Download or read book Integrated Cardiac Safety written by J. Rick Turner and published by John Wiley & Sons. This book was released on 2008-11-26 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The serious nature of cardiovascular adverse drug reactions occurring in patients makes assessment of a drug's cardiac safety profile a high priority during both development and post-approval monitoring. Integrated Cardiac Safety provides necessary guidance and methodology for professionals assessing cardiac safety of drugs throughout all stages of the drug's life, from discovery and development through postmarketing research. This self-contained, reader-friendly text is valuable to professionals in the pharmaceutical, biotechnology, and CRO industries, pharmacologists, toxicologists, government officials, and students.
Download or read book Cardiology An Integrated Approach written by Adel Elmoselhi and published by McGraw Hill Professional. This book was released on 2017-12-29 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: An innovative, cardiology-specific text that blends basic science with the fundamentals of clinical medicine A Doody’s Core Title for 2022! Cardiology: An Integrated Approach to Disease skillfully bridges the gap between the science and practice of medicine. This beautifully illustrated book seamlessly integrates the core elements of cell biology, anatomy, physiology, pharmacology, and pathology with clinical medicine. It is the perfect companion for medical students transitioning to their clinical years, as well as for practicing physicians who need a user-friendly update on the basic science underlying the practice of clinical medicine. Full-color design includes approximately 340 images and 40 tables Cases teach students how to apply principles to real-world patient situations The latest developments in the field are incorporated throughout the text End-of-chapter case-based questions with detailed explanations reinforce important concepts and assess understanding of the material
Download or read book Myocardial Protection written by Tomas A. Salerno and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myocardial protection is regarded as one of the most important, yet also most controversial aspects of cardiac surgery. There has been considerable improvement in myocardial protection strategies over recent years, utilising a variety of new approaches to treat cardiac diseases, and this text is intended to embrace the state of the art in this field. The book summarises the state of knowledge on all aspects of myocardial protection, including the latest in the treatment of cardiac diseases, robotics, pediatric surgery and the treatment of cardiac failure. Robotic surgery, valvular surgery, pediatric surgery and coronary surgery are all covered by renowned experts, producing a comprehensive, forward-looking view of the field of myocardial protection. This book should function to update physicians and surgeons interested in the field of cardiac surgery on the current state of knowledge on myocardial protection.
Download or read book Cardiovascular Safety in Drug Development and Therapeutic Use written by J. Rick Turner and published by Springer. This book was released on 2016-07-28 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: At a time when the field of cardiac safety is going through important changes, this unique book provides the rationale for, and cutting-edge explanations of, new regulatory landscapes that will likely govern cardiac safety assessments globally for the foreseeable future. Exposure-response modeling is already being accepted by regulatory agencies in lieu of the traditional Thorough QT/QTc Study, and the Comprehensive in vitro Proarrhythmia Assay initiative is well under way. Developments in the field of cardiovascular safety are also described and discussed in the book. These include the search for more efficient ways to exonerate new drugs for type 2 diabetes from an unacceptable cardiovascular liability, how best to address off-target blood pressure increases induced by noncardiovascular drugs, and the continued evolution of the discipline of Cardio-oncology. “a resource that will likely serve as a standard for years to come” - Dr Jonathan Seltzer Therapeutic Innovation & Regulatory Science, 2017;51(2):180 “I have no hesitation in recommending this book as a valuable reference source” - Dr Rashmi Shah Journal for Clinical Studies, 2017;9(1):62-63
Download or read book Strategies to Improve Cardiac Arrest Survival written by Institute of Medicine and published by National Academies Press. This book was released on 2015-09-29 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac arrest can strike a seemingly healthy individual of any age, race, ethnicity, or gender at any time in any location, often without warning. Cardiac arrest is the third leading cause of death in the United States, following cancer and heart disease. Four out of five cardiac arrests occur in the home, and more than 90 percent of individuals with cardiac arrest die before reaching the hospital. First and foremost, cardiac arrest treatment is a community issue - local resources and personnel must provide appropriate, high-quality care to save the life of a community member. Time between onset of arrest and provision of care is fundamental, and shortening this time is one of the best ways to reduce the risk of death and disability from cardiac arrest. Specific actions can be implemented now to decrease this time, and recent advances in science could lead to new discoveries in the causes of, and treatments for, cardiac arrest. However, specific barriers must first be addressed. Strategies to Improve Cardiac Arrest Survival examines the complete system of response to cardiac arrest in the United States and identifies opportunities within existing and new treatments, strategies, and research that promise to improve the survival and recovery of patients. The recommendations of Strategies to Improve Cardiac Arrest Survival provide high-priority actions to advance the field as a whole. This report will help citizens, government agencies, and private industry to improve health outcomes from sudden cardiac arrest across the United States.
Download or read book Pearson s Thoracic Esophageal Surgery written by G. Alexander Patterson and published by Churchill Livingstone. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published as two individual books in its previous editions, this acclaimed reference now comes to you as one comprehensive two-volume resource, covering the entire range of esophageal and thoracic surgery for adults and children. Sixty nine brand-new chapters and 92 new authors deliver state-of-the-art, clear how-to-do-it guidance on the latest surgical techniques for the treatment of lung infections, lung cancer, benign conditions, trauma, reflux, and more-so you can effectively manage every common and uncommon condition you encounter. A new full-color design presents outstanding visual guidance that shows you exactly how to proceed, and a logical organization throughout makes reference easy. As an Expert Consult title, this thoroughly updated 3rd edition comes with access to the complete contents online, fully searchable-enabling you to consult it rapidly from any computer with an Internet connection. Addresses all surgical diseases of the chest wall, chest cavity, upper airway, lungs, pleura, and diaphragm in adults and children, giving you the comprehensive coverage you need for the patients you see. Presents clinical commentary at the end of each chapter that offers you a variety of viewpoints regarding the pros, cons, and complications associated with the techniques used to treat a patient.
Download or read book Diseases of the Aorta written by Robert S. Dieter and published by Springer Nature. This book was released on 2019-08-27 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines various aspects of the aorta, both healthy and diseased states, in 40 chapters of in-depth research by experts in cardiovascular disease. It begins with chapters on the embryology, anatomy, genetics, and physiology of the aorta along with imaging studies used to visualize its structure. The bulk of the book focuses on acute and chronic disorders such as coarctation of the aorta, inflammatory and connective tissue disorders, acute aortic thrombosis, infections, tumors, related ocular diseases, and various aneurysms and fistulas. In addition, it explores aortic disease in pregnancy, fetal aortic disorders, and aortic trauma in children. The book highlights the epidemiology and natural history as well as medical, endovascular, and surgical treatments for each disease. It also discusses valve repair, 3D printing applications, and the role of multidisciplinary aortic centers. Diseases of the Aorta is an indispensable and authoritative resource for cardiologists, cardiovascular surgeons, interventional radiologists, radiologists, and vascular medicine specialists.
Download or read book Predictive ADMET written by Jianling Wang and published by John Wiley & Sons. This book was released on 2014-02-28 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.
Download or read book Guidelines for Cardiac Rehabilitation and Secondary Prevention Programs written by American Association of Cardiovascular & Pulmonary Rehabilitation and published by Human Kinetics. This book was released on 2004 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition addresses the cost effectiveness of interventions that educate and motivate patients to assume personal responsibility for long-term disease prevention.
Download or read book Cardiovascular Disability written by Institute of Medicine and published by National Academies Press. This book was released on 2010-12-04 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Download or read book Interventional Cardiac Electrophysiology written by Ralph J. Damiano, Jr., MD, FACC, FACS and published by Cardiotext Publishing. This book was released on 2015-05-15 with total page 1046 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interventional Cardiac Electrophysiology is the first and only comprehensive, state-of-the-art textbook written for practitioners in multiple specialties involved in the care of the arrhythmia patient. Encompassing the entire field of interventional therapy for cardiac rhythm management, from basic science to evidence-based medicine to future directions, topics include: Technology and Therapeutic Techniques – EP techniques; imaging and radiologic technology; device and ablation technology; drug therapy.Interventional Electrophysiologic Procedures – Diagnostic and physiologic EP techniques; mapping in percutaneous catheter and surgical EP procedures; catheter and surgical ablation; device implantation and management.Clinical Indications and Evidence-based Outcomes Standards – For medical and surgical EP interventions for arrhythmias.New Directions in Interventional Electrophysiology – Hybrid therapy for atrial and ventricular arrhythmias and staged therapy. This book will be essential reading for clinicians and researchers that form the health care team for arrhythmia patients: cardiologists, adult and pediatric clinical electrophysiologists, interventional electrophysiologists, cardiac surgeons practicing arrhythmia surgery, allied health care professionals, pharmacologists, radiologists and anesthesiologists evaluating arrhythmia patients, and basic scientists from the biomedical engineering and experimental physiology disciplines. Professor Sanjeev Saksena has been involved in this arena for over three decades and has brought his experience to this textbook, assembling editorial leadership from medical and surgical cardiology to provide a global perspective on fundamentals of medical practice, evidence-based therapeutic practices, and emerging research in this field. This book includes 95 videos.
Download or read book The Management of Metastatic Triple Negative Breast Cancer An Integrated and Expeditionary Approach written by Katarzyna Rygiel and published by Bentham Science Publishers. This book was released on 2023-12-20 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference is a timely exploration of two vital aspects of triple-negative breast cancer. The volume offers a holistic perspective and empowering patients to navigate the challenges of triple-negative breast cancer (TNBC) with knowledge and confidence. Understanding Ethnic Disparities and Targeted Therapies: This section provides a critical overview of the ethnic disparities and the latest targeted therapies available for patients facing advanced or metastatic triple-negative breast cancer (TNBC). Empowering Patients and Enhancing Communication: This section dives into the essential role of patient education, empowerment, effective communication with medical teams, and psychological or supportive approaches, providing invaluable insights into managing advanced or metastatic breast cancer (BC). Key Features: Introduces a groundbreaking perspective on the TNBC journey, encouraging patients to view their battle with the disease as an opportunity to leverage modern pharmacological advancements and psychological support for improved outcomes. Bridges the gap between clinical or research-related aspects of BC management and the personal needs and expectations of patients, promoting a more holistic approach. Invites perspectives from a wide range of medical professionals, from oncologists and cardiologists to psychologists and nurses, to engage in open dialogues with patients, offering practical education and crucial support. Provides a wealth of helpful resources (including an appendix) for both patients and their medical caregivers, fostering a comprehensive and supportive approach to managing TNBC. This book is an informative resource for medical professionals, researchers, and patients, who want to understand the complexities of triple-negative breast cancer and apply current knowledge in their clinical and caregiving practice.
Download or read book Principles of Safety Pharmacology written by Michael K. Pugsley and published by Springer. This book was released on 2015-06-19 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Download or read book Drug Discovery Toxicology written by Yvonne Will and published by John Wiley & Sons. This book was released on 2016-03-22 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
Download or read book A Comprehensive Guide to Toxicology in Preclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2012-11-02 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics --
Download or read book The Handbook of Medicinal Chemistry Principles and Practice written by Simon E Ward and published by Royal Society of Chemistry. This book was released on 2023-02-03 with total page 1051 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2nd edition of The Handbook of Medicinal Chemistry is a carefully curated compilation of writing from global experts. Using their broad experience of medicinal chemistry, project leadership and drug discovery from both industry, academic and charity perspectives they are able to provide unparalleled insight into the field in a single, invaluable volume.
Download or read book Systems Medicine written by and published by Academic Press. This book was released on 2020-08-24 with total page 1571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information
