Download or read book Infectious Complications in Cancer Patients written by Valentina Stosor and published by Springer Science & Business Media. This book was released on 2014-04-05 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: While advances in both the treatment of cancer and the management of its complications have led to significant improvement in patient survival, infections remain a significant cause of morbidity and mortality in patients with neo plastic disease. In this patient population, infection risk results from a complex interplay between the host’s underlying immunodeficiencies, local tumor effects and treatment-induced immunosuppression. New chemotherapeutic approaches and antimicrobial prophylaxis and treatment practices continue to shape the spectrum of infections in these patients. Clinicians who treat infections in cancer patients are continually challenged by the emergence of new pathogens and by the increasing antimicrobial resistance of established ones. The aim of this book is to emphasize unique aspects of management of infectious diseases in the cancer patient. With the increasing complexity of this patient population, optimal management requires a multidisciplinary approach and this fact is fully reflected in the contributions, all from recognized authorities in the field. Ultimately, it is hoped that this volume will assist specialists in infectious diseases and haematology/oncology in the diagnosis, management and prevention of infection and optimization of the overall care of patients with malignancies.

Download or read book Infectious Complications of Cancer written by J. Klastersky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the major developments in the therapeutic armamentarium for the treatment of infection, the morbidity and mortality of this complication remains very high in patients with compromised defences. Cancer and its treatment represents a major predisposing condition to a variety of infections. These adverse events are still with us, in spite of much progress in the therapy of infectious disease, since cancer therapy is becoming more aggressive, yet further lowering the host's capacity to cope with infections. Moreover, the pathogens adapt effectively to drugs, and at a pace that might outrun industry's capability to produce new agents. Finally, new pathogens are appearing as a consequence of both selection and severe immunosuppression. Infection is so common among cancer patients that its diagnosis and management represent a daily challenge to all oncologists, who must continually strive to keep abreast of developments in the area. The present comprehensive review of the most crucial and challenging aspects of the infectious complications in cancer patients will help them to do just that.

Download or read book Management of Infectious Complication in Cancer Patients written by Gary A. Noskin and published by Springer. This book was released on 2007-11-23 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infection is a major cause of morbidity and mortality in patients with neoplastic disease because of compromised host defenses. These defects result in an increased risk of infection and its complications. The nature of the underlying malignancy, the immunodeficiencies associated with it, and the treatments directed against it are all important determinants of infection. In recent years, the introduction of more intensive chemotherapeutic regimes and the widespread use of bone marrow and peripheral stem cell transplantation have changed the pattern of infection in many patients. Furthermore, the increasing use of central venous access devices and antimicrobial prophylaxis has changed the epidemiology of infection in these patients as well. The goal of this volume in the Cancer Treatment and Research series is to emphasize that while the management of infection in cancer patients is common, it is constantly changing. With the increasing complexity of these patients, optimal management requires a multidisciplinary approach. Ultimately, it is hoped that this book will assist clinicians in the diagnosis, management, and prevention of infection in order to optimize care for patients with cancer.

Download or read book Infection in the Cancer Patient written by R A J Spence and published by Oxford University Press. This book was released on 2006-10-12 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infection in the cancer patient is extremely common, either precipitated by the cancer itself or by the cancer therapies. Virtually all cancer patients develop an infection during their illness, often life-threatening and requiring urgent treatment. This book decribes the presentation and management of all infections met by the clinician.

Download or read book Principles and Practice of Cancer Infectious Diseases written by Amar Safdar and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Practice of Cancer Infectious Diseases is a comprehensive and insightful work dedicated to elucidating the problem of infections in cancer patients. This essential volume reviews common and less often encountered infections, while establishing the difficulties behind preventing, diagnosing, and treating infectious diseases in cancer patients. Key sections are devoted to the presentation of clinical symptoms and the identification of major etiologic agents. A cadre of leading clinicians provide a detailed assessment of the risk factors for various infections, critical strategies in preventing and managing infections, and study of the interactions between the pathogen and host's immune function and inflammatory response. With its in-depth knowledge and concise treatment of the distinct facets of infections in cancer patients, this volume is an indispensible tool for all infectious disease specialists and clinical oncologists.

Download or read book Infectious Complications of Cancer Therapy written by and published by . This book was released on 1996 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Infectious Complications of Neoplastic Disease written by Arthur E. Brown and published by Butterworth-Heinemann. This book was released on 1985 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oral Complications of Cancer Therapies written by and published by . This book was released on 1989 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizes conference discussions of types and incidence of oral complications that most frequently occur with cancer therapies, pre-treatment strategies to minimize complications, strategies for treatment during chemotherapy, and recommendations for patient treatment.

Download or read book Oral Complications of Cancer Chemotherapy written by Douglas E. Peterson and published by Springer Science & Business Media. This book was released on 1983-03-31 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new work on oral complications of cancer chemotherapy is edited by two dentists who have made pioneering contributions in this previously neglected area. Their efforts have established the invaluable role of the dentist in oncologic research and cancer patient management. The editors have collected nine chapters that will be of interest to dentists and dental hygienists, oncology nurses, and all physicians treating cancer patients with chemo therapeutic agents. Background chapters on oral complications of cancer chemotherapy, the pharmacology of chemotherapeutic agents, and principles of infection management and prevention set the stage for more specific chapters focusing on prevention and treatment of chemotherapy induced oral and dental disorders. Valuable contributions to the supportive care of the cancer patient are contained in this book. A full comprehension of this book, coupled with an appreciation for advances in other areas of supportive care, such as antiemetic therapy and pain control, will allow all those involved in cancer treatment to be more successful. Peter H. Wiernik, M.D. Emil Frei, M.D.

Download or read book Infectious Complications of Cancer Therapy written by John N. Greene and published by . This book was released on 1996 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Complications of Cancer written by Martin D. Abeloff and published by . This book was released on 1979 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Since successful cancer therapy depends on effective communication between health care personnel and patients, a practical approach to medical and surgical problems is presented. Fear of cancer can be managed. Cancer treatment centers provide management in the form of medical care, nutritional support, physical rehabilitation, and control of pain. Care of the cancer patient may involve surgery, radiation therapy and chemotherapy. Diagnosis, pathogenesis and complications of cancer are discussed. Problems accompanying cancer treatment include metastases and therapeutic side-effects. Oncologic abnormalities may accur in blood, bone, pleural and pericardical cavities, kidney, and central nervous system. Consequences of cancer, such as infection and ectopic hormone syndromes, are described.

Download or read book Infectious Complications in Bone Marrow Transplantation written by Stephen C. Schimpff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the demographics of the population shift toward an increasingly aged society, the number of individuals with cancer increases and with it the need to give the most comprehensive possible health care delivery. Although much has been written about the specific therapy best suited for the various types of cancer and about the basic and clinical research which has dramatically improved treat ment, overall patient care requires attention to supportive care, which includes such items as pain management, the use of blood products, nutrition, and psychosocial needs. Yet infection remains the leading cause of death in cancer patients and is a major cause of morbidity and hospitaliza tion, making it a major aspect of the supportive care of cancer patients. It therefore deserves a full exposition. Bone marrow transplantation is increasingly being utilized as part of a therapeutic modality in the treatment of cancer patients. Transplantation patients are at such a particularly high risk of developing a wide variety of different types of infection, that they inevitably can serve as an excellent framework for discussion of all the types of infections that occur during the treatment of cancer. The patient undergoing allogeneic bone marrow transplantation is at particularly high risk of infection due to the major perturbations of host defenses, which include granulo cytopenia, cellular immune dysfunction, humoral immune dysfunction, blood product transfusions, and vascular access devices. Each of these perturbations results in a different set of infectious disease problems.

Download or read book Infectious Complications in the Cancer Patient written by Gerald P. Bodey and published by . This book was released on 1977 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Infections in Cancer Patients written by Jean Klastersky and published by . This book was released on 1982 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Role of Infectious Complications in Children with Cancer written by Jaana Rahiala and published by . This book was released on 2000 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Infectious Complications of Neoplastic Disease written by Arthur E. Brown and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Postoperative Infectious Complications Accelerate Tumor Reoccurence and Mestastasis as a Result of Circulating Tumor Cell Interactions with Neutrophil Extracellular Traps written by Jonathan Cools-Lartigue and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Surgery remains the cornerstone of curative intent therapy for cancer patients. However, a significant proportion of patients will suffer postoperative infectious complications, which are associated with an increased risk of tumor recurrence and death from metastasis. Mitigating the adverse oncologic outcomes associated with postoperative infectious complications is not a reality in clinical practice, in part because the mechanisms underlying this phenomenon are poorly understood. Emerging evidence suggests that neutrophils can facilitate cancer progression. Neutrophil extracellular traps (NET's) are extracellular neutrophil-derived DNA webs actively released in response inflammatory cues to trap and kill invading pathogens. The role of NETs in cancer progression is unknown. However, we hypothesized that circulating tumor cells (CTC) could become trapped within NET's favoring the development of metastasis. In the present work, we demonstrate that NETs are able to trap neoplastic cells in vitro under both static and dynamic conditions. Furthermore, we demonstrate that these interactions are mediated by both tumor and NET derived [beta]1 integrins. Using a physiologically relevant model of postoperative sepsis in vivo, cecal ligation and puncture, we demonstrate widespread deposition of NETs within end organ microvasculature. Furthermore, we confirm the in vitro observations of NET mediated CTC arrest and demonstrate the importance of [beta]1 integrins in this process. More importantly disruption of NETs via exogenous administration of a neutrophil elastase inhibitor (NEi) or DNAse abrogates their adhesive effect. Finally, we demonstrate that NET trapping results in the increased development of gross metastasis, which is inhibited by NET disruption with DNAse or NEi. Taken together, these results are the first to directly implicate NETs as facilitators of metastasis in the context of severe postoperative infection." --