Download or read book Hormones Cognition and Dementia written by Eef Hogervorst and published by Cambridge University Press. This book was released on 2009-09-24 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic and clinical research on sex steroids, ageing, and cognition to integrate existing findings with emerging data.

Download or read book The Effects of Estrogen on Brain Function written by Natalie L. Rasgon and published by JHU Press. This book was released on 2006-05-05 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume reviews current data on the effects of estrogen on the central nervous system, highlighting clinical aspects of this topic. Experts from the fields of psychiatry, pharmacology, neurology, and geriatrics collaborate to clarify the known risks and benefits of hormone therapy and explore questions that remain to be elucidated. Among the topics discussed: " Preclinical data on estrogen's effects on cognitive performance " The short-lived effects of hormone replacement therapy on cognitive function " Structural and functional brain imaging data regarding estrogen's effects on the central nervous system " Preclinical efforts to develop effective NeuroSERMs for the brain " The effects of estrogen on mood Citing the ongoing confusion over the risks and benefits of estrogen therapy, the contributors emphasize the need for additional research on medication, doses, preparations, methods of administration, alternative therapies, and supplements. This volume educates researchers, clinicians, and students on the current knowledge—including the effects of estrogen on mood, cognition, and brain metabolism—and provides guidelines for clinical practice and future research. Contributors: Roberta Diaz Brinton, Ph.D., University of Southern California; Cheri L. Geist, B.A., David Geffen School of Medicine, University of California at Los Angeles; Robert B. Gibbs, Ph.D., University of Pittsburgh School of Pharmacy; Eva Hogervorst, Ph.D., University of Loughborough and University of Oxford; Pauline M. Maki, Ph.D., Neuropsychiatric Institute, University of Illinois–Chicago; Peter J. Schmidt, M.D., National Institute of Mental Health; Daniel H. S. Silverman, M.D., Ph.D., David Geffen School of Medicine, University of California at Los Angeles; Katherine E. Williams, M.D., Stanford University School of Medicine; Kristine Yaffe, M.D., University of California, San Francisco, and San Francisco VA Medical Center; Laurel N. Zappert, B.A., Stanford University School of Medicine; Liqin Zhao, Ph.D., University of Southern California

Download or read book Hormone Replacement Therapy and Cognition written by U. S. Department of Health and Human Services and published by CreateSpace. This book was released on 2013-06-28 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this systematic evidence review, we evaluate data on the use of hormone replacement therapy (HRT) to prevent cognitive decline and dementia in healthy postmenopausal women. Specifically, we reviewed the literature reporting effects of HRT on cognitive function in women without dementia. In addition, we conducted a review and meta-analysis of studies of HRT and dementia, focusing on Alzheimer disease. Results of this review have been recently published. This report is part of a larger project on the risks and benefits of HRT prepared for the U.S. Preventive Services Task Force to assist them in making recommendations. Between 3 and 8 million people in the United States have dementia. The most common type of dementia is Alzheimer disease, which affects 3 to 4 million people and is the fourth leading cause of death in the United States. The incidence of dementia is 1 percent per year in older individuals, although in the most elderly populations this rate may be as high as 2 to 3 percent. One community-based prevalence study in east Boston estimated that almost 50 percent of those aged 85 and over suffered from dementia. Most studies report that after accounting for differences in life expectancy, women have a 1.4 to 3-fold higher risk of Alzheimer disease than men. The life expectancy of demented patients is greatly reduced. Those with early-onset (before age 60) Alzheimer disease have a median survival of 6.7 to 8.1 years, while survival in those with late-onset disease is 4.8 to 6.0 years. In 1991, the annual cost of Alzheimer disease was estimated to be $67.3 billion. Given the expected growth of the elderly population, this financial cost, as well as the emotional and physical costs of caring for demented patients, will continue to increase. Observational data suggest a possible but inconsistent relationship between endogenous estrogen exposure and cognition. Women in the high estrogen phase of the menstrual cycle have been shown to perform better on tests of motor skills compared to when they are in the low estrogen phase of the cycle. Bone mineral density, hypothesized to be a marker of cumulative estrogen exposure, has been correlated with risk of cognitive deterioration. Because of the association between endogenous estrogen exposure and cognition, it can be hypothesized that hormone replacement therapy (HRT) after menopause may prevent cognitive decline and the development of dementia.

Download or read book Hormone Replacement Therapy and Cognition written by Erin LeBlanc and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: CONTEXT: Although postmenopausal hormone replacement (HRT) therapy is widely used, its risks and benefits are not well understood. Some observational data suggest that HRT may reduce the risk of cognitive decline and dementia but results have been conflicting. OBJECTIVE: To review and evaluate studies of HRT for preventing cognitive decline and dementia in healthy postmenopausal women. DATA SOURCES: Studies with English-language abstracts identified in MEDLINE (1966-December 2000), HealthSTAR (1975-December 2000), PsychINFO (1984-December 2000); Cochrane Library databases; and articles listed in reference lists of key articles. STUDY SELECTION: Randomized controlled trials and cohort studies were reviewed for the effects of HRT on cognitive decline; cohort and case-control studies were reviewed for dementia risk. No randomized controlled trials regarding dementia risk were identified. DATA EXTRACTION: Twenty-nine studies met inclusion criteria and were rated. Two reviewers rated study quality independently and 100% agreement was reached on Jadad scores and 80% agreement was reached on U.S. Preventive Services Task Force quality scores. A final score was reached through consensus if reviewers disagreed. DATA SYNTHESIS: Studies of cognition were not combined quantitatively because of heterogeneous study design. Women symptomatic from menopause had improvements in verbal memory, vigilance, reasoning, and motor speed, but no enhancement of other cognitive functions. Generally, no benefits were observed in asymptomatic women. A Bayesian meta-analysis of 12 observational studies suggested that HRT was associated with a decreased risk of dementia (summary odds ratio, 0.66; 95% confidence interval, 0.53-0.82). However, possible biases and lack of control for potential confounders limit interpretation of these studies. Eight studies received a poor quality rating, 3 fair, and 1 good. Studies did not contain enough information to assess adequately the effects of progestin use, various estrogen preparations or doses, or duration of therapy. CONCLUSIONS: In women with menopausal symptoms, HRT may have specific cognitive effects, and future studies should target these effects. The meta-analysis found a decreased risk of dementia in HRT users but most studies had important methodological limitations.

Download or read book Cognitive Performance and Menopause written by Paula Alhola and published by . This book was released on 2007 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cognitive Status During Hormone Replacement Therapy written by James Timothy Poysky and published by . This book was released on 2001 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hormone Therapy and the Brain written by Victor W. Henderson and published by CRC Press. This book was released on 1999-10-15 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an acknowledged leader in the field, this is a vital clinical reference on the influence of estrogen replacement therapy on Alzheimer's disease, visual dementia, stroke, disorders of movement, epilepsy, migraine headache, and multiple sclerosis. It opens with introductory information and an overview of estrogen and the brain and with coverage of the mechanisms of estrogen action on the brain and the neuroprotective effects of estrogen. Two sections cover the effects of estrogen replacement therapy on mood behavior and cognition and a major section focuses on Alzheimer's disease and other dementias. Another key section covers other neurological disorders, including stroke prevention after menopause, stroke protection in men, neuroprotection after stroke, movement disorders, epilepsy, migraine headache, and multiple sclerosis. Includes color illustrations, bibliographic references and index.

Download or read book Hormone Replacement Therapy and Cognition written by and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Menopause and Hormone Replacement written by Hilary O. D. Critchley and published by . This book was released on 2004 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of Hormone Replacement Therapy in Preventing Cognitive Decline in Healthy Postmenopausal Women written by Grace J. Lee and published by . This book was released on 2009 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract Hormone replacement therapy (HRT) may protect postmenopausal women from cognitive decline. The effect of HRT on the relative decline in cognitive functioning of postmenopausal women across time was examined in 104 participants (35 HRT users, 15 HRT non-users, and 54 males) who completed neuropsychological evaluations at baseline and follow-up. On language scores, HRT users demonstrated more improvement over time than did men, whereas HRT non-users performed similar to men. Additionally, more years of HRT use was associated with more improvement in HRT users' delayed verbal memory scores between baseline and follow-up, r(28) = .34,p

Download or read book Hormone Replacement Therapy and Cognition written by Erin S. LeBlanc and published by . This book was released on 2000 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hormone Replacement Therapy and The Brain written by A.R. Genazzani and published by CRC Press. This book was released on 2003-09-10 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been increased interest in the possibility that hormone replacement therapy may have a significant impact on neurological function in the aging female. It has been hypothesized that estrogens may even have a protective role in the onset of Alzheimer's or other dementias. This volume draws together leading experts to review the existing scientific data and present a consensus view that will be a practical aid to clinicians. The book offers a state-of-the-art summary of current knowledge that gives readers a better understanding of the potential benefits of hormone therapy when treating Alzheimer's and other dementias.

Download or read book Normal Human Aging written by and published by . This book was released on 1984 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Hormone Replacement Therapy on Mood and Cognition in Healthy Postmenopausal Women written by Candace Michelle Genest and published by . This book was released on 2007 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Research on the Menopause in the 1990s written by and published by . This book was released on 1996 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report reviews current research on the menopause, including studies on its symptons and their treatment, and its effects on the cardiovascular and skeletal systems. It also assesses the relevance of existing data to women in developing countries.

Download or read book Treatment of the Postmenopausal Woman written by Rogerio A. Lobo and published by Elsevier. This book was released on 2007-06-05 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt: For anyone who treats postmenopausal women, this latest edition of Rogerio Lobo's classic work combines the best from two well-known references: Menopause, and the second edition of Treatment of the Postmenopausal Woman. By adding significant discussions of the basic science behind menopause, it is possible to objectively assess the clinical value and limitations of current approaches to treatment and provide a basis and rationale for strategies that will result in better individualized and specialized care. Not only does the third edition discuss diagnosis and treatment of menopause but it covers biological, anatomical, physiological, pathobiological, and pharmacological aspects as well bringing together, in one source, all of the information needed to understand and treat postmenopausal conditions. Over 50% new material representing the vast amount of information available since the Women's Health Initiative (WHI) clinical trials were completed making this the most up-to-date reference on postmenopausal women Includes several new sections on comparisons between clinical trials and observational data, urology, and pelvic support Each section is preceded by a preface to put the area into context with many chapters having suggested treatment regimens

Download or read book Focus on Hormone Replacement Research written by Marcus I. Portallis and published by Nova Publishers. This book was released on 2004 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormone replacement therapy is now simply called hormone replacement because of research discoveries identifying possible severe risks associated with this treatment which was very favourably viewed earlier. Now the lowest effective dose and the shortest duration of treatment acceptable is advised. This new book presents state-of-the-art research from around the world in HR and its relation to endometrial cancer, cardiovascular disease, Alzheimer's disease, schizophrenia, mood and anxiety disorders, Parkinson's disease, Huntington's disease and bone mass.