Download or read book Human Neuroblastoma written by Manfred Schwab and published by Taylor & Francis US. This book was released on 1993 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Neurology of Neuroblastoma written by Nina Felice Schor and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma is the single most common solid tumor of childhood. Although children with small primary neuroblastomas alone are almost always cured by surgery, 65% of children with neuroblastoma already have large bulky tumors or metastatic disease by the time of initial diagnosis. For these children, the 5-year survival rate is only somewhere between 5% and 20% with therapies including surgery, radiation, chemotherapy, and bone marrow transplantation. Dr Schor outlines a new approach to these tumors in order to make a difference for these children. There is much information to support the notion that neuroblastomas represent a developmental aberration of the nervous system, rather than a de novo abnormality in a previously normal cell. While the remote, paraneoplastic effects of neuroblastoma are often the purview of the child neurologist, the neoplasm itself has been viewed and approached therapeutically in much the same manner as all other solid tumors, as the purview of the pediatric oncologist. This work takes the view that approaching neuroblastoma rather as a disorder of nervous system development offers new therapeutic possibilities for this common tumor of childhood.
Download or read book Neuroblastoma written by Swapan K. Ray and published by Academic Press. This book was released on 2019-01-11 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions. Comprehensively covers the histopathological characterization, molecular mechanisms, and most recent therapeutic interventions in neuroblastoma Includes recent developments and therapeutic interventions for neuroblastoma, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy Presents a broad scope that provides basic researchers, practitioners and students with the most current overview of recent advances
Download or read book Neuroblastoma written by Shahab Asgharzadeh and published by Springer Nature. This book was released on with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroblastoma written by Hiroyuki Shimada and published by BoD – Books on Demand. This book was released on 2013-05-29 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumors of neuroblastoma group are heterogenous and their molecular/genomic properties are closely related to the prognosis of patients: some children enjoy an excellent clinical course after biopsy/surgery alone, and others suffer from a fatal outcome even after an intensive treatment. Recent progress has also started disclosing critical significance of cross-talking between neuroblastoma cells and their microenvironment in predicting clinical behaviors of individual cases. In this book, the world distinguished investigators report clinical and biological characteristics of this disease.
Download or read book Neuroblastoma written by Carl E. Pochedly and published by CRC Press. This book was released on 1990-06-21 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide a comprehensive review of current knowledge and to give a thoughtful assessment of the many complex issues involved in the diagnosis and treatment of this common malignant solid tumor found in children. This up-to-date publication also reviews new concepts in histogenesis and histopathology of neuroblastoma. Divided into three main sections, this work focuses on tumor biology, clinical management, and prognosis and future perspectives. This fascinating work includes in-depth discussions on neuroblastoma in infancy and the manifestations of this tumor as it affects various organs and various parts of the body. It also provides guidelines for treatment with surgery, radiotherapy and chemotherapy. This ideal resource is loaded with information for all those who care for children with cancer, including pediatric oncologists, medical oncologists, pathologists, radiotherapists, pediatric nurse oncologists and pediatricians.
Download or read book Progressive Neuroblastoma written by H. Christiansen and published by Karger Medical and Scientific Publishers. This book was released on 2015-09-28 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma is a tumor derived from the sympathetic nervous system. It is the most common extracranial solid tumor occurring in children and exhibits a marked variability in outcome when the disease is categorized by clinical (e.g. age or stage) and biologic characteristics. This book gives an introduction into the clinical features of progressive neuroblastoma and focuses on molecular-targeted therapies and immunotherapies of this disease. It has become increasingly clear that MYCN (v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog) holds a key position in neuroblastic transformation and gene expression in normal and transformed cells. In the 14 chapters important topics such as genomic alterations in neuroblastoma and strategies for indirect molecular targeting of MYCN are discussed. Two chapters, for example, review apoptotic pathways and proapoptotic molecular targets in neuroblastoma, one focusing on the p53 pathway and the extrinsic and intrinsic pathways of apoptosis. Other chapters cover topics related to immunology in neuroblastoma, such as immune regulation in neuroblastoma, immunotherapy related to passive and active vaccination approaches and additional immunotherapy in the treatment of progressive disease. This volume will be essential reading for all clinicians and basic researchers who are involved in delivering health care to patients with progressive neuroblastoma.
Download or read book Neuroblastoma written by Carl Pochedly and published by North-Holland. This book was released on 1982 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuropsychiatric Disorders written by Manfred Gerlach and published by Springer Science & Business Media. This book was released on 2007-12-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Principles and Practice of Genitourinary Oncology written by Derek Raghavan and published by Lippincott Williams & Wilkins. This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume begins with reviews of the principles of genitourinary oncology, including molecular diagnostics, pathologic and radiologic diagnosis, retroperitoneal and pelvic surgery, endoscopic surgery, and recent innovations in radiotherapy, chemotherapy and palliative management. Also included are discussions on clinical trial design, clinical decision-making and costs of treating genitourinary cancer. The ten major sections focus on specific disease sites and cancers, and provide information on pathology, tumour markers, molecular biology, clinical presentation of cancer, diagnosis, staging and therapy for each stage of disease. The book concludes with a discussion of the nurse practitioner's role in patient support.
Download or read book Neuroblastomas New Insights for the Healthcare Professional 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastomas: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroblastomas. The editors have built Neuroblastomas: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroblastomas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neuroblastomas: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book The Genetic Basis of Human Cancer written by Kenneth W. Kinzler and published by McGraw Hill Professional. This book was released on 2002 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: -- Current coverage of diagnosis and treatment on a wide spectrum of active cancer research.
Download or read book Cancer Genomics written by Daniel A. Morgenstern and published by Elsevier Inc. Chapters. This book was released on 2013-11-21 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastoma is one of the most common childhood tumors and has a remarkably diverse pattern of presentation and clinical behavior. Current management approaches rely on risk stratification using clinical, pathological and, increasingly, genetic factors. This chapter explores the current state of knowledge of the genetic factors behind neuroblastoma and discusses how these may impact on treatment. Both segmental chromosomal abnormalities (including loss of 1p or 11q, or gain of 17q) and changes in individual genes (such as MYCN amplification, mutations in ALK and ATRX) have been implicated in neuroblastoma pathogenesis. Recent whole-genome approaches have identified multiple genetic variants (involving LMO1, BARD1, LIN28B, NBPF23 and others) that may predispose to neuroblastoma, while germline mutations in ALK and PHOX2B are associated with rare familial cases of neuroblastoma. The roles of mRNA gene expression profiling, microRNAs that regulate protein translation from mRNA and epigenetic modifications (such as DNA methylation) in neuroblastoma are also discussed. Incorporation of subsets of these genomic factors into risk stratification will ultimately lead to more personalized treatment for neuroblastoma patients.
Download or read book Neuroblastomas New Insights for the Healthcare Professional 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroblastomas: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroblastomas. The editors have built Neuroblastomas: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroblastomas in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neuroblastomas: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Advances in Neuroblastoma Research written by Audrey E. Evans and published by . This book was released on 1985 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: The search for effective treatment of neuroblastoma has stimulated an enormous increase in research, conducted in order to achieve a better understanding of the cellular and genetic basis of this unique class of tumor in children and adults. Providing a broad and comprehensive examination of recent advances in this field, this volume focuses on basic and clinically-related laboratory research, with a concentration on molecular genetics, cell biology, differentiation and innovative therapies.
