Download or read book The Future of Fentanyl and Other Synthetic Opioids written by Bryce Pardo and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deaths involving synthetic opioids, such as fentanyl, increased from roughly 3,000 in 2013 to more than 30,000 in 2018. This book provides readers with insights intended to improve their understanding of the synthetic opioid problem.

Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Download or read book Fentanyl Inc written by Ben Westhoff and published by Atlantic Monthly Press. This book was released on 2019-09-03 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: A four-year investigation into the world of synthetic drugs—from black market factories to users & dealers to harm reduction activists—and what it revealed. A deeply human story, Fentanyl, Inc. is the first deep-dive investigation of a hazardous and illicit industry that has created a worldwide epidemic, ravaging communities and overwhelming and confounding government agencies that are challenged to combat it. “A whole new crop of chemicals is radically changing the recreational drug landscape,” writes Ben Westhoff. “These are known as Novel Psychoactive Substances (NPS) and they include replacements for known drugs like heroin, cocaine, ecstasy, and marijuana. They are synthetic, made in a laboratory, and are much more potent than traditional drugs” —and all-too-often tragically lethal. Drugs like fentanyl, K2, and Spice—and those with arcane acronyms like 25i-NBOMe—were all originally conceived in legitimate laboratories for proper scientific and medicinal purposes. Their formulas were then hijacked and manufactured by rogue chemists, largely in China, who change their molecular structures to stay ahead of the law, making the drugs’ effects impossible to predict. Westhoff has infiltrated this shadowy world. He tracks down the little-known scientists who invented these drugs and inadvertently killed thousands, as well as a mysterious drug baron who turned the law upside down in his home country of New Zealand. Westhoff visits the shady factories in China from which these drugs emanate, providing startling and original reporting on how China’s vast chemical industry operates, and how the Chinese government subsidizes it. Poignantly, he chronicles the lives of addicted users and dealers, families of victims, law enforcement officers, and underground drug awareness organizers in the United States and Europe. Together they represent the shocking and riveting full anatomy of a calamity we are just beginning to understand. From its depths, as Westhoff relates, are emerging new strategies that may provide essential long-term solutions to the drug crisis that has affected so many. “Timely and agonizing. . . . An impressive work of investigative journalism.” —USA Today “Westhoff explores the many-tentacled world of illicit opioids, from the streets of East St. Louis to Chinese pharmaceutical companies, from music festivals deep in the Michigan woods to sanctioned ‘shooting up rooms’ in Barcelona, in this frank, insightful, and occasionally searing exposé. . . . Westhoff’s well-reported and researched work will likely open eyes, slow knee-jerk responses, and start much needed conversations.” —Publishers Weekly “Our 25 Favorite Books of 2019” —St. Louis Post-Dispatch “Best Books of 2019” —Buzzfeed “Best Nonfiction of 2019” —Kirkus Reviews “50 Best Books of 2019” —Daily Telegraph “Best Nonfiction Books of 2019” —Tyler Cowen “Best Books of 2019” —Yahoo Finance

Download or read book Practical Management of Pain written by Honorio MD Benzon and published by Elsevier Health Sciences. This book was released on 2013-09-12 with total page 1379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obtain all the core knowledge in pain management you need from one of the most trusted resources in the field. The new edition of Practical Management of Pain gives you completely updated, multidisciplinary overview of every aspect of pain medicine, including evaluation, diagnosis of pain syndromes, rationales for management, treatment modalities, and much more. In print and online, it is all the expert guidance necessary to offer your patients the best possible relief. "In summary, this is the best explanation of what lies behind MRI that I have read, taking what can be a dry subject and making it readily understandable and really interesting. I would recommend it to anyone starting their MRI training and anyone trying to teach MRI to others." Reviewed by RAD Magazine, June 2015 Understand and apply the latest developments in pain medicine with brand-new chapters covering disability assessment, central post-stroke pain, chronic widespread pain, and burn pain. Effectively ease your patients' pain with today's best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents (such as topical analgesics). Access up-to-the-minute knowledge on all aspects of pain management, from general principles to specific management techniques, with contributions from renowned experts in the field. Read the full text and view all the images online at expertconsult.com. Understand and apply the latest developments in pain management with brand-new chapters covering disability assessment, central post-stroke pain, widespread chronic pain, and burn pain. Effectively ease your patients' pain with today's best management techniques, including joint injections, ultrasound-guided therapies, and new pharmacologic agents (such as topical analgesics).

Download or read book The Least of Us written by Sam Quinones and published by Bloomsbury Publishing USA. This book was released on 2021-11-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apple Best Books of 2021 Longlisted for the Andrew Carnegie Medal * Shortlisted for the Zocalo Book Prize From the New York Times bestselling author of Dreamland, a searing follow-up that explores the terrifying next stages of the opioid epidemic and the quiet yet ardent stories of community repair. Sam Quinones traveled from Mexico to main streets across the U.S. to create Dreamland, a groundbreaking portrait of the opioid epidemic that awakened the nation. As the nation struggled to put back the pieces, Quinones was among the first to see the dangers that lay ahead: synthetic drugs and a new generation of kingpins whose product could be made in Magic Bullet blenders. In fentanyl, traffickers landed a painkiller a hundred times more powerful than morphine. They laced it into cocaine, meth, and counterfeit pills to cause tens of thousands of deaths-at the same time as Mexican traffickers made methamphetamine cheaper and more potent than ever, creating, Sam argues, swaths of mental illness and a surge in homelessness across the United States. Quinones hit the road to investigate these new threats, discovering how addiction is exacerbated by consumer-product corporations. “In a time when drug traffickers act like corporations and corporations like traffickers,” he writes, “our best defense, perhaps our only defense, lies in bolstering community.” Amid a landscape of despair, Quinones found hope in those embracing the forgotten and ignored, illuminating the striking truth that we are only as strong as our most vulnerable. Weaving analysis of the drug trade into stories of humble communities, The Least of Us delivers an unexpected and awe-inspiring response to the call that shocked the nation in Sam Quinones's award-winning Dreamland.

Download or read book The Extinction Market written by Vanda Felbab-Brown and published by Oxford University Press. This book was released on 2017 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizes the disturbing consequences poaching and trafficking pose globally in terms of both biodiversity and public health

Download or read book The World Heroin Market written by Letizia Paoli and published by Oxford University Press. This book was released on 2009-04-10 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heroin is universally considered the world's most harmful illegal drug. This is due not only to the damaging effects of the drug itself, but also to the spread of AIDS tied to its use. Burgeoning illegal mass consumption in the 1960s and 1970s has given rise to a global market for heroin and other opiates of nearly 16 million users. The production and trafficking of opiates have caused crime, disease, and social distress throughout the world, leading many nations to invest billions of dollars trying to suppress the industry. The failure of their efforts has become a central policy concern. Can the world heroin supply actually be cut, and with what consequences? The result of a five-year-long research project involving extensive fieldwork in six Asian countries, Colombia, and Turkey, this book is the first systematic analysis of the contemporary world heroin market, delving into its development and structure, its participants, and its socio-economic impact. It provides a sound and comprehensive empirical base for concluding that there is little opportunity to shrink the global supply of heroin in the long term, and explains why production is concentrated in a handful of countries--and is likely to remain that way. On the basis of these findings, the authors identify a key set of policy opportunities, largely local, and make suggestions for leveraging them. This book also offers new insights into market conditions in India, Tajikistan, and other countries that have been greatly harmed by the production and trafficking of illegal opiates. A deft integration of economics, sociology, history, and policy analysis, The World Heroin Market provides a rigorous and vital look into the complex--and resilient--global heroin trade.

Download or read book World Drug Report 2019 written by United Nations Office on Drugs and Crime and published by . This book was released on 1901 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2019 World Drug Report will include an updated overview of recent trends on production, trafficking and consumption of key illicit drugs. The Report contains a global overview of the baseline data and estimates on drug demand and supply and provides the reference point for information on the drug situation worldwide.

Download or read book Fentanyl written by Amy Sterling Casil and published by Mason Crest Publishers. This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fentanyl was developed as a drug that could relieve severe pain and assist doctors in performing complex surgeries. Due to its potent effects, fentanyl is often sold illegally as an ingredient in counterfeit opioid pills or mixed with heroin or cocaine. Because it is nearly impossible to gauge the strength of illegal fentanyl doses, tens of thousands of Americans have overdosed on the drug in recent years. This book provides information about the effects of fentanyl and how it contributes to the ongoing opioid crisis. Opioids are psychoactive drugs derived from the opium poppy, such as heroin or morphine, or synthetic versions that mimic their effects, such as fentanyl or oxycodone. The series Opioid Education: Devastation and the Grip on Society examines various aspects of opioid use and treatment in the United States and the rest of the world. The purpose of this series is to provide young readers with a greater understanding of the ongoing opioid crisis.

Download or read book Pain Killer written by Barry Meier and published by Random House. This book was released on 2018-05-29 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the Pulitzer Prize–winning New York Times reporter who first exposed the roots of the opioid epidemic and the secretive world of the Sackler family behind Purdue Pharma, Pain Killer is the celebrated landmark story of corporate greed and government negligence that inspired an upcoming Netflix series. “This is the book that started it all. Barry Meier is a heroic reporter and Pain Killer is a muckraking classic.”—Patrick Radden Keefe, author of Empire of Pain Between 1999 and 2017, an estimated 250,000 Americans died from overdoses involving prescription painkillers, a plague ignited by Purdue Pharma’s aggressive marketing of OxyContin. Families, working class and wealthy, have been torn apart, businesses destroyed, and public officials pushed to the brink. Meanwhile, the drugmaker’s owners, Raymond and Mortimer Sackler, whose names adorn museums worldwide, made enormous fortunes from the commercial success of OxyContin. In Pain Killer, Barry Meier tells the story of how Purdue turned OxyContin into a billion-dollar blockbuster. Powerful narcotic painkillers, or opioids, were once used as drugs of last resort for pain sufferers. But Purdue launched an unprecedented marketing campaign claiming that the drug’s long-acting formulation made it safer to use than traditional painkillers for many types of pain. That illusion was quickly shattered as drug abusers learned that crushing an Oxy could release its narcotic payload all at once. Even in its prescribed form, Oxy proved fiercely addictive. As OxyContin’s use and abuse grew, Purdue concealed what it knew from regulators, doctors, and patients. Here are the people who profited from the crisis and those who paid the price, those who plotted in boardrooms and those who tried to sound alarm bells. A country doctor in rural Virginia, Art Van Zee, took on Purdue and warned officials about OxyContin abuse. An ebullient high school cheerleader, Lindsey Myers, was reduced to stealing from her parents to feed her escalating Oxy habit. A hard-charging DEA official, Laura Nagel, tried to hold Purdue executives to account. In Pain Killer, Barry Meier breaks new ground in his decades-long investigation into the opioid epidemic. He takes readers inside Purdue to show how long the company withheld information about the abuse of OxyContin and gives a shocking account of the Justice Department’s failure to alter the trajectory of the opioid epidemic and protect thousands of lives. Equal parts crime thriller, medical detective story, and business exposé, Pain Killer is a hard-hitting look at how a supposed wonder drug became the gateway drug to a national tragedy.

Download or read book Shooting Up written by Vanda Felbab-Brown and published by Rowman & Littlefield. This book was released on 2009-12-01 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most policymakers see counterinsurgency and counternarcotics policy as two sides of the same coin. Stop the flow of drug money, the logic goes, and the insurgency will wither away. But the conventional wisdom is dangerously wrongheaded, as Vanda Felbab-Brown argues in Shooting Up. Counternarcotics campaigns, particularly those focused on eradication, typically fail to bankrupt belligerent groups that rely on the drug trade for financing. Worse, they actually strengthen insurgents by increasing their legitimacy and popular support. Felbab-Brown, a leading expert on drug interdiction efforts and counterinsurgency, draws on interviews and fieldwork in some of the world's most dangerous regions to explain how belligerent groups have become involved in drug trafficking and related activities, including kidnapping, extortion, and smuggling. Shooting Up shows vividly how powerful guerrilla and terrorist organizations — including Peru's Shining Path, the FARC and the paramilitaries in Colombia, and the Taliban in Afghanistan — have learned to exploit illicit markets. In addition, the author explores the interaction between insurgent groups and illicit economies in frequently overlooked settings, such as Northern Ireland, Turkey, and Burma. While aggressive efforts to suppress the drug trade typically backfire, Shooting Up shows that a laissez-faire policy toward illicit crop cultivation can reduce support for the belligerents and, critically, increase cooperation with government intelligence gathering. When combined with interdiction targeting major traffickers, this strategy gives policymakers a better chance of winning both the war against the insurgents and the war on drugs.

Download or read book Disease Control Priorities Third Edition Volume 4 written by Vikram Patel and published by World Bank Publications. This book was released on 2016-03-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mental, neurological, and substance use disorders are common, highly disabling, and associated with significant premature mortality. The impact of these disorders on the social and economic well-being of individuals, families, and societies is large, growing, and underestimated. Despite this burden, these disorders have been systematically neglected, particularly in low- and middle-income countries, with pitifully small contributions to scaling up cost-effective prevention and treatment strategies. Systematically compiling the substantial existing knowledge to address this inequity is the central goal of this volume. This evidence-base can help policy makers in resource-constrained settings as they prioritize programs and interventions to address these disorders.

Download or read book Drug Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Download or read book Quest for Integrity written by Peter Reuter and published by . This book was released on 1992 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Color Atlas of Family Medicine written by Richard P. Usatine and published by McGraw Hill Professional. This book was released on 2008-08-03 with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1500 superb clinical photographs cover the full scope of family medicine The Color Atlas of Family Medicine features 1500 full-color photographs depicting both common and uncommon appearances of diseases and presentations that clinicians encounter every day. No other resource offers such a comprehensive collection of these diagnosis-speeding images as this essential atlas. No matter what the presentation, all the visual guidance you need for successful patient management is right here at your fingertips. Features Complete coverage of relevant visual presentations that clinicians see and often struggle with in their day-to-day practice Organized and indexed by organ system, disease, morphology, and region--ideal for quickly finding the images and text you need at the point-of-care Evidence-graded, quick access treatment recommendations in an user-friendly format to help you provide up-to-date care for your patients Insightful legends with each photograph provide diagnostic pearls to increase your clinical observational skills Color pictures of skin conditions, eye problems, women's health issues, oral diseases, infectious diseases, endoscopies, dermoscopies, orthopedic and rheumatologic conditions fill the book with images that enhance your clinical experience and skills An encyclopedic array of colorful, high quality clinical photographs

Download or read book Contemporary Asian Drug Policy written by Bryce Pardo and published by . This book was released on 2022-02-15 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Changing patterns in drug use and supply can affect the well-being and development of Asian countries in many ways. RAND researchers discuss the shifting drug policy landscape in Asia, with a special focus on the Philippines, Thailand, and China.

Download or read book Mexico written by June S Beittel and published by . This book was released on 2020-01-04 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mexican drug trafficking organizations (DTOs) pose the greatest crime threat to the United States and have "the greatest drug trafficking influence," according to the annual U.S. Drug Enforcement Administration's (DEA's) National Drug Threat Assessment. These organizations work across the Western Hemisphere and globally. They are involved in extensive money laundering, bribery, gun trafficking, and corruption, and they cause Mexico's homicide rates to spike. They produce and traffic illicit drugs into the United States, including heroin, methamphetamine, marijuana, and powerful synthetic opioids such as fentanyl, and they traffic South American cocaine. Over the past decade, Congress has held numerous hearings addressing violence in Mexico, U.S. counternarcotics assistance, and border security issues. Mexican DTO activities significantly affect the security of both the United States and Mexico. As Mexico's DTOs expanded their control of the opioids market, U.S. overdoses rose sharply to a record level in 2017, with more than half of the 72,000 overdose deaths (47,000) involving opioids. Although preliminary 2018 data indicate a slight decline in overdose deaths, many analysts believe trafficking continues to evolve toward opioids. The major Mexican DTOs, also referred to as transnational criminal organizations (TCOs), have continued to diversify into such crimes as human smuggling and oil theft while increasing their lucrative business in opioid supply. According to the Mexican government's latest estimates, illegally siphoned oil from Mexico's state-owned oil company costs the government about $3 billion annually. Mexico's DTOs have been in constant flux. In 2006, four DTOs were dominant: the Tijuana/Arellano Felix organization (AFO), the Sinaloa Cartel, the Juárez/Vicente Carillo Fuentes Organization (CFO), and the Gulf Cartel. Government operations to eliminate DTO leadership sparked organizational changes, which increased instability among the groups and violence. Over the next dozen years, Mexico's large and comparatively more stable DTOs fragmented, creating at first seven major groups, and then nine, which are briefly described in this report. The DEA has identified those nine organizations as Sinaloa, Los Zetas, Tijuana/AFO, Juárez/CFO, Beltrán Leyva, Gulf, La Familia Michoacana, the Knights Templar, and Cartel Jalisco-New Generation (CJNG). In mid-2019, leader of the long-dominant Sinaloa Cartel, Joaquin ("El Chapo") Guzmán, was sentenced to life in a maximum-security U.S. prison, spurring further fracturing of a once hegemonic DTO. By some accounts, a direct effect of this fragmentation has been escalated levels of violence. Mexico's intentional homicide rate reached new records in 2017 and 2018. In 2019, Mexico's national public security system reported more than 17,000 homicides between January and June, setting a new record. In the last months of 2019, several fragments of formerly cohesive cartels conducted flagrant acts of violence. For some Members of Congress, this situation has increased concern about a policy of returning Central American migrants to cities across the border in Mexico to await their U.S. asylum hearings in areas with some of Mexico's highest homicide rates. Mexican President Andrés Manuel López Obrador, elected in a landslide in July 2018, campaigned on fighting corruption and finding new ways to combat crime, including the drug trade. According to some analysts, challenges for López Obrador since his inauguration include a persistently ad hoc approach to security; the absence of strategic and tactical intelligence concerning an increasingly fragmented, multipolar, and opaque criminal market; and endemic corruption of Mexico's judicial and law enforcement systems. In December 2019, Genero Garcia Luna, a former top security minister under the Felipe Calderón Administration (2006-2012), was arrested in the United States on charges he had taken enormous bribes from the Sinaloa Cartel.