Download or read book Identification and Characterization of an Escherichia Coli Ribosomal ATPase written by Michael Christopher Kiel and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein synthesis is a unifying process of all living cells. The macromolecules involved in translation, ribosomes, RNAs and protein factors, as well as the mechanisms of protein synthesis, are all largely conserved across the spectrum of cell types. In this thesis, a ribosome-associated ATPase, RbbA, is identified in 'Escherichia coli' extracts. RbbA can bind both 70S ribosomes and 30S ribosomal subunits. The ATPase activity of RbbA increases two-fold in the presence of purified 70S ribosomes. RbbA cross-reacts with antibody raised against the fungal-specific translation factor EF-3, and like EF-3, RbbA stimulates the synthesis of polyphenylalanine from a poly(U) template 'in vitro'. Cross-linking data show that RbbA lies near 30S ribosomal subunit protein S1 and binds to a poly(G)-rich region of the 30S subunit rRNA, 16S rRNA. This region of the ribosome is known as the decoding region of the ribosome and is important for the binding of aminoacyl-tRNAs to the ribosomal A-site. Upon binding of RbbA, 16S rRNA undergoes a specific conformational change that has been demonstrated previously to affect translational fidelity. EF-Tu, which escorts aminoacyl-tRNAs to the A-site of the ribosome, is also capable of binding with RbbA. Hygromycin, an antibiotic that interferes with protein synthesis by binding to the decoding center of the ribosome, is able specifically to inhibit the ribosomal ATPase activity by displacing RbbA from the ribosome. Together, the data suggest that RbbA, the first ATPase demonstrated to be involved in prokaryotic protein synthesis, plays a major role in protein chain elongation.
Download or read book Identification and Characterization of an Escherichia Coli Ribosomal ATPase written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Identification and Characterization of an Escherichia Coli Ribosomal ATPase microform written by Michael Christopher Kiel and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2000 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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Download or read book Escherichia Coli and Salmonella written by Frederick C. Neidhardt and published by . This book was released on 1996 with total page 2822 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the long–awaited second edition of an invaluable classic! Escherichia coli occupies a central role in contemporary molecular biology. It is the unicellular organism about which most is known – all molecular and cellular biologists will want a copy of this book. In 154 chapters, 250 expert authors and editors present the state of the art. Completely rewritten and restructured, the second edition offers a whole new approach to the subject.
Download or read book Bacterial Signal Transduction Networks and Drug Targets written by Ryutaro Utsumi and published by Springer Science & Business Media. This book was released on 2008-12-05 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating book encourages many microbiologists and students to enter the new world of signal transduction in microbiology. Over the past decade, a vast amount of exciting new information on the signal transduction pathway in bacteria has been unearthed.
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Download or read book Molecular Microbiology written by David H. Persing and published by John Wiley & Sons. This book was released on 2020-07-24 with total page 835 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the latest molecular diagnostic techniques in one comprehensive volume The molecular diagnostics landscape has changed dramatically since the last edition of Molecular Microbiology: Diagnostic Principles and Practice in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field. Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors. Molecular Microbiology: Diagnostic Principles and Practice Presents the latest basic scientific theory underlying molecular diagnostics Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing Illustrates and summarizes key concepts and techniques with detailed figures and tables Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance Advises on the latest quality control and quality assurance measures Explores the increasing opportunities and capabilities of information technology Molecular Microbiology: Diagnostic Principles and Practice is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians.
Download or read book Biomedical Index to PHS supported Research pt A Subject access A H written by and published by . This book was released on 1992 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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