Download or read book Identification of Therapeutic Targets and Novel Biomarkers in Prostate Cancer written by Shashwat Sharad and published by Frontiers Media SA. This book was released on 2023-02-08 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identifying Novel Molecular Biomarkers and Therapeutic Targets for Prostate Cancer written by Tanushree Shenoy and published by . This book was released on 2017 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most common malignancy in males, and the third leading cause of male cancer-related death in the Western world. Although most prostate cancers are diagnosed at an early and treatable stages, predicting the outcome of prostate cancer progression and treatment has proven to be challenging because of the heterogeneous nature of the disease. Recent cancer genome studies have identified novel alterations as well as the potential actionable targets. Among these novel alterations is chromodomain helicase DNA-binding protein 1 (CHD1). CHD1 deletion occurs in as many as 20% of prostate cancers and may be associated with genomic instability. To validate the function of CHD1 in prostate cancer in vivo, we created the Pb-Cre+;Chd1L/L mouse model, whereby Chd1 is deleted in mouse prostate epithelial cells, and engineered CHD1-deleted prostate cancer cell lines. We found that while Chd1 deletion alone does not induce prostate cancer in vivo, it confers DNA damage sensitivity and homologous recombination impairment, making CHD1-deficient cells sensitive to PARP inhibitors and Platinum-based drugs. A metastatic castrate-resistant prostate cancer patient whose tumors had CHD1 deletion was responsive to carboplatin, suggesting that CHD1 status may be a biomarker for PARP inhibitor and platinum treatment responsiveness.

Download or read book Circulating Biomarkers In Prostate Cancer written by Yafeng Ma and published by Frontiers Media SA. This book was released on 2024-02-27 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the era of precision oncology, liquid biopsy techniques, specifically the use of circulating tumor cells (CTCs), cell free circulating tumor DNA (ctDNA) and extracellular vesicles particularly exosomes, represent a paradigm shift in the conventional use of tissue based biomarkers. Compared to tissue biopsy, liquid biopsy is cost-effective, readily accessible and less invasive, minimizing the bias of sampling and offering the opportunity for serial monitoring. Circulating biomarkers detected in liquid biopsy (blood and urine, etc.) are helping in understanding cancer genomic landscape and evolution, thus have been largely studied in term of cancer screening, risk stratification and early detection of minimal residual disease. Castration-resistant prostate cancers (CRPCs) are the late stage of prostate cancers. With significant progress towards the treatment of CRPCs, for example, androgen receptor-signalling (ARS) targeted therapy and immunotherapy, there is an urgent need to identify novel biomarkers to improve the survival rate and prognosis of CRPCs. The study of such biomarkers associated signal pathways and immune status has become a major focus in research to help understanding the responses to drug resistance and ineffective treatments. The discovery of these biomarkers in selecting potentially responsive patients will improve outcomes, and reduce treatment costs and, most importantly, significantly improve patient’s quality of life.

Download or read book MicroRNAs Novel Biomarkers and Therapeutic Targets for Human Cancers written by Takahiro Ochiya and published by MDPI. This book was released on 2018-10-16 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers" that was published in JCM

Download or read book Pharmacological Reactivation of Epigenetically Regulated Genes for Identification of Therapeutic Targets and Putative Biomarkers in Prostate Cancer written by and published by . This book was released on 2015 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification of Metastasis driving Genes as Potential Therapeutic Targets Biomarkers for Metastatic Prostate Cancer written by Yan Ting Chiang and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Prostate Cancer and the Search for Novel Biomarkers written by Taha Alexander Haj-Ahmad and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Identification of Novel Biomarkers in the Development and Progression of Early Prostate Cancer written by Krishan K. Rasiah and published by . This book was released on 2006 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification of Potential Therapeutic Targets in Prostate Cancer written by Christopher P. Karch and published by . This book was released on 2011 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2020-07-21 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Download or read book Identification of Novel Prostate Cancer Biomarkers Using High throughput Technologies written by René Böttcher and published by . This book was released on 2016 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification and Characterization of Prostate Cancer Associated Protein Biomarkers Using High Throughput Mass Spectrometry written by and published by . This book was released on 2006 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer (PCa) remains to be the most common non-skin cancer in the US. Currently available screening tests for PCa including prostate specific antigen (PSA) test, digital rectal examination (DRE) and prostate biopsy, call for more accurate and non-invasive techniques to detect, diagnose, and stratify the disease based on molecular markers present in the body fluids. Using MALDI-TOF mass spectrometry protein fingerprint profiling, we generated decision tree algorithms to classify cancer from non-cancer. We have also devised strategies to isolate and identify protein biomarkers from the fingerprint profiles of PCa patients in the clinical gray-area where PSA fails to detect cancer. Identification of such cancer biomarkers will assist in development of better non-invasive diagnostic tools for prostate cancer and may also lead to better therapeutic targets.

Download or read book Role of Biomarkers in Medicine written by Mu Wang and published by BoD – Books on Demand. This book was released on 2016-08-17 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.

Download or read book Genitourinary Pathology E Book written by Ming Zhou and published by Elsevier Health Sciences. This book was released on 2014-10-20 with total page 723 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genitourinary Pathology, by Drs. Ming Zhou and Cristina Magi-Galluzzi, a volume in the Foundations in Diagnostic Pathology Series, packs all of today's most essential information on genitourinary pathology into a compact, high-yield format! Well-organized and segmented by type of infectious organism, the book's pragmatic approach complemented by abundant full-color, high-quality photomicrographs and clinical photos, and at-a-glance tables makes it easy to access the information you need to quickly and accurately detect and identify molecular and genetic mechanisms of disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Easily review normal histology before examining abnormal findings so you can avoid false positives. Gain a superb visual understanding of important histologic features with hundreds of full-color illustrations representing a wide variety of pathologic lesions. Benefit from the same highly practical format as other titles in this series: consistent headings throughout, summary boxes for pathologic and clinical features, high quality photomicrographs and clinical photos, and a logical organization by type of infectious organism. Avoid incorrect diagnoses with a separate section on artifacts and pitfalls that highlights common problems you may encounter. Get up-to-date, comprehensive coverage of the field, including new renal cell carcinoma subtypes and intraductal carcinoma of the prostate; newer immunohistochemical and molecular markers; and updates to the Gleason Grading system for prostate cancer, Fuhrman Grading system for renal cell carcinoma, and TNM classification for GU malignancies.

Download or read book Molecular Biology of Cancer Translation to the Clinic written by and published by Academic Press. This book was released on 2010-12-16 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology over the last several decades are being steadily applied to our understanding of the molecular biology of cancer, and these advances in knowledge are being translated into the clinical practice of oncology. This volume explores some of the most exciting recent advances in basic research on the molecular biology of cancer and how this knowledge is leading to advances in the diagnosis, treatment, and prevention of cancer. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Download or read book Identification of Micro RNAs and Their Messenger RNA Targets in Prostate Cancer and Biological Fluids written by Kanika Sharma and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the second most common cancer in the United States that affects men today. To better treat this disease accurate biomarkers and successful therapeutic treatments are needed. A novel approach to understand the mechanisms behind prostate cancer tumor formation lies in identifying dysregulated micro-RNAs (miRNAs), which are a class of small (18-24 nucleotides) non-coding RNAs that regulate gene expression posttranscriptionally by either inhibiting protein synthesis or signaling messenger-RNA for degradation. Multiple miRNAs were discovered in our highly tumorigenic and metastatic prostate cancer progression model M12 cell line compared to its weakly tumorigenic P69 parental cell line. Various analyses such as human panel analyses, single-miR analyses and patient tumor biopsy samples were analyzed to determine dysregulated miRNAs that contributed to the progression and metastasis of prostate cancer. Together with performing experiments to identify miRNAs, a de novo next generation sequencing approach was applied to identify miRNAs naturally present in biological fluids of normal and healthy subjects. Since, these miRNAs are highly dysregulated in many diseases, including cancer, they can act as potential biomarkers or therapeutic targets to improve treatments for prostate cancer. Essential miRNAs studied for this research were miR-17-3p that is known to target the ErbB2 mRNA; miR-299-5p that directly targets osteopontin (OPN) mRNA, and miR-147b that directly targets many mRNAs, such as COL4A2, ALDH5A1, NDUFA4, SDHD, and IER5. A wide range of miRNAs were identified in six biological fluids: venous blood, menstrual blood, vaginal fluid, semen, saliva, and feces. There were some miRNAs that were common to all 6 body fluids, some unique to each body fluid, and some miRNAs that literature suggested could potentially be biomarkers or normalizers for body fluid characterization.

Download or read book Identification of Prostate Cancer Biomarkers for Diagnosis and Stratification of Disease written by Ammara Muazzam and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: