Download or read book Insights into Human Neurodegeneration Lessons Learnt from Drosophila written by Mousumi Mutsuddi and published by Springer Nature. This book was released on 2019-12-05 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.

Download or read book Life Extension written by Alexander M. Vaiserman and published by Springer. This book was released on 2015-06-09 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

Download or read book Unraveling Neurodegeneration Insights from the Drosophila Model written by 1st Veer Bhan, 1st and published by . This book was released on 2023-10-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative illnesses like Alzheimer's, Parkinson's, and ALS are devastatingconditions without cures. As populations age, these diseases are rising globally, creating anurgent need for insights into their mechanisms and treatments. The common fruit flyDrosophila melanogaster has emerged as a remarkably versatile model system to studyneurodegeneration. With a complex yet accessible nervous system, ease of geneticmanipulation, and conserved disease-related genes, the fly provides a powerful platform fordissecting the intricate biology underlying these disorders.This book provides a comprehensive overview of Drosophila neurodegeneration researchspanning over four decades. It introduces the genetics and prevalence of majorneurodegenerative diseases, along with the advantages of the fly model. Detailed case studieshighlight seminal findings from Drosophila models of Alzheimer's, Parkinson's, and ALSdiseases. The book explores cellular pathways implicated in neurodegeneration, includingprotein misfolding, oxidative stress, mitochondrial dysfunction, and neuroinflammation. Itdiscusses techniques for genetic manipulation, behavioral assays, and drug screening in flies.Emerging technologies like CRISPR/Cas9 genome editing are enabling new horizons.Importantly, the book examines therapeutic approaches informed by fly studies, such asTargeting neuroprotective genes and disease-modifying factors. It also covers ethicalconsiderations around animal research and the need for thoughtful public engagement. Thebook concludes by underscoring unanswered questions and future research directions, whileemphasizing the importance of collaborative, translational research in bringing treatmentsfrom bench to bedside.

Download or read book Altered Metabolism A Major Contributor of Comorbidities in Neurodegenerative Diseases written by Namita Agrawal and published by Springer Nature. This book was released on with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Genetics of Axial Patterning Growth and Disease in Drosophila Eye written by Amit Singh and published by Springer Nature. This book was released on 2020-05-18 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.

Download or read book Handbook of Animal Models in Neurological Disorders written by Colin R Martin and published by Elsevier. This book was released on 2022-11-29 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Animal Models in Neurological Disorders will better readers' understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction. - Summarizes animal models for a variety of neurological conditions - Contains chapter abstracts, key facts, a dictionary and a summary - Covers both neurodegenerative diseases and other neurological conditions - Compares and contrasts different models and experimental systems - Includes sections on Alzheimer's, Parkinson's, brain injury, migraine, multiple sclerosis, and more

Download or read book Anti Aging Drug Discovery on the Basis of Hallmarks of Aging written by Sandeep Kumar Singh and published by Academic Press. This book was released on 2022-07-19 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals. - Covers different aspects of anti-aging research, from foundational knowledge to future perspectives - Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs - Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others

Download or read book Transcriptome Profiling written by Mohammad Ajmal Ali and published by Elsevier. This book was released on 2022-10-07 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcriptome Profiling: Progress and Prospects assists readers in assessing and interpreting a large number of genes, up to and including an entire genome. It provides key insights into the latest tools and techniques used in transcriptomics and its relevant topics which can reveal a global snapshot of the complete RNA component of a cell at a given time. This snapshot, in turn, enables the distinction between different cell types, different disease states, and different time points during development. Transcriptome analysis has been a key area of biological inquiry for decades. The next-generation sequencing technologies have revolutionized transcriptomics by providing opportunities for multidimensional examinations of cellular transcriptomes in which high-throughput expression data are obtained at a single-base resolution. Transcriptome analysis has evolved from the detection of single RNA molecules to large-scale gene expression profiling and genome annotation initiatives. Written by a team of global experts, key topics in Transcriptome Profiling include transcriptome characterization, expression analysis of transcripts, transcriptome and gene regulation, transcriptome profiling and human health, medicinal plants transcriptomics, transcriptomics and genetic engineering, transcriptomics in agriculture, and phylotranscriptomics. - Presents recent development in the tools and techniques in transcriptomic characterization - Integrates expression analysis of transcripts and gene regulation - Includes the application of transcriptomics in human health, genetic engineering and agriculture

Download or read book Reproductive and Developmental Toxicology written by Ramesh C Gupta and published by Academic Press. This book was released on 2011-04-04 with total page 1243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife. - Provides a complete, integrated source of information on the key risk stages during reproduction and development - Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment - Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Download or read book Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America written by Agustín Ibáñez and published by Frontiers Media SA. This book was released on 2018-06-21 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Download or read book Drosophila melanogaster written by Farzana Khan Perveen and published by BoD – Books on Demand. This book was released on 2018-02-28 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.

Download or read book Drosophila Melanogaster Models of Motor Neuron Disease written by Ruben J. Cauchi and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motor neuron diseases are the most catastrophic of neurodegenerative disorders. The cognitive function is spared, but the motor neuron degeneration translates into progressive muscle weakness and paralysis that propel the afflicted patient to eventual death. Neurodegenerative disorders constitute one of the major challenges of modern medicine in view of the current lack of effective therapies. The fruit fly, Drosophila melanogaster, has a distinguished history as an important model organism capable of shaping our fundamental understanding of life. Remarkably, the vast majority of all known human disease genes have a similar fly counterpart and at the molecular and physiological level, the basic principles of neuromuscular function are amazingly conserved between humans and Drosophila. Combine this with the presence of numerous genetic tools developed over the last century allowing genes and the proteins they encode to be manipulated swiftly to decipher their in vivo function and you have a superb genetic animal model organism of disease.This publication singles out the past and recent accomplishments of Drosophila in modelling motor neuron disease including amyotrophic lateral sclerosis (Lou Gehrigs disease), hereditary spastic paraplegias, Charcot-Marie-Tooth disease, spinal and bulbar muscular atrophy (Kennedys disease) and spinal muscular atrophy. The emphasis is on recent developments including the emerging molecular pathways underpinning these disorders. Genetic screens aimed at identifying novel genes that cause motor neuron degeneration or finding modifiers of the phenotype resulting from the disruption of disease-causative genes are also tackled. Importantly, this collection provides an inspiring look at the indispensability of the fruit fly, and of model organisms in general, to neuroscience research.

Download or read book Drosophila as a model to study Neurodegenerative diseases written by Udai Pandey and published by Frontiers Media SA. This book was released on 2023-09-27 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Physiological Systems in Insects written by Marc J. Klowden and published by Academic Press. This book was released on 2022-09-24 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiological Systems in Insects, Fourth Edition explores why insects have become the dominant animals on the planet. Sections describe the historical investigations that have led us to our current understanding of insect systems. Integrated within a basic physiological framework are modern molecular approaches that provide a glimpse of the genetic and evolutionary frameworks that testify to the unity of life on earth. This updated edition describes advances that have occurred in our understanding of hormone action, metamorphosis, and reproduction, along with new sections on the role of microbiomes, insecticide action and its metabolism, and a chapter on genetics, genomics and epigenetic systems. The book represents a collaborative effort by two internationally known insect physiologists who have instructed graduate courses in insect physiology. As such, it is the ideal resource for entomologists and those in other fields who may require knowledge of insect systems. - Presents updated information on key physiological principles - Covers detailed and instructive figures for visual enhancement - Provides flowing text without the interruption of citations - Includes evolutionary considerations throughout, also providing a discussion on the implications of molecular techniques and discoveries - Encourages further reading with a complete bibliography at end of each chapter

Download or read book Handbook of Computational Neurodegeneration written by Panagiotis Vlamos and published by Springer Nature. This book was released on 2023-07-25 with total page 1031 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Computational Neurodegeneration provides a comprehensive overview of the field and thus bridges the gap between standard textbooks of research on neurodegeneration and dispersed publications for specialists that have a narrowed focus on computational methods to study this complicated process. The handbook reviews the central issues and methodological approaches related to the field for which the reader pursues a thorough overview. It also conveys more advanced knowledge, thus serving both as an introductory text and as a starting point for an in-depth study of a specific area, as well as a quick reference source for the expert by reflecting the state of the art and future prospects. The book includes topics that are usually missing in standard textbooks and that are only marginally represented in the specific literature. The broad scope of this handbook is reflected by five major parts that facilitate an integration of computational concepts, methods and applications in the study of neurodegeneration. Each part is intended to stand on its own, giving an overview of the topic and the most important problems and approaches, which are supported by examples, practical applications, and proposed methodologies. The basic concepts and knowledge, standard procedures and methods are presented, as well as recent advances and new perspectives.

Download or read book Neurodegenerative Diseases written by M. Flint Beal and published by Cambridge University Press. This book was released on 2005-06-02 with total page 1009 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

Download or read book Model Cases written by Monika Krause and published by University of Chicago Press. This book was released on 2021-09-03 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: We all know scientists study a predictable set of organisms when performing research, whether they be mice, fruit flies, or less commonly known but widely used species of snail or worm. But when we think of the so-called humanistic social sciences, we envision a different kind of research attuned to historical power relations or the unique experiences of a social group. In Model Cases, sociologist Monika Krause uncovers the ways the humanities and social sciences are shaped by and dependent on a set of canonical research objects of their own, often in unacknowledged ways. Krause shows that some research objects are studied repeatedly and shape the understanding of more general categories in disproportionate ways. For instance, Chicago comes to be the touchstone for studies of the modern city, or Michel Foucault's analysis of Bentham's prison a guiding light for understanding contemporary power relations. Moving through classic cases in the social sciences, Krause reveals the ways canonical examples and sites have shaped research and theory, showing how they can both help and harm the production of knowledge. In the end, she argues, model cases have great potential to serve scholarship--as long as they are acknowledged and examined with acuity.