Download or read book Immunopathological Airway Remodeling in Response to Chronic Infection with Mycoplasma Pulmonis written by Arin B. Aurora and published by . This book was released on 2004 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Target Pattern Recognition in Innate Immunity written by Uday Kishore and published by Springer Science & Business Media. This book was released on 2010-01-01 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Target pattern recognition in innate immunity is responsible for the immediate, usually protective, responses shown against invading microorganisms, and it is the principal feature of self and non-self recognition by virtue of the recognition of structures on the microbial pathogens, which are not found on host cells. This is an area that has been very actively researched, over approximately the past 12 years, and therefore this volume provides a timely comprehensive, and up to date, summary of the types and range of cell surface, intracellular, and secreted, host proteins involved in the recognition of microbial products, and of the protective mechanisms triggered as a result of the recognition events. The Toll-like receptors, first described in Drosophila and now well-characterised on human cells, provide an excellent demonstration of the wide range of different microbial products recognised by this family of receptors and of the signalling pathways which are triggered thus leading to induction of inflammatory cytokines and the activation of genes producing antimicrobial products. In addition, several cell surface proteins involved in target pattern recognition have been described on the surfaces of macrophages (macrophage mannose receptor and macrophage scavenger receptors), and on dendritic cells (DEC205), and to be involved with the uptake and clearance of whole microorganisms and polyanioic ligands. Pattern recognition is also utilised by intracellular receptors, with NOD-like receptors in the cytosol recognizing microbial molecules and activating the production of inflammatory cytokines or pathways that induce the production of inflammatory molecules. Secreted proteins, such as the pentraxins, which includes the acute phase reacting, C-reactive protein (CRP) and serum amyloid protein (SAP), and the collectins (mannan binding lectin, lung surfactant protein A and D) and ficolins can also readily recruit killing and clearance systems. Indeed, the serum complement system, which is one of the major defence systems in the bloodstream, is efficiently activated by CR P on its binding to the phosphocholine groups of microbial phospholipids—and the subsequent interaction of the bound CR P with C1q—to give classical pathway activation, or MBL, or ficolin, binding to arrays of mannose or N-acetyl-glucosamine residues, respectively, on the surfaces of microorganisms—to give lectin pathway activation. Also, in addition to the activation and clearance events associated with complement activation by some of the secreted pattern recognition receptors, it is accepted that all these pattern recognition receptors can generally accelerate the uptake and clearance of microbes via phagocytic cells. In view of the growing interest in the cross-talk between innate and adaptive immunity, a thorough understanding of the initial recognition and triggering events, mediated via innate immune receptors, as addressed in this volume, is clearly very useful in helping to also fully understand the mechanisms of activation and control of the adaptive immune system—and to allow a full assessment of the relative roles played by innate immunity and adaptive immunity against a particular infection in higher organisms.
Download or read book Immunopathology in Toxicology and Drug Development written by George A. Parker and published by Springer. This book was released on 2017-03-27 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2004 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book McDonald and Avery s Dentistry for the Child and Adolescent E Book written by Jeffrey A. Dean and published by Elsevier Health Sciences. This book was released on 2015-08-10 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: You can count on McDonald: the go-to source for expert, complete coverage of oral care for infants, children, and teenagers for over half a century. McDonald and Avery’s Dentistry for the Child and Adolescent, 10th Edition discusses pediatric examination, development, morphology, eruption of the teeth, and dental caries in depth — and emphasizes prevention and the treatment of the medically compromised patient. Boasting a new design and handy Evolve site, this new edition by Jeffrey A. Dean equips you with the latest diagnostic and treatment recommendations in the fast-growing field of pediatric dentistry. Complete, one-source coverage includes the best patient outcomes for all of the major pediatric treatments in prosthodontics, restorative dentistry, trauma management, occlusion, gingivitis and periodontal disease, and facial esthetics. A clinical focus includes topics such as such as radiographic techniques, dental materials, pit and fissure sealants, and management of cleft lip and palate. Practical discussions include practice management and how to deal with child abuse and neglect. Evolve site provides you with the best learning tools and resources. UPDATED! More emphasis on preventative care and treatment of medically compromised patients helps you provide more effective care. NEW! Easier-to-follow design.
Download or read book Medical Microbiology written by Patrick R. Murray and published by . This book was released on 1998 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: A clinically relevant introduction focusing on those microbes that cause disease in humans. Following basic principles, basic concepts in the immune response, and general principles of laboratory diagnosis, sections cover bacteriology, virology, mycology and parasitology. Chapters in these sections begin with etiology, then discuss epidemiology, host defenses, identification, diagnosis, prevention, and control. Expanded information on immunology and a new chapter on arthropods are included. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Molecular Medical Microbiology written by Yi-Wei Tang and published by Academic Press. This book was released on 2023-11-21 with total page 3535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Medical Microbiology, Third Edition presents the latest release in what is considered to be the first book to synthesize new developments in both molecular and clinical research. The molecular age has brought about dramatic changes in medical microbiology, along with great leaps in our understanding of the mechanisms of infectious disease. This third edition is completely updated, reviewed and expanded, providing a timely and helpful update for microbiologists, students and clinicians in the era of increasing use of molecular techniques, changing epidemiology and prevalence, and increasing resistance of many pathogenic bacteria. Written by experts in the field, chapters include cutting-edge information and clinical overviews for each major bacterial group, along with the latest updates on vaccine development, molecular technology and diagnostic technology. Completely updated and revised edition of this comprehensive and accessible reference on molecular medical microbiology Includes full color presentations throughout Delves into in-depth discussions on individual pathogenic bacteria in a system-oriented approach Includes a clinical overview for each major bacterial group Presents the latest information on vaccine development, molecular technology and diagnostic technology Provides more than 100 chapters on all major groups of bacteria
Download or read book Feline Anesthesia and Pain Management written by Paulo Steagall and published by John Wiley & Sons. This book was released on 2017-12-18 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Feline Anesthesia and Pain Management offers a definitive and practical guide to feline anesthesia and pain management. The only book offering detailed practical information on anesthesia and pain management in cats, one of the world's most popular pets World renowned author team Quick reference format with full color illustrations Offers detailed practical information on anesthesia and pain management tailored to the unique needs of cats Includes a team of world-renowned authors who are experts in veterinary anesthesia and analgesia Uses a quick reference format that makes the information easy to find and follow Presents full color images to illustrate concepts
Download or read book Taxonomy of Prokaryotes written by and published by Academic Press. This book was released on 2011-12-05 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taxonomy of Prokaryotes, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the microbiologist interested in this specialty, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology. Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research.
Download or read book Pulmonary Immunotoxicology written by Mitchell D. Cohen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary Immunotoxicology is a comprehensive exploration of the effects of various inhaled materials upon the immune system of the respiratory tract. It will be useful to investigators in the field of pulmonary toxicology and immunotoxicology, and to those involved in administration and regulation of matters related to inhaled materials. It can also serve as a textbook for a course in pulmonary immunotoxicology at graduate or advanced undergraduate level. Pulmonary Immunotoxicology comprises four sections. The first provides basic background concepts essential for understanding pulmonary immunotoxicology, including discussions of the normal structure and function of the respiratory system, its basic immunology, and the manner by which inhaled particles and gases are removed from the air and deposited upon respiratory tract surfaces. The second section provides an overview of the major types of pathological consequences which can arise from immunomodulation within the respiratory tract, including hypersensitivity and asthma, inflammation and fibrosis, as well as immunosuppression and autoimmunity. The third section, which comprises the largest portion of the book, deals specifically with major classes of airborne agents that are known to alter the immune function of the respiratory tract. These are arranged into major classes: organic agents, metals, gases, particles, biologics, and complex mixtures. The fourth and final section of the book explores the area of risk assessment, including discussions of the basic concepts of risk assessment as they apply specifically to immunotoxicologic effects upon the lungs, and the use of biomarkers as indices of potential pulmonary immunotoxic responses to inhaled materials.
Download or read book Infectious Diseases of Wild Mammals written by Elizabeth S. Williams and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious Diseases of Wild Mammals, Third Edition presents the latest information on the diagnosis and treatment of infectious disease in both free-ranging and captive wild mammals. Editors Elizabeth Williams and Ian Barker have recruited 71 contributors, all noted experts in their fields, to update this new edition. This reference provides valuable information on each disease, including Etiology History Distribution Epidemiology Clinical signs Pathology Immunity Diagnosis Treatment Control This latest edition is a leading reference book for Wildlife biologists, managers, and rehabilitators Biology students Conservationists Public health workers
Download or read book Aging and Age Related Disorders written by Stephen Bondy and published by Springer Science & Business Media. This book was released on 2010-09-02 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Features that characterize the aging process include the gradual accumulation of cell damage after prolonged exposure to oxidative and inflammatory events over a lifetime. In addition to the accretion of lesions, the intrinsic levels of pro-oxidant and aberrant immune responses are elevated with age. These adverse events are often further enhanced by the chronic and slow progressing diseases that characterize the senescent brain and cardiovascular system. The incidence of some disorders such as Alzheimer's disease and vascular diseases are sufficiently prevalent in the extreme elderly that these disorders can arguably be considered "normal". Aging and Aging-Related Disorders examines the interface between normal and pathological aging, and illustrates how this border can sometimes be diffuse. It explores and illustrates the processes underlying the means by which aging becomes increasingly associated with inappropriate levels of free radical activity and how this can serve as a platform for the progression of age-related diseases. The book provides chapters that examine the interactive relationship between systems in the body that can enhance or sometimes even limit cellular longevity. In addition, specific redox mechanisms in cells are discussed. Another important aspect for aging discussed here is the close relationship between the systems of the body and exposure to environmental influences of oxidative stress that can affect both cellular senescence and a cell’s nuclear DNA. What may be even more interesting to note is that these external stressors are not simply confined to illnesses usually associated with aging, but can be evident in maturing and young individuals. A broad range of internationally recognized experts have contributed to this book. Their aim is to successfully highlight emerging knowledge and therapy for the understanding of the basis and development of aging–related disorders.
Download or read book A Manual of Adverse Drug Interactions written by John Parry Griffin and published by Butterworth-Heinemann. This book was released on 1984 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antibiotic and Chemotherapy written by Roger G. Finch and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The completely revised and updated New Edition of this respected resource presents globally-relevant coverage of all types of antimicrobial agents used in human medicine, providing authoritative guidance on the principles and practice of antimicrobial chemotherapy. In addition to full coverage of every commonly used antibiotic agent, it includes complete coverage of all antiviral, antiprotozoan and anthelminthic agents. And, its unique 3-part structure makes it easy to locate information: Part I covers general aspects of treatment; Part II reviews every agent, including antimicrobial activity, pharmacokinetics, clinical use, and available preparations; Part III details the treatment of particular infections. Discusses the increasing problem of multi-drug resistance and the wide range of new antiviral therapies now available for the treatment of HIV and other viral infections. Reviews all of the new antimicrobial agents in detail. Features more clinically focused sections on Pharmacokinetics. Details new antifungal therapies, including voriconazole, liposomal, and amphotericin B. Presents new tables on major drug interactions, placental transfer, and concentrations of agents in breast milk. Features new sections on liver failure, drug development and licensing, and the implications of xenotransplantation. Presents expanded coverage of Quinolone as well as new antimalarial combination therapies. Offers cross-references to key web sites, for up-to-date information on treatment and drug resistance.
Download or read book ASM Style Manual for Journals and Books written by American Society for Microbiology and published by . This book was released on 1991 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Death Regulation in Health and Disease Part A written by and published by Academic Press. This book was released on 2020-04-02 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Death Regulation in Health and Disease - Part A, Volume 351, the latest release in the International Review of Cell and Molecular Biology reviews current advances in cell and molecular biology. The series publishes timely topics authored by prominent cell and molecular biologists. This release is part of a 3-part series which comprises a comprehensive view of cell death regulation in a variety of biological contexts. Chapters cover Membrane dynamics in cell death regulation, The role of necroptosis in intestinal dysfunction, Regulation of cell death in the cardiovascular system, Cell death in bacterial and viral infection, and much more. Provides a comprehensive collection of front-of-the line research in the field of cell death regulation Authored by established and active cell and molecular biologists and drawn from international sources Includes invited review articles that cover selected topics in multiple organisms and disease settings
Download or read book Tumor Microenvironment and Cellular Stress written by Constantinos Koumenis and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
