Download or read book Inverse Control by Mirroring Joint Dynamics Within the Olivo cerebellar Complex written by Rodrigo Alvarez Icaza Rivera and published by Stanford University. This book was released on 2011 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this dissertation, I revisit Kawato's proposal, that the cerebellum predictively modulates descending motor commands, to achieve smooth and coordinated motion, by acquiring an inverse model of the biomechanical plant, and extend it by describing a novel and precise mapping between a cerebellar multizonal microcomplex and a joint's inverse model. This mapping renders two novel predictions: First, inferior olive's oscillations mirror the biomechanical joint's oscillations. Second, deep cerebellar neurons implement a gain factor, set by Purkinje cell inhibition, on inferior olive's signals to mirror the spinal cord's gain. I use biophysical modeling to show that oscillations within the inferior olive match the range of natural frequencies and damping ratios of biophysical joints, and that deep cerebellar neurons enable a multiplicative interaction between the Purkinje and the olivary pathways. Furthermore, I determine the effects of current injection into the inferior olive and the deep cerebellar nuclei and use these results within a control theory model to predict that experimentally disturbing the inferior olive will introduce motor output ringing, while disturbing the deep nuclei will also scale motor output. In both cases, manipulating the inverse model implemented by microzonal microcomplex will unmask the joint's natural dynamics as observed by motor ringing at the joint's natural frequency.
Download or read book Inverse Control by Mirroring Joint Dynamics Within the Olivo cerebellar Complex written by Rodrigo Alvarez Icaza Rivera and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this dissertation, I revisit Kawato's proposal, that the cerebellum predictively modulates descending motor commands, to achieve smooth and coordinated motion, by acquiring an inverse model of the biomechanical plant, and extend it by describing a novel and precise mapping between a cerebellar multizonal microcomplex and a joint's inverse model. This mapping renders two novel predictions: First, inferior olive's oscillations mirror the biomechanical joint's oscillations. Second, deep cerebellar neurons implement a gain factor, set by Purkinje cell inhibition, on inferior olive's signals to mirror the spinal cord's gain. I use biophysical modeling to show that oscillations within the inferior olive match the range of natural frequencies and damping ratios of biophysical joints, and that deep cerebellar neurons enable a multiplicative interaction between the Purkinje and the olivary pathways. Furthermore, I determine the effects of current injection into the inferior olive and the deep cerebellar nuclei and use these results within a control theory model to predict that experimentally disturbing the inferior olive will introduce motor output ringing, while disturbing the deep nuclei will also scale motor output. In both cases, manipulating the inverse model implemented by microzonal microcomplex will unmask the joint's natural dynamics as observed by motor ringing at the joint's natural frequency.
Download or read book The Cerebellum and Cognition written by and published by Academic Press. This book was released on 1997-10-02 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cerebellum and Cognition pulls together a preeminent group of authors. The cerebellum has been previously considered as a highly complex structure involved only with motor control. The cerebellum is essential to nonmotor functions, and recent research has revealed new medically important roles of the cerebellum and cognitive processes. - Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries - Comprehensive coverage of cerebellum in motor control and cognition - New developments regarding the cerebellum and motor systems - Therapeutic implications of cerebellar contributions to cognition - Preeminent group of contributors
Download or read book The Neural Control of Movement written by Patrick J. Whelan and published by Academic Press. This book was released on 2020-08-31 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: From speech to breathing to overt movement contractions of muscles are the only way other than sweating whereby we literally make a mark on the world. Locomotion is an essential part of this equation and exciting new developments are shedding light on the mechanisms underlying how this important behavior occurs. The Neural Control of Movement discusses these developments across a variety of species including man. The editors focus on highlighting the utility of different models from invertebrates to vertebrates. Each chapter discusses how new approaches in neuroscience are being used to dissect and control neural networks. An area of emphasis is on vertebrate motor networks and particularly the spinal cord. The spinal cord is unique because it has seen the use of genetic tools allowing the dissection of networks for over ten years. This book provides practical details on model systems, approaches, and analysis approaches related to movement control. This book is written for neuroscientists interested in movement control. Provides practice details on model systems, approaches, and analysis approaches related to movement control Discusses how recent advances like optogenetics and chemogenetics affect the need for model systems to be modified (or not) to work for studies of movement and motor control Written for neuroscientists interested in movement control, especially movement disorders like Parkinson's, MS, spinal cord injury, and stroke
Download or read book A Textbook of Neuroanatomy written by Maria A. Patestas and published by John Wiley & Sons. This book was released on 2016-02-17 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Newly revised and updated, A Textbook of Neuroanatomy, Second Edition is a concise text designed to help students easily master the anatomy and basic physiology of the nervous system. Accessible and clear, the book highlights interrelationships between systems, structures, and the rest of the body as the chapters move through the various regions of the brain. Building on the solid foundation of the first edition, A Textbook of Neuroanatomy now includes two new chapters on the brainstem and reflexes, as well as dozens of new micrographs illustrating key structures. Throughout the book the clinical relevance of the material is emphasized through clinical cases, questions, and follow-up discussions in each chapter, motivating students to learn the information. A companion website is also available, featuring study aids and artwork from the book as PowerPoint slides. A Textbook of Neuroanatomy, Second Edition is an invaluable resource for students of general, clinical and behavioral neuroscience and neuroanatomy.
Download or read book Stroke Syndromes 3ed written by Louis R. Caplan and published by Cambridge University Press. This book was released on 2012-07-12 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of dysfunction due to stroke, this revised edition remains the definitive guide to stroke patterns and syndromes.
Download or read book Permanent Present Tense written by Suzanne Corkin and published by Basic Books. This book was released on 2013-05-14 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1953, 27-year-old Henry Gustave Molaison underwent an experimental "psychosurgical" procedure -- a targeted lobotomy -- in an effort to alleviate his debilitating epilepsy. The outcome was unexpected -- when Henry awoke, he could no longer form new memories, and for the rest of his life would be trapped in the moment. But Henry's tragedy would prove a gift to humanity. As renowned neuroscientist Suzanne Corkin explains in Permanent Present Tense, she and her colleagues brought to light the sharp contrast between Henry's crippling memory impairment and his preserved intellect. This new insight that the capacity for remembering is housed in a specific brain area revolutionized the science of memory. The case of Henry -- known only by his initials H. M. until his death in 2008 -- stands as one of the most consequential and widely referenced in the spiraling field of neuroscience. Corkin and her collaborators worked closely with Henry for nearly fifty years, and in Permanent Present Tense she tells the incredible story of the life and legacy of this intelligent, quiet, and remarkably good-humored man. Henry never remembered Corkin from one meeting to the next and had only a dim conception of the importance of the work they were doing together, yet he was consistently happy to see her and always willing to participate in her research. His case afforded untold advances in the study of memory, including the discovery that even profound amnesia spares some kinds of learning, and that different memory processes are localized to separate circuits in the human brain. Henry taught us that learning can occur without conscious awareness, that short-term and long-term memory are distinct capacities, and that the effects of aging-related disease are detectable in an already damaged brain. Undergirded by rich details about the functions of the human brain, Permanent Present Tense pulls back the curtain on the man whose misfortune propelled a half-century of exciting research. With great clarity, sensitivity, and grace, Corkin brings readers to the cutting edge of neuroscience in this deeply felt elegy for her patient and friend.
Download or read book The Cerebellum as a Neuronal Machine written by John C. Eccles and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has had a three-fold origin, corresponding to the discoveries made by the three authors and their collaborators during the last few years - mostly since 1962. A most fruitful symposium on the cerebellum was held in Tokyo at the time of the International Physiological Congress in September 1965, and there was then formulated the project of writing this book so as to organize all this new knowledge and make it readily available, and to give opportunity for the con ceptual developments that may be seen in Chapters XI, XII and XV in particular. The present account of the physiological properties of the cerebellar cortex is based to a large extent on systematic investigations that were concerned with discovering the mode of operation of the constituent neuronal elements of the cerebellar cortex. This work was carried out in the Physiology Department of the Australian National University from 1963 to 1966 in collaboration with several visiting scientists - initially Drs. ANDERSEN, OscARssaN and VooRHOEVE and later Drs. LuNAs, SAsAKI and STRATA - to all of whom grateful thanks are extended for a great many of the figures, and even more significantly for the original and critical contributions that they made to so many aspects of this exploration into the mode of operation of the neural machinery of the cerebellar cortex.
Download or read book Oxford Textbook of Neurorehabilitation written by Volker Dietz and published by Oxford University Press, USA. This book was released on 2015 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the Oxford Textbooks in Clinical Neurology series, this textbook will provide the reader with an understanding of the theoretical underpinnings of neurorehabilitation, as well as a clear idea about how (and why) to approach treatment decisions in individual patients.
Download or read book Clinical Pathways in Stroke Rehabilitation written by Thomas Platz and published by Springer Nature. This book was released on 2021-01-14 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on practical clinical problems that are frequently encountered in stroke rehabilitation. Consequences of diseases, e.g. impairments and activity limitations, are addressed in rehabilitation with the overall goal to reduce disability and promote participation. Based on the available best external evidence, clinical pathways are described for stroke rehabilitation bridging the gap between clinical evidence and clinical decision-making. The clinical pathways answer the questions which rehabilitation treatment options are beneficial to overcome specific impairment constellations and activity limitations and are well acceptable to stroke survivors, as well as when and in which settings to provide rehabilitation over the course of recovery post stroke. Each chapter starts with a description of the clinical problem encountered. This is followed by a systematic, but concise review of the evidence (RCTs, systematic reviews and meta-analyses) that is relevant for clinical decision-making, and comments on assessment, therapy (training, technology, medication), and the use of technical aids as appropriate. Based on these summaries, clinical algorithms / pathways are provided and the main clinical-decision situations are portrayed. The book is invaluable for all neurorehabilitation team members, clinicians, nurses, and therapists in neurology, physical medicine and rehabilitation, and related fields. It is a World Federation for NeuroRehabilitation (WFNR) educational initiative, bridging the gap between the rapidly expanding clinical research in stroke rehabilitation and clinical practice across societies and continents. It can be used for both clinical decision-making for individuals and as well as clinical background knowledge for stroke rehabilitation service development initiatives.
Download or read book Development of the Cerebellum from Molecular Aspects to Diseases written by Hassan Marzban and published by Springer. This book was released on 2017-07-27 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.
Download or read book Computational Theories and Their Implementation in the Brain written by Lucia Vaina and published by Oxford University Press. This book was released on 2017 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: David Marr is known for his research on the brain in the late 60s and 70s, becoming one of the main founders of Computational Neuroscience when neuroscience was in its infancy. Written by distinguished contributors, this book evaluates the extent to which his theories are still valid and identifies areas that need to be altered.
Download or read book The olivo cerebellar system written by Egidio D'Angelo and published by Frontiers Media SA. This book was released on 2016-04-29 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last decades, investigations on the olivo-cerebellar system have attained a high level of sophistication, which led to redefinitions of several structural and functional properties of neurons, synapses, connections and circuits. Research has expanded and deepened in so many directions and so many theories and models have been proposed that an ensemble review of the matter is now needed. Yet, hot topics remain open and scientific discussion is very lively at several fronts. One major question, here as well as in other major brain circuits, is how single neurons and synaptic properties emerge at the network level and contribute to behavioural regulation via neuronal plasticity. Other major aspects that this Research Topic covers and discusses include the development and circuit organization of the olivo-cerebellar network, the established and recent theories of learning and motor control, and the emerging role of the cerebellum in cognitive processing. By touching on such varied and encompassing subjects, this Frontiers Special Topic aims to highlight the state of the art and stimulate future research. We hope that this unique collection of high-quality articles from experts in the field will provide scientists with a powerful basis of knowledge and inspiration to enucleate the major issues deserving further attention.
Download or read book Brain Mechanisms and Spatial Vision written by D.J. Ingle and published by Springer Science & Business Media. This book was released on 1984-12-31 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains chapters derived from a N. A. T. O. Advanced Study Institute held in June 1983. As the director of this A. S. I. it was my hope that some of the e1ectrophysiologists could express the potentialities of their work for perceptual theory, and that some perceptionists could speculate on the underlying "units" of perception in a way that would engage the imagination of physio logists. The reader will have to be the judge of whether this was achieved, or whether such a psychophysiological inter1ingua is still overly idealistic. It is clear that after the revolution prec~pitated by Hube1 and Weisel in understanding of visual cortical neurons we still have only a foggy idea of the behavioral output of any particular species of cortical detector. It was therefore particularly unfortunate that two persons who have made great strides in correlating interesting facets of cat cortical physio logy with human psychophysics (Max Cynader and Martin Regan of Dalhousie University) were unable to attend this meeting. Never theless, a number of new and challenging ideas regarding both spatial perception and cortical mechanisms are represented in this volume, and it is hoped that the reader will remember not only the individual demonstrations but the critical questions posed by the apposition of the two different collections of experimental facts. David Ingle April 1984 VII TABLE OF CONTENTS PREFACE V D. N. Lee and D. S. Young Visual Timing of Interceptive Action 1 J. J.
Download or read book Biomechanics and Motor Control written by Mark L. Latash and published by Academic Press. This book was released on 2015-10-06 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics and Motor Control: Defining Central Concepts provides a thorough update to the rapidly evolving fields of biomechanics of human motion and motor control with research published in biology, psychology, physics, medicine, physical therapy, robotics, and engineering consistently breaking new ground. This book clarifies the meaning of the most frequently used terms, and consists of four parts, with part one covering biomechanical concepts, including joint torques, stiffness and stiffness-like measures, viscosity, damping and impedance, and mechanical work and energy. Other sections deal with neurophysiological concepts used in motor control, such as muscle tone, reflex, pre-programmed reactions, efferent copy, and central pattern generator, and central motor control concepts, including redundancy and abundance, synergy, equilibrium-point hypothesis, and motor program, and posture and prehension from the field of motor behavior. The book is organized to cover smaller concepts within the context of larger concepts. For example, internal models are covered in the chapter on motor programs. Major concepts are not only defined, but given context as to how research came to use the term in this manner. - Presents a unified approach to an interdisciplinary, fragmented area - Defines key terms for understanding - Identifies key theories, concepts, and applications across theoretical perspectives - Provides historical context for definitions and theory evolution
Download or read book How the Brain Evolved Language written by Donald Loritz and published by Oxford University Press. This book was released on 2002-02-28 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: How can an infinite number of sentences be generated from one human mind? How did language evolve in apes? In this book Donald Loritz addresses these and other fundamental and vexing questions about language, cognition, and the human brain. He starts by tracing how evolution and natural adaptation selected certain features of the brain to perform communication functions, then shows how those features developed into designs for human language. The result -- what Loritz calls an adaptive grammar -- gives a unified explanation of language in the brain and contradicts directly (and controversially) the theory of innateness proposed by, among others, Chomsky and Pinker.
Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
