lower vertebrate systems. New chapters include "Somatic mutation and B cell Maturation", "Antigen receptors" and "B lymphocyte tolerance in the mouse." For the immunologist, there are detailed descriptions of the molecular mechanisms which generate this diverse range of antibodies and the tight regulation of the genes encoding them. Molecular biologists will find discussions of important phenomena including gene rearrangement, differential splicing and deletion in the context of immunoglobulin genes. The excitement of research on immunoglobulin genes is conveyed by the range and complexity of issues discussed here; the book contains invaluable information for clinicians and research scientists with an interest in the immune response. * Conveys the excitement of research on immunoglobulin genes by the range and complexity of issues * Contains invaluable information for clinicians and research scientists with an interest in the immune response * For the Immunologist * Detailed descriptions of the molecular mechanisms generating this diverse range of antibodies and the regulation of genes encoding them * For the Molecular Biologist * Discusses important phenomena including gene rearrangement, differential splicing, and deletion in the context of immunoglobulin genes.
