Download or read book Genomics in the Cloud written by Geraldine A. Van der Auwera and published by "O'Reilly Media, Inc.". This book was released on 2020-04-02 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data in the genomics field is booming. In just a few years, organizations such as the National Institutes of Health (NIH) will host 50+ petabytesâ??or over 50 million gigabytesâ??of genomic data, and theyâ??re turning to cloud infrastructure to make that data available to the research community. How do you adapt analysis tools and protocols to access and analyze that volume of data in the cloud? With this practical book, researchers will learn how to work with genomics algorithms using open source tools including the Genome Analysis Toolkit (GATK), Docker, WDL, and Terra. Geraldine Van der Auwera, longtime custodian of the GATK user community, and Brian Oâ??Connor of the UC Santa Cruz Genomics Institute, guide you through the process. Youâ??ll learn by working with real data and genomics algorithms from the field. This book covers: Essential genomics and computing technology background Basic cloud computing operations Getting started with GATK, plus three major GATK Best Practices pipelines Automating analysis with scripted workflows using WDL and Cromwell Scaling up workflow execution in the cloud, including parallelization and cost optimization Interactive analysis in the cloud using Jupyter notebooks Secure collaboration and computational reproducibility using Terra

Download or read book NASA Technical Note written by and published by . This book was released on 1967 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Process Centrifugal Compressors written by Klaus H. Lüdtke and published by Springer Science & Business Media. This book was released on 2004-02-09 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originating in the process compressor industry, this text primarily addresses: rotating equipment engineers, project engineers, engineering contractors, and compressor user companies in oil and gas field operations, natural gas processing, petroleum refining, petrochemical processing, industrial refrigeration, and chemical industries. It enables the reader to assess compressors and defines the constraints influencing the compressor design.

Download or read book Practical Guide to Life Science Databases written by Imad Abugessaisa and published by Springer Nature. This book was released on 2022-01-06 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the latest information of life science databases that center in the life science research and drive the development of the field. It introduces the fundamental principles, rationales and methodologies of creating and updating life science databases. The book brings together expertise and renowned researchers in the field of life science databases and brings their experience and tools at the fingertips of the researcher. The book takes bottom-up approach to explain the structure, content and the usability of life science database. Detailed explanation of the content, structure, query and data retrieval are discussed to provide practical use of life science database and to enable the reader to use database and provided tools in practice. The readers will learn the necessary knowledge about the untapped opportunities available in life science databases and how it could be used so as to advance basic research and applied research findings and transforming them to the benefit of human life. Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Download or read book Information Modelling and Knowledge Bases XXV written by IOS Press and published by IOS Press. This book was released on 2014-01-14 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because of our ever increasing use of and reliance on technology and information systems, information modelling and knowledge bases continue to be important topics in those academic communities concerned with data handling and computer science. As the information itself becomes more complex, so do the levels of abstraction and the databases themselves. This book is part of the series Information Modelling and Knowledge Bases, which concentrates on a variety of themes in the important domains of conceptual modeling, design and specification of information systems, multimedia information modeling, multimedia systems, ontology, software engineering, knowledge and process management, knowledge bases, cross-cultural communication and context modeling. Theoretical disciplines, including cognitive science, artificial intelligence, logic, linguistics and analytical philosophy, also receive attention. The selected papers presented here cover many areas of information modeling and knowledge bases including: theory of concepts, semantic computing, data mining, context-based information retrieval, ontological technology, image databases, temporal and spatial databases, document data management, software engineering, cross-cultural computing, environmental analysis, social networks, WWW information management, and many others. This new issue also contains papers initiated by the panels on: “Cross-cultural Communication with Icons and Images” and “Conceptual Modelling of Collaboration for Information Systems”. The book will be of interest to all those interested in advances in research and applications in the academic disciplines concerned.

Download or read book Advances in Thermofluids and Renewable Energy written by Pinakeswar Mahanta and published by Springer Nature. This book was released on 2021-10-21 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprises the select proceedings of the International Conference on Recent Trends in Developments of Thermofluids and Renewable Energy (TFRE 2020). The major topics covered include aerodynamics, alternate energy, bio fuel, bio heat transfer, computational fluid dynamics, control mechanism for constant power generation, and energy storage. The book also discusses latest developments in the fields of electric vehicles, hybrid power systems, and solar and renewable energy. Given the scope of its contents, this book will be useful for students, researchers, and professionals interested in the field of thermofluids and renewable energy resources.

Download or read book Gene Therapy in Neurological Disorders written by Mingjie Li and published by Academic Press. This book was released on 2018-05-25 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system. Provides background information and experimental details of gene therapy tools applied for neuroscience research and neurological disorders Covers a broad range of gene delivery and regulation tools, therapeutic agents, and target cells, including emerging new technologies such as CRISPR/Cas9 genome editing Discusses applications of gene therapy tools to neurological disorders including neurodegeneration, muscular dystrophy, trauma and chronic pain, and neoplastic diseases

Download or read book NASA Technical Paper written by and published by . This book was released on 1986 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Aircraft Propulsion written by Saeed Farokhi and published by John Wiley & Sons. This book was released on 2021-09-14 with total page 1045 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore the latest edition of a leading resource on sustainable aviation, alternative jet fuels, and new propulsion systems The newly revised Third Edition of Aircraft Propulsion delivers a comprehensive update to the successful Second Edition with a renewed focus on the integration of sustainable aviation concepts. The book tackles the impact of aviation on the environment at the engine component level, as well as the role of propulsion system integration on fuel burn. It also discusses combustion emissions, including greenhouse gases, carbon monoxide, unburned hydrocarbons (UHC), and oxides of nitrogen (NOx). Alternative jet fuels, like second generation biofuels and hydrogen, are presented. The distinguished author covers aviation noise from airframe to engine and its impact on community noise in landing and takeoff cycles. The book includes promising new technologies for propulsion and power, like the ultra-high bypass (UHB) turbofan and hybrid-electric and electric propulsion systems. Readers will also benefit from the inclusion of discussions of unsteady propulsion systems in wave-rotor combustion and pulse-detonation engines, as well as: A thorough introduction to the history of the airbreathing jet engine, including innovations in aircraft gas turbine engines, new engine concepts, and new vehicles An exploration of compressible flow with friction and heat, including a brief review of thermodynamics, isentropic process and flow, conservation principles, and Mach numbers A review of engine thrust and performance parameters, including installed thrust, rocket thrust, and modern engine architecture A discussion of gas turbine engine cycle analysis Perfect for aerospace and mechanical engineering students in the United States and overseas, Aircraft Propulsion will also earn a place in the libraries of practicing engineers in the aerospace and green engineering sectors seeking the latest up to date resource on sustainable aviation technologies.

Download or read book Sr 71 Blackbird Pilot s Flight Manual written by Periscope Film Com and published by Lulu.com. This book was released on 2006-05-02 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: En instruktionsbog (Flight Manual) for SR-71 Blackbird.

Download or read book Plant Stress Tolerance written by Ramanjulu Sunkar and published by Springer Nature. This book was released on with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Compaction and cementation controls on reservoir quality in Buntsandstein red beds written by Schmidt, Christina and published by KIT Scientific Publishing. This book was released on 2022-05-02 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reservoir quality in fluvial siliciclastic rocks is variable. Permeability is influenced by micron-scale grain coatings or bedding style on the m-/km-scale. Outcrops allow the analysis of depositional environments and diagenesis, thus an investigation of reservoir quality controls. A process-oriented approach is used to understand variability in a meander deposit, compaction and cementation behavior of lithofacies types during burial and the discrepancy between porosity and permeability values.

Download or read book Molecular Approaches To Tumor Immunotherapy written by Yang Liu and published by World Scientific. This book was released on 1998-12-28 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The articles in this book are contributed by leading scientists working in the fields of immunology, tumor immunotherapy, and gene therapy. The book identifies the opportunities that modern immunology and molecular biology have provided for tumor therapy. Moreover, it contains critical essays that analyze the progress and obstacles of tumor immunotherapy.

Download or read book Diagenetic controls on fluid flow and mechanical properties in Rotliegend reservoir sandstones written by Monsees, Alexander C. and published by KIT Scientific Publishing. This book was released on 2021-10-28 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reservoir quality of Rotliegend sandstones is mainly controlled by their permeability, and porosity, and their mechanical properties. Thus, diagenetic porosity-reducing processes need to be understood to evaluate reservoir quality and geotechnical properties in sandstones. Best reservoir qualities are achieved in mature sandstones with large amounts of quartz cementation. The relative length of grain-contacts compared to the respective grain diameter is identified as proxy for rock strength.

Download or read book Bioinformatics Data Skills written by Vince Buffalo and published by "O'Reilly Media, Inc.". This book was released on 2015-07 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn the data skills necessary for turning large sequencing datasets into reproducible and robust biological findings. With this practical guide, youâ??ll learn how to use freely available open source tools to extract meaning from large complex biological data sets. At no other point in human history has our ability to understand lifeâ??s complexities been so dependent on our skills to work with and analyze data. This intermediate-level book teaches the general computational and data skills you need to analyze biological data. If you have experience with a scripting language like Python, youâ??re ready to get started. Go from handling small problems with messy scripts to tackling large problems with clever methods and tools Process bioinformatics data with powerful Unix pipelines and data tools Learn how to use exploratory data analysis techniques in the R language Use efficient methods to work with genomic range data and range operations Work with common genomics data file formats like FASTA, FASTQ, SAM, and BAM Manage your bioinformatics project with the Git version control system Tackle tedious data processing tasks with with Bash scripts and Makefiles

Download or read book Chronic Lymphocytic Leukemia written by Federico Caligaris-Cappio and published by Springer Science & Business Media. This book was released on 2005-12-29 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient.

Download or read book Introduction to the Characterization of Residual Stress by Neutron Diffraction written by M.T. Hutchings and published by CRC Press. This book was released on 2005-02-28 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 25 years the field of neutron diffraction for residual stress characterization has grown tremendously, and has matured from the stage of trial demonstrations to provide a practical tool with widespread applications in materials science and engineering. While the literature on the subject has grown commensurately, it has also remained