Download or read book Hydrolytically Stable Thiol ene Polymer Substrates for Neural Interface Devices written by Seyedmahmoud Hosseini and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioelectronics devices can be described as the combination of materials and electronics to interface with biological systems, and are typically used to detect and modulate biological signals in order to control bodily functions with promise to treat and perhaps cure diseases. Neural interface systems represent a class of bioelectronic devices that facilitate connection between the outside world and the nervous system through conducting electrodes which transduce electric signals to and from the bioelectronic device (and thus to and from the body) to treat or help people with neurological disorders. One type of device used in neural interface systems today is composed of a substrate and one or multiple electrodes whose purpose is to add, remove or block information from various parts of the central or peripheral nervous system. The performance of the so-called electrode-tissue interface (or how the device connects to the nervous system) varies depending upon the nature of the electrode/substrate combination. A driving disadvantage of many typical electrodes fabricated on hard materials is the resulting inflammatory reaction that may lead to electrode failure or adverse signal recording, stimulating or blocking. Using polymers as a substrate, with a Young's modulus in the MPa range after insertion at an initially higher modulus, upon which to fabricate electrodes, has been proposed as a design mechanism to help address many of the mechanical mismatch issues associated with stiff materials. In particular, one class of materials has been explored extensively in this space over the past half-decade: thiol-based shape memory polymers. Thiol-ene/acrylate copolymers were introduced in 2012 to tackle several of the physical mismatch problems resulting in a half decade of efforts to understand effects of these materials on the underlying physiology acutely and sub-chronically in small animal models. Using shape memory polymers has led over the past half-decade to the optimization of devices (cortical probes, cochlear implants, nerve cuffs, spinal cord simulators and others) which are stiff enough to be effectively handled by surgeons, implanted, and subsequently demonstrated reduced stiffness after insertion into neural tissue and a different physiological response than materials which are always stiff. Currently, most of the commercially available monomers used in the design and fabrication of shape memory based neural interfaces contain chemical structures with ester functional groups, which increase the polymers’ susceptibility to hydrolytic degradation under moist conditions. Hydrolysis of polymer substrates can lead to many adverse effects for neural interfaces, producing specific by-products at different points after implantation. Therefore, the degraded polymer often is the culprit for worsening device performance: as a direct result of the ester-mediated degradation of these polymers, leakage channels develop through the device and negatively affect the subchronic and chronic electrical performance of devices. In this research, a series of novel thiol-ene formulations have been designed, formulated, polymerized and tested in actual devices. These new materials demonstrate a glass transition temperature and modulus similar to leading shape memory polymer neural interfaces in the published literature, but these novel formulations do not contain ester groups anywhere in the polymer network, allowing exploration of the hypothesis that this approach minimizes hydrolytic instability under the conditions to which neural interfaces are subjected. The synthesis of several new monomers was optimized and a novel polymer composition was designed and realized through photopolymerization from these new building blocks to have similar in vivo softening capabilities as previously reported polymers. Dynamic mechanical analysis (DMA) of the hydrolytically stable polymer reveals that the polymer has a glass transition temperature above body temperature when dry and below body temperature after being soaked in physiologically representative media such as phosphate buffered saline (PBS). Thus, the novel polymers in and around this resulting design space are able to soften under physiological conditions to a modulus which is much closer to the tissue than the as-inserted devices. To verify the improved stability of the new material against hydrolysis, accelerated aging tests were performed. Weight loss and mechanical properties were determined and compared to ester-containing polymer compositions. Resulting polymers are proposed as a candidate for translation into next-generation bioelectronic devices as substrates that help overcome a major limitation with previous shape memory polymer based neural interfaces.

Download or read book Bridging the Gap in Neuroelectronic Interfaces written by Jeffrey R. Capadona and published by Frontiers Media SA. This book was released on 2020-07-09 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Neuroengineering written by Nitish V. Thakor and published by Springer Nature. This book was released on 2023-02-02 with total page 3686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.​

Download or read book Shape Memory Polymers for Biomedical Applications written by L Yahia and published by Elsevier. This book was released on 2015-03-19 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shape memory polymers (SMPs) are an emerging class of smart polymers which give scientists the ability to process the material into a permanent state and predefine a second temporary state which can be triggered by different stimuli. The changing chemistries of SMPs allows scientists to tailor important properties such as strength, stiffness, elasticity and expansion rate. Consequently SMPs are being increasingly used and developed for minimally invasive applications where the material can expand and develop post insertion. This book will provide readers with a comprehensive review of shape memory polymer technologies. Part 1 will discuss the fundamentals and mechanical aspects of SMPs. Chapters in part 2 will look at the range of technologies and materials available for scientific manipulation whilst the final set of chapters will review applications. - Reviews the fundamentals of shape memory polymers with chapters focussing on the basic principles of the materials - Comprehensive coverage of design and mechanical aspects of SMPs - Expert analysis of the range of technologies and materials available for scientific manipulation

Download or read book Chitosan Based Hydrogels written by Kangde Yao and published by CRC Press. This book was released on 2016-04-19 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to their unique properties, chitosan-based materials have emerged as useful resources in a variety of medicines, drug controlled-release carriers, tissue engineering scaffolds, and immobilized enzymes. But many of these materials have yet to reach the commercial market. Therefore, more work must be completed to fill the gap between research and

Download or read book Neural Microelectrodes Design and Applications written by Stuart Cogan and published by . This book was released on 2019 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural electrodes enable the recording and stimulation of bioelectrical activity in the nervous system. This technology provides neuroscientists with the means to probe the functionality of neural circuitry in both health and disease. In addition, neural electrodes can deliver therapeutic stimulation for the relief of debilitating symptoms associated with neurological disorders such as Parkinson's disease and may serve as the basis for the restoration of sensory perception through peripheral nerve and brain regions after disease or injury. Lastly, microscale neural electrodes recording signals associated with volitional movement in paralyzed individuals can be decoded for controlling external devices and prosthetic limbs or driving the stimulation of paralyzed muscles for functional movements. In spite of the promise of neural electrodes for a range of applications, chronic performance remains a goal for long-term basic science studies, as well as clinical applications. New perspectives and opportunities from fields including tissue biomechanics, materials science, and biological mechanisms of inflammation and neurodegeneration are critical to advances in neural electrode technology. This Special Issue will address the state-of-the-art knowledge and emerging opportunities for the development and demonstration of advanced neural electrodes.

Download or read book Shape Memory Polymers written by Jinlian Hu and published by Smithers Rapra. This book was released on 2014-05-27 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shape-memory polymers (SMP) are a unique branch of the smart materials family which are capable of changing shape on-demand upon exposure to external stimulus. The discovery of SMP made a significant breakthrough in the developments of novel smart materials for a variety of engineering applications, superseded the traditional materials, and also influenced the current methods of product designing. This book provides the latest advanced information of on-going research domains of SMP. This will certainly enlighten the reader to the achievements and tremendous potentials of SMP. The basic fundamentals of SMP, including shape-memory mechanisms and mechanics are described. This will aid reader to become more familiar with SMP and the basic concepts, thus guiding them in undergoing independent research in the SMP field. The book also provides the reader with associated challenges and existing application problems of SMP. This could assist the reader to focus more on these issues and further exploit their knowledge to look for innovative solutions. Future outlooks of SMP research are discussed as well. This book should prove to be extremely useful for academics, R&D managers, researcher scientists, engineers, and all others related to the SMP research.

Download or read book Biomedical Microsystems written by Ellis Meng and published by CRC Press. This book was released on 2011-06-22 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Poised to dramatically impact human health, biomedical microsystems (bioMEMS) technologies incorporate various aspects from materials science, biology, chemistry, physics, medicine, and engineering. Reflecting the highly interdisciplinary nature of this area, Biomedical Microsystems covers the fundamentals of miniaturization, biomaterials, microfabrication, and nanotechnology, along with relevant applications. Written by an active researcher who was recently named one of Technology Review’s Young Innovators Under 35, the book begins with an introduction to the benefits of miniaturization. It then introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author also covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. For readers with a limited background in MEMS and bioMEMS, this book provides a practical introduction to the technology used to make these devices, the principles that govern their operation, and examples of their application. It offers a starting point for understanding advanced topics and encourages readers to begin to formulate their own ideas about the design of novel bioMEMS. A solutions manual is available for instructors who want to convert this reference to classroom use.

Download or read book Advanced Healthcare Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-05-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers

Download or read book Polymeric Biomaterials Revised and Expanded written by Severian Dumitriu and published by CRC Press. This book was released on 2001-11-29 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering nearly 7000 references-3900 more than the first edition-Polymeric Biomaterials, Second Edition is an up-to-the-minute source for plastics and biomedical engineers, polymer scientists, biochemists, molecular biologists, macromolecular chemists, pharmacists, cardiovascular and plastic surgeons, and graduate and medical students in these disciplines. Completely revised and updated, it includes coverage of genetic engineering, synthesis of biodegradable polymers, hydrogels, and mucoadhesive polymers, as well as polymers for dermacosmetic treatments, burn and wound dressings, orthopedic surgery, artificial joints, vascular prostheses, and in blood contacting systems.

Download or read book Biosynthetic Polymers for Medical Applications written by Laura Poole-Warren and published by Elsevier. This book was released on 2015-11-23 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosynthetic Polymers for Medical Applications provides the latest information on biopolymers, the polymers that have been produced from living organisms and are biodegradable in nature. These advanced materials are becoming increasingly important for medical applications due to their favorable properties, such as degradability and biocompatibility. This important book provides readers with a thorough review of the fundamentals of biosynthetic polymers and their applications. Part One covers the fundamentals of biosynthetic polymers for medical applications, while Part Two explores biosynthetic polymer coatings and surface modification. Subsequent sections discuss biosynthetic polymers for tissue engineering applications and how to conduct polymers for medical applications. - Comprehensively covers all major medical applications of biosynthetic polymers - Provides an overview of non-degradable and biodegradable biosynthetic polymers and their medical uses - Presents a specific focus on coatings and surface modifications, biosynthetic hydrogels, particulate systems for gene and drug delivery, and conjugated conducting polymers

Download or read book Modification of Polymers written by Charles E. Carraher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sheer volume of topics which could have been included under our general title prompted us to make some rather arbitrary decisions about content. Modification by irradiation is not included because the activity in this area is being treated elsewhere. We have chosen to emphasize chemical routes to modification and have striven to pre sent as balanced a representation of current activity as time and page count permit. Industrial applications, both real and potential, are included. Where appropriate, we have encouraged the contributors to include review material to help provide the reader with adequate context. The initial chapter is a review from a historical perspective of polymer modification and contains an extensive bibliography. The remainder of the book is divided into four general areas: Reactions and Preparation of Copolymers Reactions and Preparation of Block and Graft Copolymers Modification Through Condensation Reactions Applications The chemical modification of homopolymers such as polyvinylchlo ride, polyethylene, poly(chloroalkylene sulfides), polysulfones, poly chloromethylstyrene, polyisobutylene, polysodium acrylate, polyvinyl alcohol, polyvinyl chloroformate, sulfonated polystyrene; block and graft copolymers such as poly(styrene-block-ethylene-co-butylene block-styrene), poly(I,4-polybutadiene-block ethylene oxide), star chlorine-telechelic polyisobutylene, poly(isobutylene-co-2,3-dimethyl- 1,3-butadiene), poly(styrene-co-N-butylmethacrylate); cellulose, dex tran and inulin, is described.

Download or read book Spinal Cord Injury SCI Repair Strategies written by Giuseppe Perale and published by Woodhead Publishing. This book was released on 2019-10-30 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. - Covers current and future repair strategies for spinal cord injury repair - Focuses on key research trends, clinics, biology and engineering - Provides fundamentals on regenerative engineering and tissue engineering

Download or read book New Frontiers in Organoselenium Compounds written by Eder João Lenardão and published by Springer. This book was released on 2018-06-29 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent advances in and perspectives on the use of organoselenium compounds, primarily highlighting the new frontiers in the field of Green Chemistry, their therapeutic and biological relevance and new materials. Throughout its 200 pages, readers will find an updated and comprehensive review of new aspects of organoselenium chemistry and biochemistry. Fully referenced and written in an easy to read style, it offers readers a primary resource for including organoselenium derivatives in their projects. This book will be of interest to specialists, students and researchers involved in a broad range of fields, from synthetic green chemistry to medicinal chemistry and the chemistry of natural products. The connection between organoselenium compounds and green chemistry, despite having only recently emerged, is one of the subjects of this book. The first chapter highlights the use of Se-containing molecules as reagents and catalysts in new green protocols to access important organic transformations. The book provides a wealth of examples of bioactive Se-containing molecules, especially focusing on those with potential therapeutic uses. The second chapter focuses on the state of the art concerning the role of organoselenium compounds as antioxidants, GPx mimics, and derivatives endowed with different bioactive properties. “Organoselenium in nature” is the title of the third chapter, which equips readers with essential information on the main natural organoselenium compounds and where they are found. Selected aspects of the metabolism of selenium in plants and microorganisms are also discussed. In closing, the book includes a chapter dedicated to recent advances concerning the nonbonding interactions between organochalcogen compounds. This is currently a hot topic in selenium chemistry and biochemistry, and here readers will find key insights into the chalcogen bond and its role in the biological activity of organoselenium compounds.

Download or read book Biodegradable Polymers in Clinical Use and Clinical Development written by Abraham J. Domb and published by John Wiley & Sons. This book was released on 2011-05-12 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on biodegradable polymers that are already in clinical use or under clinical development. Synthetic and natural polymers will be included. This excludes polymers that have been investigated and did not reach clinical development. The purpose of this book is to provide updated status of the polymers that are clinical use and those that are now being developed for clinical use and hopefully will reach the clinic during the next 5 years. The book provides information that of interest to academics and practicing researchers including chemists, biologists and bioengineers and users: physicians, pharmacists.

Download or read book Thiol X Chemistries in Polymer and Materials Science written by Andrew B. Lowe and published by Royal Society of Chemistry. This book was released on 2013 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive resource on thiol-x chemistries for postgraduates, academics and industrial practitioners interested in polymer and materials applications from leading experts in the field.

Download or read book Smart Materials Micro Nanosystems written by Pietro Vincenzini and published by Trans Tech Publications Ltd. This book was released on 2008-09-02 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection comprises 77 peer-reviewed papers which, together, offer a wealth of up-to-date information on “Smart Materials & Micro/Nanosystems”. Volume is indexed by Thomson Reuters CPCI-S (WoS). They are grouped under the rubrics: chapter 1 - Ferroelectrics, piezoelectrics, electrostrictive and magnetostrictive materials; chapter 2 - Stimuli responsive polymers and gels; chapter 3 - Shape memory polymers & magnetorheological fluids; chapter 4 - Smart multifunctional materials and composites; chapter 5 - Hybrid active materials systems; chapter 6 - Smart nanocomposites and nanomaterials; chapter 7 - Mems / nems; chapter 8 - Recent developments in electrical writable organic memory devices. This special volume has also been published online in the series, “Advances in Science and Technology” Vol. 54.