Download or read book Human Slices written by Gloria Bowman and published by Xlibris. This book was released on 2001-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Slices is a love story about a woman who is happily childfree. It's her natural choice. She spells her name S-A-L-M but pronounces it Sam. "The l is silent," she says. It's her way of combining her given name, Samantha, with her father's nickname for her, Little Salmon. It's the late 1980s in Chicago, and she and her friends, all in their thirties, are thinking about what's next in their lives and how, and if, they're going to determine their own destinies. On a promising spring day, Salm visits the Museum of Science and Industry and makes her way to the human slices exhibit. It's always been one of her favorite displays, a series of cross-sections of the human body, real flesh and bones. She is fascinated by the thought that the same shapes and forms are stacked inside her own body, influencing her moves and decisions. When a tall, intriguing man approaches the exhibit, Salm makes a natural choice: She follows him.
Download or read book Digital Human Modeling written by Vincent D. Duffy and published by Springer. This book was released on 2007-08-24 with total page 1083 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the First International Conference on Digital Human Modeling, DHM 2007, held in Beijing, China in July 2007. The papers thoroughly cover the thematic area of digital human modeling, addressing the following major topics: shape and movement modeling and anthropometry, building and applying virtual humans, medical and rehabilitation applications, as well as industrial and ergonomic applications.
Download or read book Atlas of the Visible Human Male written by Victor M. Spitzer and published by Jones & Bartlett Learning. This book was released on 1998 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of the Visible Human reference text completely catalogs the internal human male in a way never before possible. The latest in high-definition computers were used to compile cuts taken from one cadaver into three different perspectives: transverse, coronal, and sagittal. This text is an invaluable reference for professionals, students, and anyone interest in the fascinating detail of the human body.
Download or read book Simulating Humans written by Norman I. Badler and published by Oxford University Press, USA. This book was released on 1993-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of simulated human figures is an active research area in computer graphics, and Norman Badler's group at the University of Pennsylvania is one of the leaders in the field. This book summarizes the state of the art in simulating human figures, discusses many of the interesting application areas, and makes some assumptions and predictions about where the field is going.
Download or read book The Transparent Body written by Jose Van Dijck and published by University of Washington Press. This book was released on 2011-05-01 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the potent properties of X rays evoked in Thomas Mann's Magic Mountain to the miniaturized surgical team of the classic science fiction film Fantastic Voyage, the possibility of peering into the inner reaches of the body has engaged the twentieth-century popular and scientific imagination. Drawing on examples that are international in scope, The Transparent Body examines the dissemination of medical images to a popular audience, advancing the argument that medical imaging technologies are the material embodiment of collective desires and fantasies--the most pervasive of which is the ideal of transparency itself. The Transparent Body traces the cultural context and wider social impact of such medical imaging practices as X ray and endoscopy, ultrasound imaging of fetuses, the filming and broadcasting of surgical operations, the creation of plastinated corpses for display as art objects, and the use of digitized cadavers in anatomical study. In the early twenty-first century, the interior of the body has become a pervasive cultural presence - as accessible to the public eye as to the physician's gaze. Jose van Dijck explores the multifaceted interactions between medical images and cultural ideologies that have brought about this situation. The Transparent Body unfolds the complexities involved in medical images and their making, illuminating their uses and meanings both within and outside of medicine. Van Dijck demonstrates the ways in which the ability to render the inner regions of the human body visible - and the proliferation of images of the body's interior in popular media - affect our view of corporeality and our understanding of health and disease. Written in an engaging style that brings thought-provoking cultural intersections vividly to life, The Transparent Body will be of special interest to those in media studies, cultural studies, science and technology studies, medical humanities, and the history of medicine.
Download or read book Human based Systems for Translational Research written by Robert Coleman and published by Royal Society of Chemistry. This book was released on 2014-12-08 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a history and discussion of the use of human tissues as an alternative to animal-based testing for assessing the efficacy and safety of new medicines. Beginning by providing a historical background to animal-based testing, this text then describes in detail the issues relating to access to human cells and tissue and the rules and regulations governing their use. The book illustrates what is currently possible in humanising medicines research and development, and suggests more rational and reliable means of developing safe and effective drugs for the future than those on which we currently rely. Early chapters establish the need to generate more data in human-derived test systems, and the need for resources such as tissue banks and standardised processes whilst highlighting the barriers that have prevented such developments so far. Subsequent chapters explore the alternatives to current animal toxicology studies, including stem cells and computational models, with balanced views of the technical challenges and opportunities these offer. In addition, useful information on computational methods and pharmacokinetics are included. This book is an essential read for anyone engaged in translational drug discovery who wishes to consolidate their understanding and broaden their awareness of the key issues involved in accessing primary human tissue and the advantages of doing so.
Download or read book Drug Drug Interactions Scientific and Regulatory Perspectives written by and published by Academic Press. This book was released on 1997-11-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: DrugDrug Interactions is a comprehensive review of the scientific and regulatory perspectives of drugdrug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drugdrug interactions, the prediction of drugdrug interaction potential of new drugs, and the avoidance of clinically significant drugdrug interaction in patients. - Provides useful references on the science of drug-drug interactions - Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint - Contains original data from academic and industrial laboratories - Presents an overview of regulatory agency positions
Download or read book Neuropsychopharmacology written by W.E. Jr. Bunney and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Topics in Nonclinical Drug Development written by Philip Bentley and published by CRC Press. This book was released on 2023-11-03 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume in the CURRENT TOPICS IN NONCLINICAL DRUG DEVELOPMENT SERIES explores the critical issues and current topics in nonclinical drug development. This second volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Select topics include: Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology. Current approaches to carcinogenicity testing. Predicting drug-drug interactions. Current understanding of idiosyncratic drug reaction. Assessing cardiovascular risks beyond QT interval. Use of 3D cell cultures in toxicology and ADME. Development of small molecule-antibody complexes. Differentiating adverse from non-adverse findings in nonclinical studies. Current Topics in Nonclinical Drug Development: Volume 2 will aid toxicologists, toxicologic pathologists, consultants, regulators, study directors, and nonclinical scientists dealing with day-to-day issues encountered in drug development and assist in formulating strategies for resolution of these issues. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.
Download or read book Drug Discovery and Evaluation Safety and Pharmacokinetic Assays written by Franz J. Hock and published by Springer Nature. This book was released on 2025-02 with total page 2751 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily conducted to confirm whether the selected compound possesses a suitable half-life for sufficient exposure and efficacy and, whether it has the desired properties specificity to the intended route of administration. Safety aspects relied predominantly on the conduct of single and repeat toxicologydose studies, which inform changes in organ structure rather than organ function. Both toxicological and pharmacokinetic studies are adapted to the progress of studies in clinical pharmacology and clinical trials. The new edition of this well and broadly accepted reference work contains several innovative and distinguished chapters. This "sequential" strategy has been abandoned with this new version of the book for several reasons: - Of the possible multitude of negative effects that novel drugs may impart on organ function, e.g. ventricular tachy-arrhythmia, many are detected too late in non-clinical studies to inform clinicians. On the other hand, negative findings in chronic toxicity studies in animals may turn out to be irrelevant for human beings. - New scientific approaches, e.g. high-throughput screening, human pluripotent stem cells, transgenic animals, knock-out animals, in silico models, pharmaco-genomics and pharmaco-proteomics, as well as Artificial Intelligence (AI) methods offered new possibilities. - There are several examples, that show that the "druggability" of compounds was considerably underestimated when the probability of success of a new project was assessed. The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. Research and development scientists, involving the following changes, therefore adopted a change of strategy: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization). - The term "Safety Pharmacology" was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group and the Safety Pharmacology Society (SPS) was launched. The discipline provided for evaluation, development and validation of a multitude of safety tests outlined in the 'Core Battery of Studies'. - Characterizing the exposure profile of a drug by conducting pharmacokinetic studies that evaluates the absorption, distribution, metabolism and excretion should to be investigated at an early stage of development as results contribute to the selection of a compound for further development. Advancements in Toxicology were achieved by the introduction of new methods, e.g., in silico methods, genetic toxicology, computational toxicology and AI. The book is a landmark in the continuously changing world of drug research and developments. As such, it is essential reading for many groups: not only for all students of pharmacology and toxicology but also for industry scientists and physicians, especially those involved in clinical trials of drugs, and for pharmacists who must know the safety requirements of drugs. The book is essential for scientists and managers in the pharmaceutical industry who are involved in drug discovery, drug development and decision making in the development process. In particular, the book will be of use to government institutions and committees working on official guidelines for drug evaluation worldwide.
Download or read book The molecular mechanisms of epilepsy and potential therapeutics written by Tobias Engel and published by Frontiers Media SA. This book was released on 2022-12-26 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Encyclopedia of Basic Epilepsy Research written by and published by Academic Press. This book was released on 2009-05-27 with total page 1853 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research
Download or read book Advances in Biomedical and Molecular Neuroscience written by Robert J. Harvey and published by Frontiers Media SA. This book was released on 2022-04-04 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pancreas Imaging Across the Spectrum written by Amelia K. Linnemann and published by Frontiers Media SA. This book was released on 2022-02-11 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Technological Adoption and Trends in Health Sciences Teaching Learning and Practice written by Marcos-Pablos, Samuel and published by IGI Global. This book was released on 2022-02-11 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of technology in health sciences has a direct impact on health outcomes, as well as on the quality and the safety of healthcare processes. In addition, the use of new technological developments in medical education has proven to be greatly effective and creates realistic learning environments to experience procedures and devices that will become common in medical practice. However, bringing new technologies into the health sector is a complex task, which is why a comprehensive vision of the health sciences ecosystem (encompassing many different areas of research) is vital. Technological Adoption and Trends in Health Sciences Teaching, Learning, and Practice obtains an overview of the technological trends within the health sciences ecosystem, identifies the strengths and weaknesses of the research presented to date, and depicts possible future research directions within health science education and practice. Covering topics such as artificial intelligence and online laboratories, it is ideal for health sciences educators and practitioners, technological solution providers, health organizations, health and care workers, regulators, governing bodies, researchers, academicians, and students.
Download or read book Heme Oxygenase in Biology and Medicine written by Nader G. Abraham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research.
Download or read book Models of Seizures and Epilepsy written by Asla Pitkänen and published by Academic Press. This book was released on 2017-06-14 with total page 1180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. - Provides a comprehensive reference detailing animal models of epilepsy and seizure - Offers insights on the use of novel technologies that can be applied in experimental epilepsy research - Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques - Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments
