Download or read book Investigation of Allicin on Gut Microbiota liver brain Interaction in Mice with Alcoholic Fatty Liver Disease written by 裴尤德 and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disruptions in Hepatic One Carbon Metabolism and the Gut Microbiome During the Progression of Non alcoholic Fatty Liver Disease written by Russell Ryan Fling and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The etiology of non-alcoholic fatty liver disease is complex, with multiple contributing factors including dietary, environmental, gut microbiome and genetic mechanisms. Accumulating evidence suggests exposure to polychlorinated dibenzo-p-dioxins and similar compounds may increases risk for NAFLD development. These environmentally persistent dioxin-like compounds bind and activate the aryl hydrocarbon receptor, a transcription factor that regulates intestinal homeostasis, xenobiotic and central metabolism. In a AhR-dependent manner, mice orally gavaged with 2,3,7,8-tetracholordibenzo-p-dioxin (TCDD) exhibit steatosis progressing to steatohepatitis with fibrosis akin to NAFLD progression. NAFLD and hepatocellular carcinoma (HCC) is also closely correlated with dysregulation of central metabolism e.g., hepatic one carbon metabolism (OCM), and gut dysbiosis contributing to NAFLD progression and worsening prognosis. This report investigates mechanisms involved in the dysregulation of the gut microbiome and OCM associated pathways relevant to NAFLD progression through comparisons of molecular analyses of TCDD-treated mice to human NAFLD and HCC. OCM describes the biosynthesis, homeostasis, and utilization of the cell's main methyl donor, S-adenosylmethionine (SAM) including high flux anabolic biosynthesis of polyamines, phosphatidylcholine and creatine. In later stages of NAFLD, OCM is dysregulated with altered OCM gene expression as well as SAM and s-adenosylhomocysteine (SAH) levels. To assess TCDD-elicited effects on OCM, mice were orally gavaged with TCDD every 4 days for 28 days. Serum and livers collected at early (8 days) and late (28 days) time points were subjected to metabolomic analyses with integration of chromatin immunoprecipitation sequencing, transcriptomics and protein levels. Results from these studies suggest AhR-mediated repression of OCM required prolonged repeated TCDD-treatment and indirect effects elicited by AhR activation e.g., oxidative stress.Gut dysbiosis with disrupted enterohepatic bile acid metabolism is commonly associated with NAFLD and recapitulated in TCDD-treated mice. Similar to NAFLD, TCDD also increases systematic levels of secondary bile acids. These microbial transformed secondary bile acids are involved in modulation of host bile acid signaling pathways relevant to NAFLD. To investigate the effects of TCDD on the gut microbiota, the cecum contents of TCDD-treated mice were subjected to shotgun metagenomic sequencing. Taxonomic analysis identified dose-dependent increases in Lactobacillus species, notably Lactobacillus reuteri. Top enriched species were also associated with increased abundances of bile salt hydrolase sequences, responsible for the initial deconjugation reaction in secondary bile acid metabolism. L. reuteri levels were also attributed to enrichment of mevalonate-dependent isopentenyl diphosphate (IPP) biosynthesis genes, a pathway that was also elevated in cirrhosis patients. These results extend the role of Lactobacilli in the AhR/intestinal axis and NAFLD progression as well as highlight the similarities between TCDD-elicited phenotypes in mice to human NAFLD. Collectively, these studies evaluated TCDD-elicited mechanisms involved in disruptions in host and microbial metabolism, highlighting the AhR's role in NAFLD progression.
Download or read book Regulation of Hepatic Drug Metabolism by the Interaction of Host and Gut Microbiome derived Bile Acids and Hepatic LncRNAs written by Joseph Leo Dempsey and published by . This book was released on 2020 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver is a critical organ for nutrient homeostasis and xenobiotic biotransformation. The gut microbiome regulates important host metabolic pathways in liver including xenobiotic metabolism and intermediary metabolism, such as the conversion of primary bile acids (BAs) into secondary BAs and is an important factor of healthy development. The nuclear receptors pregnane X receptor (PXR/NR1I2) and constitutive androstane receptor (CAR/Nr1i3) are well-known regulators for xenobiotic metabolism and disposition in liver. However, little is known regarding the age specificity of secondary BA metabolism or other microbial metabolites and the potential effects of PXR and CAR on the composition and function of the gut microbiome. Additionally, altered expression of long noncoding RNAs (lncRNAs) by environmental chemicals modulates the expression of xenobiotic metabolizing genes and transporters; yet little is known regarding how lncRNAs are regulated by PXR, affecting xenobiotic metabolism. Therefore, the goal of my dissertation was to use a multi-omics approach, including transcriptomics (RNA-seq), targeted metabolomics (UPLC-MS/MS for BAs and GC-MS/MS for short-chain fatty acids), targeted proteomics (LC-MS), and 16S rRNA gene sequencing as well as bioinformatics, to strategically investigate the modulation of hepatic xenobiotic metabolizing genes through gut microbiome-mediated, age-dependent, and transcriptional mechanisms. To achieve this goal, multi-omics analysis of various tissues were performed in male and female conventional (CV) and germ-free (GF) mice at various ages: postnatal days 1, 5, 10, 15, 25, 60, and 120. With increasing age, the gut microbiome in mice become more diverse and had increased functional capacity to produce secondary BAs, including the family S24-7. Twenty-seven bacteria were positively associated with secondary unconjugated, deoxy, and keto BAs with nine of these BAs only produced in CV mice. Short-chain fatty acids (SCFAs) were found in livers of CV mice only with six SCFAs increasing with age. Global analysis of hepatic RNA expression showed an age-specific enrichment of KEGG pathways, including xenobiotic metabolism for adult CV and GF mice. Differentially expressed drug-metabolizing enzymes and transporters exhibited age and sex specific expression patters with more genes differentially expressed with increasing age. Overall, the age-specific gut microbiome impacts host xenobiotic metabolism likely through circulation of metabolites (e.g. BAs and SCFAs). Inversely, to test how the liver (specifically PXR and CAR) regulates gut microbiota and secondary BA synthesis, nine-week-old male CV and GF mice were orally gavaged with corn oil, PXR agonist pregnenolone-16 alpha-carbonitrile (PCN; 75 mg/kg), or CAR agonist 1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene, 3,3' ,5,5' -tetrachloro-1,4 bis(pyridyloxy)benzene (TCPOBOP; 3 mg/kg) once daily for four days. PCN and TCPOBOP decreased two taxa in the Bifidobacterium genus, which corresponded with decreased gene abundance of the BA-deconjugating enzyme bile salt hydrolase (bsh). In liver and small intestinal content of GF mice, there was a TCPOBOP-mediated increase in total, primary, and conjugated BAs corresponding with increased Cyp7a1 mRNA. Bacteria from the genera Bifidobacterium, Dorea, Peptociccaceae, Anaeroplasma, and Ruminococcus positively correlated with T-UDCA in LIC, but negatively correlated with T-CDCA in serum. Therefore, PXR and CAR activation down-regulates BA-metabolizing bacteria in the intestine and modulates BA homeostasis in a gut microbiota-dependent manner. To understand how lncRNAs may impact hepatic xenobiotic metabolism, RNA-Seq was performed from livers of adult male C57BL/6 mice treated with corn oil, the PXR agonist PCN, or the CAR agonist TCPOBOP. PXR activation differentially regulated 193 lncRNAs with 40% also regulated by CAR. Among differentially expressed lncRNAs, the lncRNA-PCG pairs displayed a high co-regulatory pattern by PXR and CAR activation. Combining the RNA-Seq data with a published PXR ChIP-Seq dataset (Cui et al., 2010b), 774 expressed lncRNAs with direct PXR-DNA binding sites, and 26.8% of differentially expressed lncRNAs had changes in PXR-DNA binding following PCN exposure. Therefore, some lncRNAs are regulated by PXR and CAR activation and that they may be important regulators of xenobiotic metabolism. Taken together, there is an age-dependent interaction in the gut-liver axis that exhibits a circulatory patter such that BA homeostasis is both governed by both the gut microbiome and the host liver, with modifications to either biocompartment impacting the other biocompartment. Targeting the gut-liver axis and lncRNAs may lead to the design of novel therapies alleviated toxicities through control of hepatic xenobiotic metabolism.
Download or read book Human Maternal Obesity in the Development of Nonalcoholic Fatty Liver Disease in a Germ free Mouse Model written by Taylor Kristina Soderborg and published by . This book was released on 2019 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maternal metabolism and obesity contribute significantly to the risk of obesity and non-alcoholic fatty liver disease (NAFLD) in the next generation, however the causal drivers of this relationship are currently unclear. Metabolic diseases in the pediatric population pose a unique challenge as the mechanisms driving their onset and progression are hypothesized to be the result of programming by early life exposures in addition to lifestyle factors. The earlier onset of obesity and NAFLD in the pediatric population is associated with a worse natural history and progression of these conditions compared to adults. At the time of diagnosis, half of pediatric patients have the more progressive, inflammatory version of NAFLD, non-alcoholic steatohepatitis (NASH), and those diagnosed in childhood have a worse prognosis that adults. Despite the alarming rate of pediatric NAFLD worldwide, particularly in obese youth, at present there are no interventions that have convincingly demonstrated efficacy to alter the progression of this disease. Importantly, given the involvement of inflammation in pediatric NASH, as demonstrated by a unique periportal inflammation, it is likely that the pathogenesis of NAFLD in children may have distinct features from that in adults. Evidence of leaky gut barriers in children with NASH in addition to histological evidence portal inflammation, suggests that the early gut microbiome may play a significant role in pediatric NAFLD. Early life dysbiosis has been found in offspring of obese and/or high fat diet fed mothers in both human, non-human primate and murine models. Research in humans also suggests that excessive gestational weight gain (EWG) and gestational diabetes mellitus (GDM) can also influence offspring microbiome composition. However, there are very limited prospective human data on the influence of commonly co-morbid metabolic conditions, such as EWG and obesity, or, GDM and obesity, on offspring gut colonization. Importantly, while there is correlative data associating early dysbiosis with worse metabolic outcomes in human offspring, causality has not yet been established. Throughout the following work we build upon the existing knowledge of how maternal phenotype influences human offspring microbiome composition and develop mechanistic connections between the altered gut microbiota and metabolic disease risk in a germ-free mice model. We demonstrate in a germ-free mouse model a causative role for this dysbiosis in predisposition to obesity and NAFLD upon exposure to a western style diet. Specifically, we discovered that dysbiosis results in a hypo-responsive bone marrow derived macrophage with dysfunction of both classical and alternative metabolism in a germ-free mouse model. Similar to the influence of maternal obesity on the human infant gut microbiome, we find that EWG and GDM independently and through their interaction with obesity, uniquely influence the composition of the human offspring microbiome at 2 weeks of life. Our findings suggest that maternal metabolic phenotype influences the colonization of the early human infant gut with lasting alterations of the innate immune system, as suggested by our germ-free mouse model. These results expand upon the current understanding of how maternal metabolic obesity, EWG and GDM in humans influences the human offspring gut microbiome and also provide insight to the mechanism by which maternal obesity could potentially cause NAFLD, as demonstrated in germ-free mice. This work supports targeting the early life microbiome in the development of effective preventative measures to impair the perpetuation of metabolic disease in the next generation.
Download or read book Veterinary Herbal Medicine written by Susan G. Wynn and published by Elsevier Health Sciences. This book was released on 2006-11-29 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: This full-color reference offers practical, evidence-based guidance on using more than 120 medicinal plants, including how to formulate herbal remedies to treat common disease conditions. A body-systems based review explores herbal medicine in context, offering information on toxicology, drug interactions, quality control, and other key topics. More than 120 herbal monographs provide quick access to information on the historical use of the herb in humans and animals, supporting studies, and dosing information. Includes special dosing, pharmacokinetics, and regulatory considerations when using herbs for horses and farm animals. Expanded pharmacology and toxicology chapters provide thorough information on the chemical basis of herbal medicine. Explores the evolutionary relationship between plants and mammals, which is the basis for understanding the unique physiologic effects of herbs. Includes a body systems review of herbal remedies for common disease conditions in both large and small animals. Discusses special considerations for the scientific research of herbs, including complex and individualized interventions that may require special design and nontraditional outcome goals.
Download or read book Providing Healthy and Safe Foods As We Age written by Institute of Medicine and published by National Academies Press. This book was released on 2010-11-29 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.
Download or read book Taurine 11 written by Jianmin Hu and published by Springer Nature. This book was released on 2019-08-29 with total page 1081 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers a selection of original articles and critical reviews presented at the 21st International Taurine Meeting, held in Shenyang, China in May 2018, which discussed and disseminated the latest findings on taurine, especially in human life. The book is divided into eight parts, which respectively address: Taurine and Metabolism, Taurine and Nutrition, Taurine and Organ Dysfunction, Taurine and Heart Health, Taurine and Anti-cancer, Taurine and Anti-oxidation / Anti-microbial, Taurine and Neuroprotection, and Taurine and Anti-inflammatory. These latest discoveries concerning the functions and advantageous effects of taurine on the health of various human body systems will not only advance the treatment of human diseases and the quality of human life, but also promote further research into the applications of taurine in human health.
Download or read book Fiber Fueled written by Will Bulsiewicz, MD and published by Penguin. This book was released on 2020-05-12 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The instant New York Times, USA Today, and Publisher's Weekly bestseller A bold new plant-based plan that challenges popular keto and paleo diets, from an award-winning gastroenterologist. The benefits of restrictive diets like paleo and keto have been touted for more than a decade, but as renowned gastroenterologist Dr. Will Bulsiewicz, or "Dr. B," illuminates in this groundbreaking book, the explosion of studies on the microbiome makes it abundantly clear that elimination diets are in fact hazardous to our health. What studies clearly now show--and what Dr. B preaches with his patients--is that gut health is the key to boosting our metabolism, balancing our hormones, and taming the inflammation that causes a host of diseases. And the scientifically proven way to fuel our guts is with dietary fiber from an abundant variety of colorful plants. Forget about the fiber your grandmother used to take--the cutting-edge science on fiber is incredibly exciting. As Dr. B explains, fiber energizes our gut microbes to create powerhouse postbiotics called short-chain fatty acids (SCFAs) that are essential to our health. SCFAs are scientifically proven to promote weight loss, repair leaky gut, strengthen the microbiome, optimize the immune system, reduce food sensitivities, lower cholesterol, reverse type 2 diabetes, improve brain function, and even prevent cancer. Restrictive fad diets starve the gut of the critical fiber we need, weaken the microbes, and make our system vulnerable. As a former junk-food junkie, Dr. B knows firsthand the power of fiber to dramatically transform our health. The good news is that our guts can be trained. Fiber-rich, real foods--with fruits, vegetables, whole grains, seeds, nuts, and legumes--start working quickly and maintain your long-term health, promote weight loss, and allow you to thrive and feel great from the inside out. With a 28-day jumpstart program with menus and more than 65 recipes, along with essential advice on food sensitivities, Fiber Fueled offers the blueprint to start turbocharging your gut for lifelong health today.
Download or read book High Calorie Diet and the Human Brain written by Akhlaq A. Farooqui and published by Springer. This book was released on 2015-03-25 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this monograph is to present readers with a comprehensive and cutting edge description of neurochemical effects of diet (beneficial and harmful effects) in normal human brain and to discuss how present day diet promotes pathogenesis of stroke, AD, PD, and depression in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. A diet in sufficient amount and appropriate macronutrients is essential for optimal health of human body tissues. In brain, over-nutrition, particularly with high-calorie diet, not only alters cellular homeostasis, but also results in changes in the intensity of signal transduction processes in reward centers of the brain resulting in food addiction. Over-nutrition produces detrimental effects on human health in general and brain health in particular because it chronically increases the systemic and brain inflammation and oxidative stress along with induction of insulin resistance and leptin resistance in the brain as well as visceral organs. Onset of chronic inflammation and oxidative stress not only leads to obesity and heart disease, but also promotes type II diabetes and metabolic syndrome, which are risk factors for both acute neural trauma (stroke) and chronic age-related neurodegenerative and neuropsychological disorders, such as Alzheimer disease (AD), Parkinson disease (PD) and depression.
Download or read book Stockley s Herbal Medicines Interactions written by Elizabeth M. Williamson and published by . This book was released on 2009 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains data on over 150 of the most commonly used herbal medicines, dietary supplements and nutraceuticals.
Download or read book Fascinating Facts About Phytonutrients in Spices and Healthy Food written by Louis S. Premkumar and published by Xlibris Corporation. This book was released on 2014-03-25 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: For centuries, there have been claims that healthy food garnished with exotic spices and condiments provides vital nutrients that help ward off diseases, especially preventable diseases such as diabetes and heart disease (hypertension, coronary artery disease) and promote longevity. The purpose of writing this book is to update the public about the health benefits of ingredients (phytochemicals) in spices and healthy food using existing scientific evidence. The ultimate proof of health benefits will be deciphered by the isolation and identification of specific phytochemicals acting on specific receptors in the body exerting their biological effects. The important point being emphasized is that if the physiological effect of an ingredient is glaring, it is considered to elicit a significant response. However, when the effect of an ingredient is significant, yet the effect is not readily perceivable then the usefulness goes unnoticed and can be questioned as a myth. For example, coffee has several ingredients, but only caffeine acting on the adenosine receptors stimulates the central nervous system and promotes wakefulness. Similarly, the specific active ingredient in hot chili pepper, capsaicin, activates a member of a recently identified family of receptors called transient receptor potential (TRP) channels. TRP vanilloid 1 (TRPV1), which is involved in certain modalities of pain, promotes the release of hormones in the gastrointestinal (GI) tract. Although, the bioavailability of the active ingredients is low, it is important to realize that these ingredients can cause significant local effects in the GI tract by preventing cholesterol regeneration by subduing microbiota, inhibiting precancerous growth by promoting calcium influx and stimulating nerve endings to transmit information and to release of gut hormones that are involved in regulating a variety of functions including appetite and satiety.
Download or read book Osteosarcopenia written by Gustavo Duque and published by Elsevier. This book was released on 2022-03-04 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity. - Presents diagnostic and therapeutic tips that facilitate the design and implementation of new care pathways, impacting the wellbeing of our older population - Provides cross-disciplinary understanding by experts from the bone/osteoporosis field and the muscle/sarcopenia field - Covers muscle and bone biology, mesenchymal stem cells, age-related changes and cross-talk between muscle, fat and bone, falls and fracture risk, glucose metabolism, diagnosis, imaging, and genetics of osteosarcopenia
Download or read book Microbiome and Metabolome in Diagnosis Therapy and other Strategic Applications written by Joel Faintuch and published by Academic Press. This book was released on 2019-01-03 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiome and Metabolome in Diagnosis, Therapy, and Other Strategic Applications is the first book to simultaneously cover the microbiome and the metabolome in relevant clinical conditions. In a pioneering fashion, it addresses not only the classic intestinal environment, but also the oral, gastric, lung, skin and vaginal microbiome that is in line with the latest investigations. Nonbacterial microbiomes, such as fungi and viruses are not overlooked, and the plasma microbiome is also discussed. As plasma, brain, placenta, tumor cells, and other sterile fluids and tissues, are increasingly recognized to potentially host a microbiome, albeit a limited one, this is a timely resource. The book's editors were fortunate to have the input of renowned collaborators from nearly all continents. This is truly an international effort that brings the latest in the field to students and professionals alike. - Provides comprehensive coverage on diagnosis, therapy, pharmacotherapy and disease prevention in context of the microbiome and metabolome - Focuses on the proposed physiological or pathological conditions - Presents an up-to-date, useful reference
Download or read book Toxicology and Clinical Pharmacology of Herbal Products written by Melanie Johns Cupp and published by Springer Science & Business Media. This book was released on 2000-02-03 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The herbai medicine industry is growing at an astounding rate. Trade group estimates suggest that total sales exceeded $4 billion dollars in 1999. Herbai remedies are for sale not just in health food stores, but in supermar kets, drug stores, and even discount warehouses. Along with the proliferation in sales has come a proliferation ofinformation sources. Not all ofthe sources are equally reliable, or even intelligible. Traditional herbalists c1assify thistle and mugwort as "cholagogues," substances used to make the gallbladder con tract and release bile. Medical school graduates are unlikely to have ever heard the term, or even accept the notion that most right-sided abdominal pain is a result of diminished bile flow. Heroin and cocaine may not be the only drugs to come from plants, but a practicing physician or toxicologist might be forgiven for thinking so. In 1998, 1264 papers were published about cocaine and only 17 about kava kava, an abused herb that is not without toxic side effects. Unfortunately, the majority of the papers about kava kava were published in journals not found in ordi nary hospitallibraries. In recognition ofthis fact, and ofthe obvious need for a reliable reference work on herbai toxicology, The Toxicology and Clinical Pharmacology 0/ Herbal Products was an early addition to our new series in Forensie Science and Medicine. It is very badly needed.
Download or read book WHO Monographs on Selected Medicinal Plants written by World Health Organization and published by World Health Organization. This book was released on 1999 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second volume in a series of monographs which are intended to promote information exchange and international harmonised standards for the quality control and use of herbal medicines. It contains scientific information on 30 selected plants, and each entry includes a pharmacopoeial summary for quality assurance purposes, information on its clinical application and sections on contraindications, pharmacology, safety issues, and dosage forms. It provides two cumulative indexes with entries in alphabetical order by plant name and according to the plant material of interest.
Download or read book Medicinal Plants for Holistic Health and Well Being written by Namrita Lall and published by Academic Press. This book was released on 2017-09-27 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Plants for Holistic Health and Well-Being discusses, in depth, the use of South African plants to treat a variety of ailments, including tuberculosis, cancer, periodontal diseases, acne, postmacular hypomelanosis, and more. Plants were selected on the basis of their traditional use, and the book details the scientific evidence that supports their pharmacological and therapeutic potential to safely and effectively treat each disease. Thus, this book is a valuable resource for all researchers, students and professors involved in advancing global medicinal plant research. Many plants found in South Africa are also found in other parts of the world. Each chapter highlights plants from other worldwide locations so that scientists can study which plants belong to the same family, and how similar qualities can be used to treat a specific disease. - The book details the scientific evidence that supports their pharmacological and therapeutic potential to safely and effectively treat each disease - Each chapter highlights plants from worldwide locations so that scientists can study plants belonging to the same family, and how similar species can be used to treat a specific disease - Use of traditional medicine as an efficient means to identify and further investigate South African, similar plants and plant-derived compounds in modern drug discovery - Includes a number of chapters dedicated to using medicinal plants to treat various skin disorders, which is often not covered in other books on medicinal plants - Organized by specific diseases, with vital evidence-based data related to the bioactivity, pharmacological potential, chemical structure and safety information
Download or read book Handbook of Drug Monitoring Methods written by Amitava Dasgupta and published by Springer Science & Business Media. This book was released on 2007-10-23 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.
