Download or read book Identification and Characterization of Candidate Tumor Suppressor Genes from Chromosomal Region 1p22 in Mantle Cell Lymphomas written by Asha Balakrishnan and published by . This book was released on 2004 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Characterization of Candidate Tumor Suppressor Genes Localized in the Critical Chromosomal Region 13q14 written by Leticia Serra Barrionuevo and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tumor Suppressor Genes written by Wafik S. El-Deiry and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control.
Download or read book Genetic Approaches to Identify and Characterize Regions Containing Candidate Tumor Suppressor Genes written by Jessica Anne Crowley and published by . This book was released on 2004 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book as S y sa al Ir q ya al mun aliq t al mum ras t al ahd f written by and published by . This book was released on with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification of Two Candidate Tumor Suppressor Genes on Chromosome 17p13 3 Assessment of Their Roles in Breast and Ovarian Carcinogenesis written by and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is one of the most common malignancies affecting women in the US. Despite the magnitude of this disease little is known about the molecular events that occur during its development. We have identified a region of less than 30 kbp, on chromosome l7pl3.3 by allelic loss mapping, which is altered in>50% of the breast tumors analyzed. Using positional cloning techniques we have identified a gene, OVCA2, within this region, which we believe may be a tumor suppressor gene.
Download or read book Identification and Characterization of Molecular Abnormalities of 11p Genes in Human Breast Cancer written by and published by . This book was released on 1999 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have been investigating the hypothesis that 11p15 harbors one or more breast cancer suppressor genes. We have defined a minimal region of loss of heterozygosity in breast cancer between D11S988 and D11S1318. We have also performed genetic complementation experiments on breast cancer cells using subchromosomal transferable fragments (STF), but the STFs did not prove to be sufficiently stable for these cells. We have therefore developed a novel one-step retrofitting vector containing a mammalian selectable gene that allows us to modify bacterial artificial chromosome (BAC) for genetic complementation experiments, and we have successfully introduced these into tumor cells. We are currently testing these modified BACs on MCF-7 and HuMi breast cancer cells. We have also identified two new candidate genes within the region of LOH, termed TSSC4 and TSSC6. Twelve to 98 breast cancer samples were sequenced over the entire coding sequence of 8 genes within the region of LOH. While no somatic mutations were found, we did observe a germline alteration of one gene with in a patient multiple primary breast cancers. In addition, we found a novel alteration, relaxation of splicing fidelity, affecting multiple genes, in over half of human breast cancers.
Download or read book Identification of Candidate Tumor Suppressor Genes on Chromosome 19 in Human Gliomas written by Kristen Lee Drucker and published by . This book was released on 2008 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterizing the Role of 1p36 Deletion in Breast Cancer and Identifying Candidate Tumor Suppressors written by and published by . This book was released on 2009 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 60% of human breast tumors display a deletion of one copy of the 1p36 region of the short arm of chromosome 1. Patients whose tumors carry this deletion show a three-fold increase in mortality, suggesting a biological role for this deletion in tumor development, and suggesting the presence of one or more tumor suppressors in this region. Purpose: Characterization of the unique biology of tumors with 1p36 deletion, and identification of the tumor suppressor(s) in the region may inform therapeutic strategies, and present unique therapeutic targets for this subset of breast cancer cases with relatively poor survival. Scope: The goals of this research project are to 1) develop a mouse model for 1p36 deletion in breast cancer by generating mice harboring loxP sequences flanking the deletion region, and crossing to tissue-specific Cre expressing mice, 2) perform in-vivo insertional mutagenesis in breast tumors using the two-component Sleeping Beauty transposon system (mutagenic transposons mobilized by a trans-acting transposase) to tag tumor suppressors and oncogenes during tumor development and 3) to combine these two systems to identify tumor suppressors in the 1p36 region. Technical setbacks and the observation by another group that deletion of at least part of the 1p36 region systemically does not lead to breast tumors in mice have led us to focus primarily on the Sleeping Beauty system for the last two years. We have opted for an in vitro approach in which we use lentiviral constructs to activate transposons in mammary epithelial cells, which we then transplant into recipient mice.
Download or read book A Breast Tumor Suppressor Gene on 8p22 Identification by the Genetic Suppressor Element Approach written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are currently investigating a putative tumor suppressor gene (TSG) located at chromosomal band 8p22 that is involved in breast cancer. We have proposed to apply the genetic suppressor element (GSE) approach to the identification of this TSG. Briefly, a library of short gene fragments will be introduced into a cell line which demonstrates suppression of clonogenicity in soft agar with the transfer of chromosome 8. Presumably, the 8p22 TSG is responsible for the suppression of clonogenicity, and the introduction of an "active" GSE from the library into the suppressed cells should inhibit the 8p22 TSU contained in the hybrid cells and allow reversion back to the parental phenotype, the ability to grow in soft agar. Any clones that form will be isolated and further evaluated, as a candidate for the TSU. Currently, several ESTs have been identified in the 8p22 interval using various methods. Construction of the USE library consisting of these ESTs is currently underway. All preliminary optimization experiments for retroviral library delivery have been completed. Any positive USE clones identified will be characterized and evaluated as candidate TSGs.
Download or read book Isolation and Characterization of Candidate Tumor Suppressor Genes written by Michele Genini and published by . This book was released on 1995 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2001 with total page 1876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics Abstracts written by and published by . This book was released on 2001 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Concise Handbook of Familial Cancer Susceptibility Syndromes written by and published by . This book was released on 2008 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rare Tumors and Tumor like Conditions in Urological Pathology written by Antonio Lopez-Beltran and published by Springer. This book was released on 2014-11-14 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to rare tumors and tumor-like conditions of the urinary system and male genital organs. It comprises five chapters, devoted to the kidney, bladder, prostate, testes, and penis. Each chapter begins with a brief overview of “common” tumors and tumor-like conditions and with a section on the classification of both common and rare entities. The main clinical, pathological, immunohistochemical, and molecular findings for each rare tumor or tumor-like condition are then described and discussed. Significant characteristics are also documented by representative high-quality illustrations, with emphasis on those aspects of most relevance to differential diagnosis. In addition, prognostic features are fully covered. Urological Pathology: Rare Tumors and Tumor-Like Conditions will be ideal source of core information and practical guidance for residents, fellows, pathologists, urologists, and oncologists.
Download or read book Silverberg s Principles and Practice of Surgical Pathology and Cytopathology 4 Volume Set with Online Access written by Mark R. Wick and published by Cambridge University Press. This book was released on 2015-03-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Silverberg's Principles and Practice of Surgical Pathology and Cytopathology is one of the most durable reference texts in pathology. Thoroughly revised and updated, this state-of-the-art new edition encompasses the entire fields of surgical pathology and cytopathology in a single source. Its practice-oriented format uniquely integrates these disciplines to present all the relevant features of a particular lesion, side by side. Over 4000 color images depict clinical features, morphological attributes, histochemical and immunohistochemical findings, and molecular characteristics of all lesions included. This edition features new highly experienced and academically accomplished editors, while chapters are written by the leading experts in the field (several new to this edition, bringing a fresh approach). Dr Steven Silverberg's practical approach to problem solving has been carefully preserved. The print book is packaged with access to a secure, electronic copy of the book, providing quick and easy access to its wealth of text and images.
