Download or read book Intrinsic Clocks written by Timo Partonen and published by Frontiers Media SA. This book was released on 2018-03-19 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Intrinsic Clocks" presents an array of current research activities on intrinsic clocks and their contributions to biology and physiology. It elucidates the current models for the intrinsic clocks, their molecular components and key mechanisms as well as the key brain regions and animal models for their behavioral analysis. It provides a timely view on how these clocks guide behavior, and how their disruption may cause depressive-like behavior and impairment in cognitive functions. Thereby, any specific method by which the mood-related functions of the intrinsic clocks might be influenced bears therapeutic potential and has clinical interest. The importance of some of these mechanisms was highlighted by the 2017 award of the Nobel Prize in Physiology or Medicine to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young for their discoveries of the genetic control of the daily biological rhythm. The key to the explanation was the discovery of transcription-translation feedback loops of the so-called “clock genes.”

Download or read book The Circadian Clock written by Urs Albrecht and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.

Download or read book The Analysis of Gene Expression Data written by Giovanni Parmigiani and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents practical approaches for the analysis of data from gene expression micro-arrays. It describes the conceptual and methodological underpinning for a statistical tool and its implementation in software. The book includes coverage of various packages that are part of the Bioconductor project and several related R tools. The materials presented cover a range of software tools designed for varied audiences.

Download or read book Chronobiology written by Jay C. Dunlap and published by Sinauer Associates Incorporated. This book was released on 2004 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of how solar- and lunar- related rhythms are governed by living pacemakers within organisms constitutes the scientific discipline of chronobiology. Few fields encompass the breadth of science that is associated with this subject, which is at the cutting edge of fields ranging from microbial genetics to ethology to treatment of human psychiatric illnesses. In order to recognise that no individual could do justice to the field in writing a comprehensive text, a group of experienced editors and contributors have collaborated to produce Chronobiology. Written in a clear style and fully illustrated to elucidate difficult points, the book assumes no previous background in neuroscience or maths and reduces technical terminology to a minimum. Examples from the real world and from current and classic research are included.

Download or read book Neuroendocrine Clocks and Calendars written by Francis J. P. Ebling and published by Springer Nature. This book was released on 2021-01-04 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores how daily and seasonal rhythmicity is generated, how these rhythms are synchronised by our environment, and how they regulate the neuroendocrine systems that impact our physiology and behaviour. The constraints of surviving in a seasonal environment have shaped human evolution and migration, have shaped our societies and cultures, and continue to influence our everyday lives, health and wellbeing. Identifying the mechanisms whereby seasonal rhythmicity is generated and regulates the brain and body is not only important for understanding the natural world and relevant to animal production, it also offers many insights into the human condition. Each chapter is written by an international expert in the field of chronobiology. A historical perspective on how research into photoperiodism and rhythmicity progressed is initially provided, but the main focus of this book is on the remarkable studies in the last few decades that have unravelled the molecular and cellular machinery underpinning circadian and circannual timing. Topics covered include the role of melatonin in communicating seasonal information to the brain and pituitary gland, the neuroanatomical pathways in mammals, birds and fish by which changes in photoperiod reach the hypothalamus, the role of glial cells (tanycytes) and thyroid hormone in seasonal rhythmicity, neuroplasticity across seasons, effects of changing day length on mood, regulation of “clock“ gene expression, and the role of the suprachiasmatic nucleus. This book will appeal to all students and researchers who wish to learn about current and past research on daily and seasonal rhythmicity. This is the tenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.

Download or read book Biological Timekeeping Clocks Rhythms and Behaviour written by Vinod Kumar and published by Springer. This book was released on 2017-02-15 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a concise, comprehensive and up-to-date account of fundamental concepts and potential applications of biological timekeeping mechanisms in animals and humans. It also discusses significant aspects of the organization and importance of timekeeping mechanisms in both groups. Divided into seven sections, it addresses important aspects including fundamental concepts; animal and human clocks; clock interactions; clocks and metabolism and immune functions; pineal, melatonin and timekeeping; and clocks, photoperiodism and seasonal behaviours. The book also focuses on biological clock applications in a 24x7 human society, particularly in connection with life-style associated disorders like obesity and diabetes. It is a valuable resource for advanced undergraduates, researchers and professionals engaged in the study of the science of biological timekeeping.

Download or read book What is Time written by G. J. Whitrow and published by Oxford University Press, USA. This book was released on 2003 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this engaging volume, Professor G. J. Whitrow (1912-2000) takes us on a good-humored and wide-ranging tour of the thing that clocks keep (more or less). He discusses how our ideas of time originated, and coaxes the layment to contemplate with pleasure the differences between cyclic, linear, biological, cosmic, and space-time, while providing frequent diversions into fascinating topics such as the Mayan calendar, the migration of birds, and the dances of bees. This reissue of the classic and authoritative What is Time? includes a new introduction by Dr J. T. Fraser, founder of the International Society for the Study of Time, and a bibliographic essay by Dr Fraser and Professor M. P. Soulsby of the Pennsylvania State University.

Download or read book Dopamine written by Nira Ben-Jonathan and published by CRC Press. This book was released on 2020-04-12 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule. Key Features: Explores the many different faces of dopamine as autocrine, paracrine and endocrine molecule Documents the adverse effects of antipsychotics on dopamine functions Reviews the many ways dopamine affects the cardiovascular, renal and reproductive systems Provides updates on receptor oligomerization and signaling Examines the role of dopamine in tumorigenesis Related Titles Jones, S. ed. Dopamine - Glutamate Interactions in the Basal Ganglia (ISBN 978-0-3673-8197-4) Luo, L. Principles of Neurobiology (ISBN 978-0-8153-4494-0) Sidhu, A. et al., eds. Dopamine Receptors and Transporters (ISBN 978-0-8247-0854-2)

Download or read book The Athlete s Clock written by Thomas W. Rowland and published by Human Kinetics. This book was released on 2011-04-15 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Athlete’s Clock: How Biology and Time Affect Sport Performance offers an engaging, interdisciplinary consideration of some of the most compelling questions in sport and exercise science. This unique text takes a broad look at the physiological clock, offering students, researchers, coaches, and athletes a unique approach to understanding how various aspects of time affect sport performance. The Athlete’s Clock explores the ways in which time and its relationship to athletic effort can optimize sport performance. Readers can investigate challenging questions such as these: •If physiological responses to training vary rhythmically throughout the day, what is the optimal time of day for training? •If a coach thinks that a high stroke count leads to a better time in a particular swim event, should the athlete go with it? Or is it better to stick to a more intuitively normal cadence? •Do endurance athletes consciously control their pacing, or are they under the control of unconscious processes within the central nervous system? •In what ways do aging and rhythmic biological variations over time control athletic performance? •Can athletes use cognitive strategies to subdue or overcome limits imposed by biological factors out of their control? Readers will find information on the mechanisms by which time influences physiological function—such as running speeds and muscle activation—and how those mechanisms can be used in extending the limits of motor activity. Chapter introductions cue readers to the ideas addressed in the chapter, and sidebars throughout present amusing or unusual examples of sport and timing within various contexts. In addition, take-home messages at the end of each chapter summarize important findings and research that readers may apply in their own lives. Addressing one of the most intriguing questions in sports, a conversational interview with athlete development expert, anthropologist, and sport scientist Bob Malina covers the timely topic of sport identification and talent development. The interview is an engaging discussion of how and when talent identification should take place and how talent development for young, promising athletes might proceed. The text also considers how time throughout one’s life span alters motor function, particularly in the later years. The Athlete’s Clock: How Biology and Time Affect Sport Performance blends physiological, psychological, and philosophical perspectives to provide an intelligent and whimsical look at the effects of timing in sport and exercise. This text seeks to provoke thought and further research that look at the relationship between biology, time, and performance as well as an understanding of and appreciation for the intricacies of human potential.

Download or read book Relativity written by Steve Adams and published by CRC Press. This book was released on 2017-06-30 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the essential principles and results of special relativity as required by undergraduates. The text uses a geometric interpretation of space-time so that a general theory is seen as a natural extension of the special theory. Although most results are derived from first principles, complex and distracting mathematics is avoided and all mathe

Download or read book The End of the Timeless God written by R. T. Mullins and published by Oxford University Press. This book was released on 2016-01-07 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: The claim that God is timeless has been the majority view throughout church history. However, it is not obvious that divine timelessness is compatible with fundamental Christian doctrines such as creation and incarnation. Theologians have long been aware of the conflict between divine timelessness and Christian doctrine, and various solutions to these conflicts have been developed. In contemporary thought, it is widely agreed that new theories on the nature of time can further help solve these conflicts. Do these solutions actually solve the conflict? Can the Christian God be timeless? The End of the Timeless God sets forth a thorough investigation into the Christian understanding of God and the God-world relationship. It argues that the Christian God cannot be timeless.

Download or read book Circadian Clocks written by Achim Kramer and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.

Download or read book Fish Physiology Behaviour and Physiology of Fish written by Katherine A. Sloman and published by Gulf Professional Publishing. This book was released on 2005-12-13 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, behaviour and physiology have been considered two separate fields of biology with the majority of available literature focusing on one or the other. Recently the need for a multidisciplinary approach to these topics has been realised, highlighted by some of the sessions to be held at the 2003 annual meeting of the Society for Integrative and Comparative Biology such as 'regulation of behaviour' and 'mechanisms of behaviour'. The proposed volume aims to bring together these disciplines in a comprehensive review of the available literature. Fish Physiology: Behaviour and Physiology of Fish will be novel in actively bridging these two areas of fish biology together and considering them as inextricably linked. The progression of chapters focuses on different aspects of the life history of a fish, from predator avoidance through to reproduction, each written by scientists currently bridging the gap between behaviour and physiology in their own specialised subdiscipline. Multidisciplinary and integrative research in fish biology Written by internationally recognized researchers Encompasses the whole life span of fish A wide variety of inter-related topics presented in a cohesive format

Download or read book Case Studies in Systems Biology written by Pavel Kraikivski and published by Springer Nature. This book was released on 2021-10-06 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides case studies that can be used in Systems Biology related classes. Each case study has the same structure which answers the following questions: What is the biological problem and why is it interesting? What are the relevant details with regard to cell physiology and molecular mechanisms? How are the details put together into a mathematical model? How is the model analyzed and simulated? What are the results of the model? How do they compare to the known facts of the cell physiology? Does the model make predictions? What can be done to extend the model? The book presents a summary of results and references to more relevant sources. The volume contains the classic collection of topics and studies that are well established yet novel in the systems biology field.

Download or read book Ca2 Signaling and Heart Rhythm written by Ming Lei and published by Frontiers Media SA. This book was released on 2016-07-25 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regulatory processes occur simultaneously within a cell. Yet, distinct signals can be resolved by local Ca2+ sensitive protein complexes and differential Ca2+ signal integration. In addition to its importance to normal cardiac function, such regulation is also crucial in disease conditions. Ca2+ is likely involved in ectopic cardiac rhythms in both atrial and ventricular tissues through generating triggered activity often appearing as delayed afterdepolarisations, particularly following cellular Ca overloading. Recent studies also implicate Ca2+ in Na+ channel expression and properties with consequences for conduction velocity and therefore arrhythmic substrate. At the cellular level, such regulation involves control of the activity of membrane ion channels and Ca2+ handling proteins. These in turn involve multiple extra- and intracellular signaling pathways. This e-book assembles review and original articles from experts in this field. It summarises major recent progress bearing on roles of Ca2+ in cardiac electrophysiological function encompassing both normal and abnormal cardiac function. These extend from physiological roles of Ca2+ signaling in pacemaker function, in particular generation of sino-atrial pacemaker potentials, to pathological roles of abnormal Ca2+ signaling in both atrial and ventricular arrhythmogenesis. It also seeks to bridge the gap between advances in basic science and development of new therapies.

Download or read book Targeting Leukocyte Trafficking Insights and Future Directions written by Helen Michelle McGettrick and published by Frontiers Media SA. This book was released on 2022-02-04 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Integrative and Functional Medical Nutrition Therapy written by Diana Noland and published by Springer Nature. This book was released on 2020-03-27 with total page 1088 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the application of the philosophy and principles of Integrative and Functional Medical Nutrition Therapy (IFMNT) in the practice of medicine, and the key role nutrition plays in restoring and maintaining wellness. The textbook provides an overview of recent reviews and studies of physiological and biochemical contributions to IFMNT and address nutritional influences in human heath overall, including poor nutrition, genomics, environmental toxicant exposures, fractured human interactions, limited physical movement, stress, sleep deprivation, and other lifestyle factors. Ultimately, this textbook serves to help practitioners, healthcare systems, and policy makers better understand this different and novel approach to complex chronic disorders. It provides the reader with real world examples of applications of the underlying principles and practices of integrative/functional nutrition therapies and presents the most up-to-date intervention strategies and clinical tools to help the reader keep abreast of developments in this emerging specialty field. Many chapters include comprehensive coverage of the topic and clinical applications with supplementary learning features such as case studies, take-home messages, patient and practitioner handouts, algorithms, and suggested readings. Integrative and Functional Medical Nutrition Therapy: Principles and Practices will serve as an invaluable guide for healthcare professionals in their clinical application of nutrition, lifestyle assessment, and intervention for each unique, individual patient.