Download or read book Identification and Characterization of Cancer Stem Cells in Human Anaplastic Thyroid Carcinoma written by Susan Friedman and published by . This book was released on 2008 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer Stem Cells written by Federica Papaccio and published by Springer Nature. This book was released on with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification and Characterization of Cancer Stem Cells Using Flow Cytometry written by Yasunari Kanda and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Identification and Characterization of Cancer Stem Cells Using Flow Cytometry.

Download or read book IDENTIFICATION CHARACTERIZAT written by Wing-Yuen Ho and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Identification and Characterization of CD90⁺ Cancer Stem Cells in Hepatocellular Carcinoma" by Wing-yuen, Ho, 何永源, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Hepatocellular carcinoma (HCC) is one of the most devastating malignancies worldwide with increasing incidences in both developed and developing countries. Survival rates have not been significantly improved over the past decades in spite of advances in detection and therapies for this disease, suggesting that current treatments may target the wrong cells, and miss the cancer stem cells (CSCs). The cancer stem cell hypothesis presents that tumor formation, proliferation and propagation are driven by a rare subpopulation of chemoresistant CSCs that are not killed by conventional therapies and go on to cause disease relapse. The objective of this study was to identify and characterize CSCs in HCC cell lines and human liver tumor specimens using CD90 as a potential marker. The number of CD90+ cells present in HCC cell lines was found to positively correlate with tumorigenicity potentials. Injection of as few as 2,000 sorted CD90+ cells from HCC cell lines resulted in the formation of tumor nodules in nude mice, whereas no tumors formed for CD90ˉcells in the same model. The tumor xenograft generated by injection of CD90+ cells sorted from previous xenograft in a serial xenotransplantation assay exhibited recapitulation of tumor heterogeneity to original primary tumor and consistent proportion of CD90+ and CD90ˉ cells which demonstrated self-renewal and differentiation capacities of CD90+CSCs. CD45ˉCD90+ cells were detected (0.03%-6.2%) in human liver tumor specimens, but were only present in minute quantities in normal, cirrhotic and non-tumorous tissues. More importantly, CD45ˉCD90+ cells sorted from primary HCC tumor also displayed tumorigenicity, self-renewal and lineage differentiation capacities. CD90+CSCs were found to be more resistant to therapeutic drugs compared to CD90- cells, as reflected by the results of enrichment of the CD90+ CSCs and longer survival rates after chemotherapeutic treatment. The high expression of genes, such as OCT4, MRP3, ABCG2, AKT1, BirC5, BCL2, HA and CD44, in CD90+CSCs may mediate chemoresistance. The majority of CD90+ cells co-expressed CD44, another stem cell marker. Blocking CD44 activities by anti-CD44 antibody increased apoptosis of CD90+ CSCs, sensitized CD90+CSCs to chemotherapeutic drugs in vitro, and decreased tumorigenic and metastatic potentials of CD90+CSCs in vivo, indicating that a therapeutic potential of targeting CD44. However side effects may be problematic due to the endogenous expression of CD44 in healthy tissues and normal lymphocytes. To identify novel gene targets specific to liver CSCs, a sensitive RNA-sequencing (RNA-Seq) technique was used to compare the gene expression profiles between CD90+CSCs sorted from HCC primary tumors and CD90+cells from adjacent non-tumorous tissue (CD90+NTSCs). The up-regulated genes in CD90+CSCs were associated with lipid metabolism, inflammation, and drug resistance. Among the differentially expressed genes, glypican-3 (GPC3) was specifically elevated in CD90+CSCs but not in CD90+NTSCs. Therefore, GPC3 could be a promising gene candidate for HCC therapy as targeting GPC3 should not induce damage to normal liver stem cells. In summary, CD90 is a liver CSCs marker. Identification of CD90+ CSCs in HCC provides new insight into cellular basis of hepatocarcinogenesis, recurrence and metastasis, which opens new avenues for the design of future CSC-targeted therapies. D

Download or read book Identification and Characterization of CD90 Cancer Stem Cells in Hepatocellular Carcinoma written by Wing-yuen Ho and published by . This book was released on 2013 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification and Characterization of CD90 Cancer Stem Cells in Hepatocellular Carcinoma written by Wing-yuen Ho and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Doxorubicin Fails to Eradicate Cancer Stem Cells Derived from Anaplastic Thyroid Carcinoma Cells written by and published by . This book was released on 2010 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cancer Stem Cells written by Sharmila A. Bapat and published by Wiley-Interscience. This book was released on 2008-10-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because the concept and discoveries of cancer stem cells are relatively new, scientists and researchers need an introduction to this dynamic area. Cancer Stem Cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Such a presentation facilitates a better understanding of and draws attention to stem cell and cancer biology - two fields that enhance, move, and evolve into each other continuously. It provides an informative study in designing approaches to apply stem cell principles to cancer biology while offering an overview of the challenges in developing combination stem and cancer biology targets for therapeutics. This book serves as a primer for new researchers in the field of cancer biology.

Download or read book Identification and Characterization of Cancer Stem Cells in Mouse Medulloblastoma and Glioma written by Ryan Jackson Ward and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification and Characterization of Neural like Cancer Stem Cells in Salivary Adenoid Cystic Carcinoma written by Alexander Colin Panaccione and published by . This book was released on 2016 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Identification and Characterization of Cancer Stem Cells in Mouse Medulloblastoma and Glioma written by Ryan Ward and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Frontiers in Stem Cell and Regenerative Medicine Research written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2016-04-11 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as tumors, Alzheimer’s disease and related neurodegenerative diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The second volume of this series features reviews on several key topics in this field including cardiac regeneration strategies, induced pluripotent stem cell therapeutics, stem cell therapy for peripheral nerve and cutaneous injuries, dental tissue regeneration, the potential of stem cell differentiation into ovarian cells and much more.

Download or read book Prominin 1 CD133 New Insights on Stem Cancer Stem Cell Biology written by Denis Corbeil and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​​​​​​​Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primary audience for this book is geared towards scientists and researchers with interest in cancer stem cells, stem cells, cell biology, neurobiology, and regenerative medicine.

Download or read book Cancer Stem Cells in Endocrine Tumors written by Giorgio Stassi and published by Frontiers Media SA. This book was released on 2021-09-01 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stem Cells Heterogeneity in Different Organs written by Alexander Birbrair and published by Springer Nature. This book was released on 2019-09-05 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue. As the functions of these stem cells vary, this is very important for the application of stem cells in cell therapy. This book describes the many recent developments that have revealed completely different roles of distinct stem cells within the same organ. Stem Cells Heterogeneity in Different Organs provides a timely update on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. Taken with its companion volumes, Stem Cells Heterogeneity: Novel Concepts and Stem Cells Heterogeneity in Cancer, this book is essential reading for advanced cell biology students as well as researchers and clinicians working with stem cells.

Download or read book Cancer Genetics and Psychotherapy written by Parvin Mehdipour and published by Springer. This book was released on 2017-09-20 with total page 1189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide the readers with the most comprehensive and latest accounts of research and development in this field by emphasizing on the manner of relation between doctors and cancer patients in direction of improving the patients’ style of life. This book, partly, will deal with psychotherapy by considering cancer patients, benefits, hazards and also social impacts including life style. The social supports as the key and influential paradigms will be challenged as a comparative insight by considering the global unity in order to provide a reasonable model to improve the interaction between cancer and psychological nest. In this book, the real stories of cancer patient will be also provided. The initial insight of sections includes: 1) Brief classifications and key points of clinical and histopatological aspects of each organ. 2) Brief view of genetic alterations in each organ. 3) Therapeutic aspects. 4) Brief classifications and key points of Psychology in cancer. 5) The interactions of clinical aspects with psychological field.

Download or read book Diagnostic Pathology Endocrine E Book written by Vania Nosé and published by Elsevier Health Sciences. This book was released on 2019-04-09 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the highly regarded Diagnostic Pathology series, this updated volume by Dr. Vania Nosé is a visually stunning, easy-to-use reference covering 125 of the most common endocrine pathology diagnoses. Outstanding images—more than 2,400 in all—make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Essential knowledge in all areas of endocrine pathology, including thyroid, parathyroid, pituitary, adrenal, pancreas, skin, and inherited tumor syndromes Unsurpassed visual coverage with more than 2,400 carefully annotated clinical images, gross pathology, histology, and special and immunohistochemical stains that provide clinically and diagnostically important information on typical and variant disease features Designed to help you identify crucial elements of each diagnosis along with associated differential diagnoses and pitfalls to more quickly resolve problems during routine sign out of cases Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index Thoroughly updated content throughout, reflecting new WHO classifications for endocrine diseases, recently discovered and newly described endocrine disease entities and genetic causes, and treatment changes of endocrine diseases New coverage of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), with a new chapter on the new entity NIFTP, new genetic discoveries in the development of pheochromocytoma and paragangliomas, new names that demonstrate the differentiation of certain tumors, and new information on immunoglobulin G4-related disease (IgG4-RD) involving thyroid