Download or read book Investigation of Retention Mechanisms in Reversed phase Liquid Chromatography with Reaction Kinetics written by Brian Scott Ludolph and published by . This book was released on 1989 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Study of the Mechanism of Retention in Reversed phase Liquid Chromatography written by Thomas Gerard Burke and published by . This book was released on 1980 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Study of Retention Mechanism in Reversed Phase Liquid Chromatography written by Lay Choo Tan and published by . This book was released on 1994 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Understanding Retention Mechanisms and Adjusting Selectivity of Basic Pharmaceutical Separations by Reversed phase Liquid Chromatography written by Jun Dai and published by . This book was released on 2005 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Investigations of Reversed phase Liquid Chromatography Retention Mechanisms written by Jennifer Mallette and published by . This book was released on 2010 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The experimental technique of mass spectrometric tracer pulse chromatography was used to investigate the uptake of RPLC eluents and a series of test analytes by a C (18subscript- ) bonded packing over the full element composition range. The experiments were carried out with binary eluents consisting of aqueous mixtures of acetonitrile, methanol, or tetrahydrofuran, as well as ternary eluents composed of acetonitrile, methanol, and water. The primary experimental data obtained for eluent components were in the form of excess volumes. The excess volume data were then used to determine the absolute volume of each eluent component in the stationary phase as a function of eluent composition. The absolute sorption isotherms of the eluent components were indirectly estimated by a combination of techniques specific to a limited eluent composition range. Regression analysis of the non-stationary inflection point of the excess isotherms provided an estimate of the volume of eluent sorbed by the stationary phase for organic-rich eluents. Three different assumptions were used and evaluated for the water-rich eluent compositions. The calculated void volume data were compared with the retention volume of thiourea, uracil, and acetone, solutes commonly used to estimate the volume of the mobile phase. The experimental results showed that water and thiourea did provide an accurate measure of the mobile phase volume but only over a limited range of eluent composition. Deuterated water was chosen as the unretained dead time marker for water rich eluents. With data for the water-rich eluents, the regression results from excess isotherm data was used to estimate the absolute volume of eluent sorbed by the stationary phase over the full eluent composition range. Retention factors for a series of test solutes were calculated with the thermodynamic and kinetic void volumes in order to determine the influence of immobilized eluent. It was hypothesized the retention factors of the test analytes would increase as the absolute amount of organic component in the eluent increased. However, retention factors continually decreased. Therefore, the effect of the uptake of eluent on the retention of test solutes appeared to be minimal for this particular set of test analytes. The experimental technique of mass spectrometric tracer pulse chromatography was shown to be a valid method for the investigation of the uptake of eluent by a C (subscript- ) bonded stationary phase, even with ternary eluent systems.

Download or read book Liquid Chromatography written by M.C. García-Álvarez-Coque and published by Elsevier Inc. Chapters. This book was released on 2013-01-08 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: The addition of reagents to an RPLC mobile phase enables the separation of ionizable compounds, inorganic anions, and metal ions using conventional instrumentation, silica-based materials, and hydro-organic mixtures, thanks to a variety of secondary equilibria. This gives rise to several chromatographic modes, whose main features are outlined in this chapter. The effect of the mobile phase pH on the retention of ionizable compounds is described, together with the recommended experimental practice. The mechanism of adsorption of amphiphilic anions or cations on the stationary phase to attract analytes with opposite charge or suppress the silanol activity is discussed. Different reagents, such as alkylammonium salts, surfactants (below and above the critical micelle concentration), perfluorinated carboxylate anions, chaotropic ions, and ionic liquids, are considered. The potential of metal chelation for the determination of metal ions and organic compounds is also summarized.

Download or read book Measurements of Limiting Activity Coefficients of Homologous Series of Solutes and Their Application to the Study of Retention Mechanism in Reversed Phase Liquid Chromatography written by Won Jo Cheong and published by . This book was released on 1989 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stationary Phase Solvation and the Retention Mechanism in Reversed phase Liquid Chromatography written by Lynn Alison Cole and published by . This book was released on 1990 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Liquid Chromatography written by Salvatore Fanali and published by Elsevier. This book was released on 2023-04-20 with total page 886 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liquid Chromatography: Fundamentals and Instrumentation, Third Edition offers a single source of authoritative information on all aspects of the practice of modern liquid chromatography. The book gives those working in academia and industry the opportunity to learn, refresh, and deepen their understanding of the field by covering basic and advanced theoretical concepts, recognition mechanisms, conventional and advanced instrumentation, method development, data analysis, and more. This third edition addresses new developments in the field with updated chapters from expert researchers. The book is a valuable reference for research scientists, teachers, university students, industry professionals in research and development, and quality control managers. Emphasizes the integration of chromatographic methods and sample preparation Provides important data related to complex matrices, sample preparation, and data handling Gives background information to facilitate the choice of LC sub-technique and experimental conditions, mobile and stationary phases, detectors, data processing, and more Offers comprehensive updates to all chapters Includes new chapters on chiral recognition, co-solvents and mobile phase additives, physicochemical measurements, and identification and quantitation in mass spectrometry

Download or read book Advances in Chromatography written by Eli Grushka and published by CRC Press. This book was released on 2006-10-25 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. Volume 45 of this authoritative series once again compiles the work of expert contributors in order to present timely and cutting

Download or read book Chemical Applications of the Liquid Chromatographic Reactor written by Alexander Hang-Torng Chu and published by . This book was released on 1984 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Liquid Chromatography written by R. Kaliszan and published by Elsevier Inc. Chapters. This book was released on 2013-01-08 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: In view of linear free-energy relationships, LFER, chromatographic systems are “free-energy transducers,” translating differences in the structure of analytes into quantitative differences in physicochemical properties, like retention parameters. Hence, quantitative structure property (retention) relationships, QSP(R)R, bear valuable information on analytes and the separation systems involved. We illustrate here what can be achieved from the statistically valid and physically meaningful quantitative structure-retention relationships, QSRR. In particular, one can predict retention data, confirm identification, and optimize conditions of separation of given structurally defined analytes. Also, QSPR can shed light on the molecular mechanism of separation operating on specific stationary phases. Additionally, one can assess such properties of drug analytes of pharmacokinetic importance, like lipophilicity and acidity. Also, differences in interactions of xenobiotics with biomacromolecule components of chromatographic systems can conveniently be quantified. By means of QSRR, the chromatographic behavior of analytes in diverse separation systems can be related to their pharmacological properties.

Download or read book Quantitative Structure written by Roman Kaliszan and published by Wiley-Interscience. This book was released on 1987-10-14 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of computers in numerical characterization of molecular structures has given chemists fundamentally new information on chemical structures, leading to major developments in physical, analytical, and medicinal chemistry. This book, written by a pioneer in the field, extends and updates research on quantitative structure retention relationships (QSRR) by consolidating and critically reviewing the extensive literature on the subject while providing basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Coverage includes detailed discussions of the general theories and mechanisms of chromatographic separations, prediction of retention coefficients, statistical techniques and formal requirements of QSRR studies, specific applications of chromatographic data, and much more. Also provides several carefully selected figures and tables plus extensive bibliographies.

Download or read book Selectivity and Detectability Optimizations in HPLC written by Satinder Ahuja and published by John Wiley & Sons. This book was released on 1989-06-06 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: High Performance Liquid Chromatography Edited by Phyllis Brown and Richard Hartwick This contributed volume is designed to consolidate the basic theories of chromatography along with the more exciting developments in the field. This monograph addresses some questions that concern researchers in separation science, including: what is the current state of the art in liquid chromatography; has the development of liquid chromatography plateaued; if so, what new methods will take its place or complement it; and if not, where will the new frontiers be and what direction will liquid chromatography take? 1989 (0 471-84506-X) 688 pp. Quantitative Structure-Chromatographic Retention Relationships R. Kaliszan Written by a pioneer in the field, this book extends and updates research on quantitative structure retention relationships by consolidating and critically reviewing the extensive literature on the subject, while also providing the basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Among the topics covered are the nature of chromatographic interactions, molecular interpretation of distribution processes in chromatography, topological indices as retention descriptors, and multiparameter structure-chromatographic retention relationships. 1987 (0 471-85983-4) 303 pp. Detectors for Liquid Chromatography Edited by Edward S. Yeung With its singular coverage of this fast-growing field, Detectors for Liquid Chromatography presents the state of the art in this subject area. It offers a comprehensive examination of the basic principles behind the detector response, instrumentation, and selected applications for comparison and evaluation of potential. Specifically, topics given in-depth coverage include polarimetric, indirect absorbance, refractive index detectors, absorption detectors for HPLC, FTIR and fluorometric detection, detection based on electrical and electromechanical measurements, and mass spectroscopy as an on-line detector for HPLC. 1986 (0 471-82169-1) 366 pp.

Download or read book Retention Mechanism for Reversed Phase and Hydrophilic Interaction Liquid Chromatography written by Sophie Bailes and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Retention Mechanism of Some Basic Drugs on Reversed Phase Liquid Chromatography in the Presence of the Ionic Liquid BMIMBF4 written by Azhar Salman Alhejji and published by . This book was released on 2013 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Thermodynamic and Kinetic Characterization of Solute Transfer in Reverse phase Liquid Chromatography written by Samuel Barnett Howerton and published by . This book was released on 2003 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: